This study involves the use of the histology of the mantle of a periwinkle species, Tympanotonus fuscatus, as a biomarker tool, to investigate and evaluate the ecological pollution status of two different water bodies, Bodo and Creek Road water-sides, in River State. The study involved the sampling of ten (10) feral table sized fish from two stations along the creeks of the experimental sites (Bodo and Creek Road water bodies), with similar specie, size and number from a reference site (ARAC – African Aqua-culture Centre). The test fish mantles were harvested from the fish caught from both experimental sites for histological evaluation, while the control mantles were harvested from fish harvested from ARAC. The percentage prevalence of histological alterations showed that fish from Bodo water-body had the worse outcome (25%), followed by Creek Road water-body (21.7%) and ARAC having the best outcome (6.6%). mantle histology has proven to be an explorable biomarker for evaluation of environmental status.

This study examines biometric identification system as a step towards better crime control in Cameroon, with particular interest to fingerprint biometrics, DNA identification, facial recognition as well as their respective data bases. Cameroon’s biometric identification system is a government initiative aimed at enhancing identity management, security, and access to services through the use of biometric technologies. Fingerprint biometrics, DNA identification and facial recognition technologies are used in Cameroon for crime control. Their respective databases are, however, not well developed but for AFIS (Automated Fingerprint Identification System), adopted by Cameroon government as a centralized biometric identification system for managing and authenticating identity documents. International governance on the use of biometrics for crime control has also provided Cameroon with a framework to incorporate the following in its biometric identification system: human right protection, standardization and best practices, accountability, and cross-border crime and cooperation. Legal and institutional frameworks exist that aid in biometric data collection and storage. While biometric identification systems have significant potential for crime control in Cameroon, their current effectiveness is moderate, hampered by infrastructural, legal, and operational challenges. Strengthening legal frameworks, improving infrastructure, ensuring ethical use, and fostering interagency collaboration are essential steps toward maximizing the benefits of biometric technologies in promoting security and justice.

Background: Numerous secondary metabolites present in plants, such as tannins, terpenoids, alkaloids, flavonoids, and glycosides, have demonstrated antibacterial properties in vitro. Increasing data on the antibacterial properties of medicinal plants are emerging globally. These plants generate secondary metabolites with antibacterial properties, providing an alternative for developing chemical fungicides that are both relatively safe and cost-effective. Coleus aromaticus, a member of the Lamiaceae family, possesses bitter, aromatic, digestive-stimulating, stomachic, anathematic, deodorising, diuretic, and hepatoprotective properties. Aim: The aim of current investigation is to reveal the mechanisms of C.aromaticus leaf bioactive in treating fungal infection. Methodology: Scientific validation of the current investigation was done by computational based molecular docking study of selected lead molecules against 1,3β-Glycan synthase enzyme. Result: The molecular docking results indicating binding energies of -4.02, -6.81,-4.24 and -5.18 kcal/mol for chlorogenic acid, quercetin, rosmarinic acid and rutin respectively. Conclusion: The findings indicated that each selected lead chemical for additional investigation shown significant inhibitory activity against 1,3β-Glycan synthase, hence revealing its anti-fungal potential.

This paper examines Imbolo Mbue’s How Beautiful We Were through the lens of the Integrated Model of Ideological Representation in Discourse (IMIRD) to explore how environmental risk is communicated as a tension between silence and resistance. Developed by Ogungbemi (2016), IMIRD synthesizes the ideological depth of Critical Discourse Analysis (CDA), the structural precision of Systemic Functional Linguistics (SFL), and lexical analysis to investigate how language encodes power, agency, and ideological positioning. Applying this model, the paper analyzes transitivity structures, agency assignment, and discursive silencing in Mbue’s depiction of a fictional African village devastated by corporate oil pollution. Through a close reading of narrative voice, clause structure, and dialogic framing, we demonstrate how Mbue’s linguistic choices—such as collective narration, passive constructions, and high-transitivity clauses—represent the villagers’ oscillation between voicelessness and defiant resistance. The study reveals how narrative grammar functions as a site of ideological struggle: one where corporate actors are obscured or backgrounded, while subaltern voices struggle for recognition. Ultimately, we argue that How Beautiful We Were is not only a literary account of environmental injustice but also a compelling discourse of resistance, showing how storytelling—when examined through IMIRD—operates as a vehicle for reclaiming agency, memory, and ecological justice.

To determine if targeted exercise could reduce overweight and obesity in schoolchildren, a 12-week study was conducted with 60 randomly assigned participants. One group (n=30) received an enhanced exercise intervention, consisting of two extra athletic training sessions per week in addition to their regular physical education. The control group (n=30) continued with the standard curriculum and twice-weekly physical education. Key measurements, including height, weight, waist circumference, body fat, and BMI, were taken as outcome measures. After 12 weeks, the exercise group showed significant improvements in all measured outcomes (p<0.05), indicating the program's success in combating overweight and obesity.

Background: Interactive teaching strategies have been shown to enhance student engagement and learning outcomes in medical education. However, the extent to which first-year medical students in Bangladesh perceive interactivity in lectures remains unclear. This study aimed to assess students’ perceptions of interactivity in General Embryology lecture classes. Objectives: To analyze the perceptions of Bangladeshi medical undergraduates regarding interactivity in the General Embryology lecture classes Methods: In this study two surveys were conducted on 232 undergraduates of two medical colleges of Bangladesh using a questionnaire designed by the researcher to analyze the perceptions of the undergraduates regarding how the lecturers try to make their General Embryology lectures ‘understandable and interesting’. Results: The survey results regarding the perceptions and views of the medical undergraduates show that out of the 55 questions regarding interactivity, the Embryology lectures scored three (3) or more out of four (4) in case of only two (2) of the questions. Two (2) or more was obtained in case of eighteen (18) questions only. Conclusions: These results broadly suggest lower levels of interactivity regarding General Embryology lecture classes in the eyes of Bangladeshi medical undergraduates.

Aim: To evaluate the role of the Neutrophil-to-Lymphocyte Ratio (NLR) as a biomarker for predicting acute exacerbations in COPD (AECOPD) based on current literature. Background: Chronic obstructive pulmonary disease (COPD) is one of the leading cause of morbidity and mortality worldwide. Acute exacerbations (AECOPD) have led to a major impact on patient health, which in turn lead to hospitalizations and also an increased risk to disease burden. Thus in order to optimize treatment stratergies, one have to identify those reliable biomarkers that help predict exacerbations. The neutrophil-to-lymphocyte ratio (NLR) has been a potential indicator to assess inflammation in COPD patients [1-6]. Review Results: This review critically examines six key studies on NLR and COPD exacerbations, assessing both its clinical utility as well as its limitations. Several studies have found a link between higher NLR and an increased risk of COPD exacerbations. However, changes in cutoff values, study designs and confounding factors like corticosteroid use may have an impact on prediction accuracy [1-6]. Conclusion: The NLR is a promising biomarker for determining AECOPD risk. However, consistent cutoff values and multi marker techniques are necessary for clinical use.

Artificial intelligence (AI) has significantly impacted dentistry by enhancing diagnostic accuracy, treatment planning, and patient care across various specialties, including endodontics, radiology, and periodontology. This review synthesizes findings from five key studies examining AI applications in dentistry, focusing on convolutional neural networks (CNNs) and deep learning models.AI-assisted diagnostics have shown superior accuracy compared to traditional methods, with CNNs achieving up to 94% accuracy in detecting periapical lesions and surpassing human radiologists in specific diagnostic tasks. Additionally, AI-assisted caries detection improves tooth retention and reduces treatment costs, demonstrating its potential economic benefits. However, challenges such as data biases, ethical considerations, and regulatory barriers remain future research should focus on developing transparent AI models, standardizing datasets, and addressing cost-effectiveness concerns to enhance clinical integration. Methods: A comprehensive review of five peer-reviewed articles was conducted, highlighting AI applications in dentistry. The articles were selected based on relevance to diagnostic advancements, clinical decision-making, and patient outcomes. Key methodologies included CNN-based image analysis, deep learning applications for caries detection, and neural networks for treatment optimization. Results: AI applications in dentistry demonstrated superior diagnostic performance. CNNs achieved 94% accuracy in detecting periapical lesions and surpassed human radiologists in specific diagnostic tasks. AI-assisted caries detection improved tooth retention by 62.8 years on average, with cost savings of €378 per patient compared to traditional methods. In endodontics, AI accurately identified root fractures and predicted treatment outcomes with up to 95.6% accuracy. Despite these advancements, limitations such as data biases and interpretability of AI models were noted. Conclusion: AI holds transformative potential for modern dentistry by improving diagnostic precision and clinical efficiency. However, integrating AI into routine practice requires addressing data standardization, ethical frameworks, and regulatory barriers. Future research should focus on developing transparent AI models and exploring their cost-effectiveness and long-term impact on patient care.

Against the backdrop of national policies advocating for the integration of ideological and political education into college courses and the strengthening of Chinese cultural dissemination globally, this paper aims to explore effective strategies for incorporating the narration of China’s stories into the College English curriculum. Focusing on North China Electric Power University (Baoding), the study employs a combination of teaching practice and a questionnaire to investigate the current status, pathways, and methods of integrating China’s stories in College English instruction. The research findings reveal that the integration of China’s stories in class teaching enhances students’ cross-cultural communication abilities and deepens their understanding of Chinese culture. The study highlights the feasibility of merging language learning with cultural narrative and calls for expanded extracurricular practice and long-term impact research. These findings offer practical insights for college English curriculum innovation and cultural soft power enhancement.

Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon benign lesion of the nasal cavity and paranasal sinuses with an unclear etiology. Although rare, REAH should be considered in the differential diagnosis of nasal lesions. Limited but complete surgical resection is the treatment of choice. We present a 54-year-old male patient with REAH in the left nasal cavity, with differential diagnoses including antrochoanal polyp and inverted papilloma.

Coeliac disease (CD) is an immune mediated enteropathy caused by the ingestion of gluten in genetically predisposed individuals. It is frequently associated with wide spectrum of extra-intestinal manifestations, including thromboembolism events. We report the case of a young woman known with a CD since the age of 6, who says to be compliant to the gluten free diet (GFD), and presented with bloating and anemic syndrome. The endoscopic and anathomopathological examinations revealed no abnormalities. The CT scan revealed incidentally a chronic obstruction of the inferior vena cava (IVC). the etiological work-up for thromboembolic disease was negative, concluding to a Budd-Chiari syndrome complicating her CD. She was managed with anticoagulants, specifically Direct oral anticoagulants (DOACs).

Cubosomes, lipid-based nanoparticles characterized by a bicontinuous cubic phase structure, show significant promise as drug delivery systems (DDS) due to their stability, enhanced bioavailability, and targeted delivery capabilities. This review examines the development, structural features, and drug release mechanisms of cubosomes, including diffusion-controlled, stimuli-responsive, and targeted release strategies. Applications in oncology, infectious diseases, and anti-inflammatory therapies highlight their improved therapeutic efficacy and minimized systemic side effects. Challenges related to large-scale manufacturing, particle stability, and regulatory compliance are addressed, along with potential solutions and emerging trends. The review emphasizes the potential of cubosomes in precision medicine and personalizing treatment plans, encouraging further research to meet unmet clinical needs.

In view of the considerable importance of thiadiazoles and thiazolidinones, which are the core structures in a variety of pharmaceuticals with a broad spectrum of biological activity. Synthesis of series of potential biological active 1, 3, 4 thiadiazole linked 4 thiazolidinone derivatives were obtained via a multistep synthesis sequence with a simple and convenient approach by using substituted benzoic acids, which are expected to possess enhanced antioxidant activity based on the literature survey reports. In the present study the initial compound, 5-phenyl-1, 3, 4-thiadiazol-2-amine was treated with different substituted aromatic aldehydes to produce Schiff base. The resulting Schiff base were subjected to addition reactions with thioglycolic acid to form title compounds of 2-phenyl-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one. The structure of the synthesized compounds was characterised by FT-IR, H1NMR and mass spectral analysis. The synthesized compounds were tested for antioxidant activities with standard drug using DPPH method. The results of this study revealed that, among the compound tested for antioxidant activity, TZD 5 and TZD 3 exhibited promising antioxidant activity with the IC50 value 27.50µM and 28.00µM while the value of reference compound, ascorbic acid 29.2µM. The antioxidant screening results indicate that exciting DPPH radical scavenging activity was observed in compounds (TZD 3 and TZD 5) in comparison with standard ascorbic acid. These results may also provide some significance guidance for the development of new class antioxidant.

Schwannoma is a benign peripheral nerve sheath tumor originating from Schwann cells. Its occurrence in the tongue is rare. We report the case of a 19-year-old patient presenting with a painless, slowly enlarging mass on the mobile portion of the tongue. MRI revealed a well-defined, encapsulated lesion. The mass was completely excised surgically, and histopathological examination confirmed the diagnosis of a benign schwannoma. The postoperative course was uneventful, with no recurrence observed during follow-up.

Bone marrow invasion in pediatric solid tumors is an essential area of research, as it has a significant impact on prognosis and treatment strategies. Bone marrow metastases occur when non-hematopoietic malignant cells infiltrate the bone marrow, often leading to severe hematological disorders and high mortality rates if not identified early. The mechanisms of bone marrow invasion involve tumor cells escaping into the bone marrow, forming micrometastases which can then take on aggressive forms. Bilateral bone marrow aspirates and trephine biopsies (BMAT) are essential for accurate classification, as discrepancies in results can occur. In addition to their progressive nature, pediatric solid tumors are characterized by a high metastatic potential, particularly in the bone marrow. This retrospective study analyzes a series of 52 cases of solid tumors with bone marrow invasion, diagnosed in the hematology laboratory and pediatric hemato-oncology unit (UHOP) of the Hassan II University Hospital in Fez over a six-year period, from January 2016 to December2022. Evaluation of bone marrow involvement is a key factor in therapeutic orientation and assessment of response to treatment. The presence of bone marrow metastases is associated with a poor prognosis. The haematology-biology laboratory plays an essential role in detecting extra-haematopoietic cells suggestive of bone marrow metastases, over and above standard tests. Despite advances in our understanding of spinal cord metastases, challenges remain in early detection and effective treatment, necessitating ongoing research to improve outcomes for affected children. In this article, we review the epidemiology, molecular mechanisms, clinical diagnosis, treatment and prognosis of bone marrow invasion in solid tumors in the pediatric population.