Background: The congenital bleeding disorders haemophilia A and B are estimated to affect between one in 10 000 and one in 50000 males. The clinical profile of hemophilia patients is rarely reported in India. ISTH- Bleeding Assesment Tool score is one such score which not only helps us to diagnose a bleeding diathesis but may also help us in predicting the severity of bleeding potential of any patient with bleeding diathesis. Objective: To describe the clinical and epidemiological profile of hemophiliac patients in Uttarakhand. Calculate Bleeding Assessment Tool score in all patients of haemophilia and differentiate severe haemophilia from moderate haemophilia. Material and Methods: A total of 75 patients of all age groups with haemophilia A and B were included in the study. A detailed clinical history using ISTH -BAT along with clinical assessment by the hematologist was done. Special emphasis was laid on demographic details. Coagulation studies were done on STAGOSTA compact. Chi-square test was used for Assessing BAT scores. Results: The hospital based prevalence was 1.2% for haemophilia A and 0.3% for haemophilia B in our study. There were 74 % severe haemophilia and 5% of mild haemophilia in our study. The presence of inhibitors was 6%. There was significant statistical difference between the BAT score values of moderate and severe haemophilia (p value<0.05). Conclusion: The study suggested high prevalence of haemophilia in the state along with high numbers of inhibitors. More studies are required to establish the role of bleeding assessment tool in differentiating moderate haemophilia from severe haemophilia.

This research aims to analyse the efforts of the character building of school culture based in Senior High School of Panca Budi Medan as well as supporting factors and the termination. This research uses qualitative method with the research site, namely Senior High School of Panca Budi Medan. As for the data analysis techniques using interactive analysis Model Milles & Huberman is through data reduction, data display and data verification/withdrawal conclusion. Determination of the subject using snowball sampling technique. Data collection techniques using non-participatory observation, in-depth interviews and documentation studies. From the results of the study obtained a number of schools culture that became the frame and base of character formation of students in Senior High School of Panca Budi Medan, namely; 1) Religious culture, 2) honest culture, 3) clean culture and energy saving, 4) Culture of discipline. The supporting factor for student character formation in Senior High School of Panca Budi is 1) family factors that emphasize the role of parents in strengthening the habituation of good behavior to the child of what results have been received in school; 2) The teacher's factors emphasize the teacher's involvement in shaping the student's character through education, mentoring, and the example; 3) environmental factors that include the school environment and community. In supporting the character building of the students, the school constantly engineered a conducive environment so that what the students see, hear, and feel are supportive of character building. The Community's environmental support is seen from conduciveness the daily behaviour of local residents in line with the values of characters obtained by students from the school; 4) Learners ' factors that appear to be high in enthusiasm and curiosity in understanding the importance of character value inherent in every activity that cultures in school..........................

Systemic delivery of drugs through nasal route requires extended residence time in nasal cavity. The aim of the present work is to fabricate an In-Situ nasal gel using thermoreversible polymer, PF-127 and mucoadhesive polymers HPMC E15 and PEG 6000 to improve the residence time and easy application of accurate dosage. Optimization of formulations was carried out in terms of their content uniformity, clarity, pH, gelation temperature, viscosity, mucoadhesive strength and spreadability. Drug-excipient compatibility was ascertained by FT-IR Spectroscopy. Optimization of PF-127 concentration (20 and 25%) was done to get gelation temperature of formulations in the nasal physiological temperature range (25-34℃). The regression value of ex vivo permeation kinetic study show highest linearity for F1 and F2 to the Higuchi Model whereas F3, F4, F5, F6 to the first order model & the ‘n’ value of each formulation shown that F1, F2 follow Non- Fickian release and F3, F4, F5, F6 follow Super Case II release mechanism. The value of exponent ‘n’ of Korsmeyer-Peppas model suggests the permeation from F1 & F2 is diffusion & erosion controlled, and F3, F4, F5 & F6 is due to the erosion of the polymeric chain. It can be concluded that as viscosity of the formulation is increased the release mechanism will transform from Non – Fickian to Super Case II release mechanism. Hence a clear In-Situ gel may be formulated using PF 127 which is a stable under accelerated conditions and releases the drug under controlled manner for sustained systemic delivery through nasal route.

Introduction: Gingival bleeding is one of the cardinal signs of inflammatory gum disease which if untreated can lead to periodontal disease and eventual tooth loss. This study assessed the knowledge and clinical presentation of inflammatory gum disease among Nigerians in the South-South geopolitical zone. Methods: Self-administered questionnaires were filled by all consenting patients that attended the Oral Diagnosis Clinic of the University of Port Harcourt Teaching Hospital between May and July 2017. Information elicited were socio-demographics, knowledge on causes and sequelae of gingival bleeding. Indices used were Gingival Index (GI), Sulcular Bleeding Index (SBI) and Simplified Oral Hygiene Index (OHI-S). Data was analyzed using epi-info and level of significance was set at <0.05. Results: 308 participants were recruited with M: F ratio of 1:1.3 and mean age of 34.2(±13.4) years. Two-fifth (42.1%) had gingival bleeding while brushing. Though 51 (36.4%) knew gingival bleeding is abnormal, more than half [35(59.3%)] did not know what caused their bleeding. Some reasons given for gingival bleeding while brushing were dental infection [10 (17.0%)] and hard bristled toothbrushes [98 (13.6%)]. Majority [234(70%)] didn’t know the sequelae of untreated gingival bleeding. Clinical examination showed 76(24.7%) had halitosis, 101(32.8%) bled on probing. 131(42.5%) had a gingival index of 2. Mean MGBI and OHI-S were 1.16(±0.9) and 1.74(±0.9) respectively. 33(10.7%) participants had poor oral hygiene. Conclusion: The participants had a poor knowledge of inflammatory gum diseases. There is the need to increase awareness among the populace and encourage prompt treatment thereby reducing its avoidable sequelae like tooth loss.

Vitex madiensis Oliv is a plant of the family of the Lamaceae-Viticoideae used in traditional medecine in Congo against: dysenteriform diarrheas, barreness of the women, madness, otitis, tooth decay, oral affections, malaria, inflammation of ganglia and stiffness. The aqueous extract of leaves of Vitex madiensis oliv. was the subject of an investigating by the carraghenine and the histamine induced inflammation, and on the central pain of thermal origin at the doses of 50, 100, 200 and 400 mg/kg per os. A significant anti-inflammatory effect (***p< 0,001) at the dose of 400 mg/kg from the thirst hour and at the dose of 200 mg/kg from 3hours was observed. A significant (***p< 0,001) analgesic effect was observed at the dose of 400 mg/kg from 30 minutes. These effects are due to the presence of the numerous metabolites contained in this extract.

The play "This place does not exist" has been recently released in Peru, it is promoted as a social protest against illegal mining and prostitution of teenagers in the peruvian jungle, however, a scientific analysis reveals that it has actually been carefully designed with a goal : the promotion of brain internet in the jungle. The play belongs to the millionaire media campaign to promote the cerebral internet and digital fascism. The transmission of thoughts from the cerebral Internet via wi-fi is recreated in its advertising that shows an adolescent with an open brain and an recreation of transmission of thoughts, the transmission of private life with cerebral Internet is promoted subliminally under the argument of visibility as the main way of getting out of poverty. Although this play is promoted as a social protest against slavery of teenagers of the jungle actually it promotes sexual slavery with surveillance and mind control of these teenagers with brain net.

Oral and Maxillofacial region encompasses a wide spectrum of diseases, injuries and defects involving the head, neck, face, jaws and the hard and soft tissues of the oral cavity. Soft tissue injuries, when they occur in isolation or in combination with other injuries, are among the most challenging tasks to manage by the operator. In spite of their high incidence, there are very few studies noted in the literature which systematically elaborates the management of these injuries. This articles aims at emphasizing on the various dressings that can be used in the management of soft tissue injuries of the Oral and Maxillofacial region.

There are many theories about concealed ovulation, breast development from puberty, and body hair loss in human evolution. We propose a novel theory on the association between concealed ovulation and breast development and body hair loss in human evolution. Concealed ovulation may have caused breast development from puberty and body hair loss in humans.

Glutamic oxaloacetic transaminase and lactate dehydrogenase are present in brain. The present study was undertaken to investigate whether there was any change in cerebrospinal fluid glutamic oxaloacetic transaminase and/or lactate dehydrogenase levels in Alzheimer's disease. In the present case control study cerebrospinal fluid glutamic oxaloacetic transaminase and lactate dehydrogenase levels were assayed in 162 Alzheimer's disease cases and 149 healthy controls. Glutamic oxaloacetic transaminase levels of cases were highly significantly increased with respect to the levels of controls. Lactate dehydrogenase levels of cases were not significantly increased with respect to the levels of controls. Data from the present study might help in understanding the biochemical basis of Alzheimer’s disease. It is stressed that these findings should be supplemented by further prospective research.

Existentialism is a broad philosophy and school of thought. Plenty of work of on existentialism has been carried out. The studies are built on individual writers’ work, writers’ overall background etc. The purpose of this research paper is to investigate majority of the writers' ideas that how they take existence and talk about it in terms of absurdity.

In fact, textiloma is a postoperative complication. It is very rare but well-known. Besides, it could be a strange body consists of compresses or surgical remaining field at the level of an operating area. In other words, the discovery of the abdominal textiloma is generally late. Therefore, the history is essential for diagnosis since the clinic isn’t conclusive. The clinic combines chronic transit disorders with suboclusive syndromes and the abdomen image which makes the preparation less effective. In addition to that, the ultrasound is reliable. The computed tomography allows an accurate topographical diagnosis. Some teamworkers suggest some explorations concerning the MRI. Thus, we report a case of intra-abdominal textiloma with an operated patient for a cesarean section.

Ethical decadences are increasing in our contemporary society day by day. Adultery is one of the examples of moral degradation. This study investigates the present condition and consequences of adultery and finds women commit adultery with ex-lover, relative, known person and in some cases with unknown person. Social media such as: facebook, whats app, viber, imo etc. are common tools to commit adultery in now days. Lack of moral sense, degenerate culture, lack of family bonding, technological development are the main causes for committing adultery and as consequences murder, divorce, spouse violence, domestic violence, flogging, sexually transmitted diseases, honor-killing, stoning etc are the result of adultery. It conducted based on secondary resources which are collected from books, articles, newspapers and authentic websites. This study tries to describe adultery through opportunity theory where adultery is thought a result of getting more opportunity. Legal authorities can get a clear idea about the conditions and consequences of adultery which can help the government to create policy to decrease adultery in Bangladesh.

Female migrant workers are susceptible for economic exploitation, physical violence and sexual abuse. They are at risks of sexually transmitted diseases, unwanted pregnancy, illegal termination of pregnancy and related problems. They also spread the diseases knowingly and unknowingly. There are about five millions registered and undocumented migration workers are in Malaysia. The Malaysian government is committed to stop the illegal trafficking of women and under aged girls. The health education programme and screening procedures are important to prevent the spread of HIV/AIDS.

This research was conducted with the aim of: 1) To analyze the effect of working capital turnover on profitability; 2) To analyze the effect of liquidity on profitability; 3) To analyze the effect of leverage on profitability. This type of research used in this study is casual associative research (causal associative research). The population of this research are property, real estate, and building construction companies which are included in the Kompas 100 index which are listed on the Indonesia Stock Exchange (IDX) in the period 2013-2018. The sampling technique is using purposive sampling technique. The analytical method used to test hypotheses is multiple regression analysis. The results of the study show that: 1) Working capital turnover has no effect on profitability; 2) Liquidity has no effect on profitability; and 3) Leverage has a negative effect on profitability.

Mechanical ventilation is a lifesaving modality in critically ill patients. It is achieved through passage of Endotracheal Tube in the trachea for the assistance in breathing and removal of tracheal secretions. ETT tends to interfere in the function of mucociliary ladder putting the patient at risk for accumulation of secretions which requires an utmost need for endotracheal suctioning. This invasive procedure ensures the patency of ETT and deliverance of adequate oxygenation to the patient, but lack of knowledge and malpractices of the nurses tends to put the patient at risk for certain complications. The study was aimed to evaluate the effectiveness of structured training program in enhancing performance knowledge of ICU nurses in terms of ETT suctioning. For the evaluation of knowledge and skill, a questionnaire and observational checklist was developed along with the protocol of ETT suctioning in the context of evidence based guidelines. Quasi experimental design was chosen with purposive sampling technique. The sample size was 50 students of Post Basic Diploma in ICU/CCU from various college of nursing of Lahore and Islamabad. Findings of the study proposed that post implementation knowledge and practices of ICU nurses were immensely improved with p value of 0.00, respectively. Henceforth, the structured training program proved to be promising and had a meaningful influence to enhance the performance knowledge of ICU nurses in relation to ETT suctioning guidelines.