Background: Children with ß-thalassemia major are at higher risk for myocardial dysfunction that adversely affects their quality of life. Cardiac biomarkers are valuable tool for assessment of such children. Our aim was to assess heart fatty acid-binding protein (H-FABP) versus B-type natriuretic peptide (BNP) in thalassemia patients as biomarkers of myocardial dysfunction. Methods: This controlled study involved 35 children with ß-thalassemia major and 35 healthy children. Clinical assessment, echocardiography, serum ferritin, BNP and H-FABP were done. Results: H-FABP and BNP were higher in thalassemia than healthy children. Left ventricular dimension and pulmonary pressure were significantly higher and ejection fraction was significantly lower in thalassemia patients. H-FABP has positive correlation with BNP, left ventricular dimension, pulmonary pressure, serum ferritin and the duration of blood transfusion. Conclusion: Elevated H-FABP is associated with myocardial dysfunction in otherwise asymptomatic thalassemia patients.

The damage caused by the lupus nephritis to the patient's kidney was very little studied for treatment module; however, we have the understanding the disease involving in the kidneys by an immune complex glomerulonephritis. Human genomics have been decoded since 2004, it should give clinical scientists and medical doctors a new scenery to develop some new treatment modules to cure these kinds of patients. Here we used a group of genomic data from lupus nephritis to combine the modern medicine knowledge and Traditional Chinese Medicine (TCM) so that an integration module will be subject to the clinical field. The integration model is primarily relied on a comprehensive regulation mechanism of system biology including network, topology and gene-drug interaction database. In this manual we first study the role using genomic expression signature from several databases of clinical lupus nephritis, and then we combine current medications with their immune suppress treatment and TCM with their theory and medication in order that the integration model was eventually established. In near future, we will extend a second-generation model based on the module by using a set of clinical genomic data from different patients such as individual patient genomic data, each patient symptom, laboratory results.

Cancer treatment suffers with the failure of chemotherapeutic agents because of multi drug resistance. Investigation of new molecules involves huge expenditure and time. Present investigation aims at the dual loading of anticancer agent Imatinib Mesylate along with Piperine on to bovine serum albumin nanoparticles in order to overcome multi drug resistance and to achieve the maximum therapeutic effect. Desolvation method with the addition of acetone is used to prepare the nanoparticles. Drugs and polymer are subjected to differential scanning calorimetry. Nanoparticles are evaluated for encapsulation efficiency, particle size, zeta potential and drug release studies. In-vitro anticancer activity of the nanoparticles against Human Glioblastoma Multiforme (GBM) cell line T98G is determined. Results indicated compatibility in DSC, an encapsulation efficiency of 52.456%-88.254%, particle size of 208.3nm -497.3nm, zetapotential of -16.5mV to -63.2mV and drug release of 86.256% to 94.56% in 24H. In in-vitro anticancer activity % of cell death is 68.257% to 79.658%. Results suggest increased anticancer activity with the nanoparticles dual loaded with Imatinib mesylate and Piperine.

One effort to improve competence and provide opportunities to develop employees is to provide a competitive remuneration package. The purpose of this study is to understand and uncover the behavior of Seafarers in shipping companies. Seafarers who take over professions. The approach of this research is qualitative methods, with the model of the fenomological approach (Alfraed Schutz), religious phenomenology, conventional (Bogdan Biken) and IFIAS which see social behavior as behavior oriented to the past, present and future of someone who has switched professions. The results of this study show about seaman behavior. 1. Behavior change is formed by predisposing factors, enabling factors, driving factors and information factors, 2. Transfer of aspirational professions and religiosity in pursuing life as a form of career and professional motivation, 3. For seafarers age is a very strategic consideration, where in his life he has left all the life of his social interaction in the general public, 4. The profession has experienced the initial conditions of a high tension of life caused by desire and anxiety, 5. Transfer of the profession done by someone due to a different social status with others

Much research has concentrated on the seed extracts of Piper guineense and not on the leaves which are widely consumed and hence this study. Fifteen male wistar rats weighing 150-250g were randomly divided into control, low dose (LD) and high dose (HD) groups of five rats each. LD and HD groups received 250mg/kg and 350mg/kg b.w. respectively of aqueous leaf extract of Piper guineense by gavaging. Duration of feeding was thirty days. The results showed significant increases (p<0.001) in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in both LD and HD groups compared with control. Serum total cholesterol (TC) was significantly (p<0.001) increased in both LD and HD groups compared with control. Serum triglyceride (TG) was significantly increased in HD group compared with control (P < 0.001) and LD (P<0.001) groups. High density lipoprotein (HDL-c) was significantly increased (p<0.001) in LD compared with control and decreased (p<0.001) in HD compared with control and LD groups. Low density lipoprotein (LDL-c) was significantly increased in LD (p<0.001) and HD (p<0.01) compared with control and decreased in HD (p<0.001) compared with LD. TG/HDL-c in the HD group was significantly (p<0.001) increased compared with control and LD groups. Aside RBC count and MCH which were significantly increased (p<0.05) and decreased (p<0.05) respectively in HD compared with LD group, all other haematological parameters (Hb, PCV, MCHC, MCV and WBC and platelet counts) did not differ significantly among the groups. In conclusion, consumption of aqueous leaf extract of Piper guineense causes dyslipidemia and elevation of liver enzymes but no significant effect on hematological indices.

Introduction: Rudimentary horn is a developmental anomaly of the uterus. Pregnancy in a rudimentary horn is rare. The Diagnosis of the rudimentary horn pregnancy is very difficult and needs high index of suspicion. Case: We present a case of pregnancy in a non-communicating rudimentary horn that was difficult to diagnosis in the 1st presentation. The diagnosis was suspected when the case did not respond to the medical termination of pregnancy by misoprostol; and also by mechanical methods. Following that a suspicion of an abnormally located pregnancy was made and confirmed by radiology modalities. Patient had surgical resection of the rudimentary horn. Conclusion: Despite recent advances in ultrasound, the diagnosis of pregnancy in the rudimentary horn remains difficult, and high index of suspicion is needed in these cases.

The profunda femoris artery is very important branch of femoral artery supplying the thigh. One of its important branches is medial circumflex femoral artery. Knowledge about variation in its origin is important for the surgeons and radiologists. The present study was conducted in 50 embalmed cadavers in the department of Anatomy, Stanley Medical College. The medial circumflex femoral arteries were seen originating from profunda femoris artery in 84 %. In 16% medial circumflex femoral arteries were seen originating from the femoral artery at the same level of profunda femoris artery.

This study explored whether there were correlations among internal and external control personality traits, fashion anxiety, online word of mouth, the Bandwagon effect, and consumer involvement. The online questionnaire was adopted in this study, with online consumers who used new shopping websites as sample sources. After deleting invalid questionnaires, there were 265 valid samples. The analysis results show that: (1) Consumers with the fashion anxiety characteristic care more about others and are subject to external influence. Therefore, internal and external control personality traits have a significant positive impact on fashion anxiety; (2) Consumers with external control personality traits are more likely to believe others or the external environment, leading to greater likelihood for the Bandwagon effect to result. Therefore, the internal and external control personality traits produce a positive impact on the Bandwagon effect; (3) Internal and external control personality traits produce a significant positive impact on online word of mouth; (4) Consumer involvement varies with different personality traits. Therefore, internal and external control personality traits produce a significant positive impact on consumer involvement; (5) Consumers with fashion anxiety characteristic are likely to follow others. Therefore, fashion anxiety produces a significant positive impact on the Bandwagon effect; (6) The results on the interaction between consumers’ Bandwagon effect and online word of mouth show that the Bandwagon effect and online word of mouth have a reciprocal effect; (7) Consumer involvement produces a significant positive impact on the Bandwagon effect; (8) compared to consumers with higher involvement, consumers with lower involvement trust online word of mouth more. Therefore, consumer involvement produces a significant positive impact online word of mouth.

This case report describes an unusual morphology of seven root canals in maxillary first molar tooth. The maxillary right first molar of a young male patient was treated endodontically, the second visit, the seven canals (MB1, MB2 and MB3, 2 Palatal and DB1 and DB2) was easily identified at high magnification under an operating microscope. The canals were then instrumented and obturated. It should be acknowledged that all molar teeth have more than the traditionally expected three canals. The location of root canals should be identified at high magnification under the microscope. Careful radiographic re-examination of the fillings should be done in order to identify possibly missed canals.

This research aims to analyze employee performance of rattan industries in Central Sulawesi. This is descriptive quantitative research. The research population were comprised of all employees and owners of rattan-based small- and medium-scale industries (industri kecil dan menengah or IKM) based in the city of Palu and regencies in Central Sulawesi, amounting to 245 people. Its sample size consisted of 152 people. It employed a research variable, which was employee performance that was divided into 4 dimensions: working quality, working quantity, cooperation, and sense of responsibility. Data were analyzed descriptively using the application SPSS. Findings suggest that the majority of the research respondents were male (96.9%) aged 30-40 years (42.0%). In terms of education, most respondents were senior high school graduates (96.71%) and had worked for 1-5 years (53.0%). They generally had never formally attended job training (77.0%). Employee performance based on the dimensions of working quality and sense of responsibility fell into a high category while viewed from the dimensions of working quantity and cooperation, it fell into a moderate category. Based on the findings, it can be concluded that the performance of employees of the rattan industries in Central Sulawesi was high in running a rattan business. However, employees need to strengthen their cooperation in order that their working quantity increases and their working quality improves

This paper focuses on some strategies and procedures that can be used to teach speaking to beginners and intermediate students in Senegal where the majority of the students has not only a lack of opportunities and are seldom exposed to the English language, but also are found to be silent, shy or have a profound fear of being wrong. Since more importance is given to reading and writing skills, communicative activities such as introductions, role plays, use of fables and talking tasks are efficient alternatives to improve students’ oral communication skills in junior and high secondary public schools in Senegal by integrating lessons with the National curriculum for English language. This study also claims that students’ use of mobile phones which is forbidden by the schools legislation is inevitable to improve speaking skills in the process of foreign language learning. It shows that despite resources constraints in many remote areas, it is possible to improve students’ oral communication skills in a relaxed and stress free environment.

Rape violently asserts masculinity in a patriarchal society, which assigns women a subordinate position. The study focuses on nature and consequences of rape victimization, their sufferings under criminal justice system and adaptation problems in society. As descriptive study, content analysis and case studies basic methods were used. About 211 rape cases as secondary data and 23 rape cases as primary data were estimated in 2012. Most of victims were unmarried (age between 16-20) and more become victimized by acquaintance person where anger rape committed most (48.3% from newspapers and 100% from cases studies). Refuse of love was main factor for causing rape. Offender arrested rate was low (20.2%). running of trial process were less (44%). Medical test had completed for maximum cases (90.9%).suffering too much under criminal justice system was responsible for not reporting to police. Shame, fear, helplessness, frozen feelings were active as post traumatic situation. Free movement discards and degradation of quality of life arouse for adjustment problems after victimization. Findings were presented basis on objectives and explained by social structural, cultural, and institutional victimization theory. The study conducted for social awareness and for the improvement of criminal justice system towards rape victims.

Globally, the changing demands of society require that learners be trained with innovation and creativity in mind. The United Nations Sustainable Development Goals (SDG) 2030, specifically SDG4, aim to ensure inclusive and equitable quality education and the promotion of lifelong learning opportunities for all students. The technical model of education has been known to stifle learning opportunities for students and promote inequality. In keeping with the world wide mandate for inclusive education that values that right of all students to meaningful education, what is taught and valued as outcomes for all students is an important consideration of the education system. Curricula should be seen as having a positive effect as levers for the sustainable, inclusive, fair and cohesive development of a country. This position paper focuses on current practice in Trinidad and Tobago‟s school system and describes how it is lacking with regard to the flexibility of the curriculum that is needed for inclusive education implementation. The paper gives a brief overview of the technical and post-modern perspectives of curriculum and aims to justify how a shift to the post-modern perspective might be better suited for our present time. Implications for practice relating to teacher practice, curriculum content and student outcomes, which will all result from increasing the relevance and applicability of our curriculum, are also presented

India is estimated to have the largest numbers of stillbirths globally, and the Indian government has adopted a target of <10 stillbirths per 1,000 births by 2030 through the India Newborn Action Plan (INAP) [1]. This study was conducted to analyze the maternal and fetal etiologies of intrauterine fetal death and to suggest preventive steps. 4800 patients with 25 ante partum deaths (5.20 per 1000 births) were studied in last four years. 56% were unbooked, 80% were illiterate and 60% were from very low socio economic status.16% had pre eclamptic toxemia, 12% had abruption placente, 8% had congenital anomaly in fetus and 4% mothers had anemia. Most of the etiological factors are manageable with regular ante natal care and timely treatment at tertiary care centre

Background: Hemoglobinopathies including Thalassemia with an estimated 10,000 live births each year and Sickle cell disease (SCD) with an estimated 5,200 live births each year, are a major public health problem in India specially in scheduled tribes, who have a high prevalence of socio-economic disadvantage and are frequently medically underserved [1]. In Bastar, the land of tribes as about 70% of population comprises of tribals, which is 26.76% of the total tribal population of Chhattisgarh [2]. Hence this work was an attempt to compare anthropometrically between Sickling and Non-Sickling individuals of tribal population of Bastar Division, Chhattisgarh. Aims & Objectives: To compare anthropometrically between sickling and non-sickling individuals of tribal population of Bastar division, Chhattisgarh. Material and methods: An observational case-control study of 138 sickle cell disease patients with electrophoresis/sickle solubility test positive, aged 5yrs to 30yrs and 138 sickle solubility negative age and sex matched controls was done. Anthropometrical parameters like height, weight, upper and lower limb lengths were statistically compared. Results: In males, in the age group of 5-14yrs, the parameters that were statistically significant were of axial skeleton and limb lengths. This suggests that it is the most vulnerable group. In the age group of 20-30yrs the parameters that were statistically significant were hemoglobin concentration (p<0.0001), weight (p=0.004), maximum calf circumference (p=0.02) and BMI (p=0.02). In females, statistically significant difference for hemoglobin concentration between the cases and controls in all three age groups was seen i.e.,5-14yrs(p=0.05), 15-19yrs(0.001), 20-30yrs (p<0.0001) and in the age group of 15-20yrs, t-test for weight between cases and controls in female group showed significant difference (p= 0.01). Conclusions: From the above results and low SES, it may be stated that the poor growth status of the cases may be due to the SCD and poor socio-economic conditions.