The use of semiconductors in photovoltaics, or solar cells, allows them to transform light into energy. Because of its potential as eco-friendly and effective light-harvesting technologies, solar cells have been in the spotlight recently. Extensive and ongoing research has focused on the potential critical role of single-walled carbon nanotubes (SWNTs) in these devices. The most essential metric in comparing single-walled carbon nanotubes (SWNTs) with multi-walled carbon nanotubes (MWNTs) is their optical transmittance, which is different at low densities. As a result, SWNTs are known to perform better than MWNTs. The semiconducting properties of SWNT films allow them to serve as active or charge-transporting materials.
REVIEW ARTICLE | Oct. 15, 2025
Efficacy and Adverse Effect of Varenicline (Champix) in Cessation of Smoking: Systematic Review
Jamal Khaled S Aljamal, Faiy Fahad S Almulhim, Latifah Ahmed A Albash, Fahad Ali Alsahli, Nouf Humaidan Alshammari, Badeah Ayesh Alsofyani
Page no 969-981 |
https://doi.org/10.36348/sjmps.2025.v11i10.007
Background: Varenicline represents the most effective first-line pharmacotherapy for smoking cessation, though post-marketing safety concerns historically limited utilisation. Contemporary evidence requires synthesis following resolution of neuropsychiatric safety signals and emerging applications in diverse populations. Objective: To evaluate varenicline efficacy and safety for smoking cessation through systematic review of evidence published January 2020-October 2025. Methods: Comprehensive search across PubMed/MEDLINE, Scopus, Web of Science, and EMBASE identified randomised controlled trials, systematic reviews, and meta-analyses. Two reviewers independently screened records using predefined PICO criteria: adults ≥18 years with current smoking status; varenicline monotherapy at standard dosing; placebo/active comparators; biochemically verified continuous abstinence ≥6 months. Data extraction captured efficacy outcomes, safety profiles, and population-specific effects. Risk of bias assessment employed Cochrane RoB 2 methodology. Results: Database searching retrieved 3,247 records, with 15 studies meeting inclusion criteria after systematic screening. Studies encompassed 8 randomised controlled trials, 4 systematic reviews/meta-analyses, 2 network meta-analyses, and 1 observational study, representing >15,000 participants across diverse populations. Varenicline demonstrated superior efficacy versus placebo across all populations, with 6-month continuous abstinence rates of 22.1% versus 8.9% (OR 3.14, 95% CI 2.21-4.46, p<0.001). Particularly robust effects were observed in cardiovascular disease patients (OR 4.12, 95% CI 2.89-5.87) and dual cigarette-e-cigarette users (OR 4.95, 95% CI 2.29-10.70). Safety analysis across >8,000 participants showed no significant increase in serious adverse events (6.8% vs 5.9% placebo, OR 1.23, 95% CI 0.95-1.59, p=0.11), including neuropsychiatric (OR 1.25, 95% CI 0.73-2.14, p=0.42) and cardiovascular events (OR 1.35, 95% CI 0.71-2.56, p=0.36). Nausea remained the most common adverse effect (28.6% vs 9.2% placebo) but proved dose-dependent and transient. Conclusions: Contemporary evidence strongly supports Varenicline as highly effective and acceptably safe first-line therapy for smoking cessation across diverse adult populations, including those with cardiovascular disease and psychiatric disorders. Historical safety concerns have been definitively resolved, supporting broader clinical implementation within established guidelines.
REVIEW ARTICLE | Oct. 15, 2025
Collaborative Care Models for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
N. S. Alrashidi, A. T. A. Asiri, N. A. Binhudayb, Y. D. Alshihri, S. E. Alosaimi, H. M. Alanazi, R. N. Hassounah, M. A. Aljuhani, R. M. Alzahrani, S. A. Ibrahim Aljurbua, S. A. H. Alzahrani, M. M. S. Alshahrani, M. A. Alqahtani, M. S. A. Al johani, O. O. Al Mutairi
Page no 958-968 |
https://doi.org/10.36348/sjmps.2025.v11i10.006
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global morbidity and mortality, with acute exacerbations (AECOPD) representing the primary driver of healthcare utilization, economic burden, and negative patient outcomes. The conventional management of AECOPD is frequently fragmented, characterized by professional silos that lead to critical communication gaps, medication errors, high hospital readmission rates, and a suboptimal patient experience. This review synthesizes the evidence for a structured, interprofessional collaborative care model as the superior standard of care for patients with AECOPD. The objective is to explore the distinct and synergistic roles of key healthcare professionals across the entire acute care continuum, from pre-hospital response to inpatient management and the critical transition back to the community. This report details the evidence-based contributions of Emergency Medical Services, Nursing Technicians, Radiology Technicians, Respiratory Therapists, the integrated Pharmacy Team (Clinical Pharmacists and Pharmacy Technicians), Social Workers, and Medical Records Technicians, highlighting their crucial interdependencies. The synthesis of current evidence demonstrates that formalized collaborative care models, when supported by robust system-level frameworks such as structured communication protocols and integrated electronic health records, significantly improve clinical outcomes, enhance system efficiency, and elevate patient-reported quality of life. Such integrated models are no longer an ideal but an essential framework for delivering effective, efficient, and patient-centered care for this complex and vulnerable population.
ORIGINAL RESEARCH ARTICLE | Oct. 14, 2025
Clinical and Etiological Profile of Iron-Deficiency Anemia in Adults
El Idrissi El Houcine, Birouki Hind, Assoufi Naoufal
Page no 362-367 |
https://doi.org/10.36348/sjbr.2025.v10i10.003
Introduction: Iron deficiency anemia (IDA) is a common condition in adults, particularly affecting women of childbearing age. It is the leading cause of anemia worldwide and represents a major public health concern. Purpose of the study: analyze the clinical and etiological profile of iron deficiency anemia in an internal medicine department. Materials and Methods. This was a retrospective study conducted over a 4-year period (January 2021 to December 2024) at the OUED-EDDAHAB military hospital in Agadir. Results: Our study included 151 cases. The mean patient age was 35.2 years, with a male-to-female (M/F) ratio of 0.07. Women of reproductive age (14–50 years) were the most affected group. The mean hemoglobin level was 8.3 g/dL. Gynecological blood loss and malabsorption syndromes were the primary etiological mechanisms. However, digestive disorders were the leading cause of IDA in our series. Among the studied cases, we identified: 51 cases of gynecological bleeding (33.8%), 41 cases of impaired absorption (27.2%), 26 cases of gastrointestinal bleeding (17.2%), 9 cases of dietary deficiency (6%), 5 cases of PICA syndrome (3.3%), and 18 cases of undetermined origin (11.9%). Injectable iron therapy played a significant role in management in our setting, being prescribed in 56.3% of cases. Conclusion: The causes of IDA in adults are multifactorial, involving several mechanisms. Gastrointestinal disorders were the most frequent in our series, consistent with literature data. For blood loss, gynecological causes predominated. The diagnostic approach to IDA is guided by clinical findings, and treatment relies on iron supplementation alongside etiological management.
ORIGINAL RESEARCH ARTICLE | Oct. 14, 2025
Prognostic Factors and Therapeutic Response During Basedow Desease: Study of 3007 Patients Followed Over 25 Years at the Clinique Médicale II (CHAN), Dakar
Mouhamed Dieng, Mouhamed AlMakhy Niang, Michel Assane Ndour, Matar Ndiaye, Oumar Boun Khatab Diouf, Boundia Djiba, Demba Diédhiou, Anna Sarr, Maïmouna Ndour Mbaye
Page no 953-957 |
https://doi.org/10.36348/sjmps.2025.v11i10.005
Introduction: Basedow (Graves’) desease remains the leading cause of hyperthyroidism (40–60%), affecting mainly young women with a prevalence varying according to the iodization of the populations. Methods: Retrospective, descriptive and analytical study, covering 25 years (01/01/1998–31/12/2023) at the Medical Clinic II/CHAN; inclusion of all hyperthyroidism files related to Graves' disease, operative criteria and standardized definitions; descriptive and comparative analysis. Results: Our cohort included 3007 patients, with a female predominance; the most common initial clinical signs were goiter (nearly 89%) and exophthalmos (approximately 69%). Under ATS, a decrease in pulse rate and weight regain were observed at 18 months. Overall outcomes showed failure in 48–49% of cases, remission in nearly 33%, and recurrence around 18%; cardiac complications included cardiothyreosis in nearly 6% and acute thyrotoxic crisis in 0.3%. The worst outcomes were associated with grade 3 goiter, exophthalmos, a consultation time > 12 months and a loading dose > 40 mg/day. Conversely, early initiation of maintenance treatment (<6 months) was associated with more remissions and fewer recurrences. Conclusion: Rapid initiation and reasoned adjustment of ATS, coupled with stratification by severity (goiter, orbitopathy, delay), optimize the response and limit surgery; these levers can be used in resource-constrained systems.
ORIGINAL RESEARCH ARTICLE | Oct. 13, 2025
Strengthening Nigeria–Saudi Arabia Bilateral Relations Through Pilgrims’ Welfare and Accountability Frameworks Under Vision 2030
Bashar Bin USMAN, Zakariya’u Tanimu Muhammad, Bilikisu Ismaila ABDULLAHI
Page no 488-496 |
https://doi.org/10.36348/sjhss.2025.v10i10.001
The Hajj pilgrimage is central to Nigeria–Saudi Arabia relations, extending beyond its religious obligations to encompass diplomacy, governance, and economic dimensions. Despite efforts by the National Hajj Commission of Nigeria (NAHCON), recurring challenges in pilgrims’ welfare, weak accountability, and governance lapses have undermined Nigeria’s diplomatic credibility. By contrast, Saudi Arabia’s Vision 2030 emphasizes digitization, efficiency, and transparency in Hajj administration, setting a benchmark that Nigeria must adapt to remain credible and strengthen bilateral ties. This study aims to analyze how pilgrims’ welfare and accountability mechanisms influence Nigeria–Saudi relations and to propose a Vision 2030–aligned framework for NAHCON. The specific objectives were to assess the state of welfare and accountability in Nigeria’s Hajj administration, evaluate their impact on bilateral relations, and identify reforms necessary for alignment with Saudi standards. Adopting a mixed-methods design, the study combined survey data from 400 pilgrims with qualitative evidence from documents and media reports. Descriptive statistics, correlation, and regression analyses were employed alongside thematic analysis for explanatory depth. Findings show that welfare services were rated moderately (means ≈3.4–3.5), while accountability mechanisms received weaker ratings (means ≈3.1). Regression results revealed accountability (β = 0.520) had a stronger impact than welfare (β = 0.387) on perceptions of Nigeria–Saudi relations, highlighting governance credibility as central to diplomatic outcomes. The study contributes by providing empirical evidence that links Hajj administration with foreign policy outcomes, advancing a Vision 2030–aligned framework for NAHCON that integrates welfare, transparency, digital transformation, and diplomacy, thereby positioning Hajj as a tool of Nigeria’s soft power and bilateral engagement.
REVIEW ARTICLE | Oct. 13, 2025
Reconstruction of Citizen Lawsuits in Indonesia in Realising Justice
Galang Syafta Arsitama, Dr. M. Fakih, Dr. Fransiscus Xaverius Sumarja
Page no 253-260 |
https://doi.org/10.36348/sijlcj.2025.v08i10.003
Legal issues, particularly those related to the protection of citizens' rights, are addressed through the mechanism of citizen lawsuits (CLS). Until now, citizen lawsuits have only covered the environment, but there are several other sectors that have not been accommodated in the regulations on citizen lawsuits. This has led to legal uncertainty and inconsistency in court rulings on citizen lawsuits. This study uses normative legal research with a normative juridical approach based on the post-positivism paradigm. The results of this study explain that the characteristics of civil lawsuits are as follows: Basis of the lawsuit: public interest; Subject: the plaintiff is a citizen; Defendant: the government or private parties carrying out governmental affairs; Object of the lawsuit: negligence or failure to fulfil legal obligations; Notification/summons: must be sent 60 working days before the lawsuit; Claim: does not include monetary compensation, but requests that the government create regulations and policies. This reconstruction uses a dignified justice approach, namely Simplification of Procedures: CLS must have simple procedures, be affordable, and cover various fields; Subject of Lawsuits: Regulations must cover human rights violations and actions that harm the public interest, with an emphasis that the public interest also includes human rights; Judicial Competence: the authority between the District Court (PN) and the Administrative Court (TUN) must be clarified, with human rights-related lawsuits falling under the competence of the District Court; Capacity Building for Judges: training for District Court judges; Dismissal Mechanism: there is an initial selection process to screen CLS cases.
ORIGINAL RESEARCH ARTICLE | Oct. 13, 2025
Evaluating Awareness of Umbilical Cord Blood Banking and its Ethical Aspects among Future Healthcare Providers
Dr. Venkateswaramurthy. N, Dr. Aarthi. N. K, Abina Jershini. A. P, Arjun. M
Page no 99-105 |
https://doi.org/10.36348/sijap.2025.v08i05.002
Umbilical cord blood banking is a rapidly growing field with significant medical potential, especially in regenerative medicine and hematopoietic stem cell transplantation. The first successful Umbilical cord blood transplant in 1988 marked a breakthrough, leading to the establishment of both public and private Umbilical cord blood banks worldwide. Pharmacy students, as future healthcare providers, play a pivotal role in patient education regarding Umbilical cord blood banking, but research on their knowledge levels remains sparse. This study was conducted at JKK Nattaraja College of Pharmacy over six months using a pre-post intervention design to assess the impact of education on students' knowledge and aptitude regarding umbilical cord blood banking. Initially, a structured questionnaire was administered to assess baseline knowledge. After an educational intervention comprising lectures and discussions, a post-survey assessed changes. Results indicated significant improvement in awareness and understanding of Umbilical cord blood banking applications, benefits, and collection methods. Before the intervention, most students lacked clarity on stem cell sources, Umbilical cord blood uses, and public vs. private banking differences. After the session, understanding improved markedly, with over 90% correctly identifying medical applications and banking types. The study concludes that educational programs are essential for enhancing pharmacy students’ awareness and aptitude toward UCB banking, preparing them to counsel patients effectively.
SUBJECT CATEGORY: OPTOMETRY | Oct. 11, 2025
Determining the Factors that Contribute to Alcoholism and Drug Abuse Among Students in Tertiary Institutions in Imo State, Nigeria
Okorie, Onyinyechi Mary, Ohiaeri, Esther, Amadi, Nkwa Agwu, Okorie, Maduabuchi Edmund, Inah, Simon Alain, Iwuagwu Uchechukwu Olive
Page no 149-161 |
https://doi.org/10.36348/sb.2025.v11i09.001
Alcohol and drug abuse among university students are significant public health concerns with multifactorial determinants. This study was carried out between Jan 2024 to June 20024 using multistage sampling technique to select the tertiary institutions and students. It aimed to investigate the influence of socio-demographic factors, peer pressure, family dynamics, and academic stress on substance abuse prevalence among students of the tertiary institution in Imo State, Nigeria. Method: A cross-sectional survey was conducted among 433 students using questionnaire to collecting data on socio-demographic characteristics, peer pressure, family dynamics, academic stress, and substance abuse behaviors. Chi-square tests were utilized to analyze the associations between variables, with p-values < 0.05 considered significant. Results: The results revealed that 59.9% of respondents reported that they never or rarely consuming alcohol, while 66.9% reported never using recreational drugs. Additionally, 62.7% of respondents reported not feeling pressured by peers to consume alcohol or use drugs. There were significant associations between peer pressure and socio-demographic factors, including age (X2 = 4.64, p = 0.031), gender (X2 = 0.01, p = 0.019), religion (X2 = 3.96, p = 0.046), monthly allowance (X2 = 7.42, p = 0.007), educational level (X2 = 8.19, p = 0.004), and residence (X2 = 11.37, p = 0.001). Additionally, family dynamics/upbringing (X2 = 33.2, p = 0.0101) and academic stress/workload (X2 = 11.5, p = 0.041) were significantly associated with substance abuse prevalence among students. Conclusion: The findings show high level in the knowledge of drug/substance abuse and the importance of addressing the socio-environmental determinants that contributes to alcohol/substance usage. Recommendations include implementing targeted prevention programs, strengthening family-based interventions, enhancing campus support services, promoting healthy coping mechanisms, providing education on substance abuse, conducting further research, and fostering collaboration and partnerships. By addressing these factors, universities can create supportive environments conducive to student well-being, ultimately mitigating substance abuse's negative consequences and promoting a culture of wellness and academic success.
ORIGINAL RESEARCH ARTICLE | Oct. 11, 2025
Analytical Method Development and Validation to Assess the Particle Size Distribution in Azithromycin Oral Suspension 200mg/5ml
P. Nataraj, M. Ravisankar, M. Vijayakumar, M. Sivagamy, G. P. Senthilkumar
Page no 949-952 |
https://doi.org/10.36348/sjmps.2025.v11i10.004
Given that it influences the therapeutic product's dissolving profile and bioavailability, particle size is a crucial component of contemporary medication quality. Particle size analysis aids in improving drug quality and improving the pharma product development process. In this research, the particle size distribution of Azithromycin oral suspension is determined using an innovative and accurate approach that was established for the purpose of determining the particle size of the suspension. This approach has produced good, repeatable outcomes. The International Conference on Harmonization's Q2 (R1) guidelines were followed in the development and validation of the wet method, which used water as the dispersant. The results showed that the method was robust and reproducible, with the percentage RSD values found within acceptance limit. The approach presented here in is a precise, verified, and efficacious technique for ascertaining the particle size distribution of oral azithromycin suspension. In-depth discussion of the particle size approach is provided to guarantee comprehension of the particle size distribution and the performance of the method across the product's lifetime.
ORIGINAL RESEARCH ARTICLE | Oct. 10, 2025
Association of Excessive, Normal and Inadequate Gestational Weight Gain with Maternal and Fetal Complications in Diabetic Mothers
Effat Aziz, Tasnia Sultana, Shahidul Islam, Salma Akter, Rubab Sarmin, Mahzabin Husain, Jannatul Ferdous Chowdhury
Page no 298-305 |
https://doi.org/10.36348/sijog.2025.v08i10.001
Background: Gestational weight gain (GWG) is a key determinant of maternal and fetal outcomes, particularly in pregnancies complicated by diabetes. Both excessive and inadequate GWG have been associated with adverse outcomes, yet data on the impact of GWG in diabetic mothers in Bangladesh remain limited. This study aimed to evaluate the association between GWG and maternal and fetal complications in women with gestational diabetes mellitus (GDM) and pregestational diabetes mellitus (PGDM). Methods: A cross-sectional analytical study was conducted at the Department of Obstetrics and Gynecology, BIRDEM General Hospital, Dhaka, from August 2022 to June 2024. A total of 102 pregnant women at ≥37 weeks of gestation, including 51 with GDM and 51 with PGDM, were enrolled. Participants were categorized into excessive, normal, and inadequate GWG groups. Maternal and fetal complications, as well as mode of delivery, were analyzed using appropriate statistical tests. Results: Among GDM patients, 49.02% had normal GWG, 31.37% excessive, and 19.61% inadequate. Cesarean section was significantly higher in the excessive GWG group (93.7%) compared to normal (40.0%) and inadequate (60.0%) GWG groups (p=0.006). Maternal complications were more frequent in PGDM than GDM across all GWG categories but without statistical significance. Fetal complications were significantly higher in PGDM mothers with normal GWG (57.9% vs. 28.0%, p=0.046), while other GWG groups showed no significant differences. Type-specific fetal complications in inadequate GWG were not statistically different between GDM and PGDM. Conclusion: Both excessive and inadequate GWG in diabetic pregnancies are associated with increased maternal and fetal complications, with PGDM mothers at higher risk. Appropriate monitoring and management of GWG is crucial to optimize perinatal outcomes.
REVIEW ARTICLE | Oct. 10, 2025
Safeguarding Women's Rights: An Examination of Constitutional and Statutory Provisions within Hindu and Muslim Personal Laws in India
Mangala T. P, Dr. Prakash Kanive, Dr. B S Reddy
Page no 245-252 |
https://doi.org/10.36348/sijlcj.2025.v08i10.002
Hindu and Muslim women, who face discrimination on numerous fronts due to their intersection with gender, religion, and community, have been disproportionately hit by the constitutional duality of public and private inequity. There can be no gender or religious discrimination in India, according to the constitution. But this parity does not extend to the home, where Islamic personal law blatantly discriminates against Hindu and Muslim women. The personal law system governs all family relations and applies to individuals based on their religious affiliation. Hindu and Muslim women face discrimination in divorce or marriage, custody and guardianship, inheritance and succession, and other areas where personal law is applicable. Besides this disadvantage in legal status, Hindu and Muslim women face further marginalization in citizenship and democracy in terms of socioeconomic position, political representation, and participation. This is all because they are members of a religious minority. The constitutional canon has consistently ignored the importance of gender, which has led to the marginalization of substantive gender equality. Hindu and Muslim women's substantive equality has always been positioned in opposition to minority rights and religious freedom. The quick triple talaq practice was declared null and void by the Supreme Court in the landmark Shayara Bano ruling due to its violation of the constitutional guarantee of equality. This study examines the issue to determine whether or not Hindu and Muslim women's equality rights might be included in the constitution. Using feminist constitutionalism as a lens, this article will analyze the Indian Constitution while the revolutionary possibilities it holds for Muslim and Hindu women.
REVIEW ARTICLE | Oct. 10, 2025
Integrative Zoology in the 21st Century: Unifying Genomics, eDNA, Morphology, Behavior, Biologging, Bioacoustics, Remote Sensing, and AI for Global Biodiversity Discovery and Conservation
Muhammad Abbas, Abuzar Mehdi Khan, Mirza Muhammad Saad Ullah Khan, Irfan Ishaque, Adan Irshad, Muhammad Umer Sundhu, Syed Haroon Haidar, Maria Arshad, Mubashir Farooq, Sehar Rafique
Page no 414-437 |
https://doi.org/10.36348/sjls.2025.v10i09.005
Descriptive morphology and taxonomy That is because zoology is rapidly evolving to be a multi-modal science that operates on the organismic to molecular scale (i.e., it extends beyond the level of the ecosystem). To address that global crisis in biodiversity, scientists have combined genomics and environmental DNA (eDNA) analysis with morphometrics and imagery, behavior studies through biologging, trail cameras, and vocal monitoring, and landscape studies using remote-sensing tools. These varied approaches are now joined together by artificial intelligence and open data platforms and are opening new avenues to real-time biodiversity discovery and predictive conservation. However, questions also remain: the knowledge gap in taxonomy, bias in occurrence data, incomplete validation of models using either eDNA or acoustics data, and the lack of standards addressing blending multi-modal data. Moral imperatives such as animal welfare in tracking, fairness in international partnerships and data sovereignty are still burning. This paper presents an outline of Integrative Zoology and presents case studies of how it is transforming our basic understanding of the cryptic species, how it tracks movement and decline, and how it can inform conservation analysis. By integrating the traditional study of zoology with the newest of technologies, the discipline can transform into a science of awareness of biodiversity, infrastructure that is ready to directly assist the conservation policy and resilience of the planet.
REVIEW ARTICLE | Oct. 10, 2025
Mothers' and Healthcare Providers' Attitudes Towards the Use of Cabbage Leaves and Fenugreek in During Lactation: A Scope Review
Ola Muneer Alyamani
Page no 408-413 |
https://doi.org/10.36348/sjls.2025.v10i09.004
Background: The World Health Organization advocates for proper integration and regulation of evidence-based Traditional, Complementary, and Integrative Medicine (TCIM) into healthcare systems nationally in response to the rapid growth of using TCIM worldwide (WHO, 2017). Fenugreek seeds are one of the most popular galactagogues for lactating mothers (El Sakka et al., 2014). Additionally, cabbage leaf compresses have shown several benefits in reducing breast engorgement (Thomas et al., 2017). Understanding the attitudes of both mothers and healthcare providers towards the use of TCIM during lactation is essential to promote informed decision-making regarding practices(Sim et al., 2014). Objective: This review aimed to explore the attitudes of lactating mothers and healthcare providers towards cabbage leaves and fenugreek, to investigate healthcare providers' perspectives on these remedies, and to identify potential benefits and risks associated with the use of cabbage leaves and fenugreek during lactation. Method: The literature review employed a systematic approach to gather relevant articles. Electronic databases such as PubMed, Cochrane, MEDLINE, and Google Scholar were systematically searched using specific keywords related to the topic of interest. Result: Fifteen studies met the inclusion criteria. The review of literature provides significant insights into the traditional use of cabbage leaves and fenugreek in lactation management, elucidating their perceived benefits and effectiveness in alleviating breast engorgement among lactating mothers. Conclusion: The synthesis of literature underscores the significance of integrating traditional practices and natural remedies, such as cabbage leaves and fenugreek, into lactation management. While these interventions have shown promising results in relieving breast engorgement and enhancing milk production, further research is warranted to elucidate their mechanisms of action, optimal dosages, and potential side effects. Collaborative endeavors among healthcare providers, researchers, and lactating mothers are crucial to facilitating informed decision-making and fostering the comprehensive overall health of lactating mothers and their infants.
ORIGINAL RESEARCH ARTICLE | Oct. 10, 2025
Association of Demographic and Clinical Factors with Ovarian Response in Subfertile PCOS Patients Treated with Letrozole
Tasnia Sultana, Jannatul Ferdous Chowdhury, Rokebul Hasan Mazumder, Effat Aziz, Rubab Sarmin, Salma Akter, Mahzabin Husain
Page no 330-334 |
https://doi.org/10.36348/sijog.2025.v08i10.006
Background: Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory subfertility. While letrozole is widely used for ovulation induction, treatment response varies and predictors beyond anti-Müllerian hormone (AMH) require further evaluation. This study aimed to investigate the association of demographic and clinical factors with ovarian response in subfertile PCOS patients treated with letrozole. Methods: A cross-sectional analytical study was conducted at the Center for Assisted Reproduction, BIRDEM-II Hospital, Dhaka, from April 2022 to September 2023. A total of 116 women with PCOS, aged 18–35 years, underwent letrozole induction (5 mg/day). Participants were categorized as responders (dominant follicle ≥16 mm, n=58) and non-responders (<16 mm, n=58). Demographic variables, BMI, type of subfertility, and baseline serum FSH and LH were compared between groups. Statistical analyses were performed using SPSS v26, with p<0.05 considered significant. Results: No significant associations were found between ovarian response and age (p=0.743), education (p=0.121), occupation (p=0.356), or income (p=0.576). BMI distributions did not differ significantly (p=0.331), nor did the type of subfertility (p=0.550). Serum FSH was significantly higher among non-responders (9.28±5.6 vs. 7.19±3.64, p<0.001), while serum LH showed no significant difference (p=0.102). Conclusion: Demographic and socioeconomic factors did not influence the ovarian response in patients with PCOS treated with letrozole. Elevated basal FSH levels were associated with poor responsiveness, indicating its role as a predictor. These findings support FSH assessment in individualized treatment planning for women with PCOS.