Objective: To identify the significant level of Case fatality of Covid-19 Patients with Ischemic Heart Disease in selected hospitals in Dhaka city. Method: This cross sectional study was carried out at NICVD/ Lab aid cardiac hospital/ Universal cardiac hospital from January 2023 to February 2023. Where a total of 384 adults (>18 ages) with Ischemic Heart Disease who admitted in hospital and tested positive for Covid- 19 were included as a sample population. After collecting data from sample population, data was checked and re-checked for completeness and correctness. The Collected data was analyze via statistical Software’s like STATA, SPSS etc. Results: during the study, majority were belonging to 51-60 years age group, 32.81%. followed by 27.60% were belong to 41-50 years age group and 23.18% belong to >61 years age group and majority were male, 80%.42.71% had normal weight whereas 28.13% were overweight & 24.74% were obese. 80.47% had chest pain, followed by 13.28% had dyspnea, 12.50% had cough, 10.68% had palpitation, 4.17% had vomiting. where 46.61% had STEMI, followed by 17.19% had NSTEMI, 19.27% had unstable angina, 25.78% had systemic hypertension, 21.88% had diabetes mellites, 6.77% had Heart valve disease, 4.43% had Arrhythmia. Plus, majority didn’t get their vaccination, 89.60%.49.48% had abnormal level of anxiety status whereas 55.73% had abnormal level of depression. Multivariable logistic regression found residence, age, profession, and income to be statistically significantly associated with anxiety after controlling for the other factors found to be significant at the univariate level. Plus, Chronic disease, STEMI, NSTEMI to be statistically significantly associated with anxiety after controlling for the other factors found to be significant at the univariate level. Cardiovascular Drug Therapy at Hospitalization of Covid-19 shows Medical therapy included ACE inhibitors (22.1% of the patients), ARBs (20.57%). mean length of hospital stay was 10.7±2.7 days, with an overall in-hospital mortality of 5.8% (515 of 8910 patients) in this population of patients with completed outcomes. Conclusion: Our findings indicate that health care providers, particularly cardiologists and nurses, should take extra care to detect and evaluate all heart disease patients for level of anxiety and depression in a clinical setting. There is a need to develop a quick screening approach in hospitals dealing with cardiovascular inpatients to identify those needing extra evaluation and care.

Background: The primary cause of illness and death in Bangladesh is community acquired pneumonia (CAP). Many hospitals in Bangladesh lack the resources to perform sputum cultures and sensitivity tests, making it difficult to identify the etiological agent of an infection. As a result, antibiotics are prescribed on a "empirical basis" rather than as part of a specific anti microbial treatment. The optimal antibiotic for treating CAP should be chosen using an empirical approach. Objective: The purpose of this study is to evaluate the effectiveness of various empirical antibiotic choices in the management of CAP. Methods: Eighty-two patients with CAP were included in this prospective observational research at a tertiary medical college hospital in Bangladesh. Inclusion and exclusion criteria were used to choose patients. Chest x-rays confirmed the diagnosis of CAP. The antibiotic was chosen based on clinical experience, which is an empirical method. The majority of patients received a combination antibiotic, whereas the remaining handful received monotherapy. The result served as an evaluation of the empiricism used in selecting the antibiotic. During the research, data were recorded in standardized formats. SPSS was used for the statistical analysis. Results: A total of 82 people were treated, and of them, 62 (or 76%) were men and 20 (or 24%) were women. The average age was 54.4% (9.6%). The round of antibiotics was supposed to last for a week. There were no unwanted medication reactions. No cases of lung abscess or parenchymal damage to the lungs occurred, and only one patient had paraneumonic effusion. Every single person made a full recovery. Conclusion: In many hospitals in Bangladesh, the choice of antibiotic for treating CAP is made on a "empirical" basis. Selecting an appropriate antibiotic requires better sputum culture and sensitivity testing in hospital labs.

Background: A deficiency is a public health issue for many children and adults. In wartime hardship, patients eat little meat, dark vegetables, and fruits, which can cause vitamin A deficiency and corneal dryness, erosion, ulceration, and perforation. The purpose of this study was to identify the characteristics and demographics of vitamin A insufficiency in Sudan during the 2023-2024 war. Methodology: This prospective descriptive study was carried out between June 15, 2024, and August 15, 2024, at Dr. Khalil's Ophthalmology Center in North Kordofan, Sudan. The study looked at 100 individuals who presented at the clinic complaining of deficient night vision (including full coverage during the notification period). Results: In this study, only six patients had corneal opacity, with 67% being males and 33% females. In terms of Bitto's spots, 12% are present, with males and females having 58% and 42%, respectively, and 46% having dry eyes. 52% were males and 48% were females in terms of retinal pigmentation. Only one female patient exhibited peripheral retinal pigmentation, which was due to retinitis pigmentosa; all patients had inadequate food intake; and no diarrhea was reported. Conclusion: In Sudan, the rise in vitamin deficiency can be attributed to the inadequate development of all health system programs. Additionally, the devastating war, which primarily affects young people, has forced most people to leave their homes and become either displaced or refugees. Consequently, 69% of the patients were 17 years old or younger.

Background: Cervical Intraepithelial Neoplasia (CIN) is a precancerous condition and a significant cause of cancer-related mortality among women in developing countries. In Bangladesh, its prevalence is rising due to low screening rates and late-stage diagnosis. Objective: This study aimed to determine the incidence of CIN among women attending the outpatient department of Islami Bank Medical College Hospital, Rajshahi, and to identify associated risk factors. Method: A prospective observational study was conducted in the Department of Obstetrics and Gynecology at Islami Bank Medical College Hospital, Rajshahi, Bangladesh, from January 2020 to December 2023. The study included 218 women aged 30-65 years. Screening for CIN was performed using visual inspection with acetic acid (VIA) and Pap smear/Liquid Based Cytology (LBC). Positive cases were confirmed using colposcopy. Statistical analysis was performed to determine the significance of risk factors, with a p-value <0.05 considered statistically significant. Results: Out of 218 women screened, 35 were diagnosed with CIN, yielding an incidence rate of 16.1% (95% CI: 11.5% - 21.8%). Of these, 20 cases (57.1%) were identified as CIN 1, 10 cases (28.6%) as CIN 2, and 5 cases (14.3%) as CIN 3. The incidence of CIN was significantly associated with early sexual exposure (p=0.03) and multiple sexual partners (p=0.02). The use of VIA and LBC demonstrated a combined sensitivity of 92% for CIN detection. Conclusions: The study highlights a significant incidence of CIN among the outpatient population in IBMC Rajshahi, emphasizing the need for enhanced screening and preventive strategies. Early detection of cervical cancer through VIA and LBC, followed by colposcopy, proves effective in managing CIN. Public health initiatives should focus on increasing awareness, health education, and accessibility to screening services to reduce cervical cancer incidence.

This study examined workplace humanization and job effectiveness of business education graduates in tertiary institutions in Rivers State. Two (2) objectives, research questions and null hypotheses were stated, answered, formulated and tested to guide this study. Descriptive survey design was adopted in this study and the population consists of one thousand two hundred and eighty-three business education graduates in public tertiary institutions in Rivers State and the sample size of this study was two hundred and ninety-seven respondents drawn from the population with the use of Taro Yamen formular, hence simple random sampling techniques was adopted in this study. A self-developed questionnaire titled “Workplace Humanization and Job Effectiveness of Business Education Graduates Questionnaire (WoHuJEBEGQu) was used to obtain data for this study. In addition, the said instrument employed face and content validity, which was validated by experts in the study area and a reliability index coefficient of 0.81 was obtained using test-retest method of Pearson Product Moment Correlation Coefficient (PPMC). Mean and standard deviation was used to answer and analyzed the research questions while independent t-test statistical tool was used to test the null hypotheses at 0.05 level of significance. Findings of this study revealed that job security and equity in remuneration are the variables of workplace humanization that enhances job effectiveness of business education graduates in tertiary institutions in Rivers State to a high extent. In addition, there is no significant difference in the mean responses of male and female business education graduates on extent job security and equity in remuneration enhances job effectiveness in the aforementioned institutions in Rivers State. It was therefore recommended among others that management of institutions should display equal fairness in the areas of employees’ remuneration so that there will not be room for any marginalization.

In a typical watershed area such as the Federal University of Technology, Owerri, Nigeria, watershed modelling is essential for the sustainable management of water resources, protection of ecosystems and more. In this study, we will be creating a watershed model for FUTO, this study will also cover other aspects such as estimating the depression-less flow direction, delineating the flow accumulation, extracting realistic drainage network using the Strahler’s stream order method and we will also delineate the watershed’s boundary and identify possible outlets / pour points, using the digital elevation model (DEM) gotten from Alaska satellite facility used as a main data source in combination with the PC version of ArcGIS software (ArcMap 10.7) and then we extract the hydrologic information from the DEM in ArcGIS using Hydrology tools. The estimation of depression-less flow direction is done by filling the digital elevation model (DEM). This includes performing fill on sinks to ensure proper delineation of basins and streams. If the sinks are not filled, a derived drainage network may be discontinuous. After the DEM has been filled, then we can now move on to delineating the flow accumulation in the study area. The results shows that by using watershed function in ArcGIS for watershed flow direction and accumulation in FUTO can be determined. The results also shows the drainage network that was extracted by Strahler’s method, showing different orders of streams and it also shows the watershed boundary and pour point / outlets along the Otamiri River which the watershed drains into. This work simply shows the applicability of GIS as a tool of watershed delineation and drainage extraction.

The aim was to assess the prognosis of anaemic pregnant women at the Gabriel Toure University Hospital in Bamako (Mali). Materials and Methods: This was a cross-sectional, descriptive and analytical study. It covered a period of 6 months and involved 432 patients. Results: the frequency of anaemia associated with pregnancy was 28.7% or 432 cases of anaemia among 1505 pregnant women. The mean age was 25.99 years with extremes of 15 and 45 years. Among them, the majority were housewives and constituted 77.8% of the workforce compared to only 4.9% of civil servants. The etiological factors often associated were: gestationity (3.52 with extremes of 1 and 11); primiges (29.20%); parity (3.26 with extremes of 1 and 11). The mean birth interval was 24.4 months with extremes of minus 6 months and 158 months. In 78.7% of cases, patients were transfused. The prognosis was characterized by a maternal mortality rate of 4.4% and a neonatal mortality rate of 33.3%. The mean length of hospital stay was 5.21 days. Conclusion: Anaemia in pregnant women is a pathology that causes maternal and neonatal mortality. The unavailability of blood products worsens the prognosis.

During this study period, we recorded 10187 deliveries, including 2763 caesarean sections. Surgical site infections were found in 102 caesarean sections, i.e. 3.69%. We found that age over 35 years, history of diabetes, asthma, sickle cell anemia, obesity (BMI > 30 kg/m2) and history of caesarean section were risk factors for the occurrence of an infection at the surgical site. The bacteriological profile was dominated by Staphylococcus Aureus (21%) followed by Klebsiella Pneumoniae (20%) and Escherichia Coli (16%). Superficial infection was the most common at 65%. Most of the germs were sensitive to imipenems; to the ertapenems; amikacin; gentamycin; colistin and ciprofloxacin. Klebsiella was the germ most resistant to common antibiotics.

This article proposes an innovative approach to optimizing scheduling in reconfigurable production systems, with a focus on minimizing resource allocation in a dynamic environment while considering time constraints and resource availability. We present a methodology based on intelligent Petri nets to model and solve this complex problem. Our approach aims to maximize operational efficiency and flexibility of production systems while ensuring optimal performance in the face of unforeseen events and changing market demands. We illustrate the effectiveness of our approach through a case study in a real industrial context, demonstrating the tangible benefits it offers in terms of optimizing production processes and reducing costs.

Uterine ruptures are common in Africa incidence 1 per 70 to 151 deliveries [1]. Rupture of the gravid uterus affects less than 1% of pregnant women involved in a public road accident. We report a case of uterine rupture due to direct abdominal trauma during a road accident (AVP) occurring in Kayes (Mali) [1].

Periampullary tumors are cancers that arise in the region of the ampulla of Vater, where the bile duct and pancreatic duct converge and empty into the small intestine. These tumours can be challenging to diagnose and manage given the region's transitional character and closeness to various structures. Upper gastrointestinal bleeding may be a rare clinical presentation following tumoral ulceration, erosion into blood vessels or nearby structures or secondary complications like pancreatitis or portal hypertension. Identifying the anatomical origin of these malignancies is usually a herculean task. This will require prompt oesophagogastroduodenoscopy and imaging to determine the source. Immunohistochemistry may be helpful in differentiating these tumours. We present periampullary tumour an unusual cause of upper gastrointestinal bleeding. A 52 year old male was admitted for evaluation following a 3 months history of weight loss, burning/colicky epigastric pain, easy fatiguability, dizziness, vomiting and passage of malaena.He was fully conscious on admission, pale, tachycardic with a blood pressure of 90/70mmHg. He had an international normalized ratio (INR) of 1.0. Oesophagogastroduodenoscopy showed a polypoid fungating mass at the1st and 2nd parts of the duodenum. A Computerized Tomogram scan of the abdomen showed a diffuse circumferential duodenal wall thickening of 1st and 2nd parts with reduction in luminal calibre, mildly dilated pancreatic, common bile and common hepatic ducts. Histology showed moderately differentiated adenocarcinoma. He had a side to side gastrojejunal anastomosis and cholecystojejunostomy and entero-enterotomy following which he received chemotherapy.

Monkeypox, a zoonotic disease, has become the hot topic spreading across the newspaper headlines like a forest fire. The disease is transmitted from one individual to another by close, intimate contact such as cuddling, kissing, or contact with fluids in the dermal lesions. Though it is a self-limiting disease with symptoms akin to Smallpox (but a milder version), some severe cases have been reported as well. WHO has reported the case fatality rate of Monkeypox infection to be around 3–6%, which is slightly higher than that of COVID-19. Incubation period of the disease is 6–13 days on an average (range of 5–21 days). The monkeypox virus, which was previously exclusive to West and Central African nations and caused endemic diseases in monkeys and people, has recently been linked to human infections in non-endemic areas including the United States of America (USA) and more than 30 additional countries. The monkeypox outbreak continues to be a worldwide health emergency, the highest degree of alert recognised by the World Health Organization. The Centers for Disease Control and Prevention (CDC) advises vaccination for those who have been exposed to the disease as well as those who may be at higher risk of contracting it, such as those who have been identified by public health officials as a contact of someone who has the disease.

Background: Endometrial carcinoma (EC) is a common gynecologic malignancy with significant implications for women's health. Mismatch repair deficiency (MMRd) has emerged as a critical factor influencing the pathogenesis and prognosis of EC. This study aims to investigate the clinicopathologic characteristics of MMRd EC in a Bangladeshi cohort. Methods: This cross-sectional observational study was conducted at the Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2022 to February 2023. A total of 49 patients with histologically confirmed EC were included. Data were collected through a semi-structured questionnaire and patient records. Results: Among the 49 patients, 67.35% (n=33) were MMR proficient, while 32.65% (n=16) were MMR deficient. The mean age was 55 years for MMR proficient and 55.6 years for MMR deficient patients. Hypertension was present in 69.70% of MMR proficient and 75% of MMR deficient patients, while diabetes mellitus affected 54.55% of MMR proficient and 62.50% of MMR deficient patients. MMRd patients showed higher rates of adnexal involvement (37.50% vs. 6.06%, p=0.010) and metastasis (37.50% vs. 9.09%, p=0.024). Multivariate logistic regression identified advanced FIGO stage (III & IV) as a significant predictor of MMR deficiency (adjusted OR 4.274, 95% CI: 1.691-15.515, p=0.025). Conclusion: MMRd in endometrial carcinoma is associated with more aggressive tumor features and poorer prognostic indicators. Routine evaluation of MMR status is crucial for effective prognosis and treatment planning. Addressing socioeconomic disparities and integrating targeted therapeutic strategies can improve management and outcomes for patients with MMRd endometrial carcinoma in diverse populations.

Background: Excessive and uncontrolled internet use can significantly impair daily functioning in various life domains. Despite the numerous benefits of the internet, its addictive use is a growing concern, particularly among youth, who are prone to anxiety, depression, and stress-related disorders. Understanding the current scenario is essential for devising effective interventions, yet no scientific data is available in Bangladesh. Objective: To assess between depression, anxiety, and stress among youth with problematic internet use (PIU) attending a tertiary care hospital. Methods: This cross-sectional and descriptive study was conducted at the Department of Psychiatry, Department of Bangabandhu Sheikh Mujib Medical University, from October 2020 to September 2022. Participants were interviewed using a structured socio-demographic questionnaire, the Bangla versions of the Internet Addiction Test (IAT), and the Depression Anxiety and Stress Scale-21 (DASS-21-BV). Data were analyzed using SPSS 26.0, with significance set at p<0.05. Results: Among the 90 participants (mean age: 21.33 years; 68% male, 32% female), 95% were students, and 87% were from nuclear families. Internet use exceeded one year for 83% of participants. PIU levels were minimal in 15%, moderate in 62%, and excessive in 22%. Severe depression was observed in 15% of participants, severe anxiety in 25%, and severe stress in 25%. Extremely severe levels of depression, anxiety, and stress were found in 14%, 5%, and 14% of participants, respectively. Significant risk factors for PIU included male gender (χ²=8.217; p=0.02) and over three hours of daily internet use (χ²=35.289; p=0.001). PIU was significantly associated with depression (χ²=20.380; p=0.001), anxiety (χ²=16.159; p=0.019), and stress (χ²=14.734; p=0.019). Conclusion: Depression, anxiety, and stress are significantly associated with PIU. Early risk assessment, proper internet use, and initial screening are essential for managing potential mental disorders linked to PIU.

Organic products are grown under a system of agriculture without using chemical fertilizers and pesticides, with an environmentally and socially responsible approach, and provide healthy food. It is developing rapidly and is practised in more than 120 countries. In 2022-23, the total area under the organic certification process (registered under the National Programme for Organic Production) is 10.17 million ha. This includes 5.39 million ha of cultivable area and another 4.8 million hectares for wild harvest collection. Madhya Pradesh has covered the most significant area under organic certification. In contrast, India produced around 2.9 million MT of certified organic products, which include all varieties of food products, namely Oil Seeds, fibre, Sugar cane, Cereals and millets, Cotton, Pulses, Aromatic and Medicinal Plants, Tea, Coffee, Fruits, Spices, Dry Fruits, Vegetables, Processed foods etc. The production is not limited to the edible sector; it produces organic cotton fiber, functional food products, etc. Among different states, Madhya Pradesh is the largest producer. In terms of exports, the total value was 0.31 million Mt. The organic food export realisation was around Rs. 5525.18 Crore (708.33 million USD). Products are exported to the USA, European Union, Canada, Great Britain, Switzerland, Turkey, Australia, Ecuador, the Korean Republic, Vietnam, Japan, etc. The objectives of organic farming ensure that food production has high nutritional value in adequate quantities and preserves and enhances the long-term fertility of soils.