Through this study we aim firstly, to understand the correlation between pain, intensity of pain and different clinical Data. Secondly, to highlight the accurate etiological diagnosis and be able to take the adequate decison for pain managment. This study was carried out on 200 edentulous patients who came to the departement of complete denture of dental clinic at Monastir Tunisia from february to june2019.All the patients were examined and assessed by one prosthodontist under the supervision of a professor. A questionnaire was used to record information wich was taken directly from the patient when they attend the dental clinic. The patient consent were taken verbally. The questionnaire included 19 questions divided in 3 heading: Medical history, exploration of pain and its intensity and Management strategies. The statiscal analysis were done with an SPSS's logiciel version 22.0. The results are presented in form of tables and graphics. Moreover, in this study the most common chief complaint was pain 63% of the sample. This result corroborate with other studies in litterature. Besides, a statistically significant relationship was observed between pain and patient’s satisfaction with their prosthesis (P=0.044<0,05). However, no significant difference was found between pain and other differents clinical Data (age, gender, general condition ….) (P>0.05). Neither between intensity of pain and different clinical data (P<0.05). This result came in argument with results of other worldwide researches. Finally, we came to the conclusion that management strategy of pain must follow a comprehensive, multidisciplinary and systemic approach.

A middle-aged male having multiple warts on the face was treated with homoeopathic medicine Thuja occidentalis (Thuja-occ.) prescribed in different potencies. The medicine was culled on the basis of symptom similarity. Patient was followed at regular interval. All warts on face vanished in ten months of treatment. Skin became as unsullied as nothing transpired ever.

Natural Polysaccharides have been considered to be the most promising materials in recent years because of their numerous advantages including their accessibility, non-toxic, biocompatible, biodegradable, and ease of modification.Natural substanceswith pharmacotherapy potential are currently viewed as a promising future alternative to conventional therapy.With the rapid development of analytical techniquesandbiotechnologies,a large number of methods for identifying and quantifying polysaccharides without causing adverse effects have been created, resulting in the use of natural substances with established safety. Some bioactive polysaccharides obtained from natural sources have received a lot of attention in the field of biochemistry and pharmacology in recent years.Natural polysaccharides have been found in studies to boost innate immunity by activating upstream immune cells, hence regulating adaptive immunological pathways such as T cells and improving the efficacy of immunotherapy, implying that polysaccharides have a promising future in immunotherapy. As there is no targeted therapy available but these natural polysaccharides have been shown to possess complex, important and multifaceted biological activities including antitumor, anticoagulant, antioxidant, antiviral, immunomodulatory and antihyperlipidemic activities. Their properties are mainly due to their structural characteristics and are useful for combating various diseases as well improving immunity. Thus, polysaccharides can be used as an activating agent of immune system, minimising the damage caused by infectious agents such as SARS-CoV-2. Finally, these biopolymers can still be exploited to produce new treatments and vaccines.The present paper summarizes an overview of natural polysaccharides with immune boosting properties.

The present study determines the effects of the ethanolic stem bark extract of Boswellia dalzielii H on gastric homogenate and serum levels of TNF-α and vascular endothelial growth factor (VEGF), during the healing of chronic gastric ulcer induced by acetic acid in Wistar albino rats. Round and deep chronic gastric ulcers were induced by a high concentration of acetic acid in Wistar albino rats. 75 rats with gastric ulcers were randomly assigned to five treatment groups (2-5). Rats in group 1 had no gastric ulcer and were administered with vehicle 5ml/kg. Rats in group 2, negative control had gastric ulcers and were treated with vehicle 5ml/kg. Rats in group 3 were treated with ranitidine (50mg/kg) while rats in groups 4, 5, and 6 were treated daily with 100, 200, and 400mg/kg of ethanolic stem bark extract of Boswellia dalzielli H respectively. Treatment in all the groups was by intragastric administration. Five rats from groups (2-6) were euthanized on days 3, 7, and 9 along with the control group (1). Blood was collected, serum prepared, and assayed for TNFα and VEGF using ELISA. The stomach of each animal was evaluated for gastric ulcer, assessed for histopathologic changes, and preparation of gastric tissue homogenates. Intragastric administration of graded doses of ethanolic stem bark extract of Boswellia dalzielli H and ranitidine (50mg/kg) respectively, down-regulated serum and gastric tissue levels of TNF–α significantly (p<0.05), up-regulated VEGF significantly (p<0.05), and increased gastric ulcer healing rate in a significant manner (p<0.05). The increase was time and Dose and time dependent manner when compared to control. Attenuation of TNFα and up-regulation of VEGF by graded intragastric administration of the ethanolic stem bark extract of Boswellia dalzielli promotes the healing of chronic gastric ulcer induced by acetic acid in Wister albino rats.

Introduction: Warthin like papillary thyroid carcinoma is a rare variant that bears features similar to Warthin tumour of salivary gland. It shows papillary or follicular structures lined by oncocytic cells having typical nuclear features of papillary thyroid carcinoma and marked lymphoplasmacytic infiltrate in the stroma. Case Report: A 60 year old lady presented in the ENT OPD with right sided neck swelling since 2 years. On examination the swelling was firm, non-tender, moving with deglutition and measured 4x3 cm. FNA smears of the swelling were highly cellular and comprised of cells arranged in papillary clusters. The cells were predominantly oncocytic and showed nuclear grooving and intranuclear inclusions. Cytological diagnosis of papillary thyroid carcinoma (Bethesda Category VI) was offered. Thyroidectomy specimen measured 6.5x5x3 cm and right lobe revealed gray tan tumor with numerous papillae and few cystic areas. Microscopy revealed a well circumscribed tumour, with tumour cells arranged in papillary architecture with presence of dense lymphoplasmacytic infiltrate in the stalks of papillae. The cells lining the papillae had abundant granular eosinophilic cytoplasm and many of the cells showed nuclear grooving and intranuclear inclusions. Occasional psammoma bodies were also seen. The surrounding thyroid showed features of hashimoto’s thyroiditis. A final diagnosis of Warthin like variant of papillary thyroid carcinoma was given. Conclusion: Warthin like variant of papillary thyroid carcinoma is a distinct rare variant. It is associated with good prognosis when compared with other variants of papillary thyroid carcinoma, warranting a proper identification.

Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC- RCC) was first described by Trpkov et al., as a novel entity of renal neoplasms with characteristic clinical, pathological and molecular features. ESC-RCC has female predominance with few cases reported in males. Herein, we report the first case of ESC-RCC is an elderly male patient.

Background: Sexual dysfunction as a result of the inability to achieve or maintain an erection is a common problem that increases with age. Vardenafil has shown results as an efficacious and safe therapeutic agent for treatment of erectile dysfunction. AIM: Development of a bio-analytical method for rapid quantification of vardenafil in biological fluids and its application in pharmacokinetics and bioavailability studies, clinical trials, and monitor its therapeutic levels to help attaining effective clinical results in treating erectile dysfunction. Methods: Vardenafil was extracted from plasma samples and chromatographed with eluting solvent consisting of 10mM Ammonium Acetate: Methanol (30:70) v/v at flow rate of 0.55ml/min, ESI positive mode, and m/z 489  151, 475  100 for vardenafil and sildenafil as internal standard respectively. As an application of the validated developed bioanalytical method, a comparative bioavailability study of vardenafil 20mg tablets generic product versus reference product was conducted in a randomized open label crossover design invovlving 24 volunteers. The criteria used to assess bioequivalence of the two products were Cmax, AUC 0-t, AUC 0-inf, and Tmax. Results: The average recovery of vardenafil from human plasma was 95.104 % with limit of quantitation of 0.05 ng/ml and the correlation coefficient (r2) obtained was 0.9998, moreover, statistical analysis (ANOVA) of the measured parameters showed that there was no significance between the two products. Conclusion: The developed bioanalytical LC/MS/MS method was valid for vardenafil quantification in human plasma and is suitable for application in pharmacokinetic studies and therapeutic monitoring of vardenafil in treating erectile dysfunction to ensure effective therapeutic drug levels and avoid potential undesired adverse events.

Competition in the business environment and rapid global developments have created great challenges for organizations, which increases the importance of strategic planning to ensure business continuity despite any potential crises and competitions. This study aims to clarify the impact of strategic planning on the performance of Jordanian telecom companies. In order to achieve the aim of the study, a comparison approach was adopted by reviewing previous studies that dealt with the subject and discussing the most important results that they reached. Accordingly, he concluded that strategic planning has an active and important role in developing the work of organizations so that it will be reflected positively on them. Therefore, we recommend through this study to activate strategic planning in the departments of Jordanian telecommunications companies to ensure more innovation and creativity in light of the intense competition for telecommunications services in the Jordanian market, with the need to develop a strategic plan to be evaluated periodically in line with the organization's mission and vision to ensure that it remains on the path. The correct approach that you seek in addition to the need to set short and long-term goals and strive to achieve them within the set strategic plan, in addition to the scientific contribution, there must be some obstacles represented in Research because this study during the Corona pandemic there was difficulty in collecting data or conducting interviews, so it is possible in the future to conduct this study by addressing a proposed model that addresses the variables that highlight strategic planning strategies on the performance of Jordanian telecom services companies and collect and analyze data to reach a more comprehensive scientific contribution.

This study investigated the ameliorating potential of Annona muricata on Testosterone Propionate-Induced Benign prostatic hyperplasia (BPH) in male Wistar rats. Sixty (60) adult rats weighing 150 to 250g were grouped into six (6) of ten (10) rats. Group 1 (positive control) was fed with regular rat feeds and water. Group 2 (negative control), and Groups 3 - 6 were given regular feeds, water, and 3 mg/kg propionate for 28 days to induce benign prostatic hyperplasia. Group 3 to 6 were treated with 500, 1000, 1500, and 2000 mg/kg A. muricata extract respectively for 28 more days. Semen quality, Benign prostatic hyperplasia biomarkers, oxidative stress enzymes, Biomarkers of cardiac, renal, and hepatic function, Haematological indices as well as testis histology were investigated in treatment groups relative to controls. Results of Groups 3 to 6 show a significant (p<0.05) increase in sperm motility, viability, and count, with a significant decrease (p<0.05) in dead and abnormal sperm cells relative to the negative control. Prostate-specific antigen (PSA), a BPH indicator, showed a decrease and Carcinoembryonic antigen (CEA) an increase, however, both changes were non-significant (p>0.05). Cardiac biomarkers creatinine kinase MB (CKMB), D-dimer, and myoglobin, as well as liver, were not affected. The photomicrographs showing lesion in negative control were ameliorated by different concentrations of A. muricata extract and the tissues were restored to normal in treatment Groups 3 to 6. Annona muricata possesses ameliorative potentials on testosterone propionate-induced benign prostate hyperplasia. It has a positive effect on spermatogenesis and therefore, can boost semen quality.

The body mass index (BMI) is commonly used in the assessment of obesity and overweight; however, its use in the diagnosis of adverse effects of obesity is questioned. This study aims to explore the agreement between the BMI and the calculated body fat percentage (BF%) in detecting obesity-induced ventilatory abnormalities. We carried out a cross-sectional study on a random sample of 150 healthy male students, aged 17 to 25, with a mean age of 20.8 ± 2.6 years. We measured the BMI, BF%, and pulmonary function of each participant. The students were classified into overweight-obese and normal groups based on the BMI and the BF% results. The Chi-square test was performed to analyze differences between the groups. About one-fifth of all participants had a fat mass ≥ 20%, among which 90% fulfilled the BMI definition of overweight and obesity (p < 0.05). The comparison between the two BF% groups showed that 20% of the overweight-obese group had a significant reduction in FEV1 (p= 0.025, Relative Risk= 3.00, 95% Confidence Interval= 1.13-7.99), and 23% of them had a significant reduction in FVC (p= 0.012, Relative Risk= 3.11, 95% Confidence Interval= 1.26-7.68). The changes in FEV1/FVC were statistically insignificant. The effects of the BMI categories on the dynamic lung volumes were statistically insignificant. The direct estimation of BF% is better than the calculation of BMI in the diagnosis of obesity-induced abnormalities in lung function. The use of BMI as an indicator of obesity in population health studies should be avoided.

In the Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2016 concerning Mediation Procedures, it provides settlement efforts for the plaintiffs and defendants in civil cases. Mediation is carried out by a mediator, either from a judge mediator or a non-judge mediator. The absence of a mediation meeting by the plaintiff or the defendant who has been properly summoned by the court, in article 7 paragraph (2) is stated as behavior not in good faith. In the provisions of article 22 and article 23 of the Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2016 concerning Mediation Procedures, it is stated that legal sanctions can be given by parties who do not have good intentions at mediation meetings.

This study examines the effect of board diversity on the financial performance of manufacturing firms in Nigeria. The motivation for the study lies in the increased quest to establish the most appropriate board with the optimum mix needed to guarantee the absence of corporate failure. The study comprises of 64 listed manufacturing firms as at 31st December 2020, and sample size of 20 listed manufacturing firms were selected using purposive sampling technique. Data were obtained from annual reports of the selected firms from 2011 to 2020. Descriptive statistics and panel regression estimation techniques were used to analyze the data collected. The findings shown that board diversity has an insignificant effect on performance except for financial expertise diversity with a positive effect on financial performance, and there is a presence of long run relationship with firm performance. Based on these findings, the study therefore concludes that diversity on the board in terms of gender, ethnicity and educational background will not really improve or reduce performance of the firms while diversity in terms of financial expertise will do. Thus, it is recommended that greater measures need to be taken by manufacturing firms in Nigeria to have a higher percentage of board members with financial expertise, and directors with certified financial expertise should be allowed to stay longer on the boards to guarantee improved performance in the long run.

Atherosclerotic heart disease due to the accumulation of large amount of lipids present in the blood vessels of arteries. Many animal models have been developed to study atherosclerosis, and allow for careful control of experimental conditions, food and environmental risk factors. Experimental animal models of atherosclerosis have become a valuable tool for providing information on the etiology, pathophysiology, and the mechanism of action of various drugs and compounds used in the treatment and complications of the disease. Compared to human models, the animal model is more easily manageable, as the combined effects of dietary and environmental factors can be controlled. Different models have their own advantages and disadvantages.

The aim of this quality improvement practice project was to improve noted delays in the time to antibiotic administration in paediatric febrile neutropenic patients seen at King Faisal Specialist Hospital and Research Centre (KFSH&RC), Saudi Arabia. Larrabee’s 6-step Model for Change of evidence-based practice guided the project. Clinical audit, nursing knowledge survey, comprehensive literature and international clinical guideline review were used to identify and design a clinical care pathway for paediatric febrile neutropenic patients at KFSH&RC. Post-implementation clinical audit showed a reduction in time to antibiotic administration and increased self-efficacy and knowledge among nursing staff in relation to managing the care of febrile neutropenic patients. This reflects similar improvements seen internationally in other centres following the introduction of a clinical pathway. This nursing led practice change was the first of its kind for KFSH&RC. It demonstrated that with support from key stakeholders, Larrabee’s model for evidence- based practice change can be used for introducing a nurse-led clinical care pathway in Saudi Arabia. Highlights •A new clinical care pathway introduced in Saudi Arabia improved time to antibiotic administration in paediatric febrile neutropenic patients. •Implementing a nurse-led clinical care pathway increased nurses’ confidence with managing children with febrile neutropenia and the skills and knowledge related to the accessing and delivering medication via central access devices •With key local stakeholder support evidence-based change frameworks such as that proposed by Larrabee can be used to improve nursing management in Saudi Arabia.

Chromium (VI) is a thoughtful and common environmental chemical. In nature, chromium can be found both as chromium (VI) or as chromium (III).Chromium (III) is less lethal and definitely adsorbed ins oils and waters, whereas chromium (VI), which is the most toxic form, is not eagerly adsorbed and maximum of its salts are soluble. Numerous bacteria have been noticeable that can change extremely water-soluble and toxic Cr(VI) to unsolvable and rather non-toxic Cr(III), bacterial bioremediation of Cr(VI) contamination is controlled by a number of difficulties, in precise chromium poisonousness to the remediating cells. Cr (VI) is a lethal, resolvable environmental contaminant. Bacteria can decrease chromate to the unsolvable and less poisonous Cr (III). The Hexavalent form of chromium is the most toxic and cancer-causing and produces health dangerous effect. Hexavalent chromium is of specific environmental worry due to its toxicity and flexibility and is thought-provoking to remove from industrial waste water. Reducing Cr (VI) to Cr (III) makes simpler its removal from effluent and also reduces its poisonousness and mobility. So, we can apply the modern biotechnology for the elimination of numerous toxic complexes.