A group of neoplasms that share the characteristic light microscopic appearance of being composed of relatively small, round to round-spindled, monotonous, seemingly undifferentiated cells. It comprises all significant categories of neoplasms- carcinomas, sarcomas, lymphomas, and neuroendocrine- neuroectodermal tumors. Hence microscopic similarity between them and the diagnosis in routine histologic examination extremely difficult. This heterogeneous group of lesions becomes a diagnostic challenge. The diagnosis depends on clinical, radiological, pathological and genetic features. Each lesion has its own has distinctive features but histopathologically termed as ‘round cell tumors’. This article provides an insight into this group of intriguing round cell lesions, which are characterized by varied histopathological features and their associated confirmatory immuno-histochemical markers for a reliable and a consistent diagnosis.

Confidence is an important aspect of one’s personality and a confident smile makes the picture complete. With the increased awareness and changing times people seeking dental treatment for aesthetic purpose has significantly increased. One of the commonest cause for unaesthetic smile is the presence of discolored teeth. Though there are various reasons for the discoloration of the teeth, Flourosis which is endemic in various parts of world is one of the major causes of the discoloration. Various treatment options are available to conceal the discoloration. This case report represents one such modality of smile makeover using ceramic laminate veneers.

During pregnancy there is a physiological hypercoagulability which may be increased by genetic risk factors and / or acquired thrombosis. This increases the risk of thromboembolism and the risk of thrombosis in placental vessels and thus termination of pregnancy. Among genetic risk factors for thrombosis, factor V Leiden and mutated factor II are responsible for spontaneous miscarriages, which are essentially late. The rare deficits in antithrombin, protein C and protein S are also involved. Factor V Leiden is a thrombophilic condition that can lead to serious thromboembolic events and in pregnant women recurrent miscarriages. We report the case of a 36-year-old woman who presented 6 miscarriages that led to the diagnosis of thrombophilia by resistance to activated protein C and whose last 4 pregnancies were well followed by anticoagulant treatment with low molecular weight heparin aspirin.

Background: Hyponatremia, which is defined as plasma sodium concentration of less than 135meq/L, occurs primarily due to imbalance in water homeostasis, antidiuretic hormone (ADH) regulation and renal handling of filtered sodium. The two most common causes are effective circulating volume depletion causing non-osmotic release of ADH and the syndrome of inappropriate ADH secretion, disorders in which ADH secretion is not suppressed despite decrease in plasma osmolality. Methods: Observational Study conducted at Medicine wards and, Medicine OPD of SMS hospital, Jaipur. Patients were interviewed for demographic data such as age and sex. History of other comorbid conditions along with presenting complaints was noted. Further these patients were subjected to a physical examination for clinical signs. These findings were recorded on a predesigned and pretested proforma. Results: In our study, lethargy(50.4%), headache(42.3%) and anxiety(31.7%) were most common symptoms. Majority of the cases were admitted and treated in the ward i.e. 249(87.7%), while few patients were treated in ICU i.e.35 (12.3%). Conclusion: Based on the findings of this study it may be concluded that, hyponatremia can present with protean clinical manifestations. The presentation can vary from mild symptoms such as vomiting, lethargy, malaise to severe forms such as confusion, seizure and coma.

Cases of leptospirosis in Indonesia increased dramatically in 2018 by 895 cases with 148 death cases due to leptospirosis in 2018. Risk factors were found in more than half of leptospirosis events including environmental conditions, the presence of rodents, waste water disposal, waste disposal facilities, history of contact with rats, presence of rivers, and history of flooding. Previous research has reported the finding of mice containing Leptospira in post-flood areas in Indonesia. Therefore this study aimed to determine the relationship of environmental conditions with the presence of Leptospira bacteria in rats in flood-prone areas. This research is an analytic study with cross sectional approach. Data obtained by observing the type of rat, the process of surgery and taking rats, rats calculation of success traps and observation of environmental conditions. The polymerase chain reaction (PCR) test was carried out in the Microbiology Laboratory of Hasanuddin University Hospital. Statistical tests with fisher exact were used to determine the relationship of environmental conditions with the presence of Leptospira bacteria in rats. The results of this study found 100% Mus musculus, 53.3% Rattus norvegicus, 22.2% Rattus tanezumi infected with Leptospira bacteria. The results showed the presence of sewers with stagnant water (0,000), presence of standing water other than sewers (0,026), presence of sewage waste (0,005), presence of waste other than ditches (0,007), smell of rat urine (0,049) and pH of stagnant water the optimum (0.001) with a p-value < 0,05. We recommend to the Paccerakkang inhabitants who reside in flood-prone areas, to always maintain environmental conditions such as cleaning the environment suspected of being a habitat for rats.

Works on risk analysis focused on activity in the operating room or in intensive care is rare. In fact, the operating room remains one of the units where the patient's medication management process is complex, which tends to increase the risk of ME as well as the severity of its consequences. In anesthesia, attention should be paid more specifically to errors during the preparation and administration of drugs, because these are actions that are performed many times every day. The analysis of this adverse event in our patient made it possible to classify this adverse event in the category of administrative errors. The administration of vancomycin should be done by slow infusion when it has been administered to our patient by direct intravenous route, this type of error is part of the volume or flow errors. Medication administration error can be prevented by providing coaching and continuing education for practitioners. It is also necessary to label the medication storage compartments of the anesthesia cart; the correct identification of drug ampoules and to ensure that there is only one packaging of the same product.

Adolescence can be a time of both disorientation and discovery. The transitional period can raise questions of independence and identity; as adolescents cultivate their sense of self, they may face difficult choices about academics, friendship, sexuality, gender identity, drugs, and alcohol. Many contemporary personality psychologists believe that there are five basic dimensions of personality such as extraversion, agreeableness, openness, conscientiousness and neuroticism. The main objectives of the present study are to find out the differences in Big Five Personality Traits (extraversion, agreeableness, openness, conscientiousness and neuroticism.) among Kashmiri and North East Adolescents. The five null hypotheses were formulated to test the sample. A sample of 60 adolescents was taken of the students of two cultures as Kashmiri and North East from Mewar University, Chittorgarh (Rajasthan). The Purposive Sampling Technique has been used as per the nature of subjects included in research. The Big Five Personality Inventory designed by Dr. Arun Kumar Singh and Dr. Ashok Kumar from Patna University (Bihar) which is published by National Psychological Corporation, Agra was used to collect the data on five dimensions. The mean, standard deviation and “t” test were used to analyse the collected data. In conclusion, it can be said that there is significant difference between North East Adolescents and Kashmiri Adolescents in relation to Big Five Personality Traits. The results of the present study indicate that there is no significant difference between North East Adolescents and Kashmiri Adolescents in relation to the dimension of Extraversion. There is significant difference among North East Adolescents and Kashmiri Adolescents in relation to Openness, Conscientiousness, Agreeableness and Neuroticism.

Both China and India are two neighboring nations sharing long borders. China is a North East Asian country, and India is a South Asian country bordering with Bangladesh, Pakistan, Nepal, Bhutan and Myanmar. China shares borders with South Asia, South East Asia, North East Asia, Central Asia, West Asia and Russian Federation. Geopolitically and geo-strategically it is located in a center point. According to its size of population and by GDP purchasing power parity (PPP), it has been turned into as number one country in the World. China’s economy is rapidly growing, and it will emerge as a global super power within very short time. However, India is a large country in the context of both geographical size and population. It is the second largest country in world taking into account of its size of population. It is a rising economy, and it has been turned into third largest economy by GDP purchasing power parity (PPP). In this study, some important geopolitical issues of Sino-Indian relations have been discussed in the context of BRI. Friendly relations between China and India are very crucial to ensure peace, security, stability, connectivity and, of course, economic development in the entire region. The main objective of this study is to provide some policy recommendations to improve the relations between China and India. The study is based on secondary data with some field level data which were collected through focus group discussions and observation.

Cervical cancer constitutes global health issue. Human Papilloma Virus Vaccine (HPV) has been associated with its prevention. Despite importance of the vaccine, studies have shown that diverse factors could impede its uptake. Therefore, this study assessed these perceived psychosocial barriers, as well as the uptake of HPV among Female Civil Servants in Delta State, Nigeria. Methods: The design was descriptive and cross-sectional. Multistage sampling technique was used to select 435 women, who consented. A structured questionnaire of 0.7 reliability coefficient was used to collect data at the Secretariat. Data were analyzed using frequency counts and the results were presented in tables and charts. Result: Mean age of participants was 326.7 years. Many, (44.4%) of them had adequate knowledge of the HPV and most (94.7%), had not vaccinated their female adolescents. Cost (54.5%) and inaccessibility (51.3%) were projected as deterring factors. Psychosocial factors isolated were taboo and On the whole, 68.0% were enthusiastic about compliance with vaccination, later. Conclusion: Human Papilloma Vaccine is the primary prevention tool that could reduce the incidence of cervical cancer gobally. Subsidizing its cost by stakeholders and inclusion of National Immunization Programme could improve uptake. In addition, creating awareness about the vaccine, could improve knowledge, therefore ensuring that perceived barriers do not deter people from utilizing services. Active counselling by nurses / midwives will reduce fears, correct misconception and enhance uptake. Ultimately, there will be reduction in the global burden of cervical cancer.

Ritonavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed–dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated Raman biospectroscopy of liquid sample of Ritonavir was investigated. The stimulated Raman diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) was led to increase in stimulated Raman signal but after breakdown threshold of liquid sample, more increasing of energy was led to decrease in stimulate Raman signals and for energies higher than 20 (mJ), they were disappeared.

Achievement goal setting and self-efficacy are two critical variables influencing learning achievements. Many scholars have studied the relationship between two variables by correlation analysis, regression analysis or path analysis. These methods, however, neglect the measurement error at all, which are inconsistent with the reality. Through a questionnaire survey among 266 first-year academic engineering graduate students, this study aims to clarify the relations among achievement goal setting, self-efficacy (SE) and English learning achievement (ELA) of engineering graduate students. Integrating the advantages of conventional statistical methods, Structural Equation Model (SEM) not only takes the measurement error into consideration, but also could study the structures of constructs and the relations among them at same time. The result shows that: 1)Achievement approach goal has a direct positive influence on English learning achievement, mastery approach goal and performance avoidance goal having direct negative influence, and mastery avoidance goal hasn’t obvious influence on English learning achievement; 2) Mastery approach goal has the best impact on self-efficacy, while performance avoidance goal has the worst impact on self-efficacy; 3) Self-efficacy, a mediating variable between achievement goal setting and English learning achievement, could improve English learning achievement efficiently.

Streptococcus iniae is a gram-positive, sphere-shape and pathogenic bacterium that usually causes infections in fishes as well as human. Glutamate racemase is a key enzyme that is involve in synthesis of peptidoglycan layer of bacteria cell wall. Biochemical properties and nature of this enzyme are highly specific and varies among pathogenic species. The unique features structural, molecular and biochemical properties associated with MurI gene as well as functional properties of glutamate racemase in the pathogenicity of S.iniae remain unclear. The purpose of this review paper focusing on the methods that used for the evaluation of biochemical properties of glutamate racemase for functioning in bacterial cell wall focusing on MurI Gene in S.iniae as well knockout of MurI gene in S.iniae also the discussing the methods used for the determination for the biochemical properties associated with pathogenicity at molecular level. Specific primers are used for the gene knockout plasmid construction region for MurI gene of bacterial strain such as S.iniae. These are further amplified by the PCR. DNA sequencing is use to clone the DNA fragments. The LB medium is the medium especially use for the S.iniae wild type (WT) and ΔMurI mutant cultures. Bioscreen machine is use to measure the optical density. The special type of the microscope such as fluorescence microscope is uses for the bacterial viability. TSYE agar plates are used for the measurement of the live bacteria in the form of percentage by plating on. SDS-PAGE is uses to check the purity of expressed proteins determined by the SDS-PAGE. This review helpful for drug discovery and development of new antibiotics by utilizing the MurI gene as a target against S.iniae.

In Sudan, invasive Cervical cancer is the one of the most common causes of death. The Herpes simplex virus ( HSV-2) is second common causes of the invasive cervical cancer , with fraction progress to cervical cancer disease pointing to possible the role of additional risk factors in development of disease which include: host genetic factor and other infection such as HPV-16, for that women should have regular cervical screening test to detect early cervical cancer. Materials & Methods: This is a retrospective cross sectional study that includes about 75 embedded paraffine wax tissue blocks using immune histochemical stain from patients previously diagnosed as cervical cancer and expression of herpes simplex virus. Details of the patients information taken from medical reports .The analysis done by SPSS. Result: The mean age in this study is 60 with group range between (61-70) years (83.3 %), The Herpes Simplex virus is express only in squamous cell carcinoma. Discussion: The mean age is 60 with age group (61-70) (n= 5: 20%) expression of HSV-2 with (P= 0.136), and the expression of HSV-2 with squamous cell carcinoma of tumor type (n= 6:10.90%) with (P= 0.476), histological grade well differentiated (n=6:11.10%) with (P= 0.477). Conclusion: The expression of HSV-2 was insignificant in age group. The expression of HSV-2 was insignificant in tumor type squamous cell carcinoma. The expression of HSV-2 was insignificant in histological grade.

The recent outbreak of an unusual viral pneumonia in Wuhan, China, and then a pandemic has created a panic world over. Genetic and Phylogenetic studies revealed that the causative virus is SARC-CoV-2 and the disease it caused is given the name COVID-19. It (Coronavirus) is a member of the family Coronaviridae and subfamily Coronavirinae and belongs to the order Nidovirales. The Coronavirus Study Group of the International Committee on Taxonomy of Viruses termed the virus as SARS-CoV-2. The virus enters into the cell through ACE2 receptors. It is important to understand the basics of genetic and Phylogenetic properties of the virus. This knowledge will ultimately help in the development of vaccines and drug treatment. In this article, an effort is made to explain the basics of coronavirus and its transmission, to the host cell.

This research to examine The Influence of Government Transparency, Implementation of the government accounting standards and Internal Control System on Quality of financial statements. Population in this research is all villages in the government of Kabupaten Bandung government environment. The number of sample the respondent on this is as many as 73 of village staff and using a technique the withdrawal of sample by means of clusters of random sampling. Data were collected using a questionnaire which used interval scale. Distribution and collection of questionnaires was carried out in November 2019 and the number of questionnaires returned was 70 questionnaires or 96%. The results of testing showed transparency the government did not influenced the quality of the financial statements in the village administration Bandung regency, while the implementation of the government accounting standards and internal control system influenced the quality of the financial statements in the village administration Bandung regency.