Virtual Learning Environment (VLE) in higher learning institutions presents a podium for academic material accessibility that entails creation, evaluation, communication and general course administration with customizable interfaces. Virtual learning environments are online based platforms which are used to ease the student’s course content access and improving learning ability. Virtual learning environments bear features such as collaborative tools, embedded external recourses, detailed reporting logs, roles and permissions and calendars. However without finding out the factors for the low adoption rates, the effort to implement VLE remains in question. This paper discovers the factors that have brought about the low adoption rates of VLE in higher learning institution. The study adopted both qualitative and quantitative case study research approach and a purposive (non-probability) sampling technique where both staff and student respondents were selected from the case study institutions. A survey questionnaire was administered to 22 staff members and 305 students making a total of 327 respondents using Chris Morgan (1999) formula for sample determination. The results indicated power fluctuations, poor internet connections, and luck of management support, slow computers, and skills to access the VLE platforms as the major factors. The research suggests that, institutional readiness assessment, Virtual learning environments implementation framework, implementation policy formulation, training of trainers and improving the infrastructure should be given a high priority if VLE are to be successfully implemented in higher learning institutions.

We had investigated the xanthine oxidase inhibitory activity and uric acid lowering effect of newly marketed xanthine oxidase inhibitor, febuxostat and compared its effect with allopurinol in vitro. In hyperuricemic animal model serum uric acid, lowering effect of these drugs was evaluated. Serial dilutions of febuxostat and allopurinol were made, ranging from100 µg/ml to 0.75µg/ml. Xanthine oxidase inhibition was carried out in vitro. Hyperuricemia was induced in Wistar rats by potassium oxonate injection on day 1, 3 and 7. Febuxostat and allopurinol (5mg/kg) once daily was given for 7 days. Serum uric acid was measured on day zero, 1, 3 and 7 by uricase method. Michaelis Menten equation was applied to calculate IC50, Vmax and Km. IC50 of allopurinol and febuxostat were 9.07 and 8.77 µg/ml respectively. Km and Vmax of febuxostat were 8.89 and 107.13 where as allopurinol showed Km 7.77 and Vmax 194.14.Graded dose response was observed for both allopurinol and febuxostat. Hyperuricemia was successfully induced with potassium oxonate. Treatment with allopurinol reduced serum uric acid levels up to 3.21±0.8mg/dl on day 7, but reduction was less than febuxostat 0.81 ± 0.12 mg/dl. From this study, we have concluded that febuxostat is an effective option for cases of hyperuricemia.

Higher education is not a form of cost but is one form of investment. This form of return can be in the form of a high bargaining value when the relevant person gets a job offer. Higher education not only has economic value in individuals, but in society One of the economic values of higher education is the existence of employment opportunities for the community when higher education is held in a location where economic value can be in the form of employee recruitment or the opening of new jobs in the informal sector for the surrounding community. The challenge for the education sector is to develop educational systems capable of improving basic education equity, education quality and relevance of education to development needs, as well as science and technology education. Because everything that has been proven to have direct and indirect impact on economic growth of the Indonesia Economic.This study uses a qualitative approach with study methods case. The data analyzed is the result of interviews with the field of service and direct observation in the field of services and general fields, and review documents at Private Universities in Surabaya

The aim of the present study was to increase the solubility and thereby improve the oral bioavailability of Furosemide by incorporating the drug in nanostructured lipid carriers (NLC) and in solid lipid nanoparticle (SLN) and also to compare the efficiency of NLC over SLN. Both the NLC and SLN were prepared by solvent diffusion method using labrafil m 2130 as solid lipid, capryol pgmc as liquid lipid, and tween 80 as surfactant. Properties of Furosemide loaded NLCs & SLNs such as drug content, entrapment efficiency, loading capacity, particle size, PDI , zeta potential, morphology, storage stability, in vitro drug release and mechanism of drug release were investigated and compared. Drug content, entrapment efficiency, loading capacity, average particle size, PDI and zeta potential of Furosemide NLC were found to 83.56%, 75.50%, 25.63%, 99.24nm, 0.302 and -31.2mV and that of Furosemide SLN were found to 84.55%, 71.07%, 24.62%, 193.4nm, 0.835 and -36.1mV respectively. Morphology study by scanning electron microscopy (SEM) analysis showed spherical particles with smooth surfaces. As compared to in-vitro drug release of Furosemide pure drug, both the NLC and SLN showed fast initial release followed by a sustained release, best fitted to Higuchi equation. Pure drug followed Zero order release kinetics. Furosemide NLC showed higher entrapment efficiency, drug loading capacity, in-vitro drug release, reduced the drug expulsion in storage when compared to SLN. This investigation demonstrated the efficiency of NLC over SLN for improved oral bioavailability of Furosemide and it was deduced that the liquid lipid (capryol pgmc)was the principal formulation factor responsible for the improvement in characteristics and pharmacokinetics of NLCs.

This study was designed to investigate the influence of Postate cancer awareness campaigns on the knowledge, attitude and practices of men in SouthEastern Nigeria. The study employed the survey method of enquiry. The population of the study is 8,184,951 adult males in South-Eastern Nigeria. Five research questions guided the study. The data was analysed using Statistical Package for Social Science (SPSS). The result of the data analysed revealed that the awareness and knowledge level on postate cancer is relatively low among the men in South-Eastern Nigeria. Also, most information on postate cancer were made known to the respondents by medical practitioners, however, those respondents that are exposed to the campaigns agreed that the campaigns have influenced their behavior positively. The study recommends that, awareness campaigns should be well structured both in English and the target audience local language to sufficiently and effectively convey the Prostate cancer campaign messages. Thus, the risks and the effects of the negative attitudes of men towards this campaigns must obviously be stated citing relevant examples. Also, campaign planners should involve the target audience/opinion leaders as participants in the campaign and too, lower the age for screening, so that early detection and prevention can be detected before it becomes late. There must always be emotional, physical and psychological appeal in the campaign messages.

А device for the isolation of nucleotide complex from biomass of Saccharomyces cerevisiae cells was developed, and the biological active substances in the extract were analyzed. The isolated nucleotide preparation can be used to stop oxidative stress and improve immunity. The developed device allows extraction of biologically active substances from Saccharomyces cerevisiae cells in series by extractants: distilled water under the action of an alternating voltage with a frequency of 105 Hz, a solution of hydrochloric acid with pH = 1.0-1.5 without using voltage. After acid extraction, the extract was neutralized with sodium hydroxide solution. The extracts obtained were combined and dried. The technical result of the device is a more complete two-fold extraction of the nucleotide complex from native Saccharomyces cerevisiae biomass. The use of our constructed device makes extraction of biologically active substances easier and complete. The content of biologically active substances, such as adenine nucleotides, amino acids, vitamins, micro-, macro- elements in the obtained extract was analyzed. A comparison of the activating effect of the isolated nucleotide preparation on Ca2+-dependent NO - synthase with T-activin was performed. Experiments showed that the nucleotide preparation, obtained by new device has a pronounced activating effect on Ca2+ -dependent NOS from rat thymocytes.

This study aims to analyze the behavior of the use of Information Systems in registered taxpayers at the Palembang Middle Tax Service Office through the Unified Theory of Acceptance and Use of Technology. Specifically the purpose of this study was to examine trust in government, hedonic motivation, and social influence on the Behavior Intention and User Behavior of e-faktur and test Behavior Intentions towards User Behavior of e-faktur. This research is Quantitative Descriptive Research. The sampling method is proportional stratified random sampling method. The number of samples was 282 respondents are director and accounting major in company who registered in Middle Tax Service Office Palembang. The method in this study is statistics using SmartPLS 3.0. The results of this study indicate that trust in government has a significant effect on Behavior Intention whereas behavior does not have an effect as well as Hedonic Motivation which has a significant positive effect on behavioral intentions while behavior does not affect. Social Influence does not have a significant effect on the Behavior Intention and User Behavior of e-faktur. As well as Variable Intentions of Behavior towards User Behavior e-faktur has a significant effect. In the next study we suggested adding gender, age, experience and voluntary variables.

Multiple sclerosis (MS) is an important cause of neurological disability. Familial MS is uncommon in India and is seen mostly in the high prevalence countries like United States of America, Canada and New Zealand. In the present paper, two members of the same family were diagnosed as having MS. As the disease is uncommon, there was initial diagnostic difficulty in the first case. The clinical and radiological findings are described with a note on the treatment and follow up.

Poverty is a serious issue which is faced by masses around the world. This study aims to determine whether the microfinance institutions established for the purpose of reduction of poverty have been successful in achieving their objective or not. Primary data was collected for the proposed research study through structured questionnaires. In order to analyze the collected data multiple liner regression and paired t-test were applied. Outcomes illustration that microfinance has a durable positive effect on children education and enterprise financial performance. Though, there is varied indication found on food security, household expenses and household assets. No effect has been detected on housing and income smoothening of enterprise. Among other independent variables, it was exposed that number of salaried persons was originate to be very important variable contributing to the wellbeing of the microfinance clients

Diabetes is a chronic condition that occurs extremely due to a combination of sedentary lifestyle and following an imbalanced diet. Thus the medications are to be taken for life time. So there is a need for the prescribers to prescribe the medication which would be cost effective to the patients. This study was planned to analyse cost variations of antidiabetic drugs available in Indian market. There is a wide range of variations as the price of drug marketing in India. This paper gives the information regarding the drugs available for diabetes, their available brands, average cost and cost variations. Which help the physician in giving the drugs to the respective patient which are effective to them as well as which are cost efficient and are afforded easily by the patient. As a result of which there will less medication non-adherence and increased patient compliance. It was conducted by taking the maximum and minimum cost of anti- diabetic agents manufactured by different brands of same drug, strength and dosage forms. The data is obtained from the current index of medical specialties [CIMS] April-July 2018. The cost ratio and percentage cost variations were calculated for each anti-diabetic drug. The average percentage price variation of different brands of the same oral anti-diabetic drugs in Indian market is very wide.

China’s foreign exchange reserves kept growing quickly for a decade; however, they have decreased since 2014. The paper aims to test for a break date probably existing on the trend function of foreign exchange reserve series. Monthly series covered the period from January 2000 to March 2018. A standard ADF unit root test, an ERS DF-GLS test along with the modified AIC, and an MZα test along with GLS detrending were conducted. Structural shift tests were the Perron test (in a mixed IO Model C and Model A or crash model), and the Zivot-Andrews test (in a mixed IO Model C and Model A). Empirical analyses show that at least two unit roots exist in the variable, implying a robust long memory. A break point took place most likely in January 2014. US exit out of quantitative easing (QE) and federal funds interest rate hikes may be (at least partially) attributable to the shift.

Smooth and complication free postoperative period is always desired after completion of surgery in every case but it becomes more important in case in ceaserean section as patient has to start nurture newborn immediately. All the techniques for multimodal analgesia have some or other side effects and thus they have to be used very cautiously in postoperative ceaserean section patient as they can adversely affect health of the baby also. Local infiltration of ropivacaine is effective analgesic and wit lesser side effects than pharmacological drugs. Our hypothesis is that local ropivacaine infiltration reduces postoperative pain in patients undergoing ceaserean section. This randomized control study was conducted on 60 patients of ASA grade 1 and 2 after taking ethics committee approval. Group I (n=30) is control group with no local infiltration and Group II (n=30) local infiltration of 20 ml Inj. Ropivacaine 0.2% at incision site. Diastolic, systolic and mean blood pressure, heart rate were measured throughout the procedure. Time of rescue analgesia and VAS score was recorded postoperatively. local infiltration of 0.2% ropivacaine provides postoperative analgesia. Mean duration of rescue analgesia in group I was 115.67±4.09 that was significant (p<0.05) in comparison to group II 147.17±4.67. local infiltration of 0.2% ropivacaine reduces postoperative pain in patients of ceaserean section under spinal anaesthesia.

This paper examined the effect of pension industry investment on financial intermediation in Nigeria. The study used Ex-post facto research design. Its specific objectives were to examine the effect of Pension fund investment in Federal government bonds, Pension fund investment in State government bonds and Pension fund investment in Private sector bonds on financial intermediation in Nigeria. Ordinary Least Square regression was used as analysis technique. It was found that Pension fund investment in Federal government bonds has positive and no significant effect on financial intermediation in Nigeria; Pension fund investment in State government bonds has negative and no significant effect on financial intermediation in Nigeria; and Pension fund investment in Private sector bonds has positive and no significant effect on financial intermediation in Nigeria. This implies that a unit change in pension fund investment do not lead to significant increase in financial intermediation. Based on the findings of the study it was concluded that pension industry investments have insignificant effect on depth and liquidity of financial intermediation in Nigeria. It was recommended that the pension industry should spread its investments beyond financial instruments in order to widen its investments portfolio and aid a larger sphere of the economy with its intermediation.

Vernal keratoconjunctivitis (VKC) is an unusually severe allergic eye disease, occurring mainly in children. Giant papillae are frequently observed on the upper tarsal conjunctiva and expose, sometimes, to severe corneal complications, involving the visual prognosis. Other allergic states, conjunctival staphylococcus aerus and worm intestinal infection, were frequently associated with VKC. We report the case of a 9-year-old girl followed for five years for severe vernal keratoconjunctivitis resistant to treatment with topical corticosteroid. In front of, the high ASLO title, the isolation of pyogenic streptococcus in the throat swab culture, and the presence of a chronic pansinusitis, the diagnosis of a post-streptococcal syndrome was retained. The patient is treated with protected amoxicillin for 12 days. The evolution was spectacular with almost total disappearance of the giant papillae without any recurrence, after 6 months of follow-up. In our knowledge, this case is the first case of vernal keratoconjunctivitis with giant papillae reported as being a post-streptococcal immune complication. Ophthalmologists, confronted to vernal keratoconjunctivitis, should consider post-streptococcal syndrome as a possible cause. The search for an increasing title of ASLO and streptococcal infectious evidence can establishes the association.

It has been observed in the recent time that the bulk of studies on foreign capital flows in Nigeria focused on aggregate economic performance, neglecting the performance of industrial sub-sector. In order to move the frontiers of knowledge in this regard, the paper critically examined the relationship between international capital flows and industrial performance in Nigeria using Cointegration, DOLS and Granger Causality Approach. The study extracted data from CBN Statistical Bulletin and UNCTAD investment report from 1990-2015. Consequently, in order to address the objective of this study necessary diagnostic tests such as unit roots, co-integration and Pairwise Granger Causality Tests were estimated. The findings that emerged from this paper is as follows: long-run effect shows that foreign direct investment and external debt have a significant positive relationship with industrial performance in Nigeria. However, the remittances though have a positive relationship with industrial performance in Nigeria, but are not significant. Also, there is a unidirectional causality which runs from industrial performance to FDI inflows in Nigeria. Hence, this paper recommends that Nigerian government should see inflows of foreign capital as a viable catalyst that has the capacity to propel the expansion of the country`s industrial sector, and the policy makers in the country should embark on policy measures that will ensure the sustainability of foreign direct investment inflows and external debt towards the direction of industrial sectors in Nigeria. In the same vein, larger percentage of remittances should be tailored towards industrial sector in the country. If foreign capital flows is sustained there will be industrial revolution in the economy in the nearest future.