The emergence of antibiotic-resistant bacteria poses a critical challenge to global public health, necessitating the exploration of alternative therapeutic strategies. This study investigates the antimicrobial potential of bioactive compounds derived from four medicinal plants: Chrysopogon zizanioides, Asteracantha longifolia, Asparagus racemosus, and Tinospora cordifolia. These plants, traditionally used in various medicinal systems, contain compounds such as khusimol, stigmasterol, lupeol, shatavarin IV, asparagamine A, tinosporin, and cordifolioside A, which have shown promising antimicrobial properties against resistant pathogens. Two formulations were developed: Formulation 1, designed for oral administration, and Formulation 2, a topical cream, both targeting antibiotic-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Escherichia coli (MDR E. coli). The Minimum Inhibitory Concentration (MIC) of each extract and formulation was determined using a microdilution method. Results indicate that these plant-based formulations exhibit significant inhibitory effects on bacterial growth, with potential applications as complementary therapies to conventional antibiotics. This study highlights the potential of these medicinal plants as sources of novel antimicrobial agents, providing a sustainable approach to combating antibiotic resistance.

In the era of big data, organizations are increasingly leveraging advanced analytics to extract valuable insights from vast and complex datasets. Management Information Systems (MIS) play a crucial role in collecting, processing, and analyzing data to support decision-making. Integrating big data analytics into MIS can enhance business intelligence and improve organizational performance. This study aims to investigate the integration of big data analytics into MIS and its impact on business intelligence. Specifically, the study seeks to identify the challenges and opportunities associated with this integration and explore best practices for implementation. A qualitative research approach was adopted for this study. Data was collected through semi-structured interviews based on a survey of over 312 information technology (IT) professionals from 21 industries with IT managers and business analysts from January 2022 to December 2023. Thematic analysis was used to analyze the data and identify key themes related to integrating big data analytics into MIS. The findings indicate that integrating big data analytics into MIS can significantly improve business intelligence. According to the respondents, on average, there was a 30% increase in the accuracy of decision-making processes after the integration. Additionally, organizations reported a 25% reduction in operational costs and a 20% increase in revenue as a result of the integration. Moreover, 70% of the respondents agreed that integrating big data analytics into MIS improved their organization's overall performance. Integrating big data analytics into MIS offers numerous benefits, including improved decision-making, cost savings, and revenue growth. However, organizations must overcome challenges such as data privacy and security concerns and the need for skilled personnel to manage and analyze big data. Overall, this study highlights the importance of integrating big data analytics into MIS for enhancing business intelligence and achieving organizational success.

Thymol (2-isopropyl-5-methyl-phenol) is a natural monoterpene phenolic antioxidant that has anti-inflammatory and anti-apoptotic potentials in experimental studies. Literatures are scarce on effects of hexachlorobenzene-induced hepatic damage. Therefore, this study investigated the ameliorating potential of thymol (THY) on hexachlorobenzene (HCB)-induced hepatic damage as well as the effects on the antioxidant status, polyamine catabolism, inflammatory and apoptotic processes. Thirty-two adult male rats were daily treated orally by gavage for 25 days and allocated into four groups; control group received corn oil, HCB alone group (15 mg/kg b.wt), THY-treated group (100 mg/kg b.wt) and HCB + THY-treated group. The results showed that HCB significantly reduced the body weight with concurrent increase in relative liver weight accompanied by widespread histological aberrations. Furthermore, HCB-treated rats revealed increases in hepatic putrescine oxidase, spermine oxidase, and myeloperoxidase activities, tumor necrosis-α and interleukin-1β levels, caspase-3 activity, induced oxidative damage as evidenced by elevated malondialdehyde (MDA) levels and significant reduction in antioxidant enzyme activities and reduced glutathione (GSH). However, co-administration of THY with HBC abated the hepatic damage by preventing the generation and release of reactive oxygen species, improving the antioxidant system, down-regulated polyamine catabolism, inflammatory and apoptotic responses. The findings of this study revealed that HCB acts as a hepatotoxicant and thymol might be a possible future therapeutic agent for HCB-induced hepatic damage.

Vaginal malformations can be diagnosed by ultrasound in a large number of cases. The prevalence of uterovaginal aplasia usually reported in the literature is 1/4000 to 1/10,000. Objectives: We tell you about the difficulties of diagnosis with ultrasound, the difficulties of managing our case of vaginal aplasia. Observation: This was a 20-year-old patient saleswoman, single. History of the disease: was marked by cyclic pelvic headache for 6 months with primary amenorrhea. She has no particular medical-surgical history. On physical examination: Secondary sexual characteristics were developed. On inspection of the vulva, normal pubic hair was noted. Examination of the vulva showed the labia majora and labia minora present and normal-looking. A hymen could not be identified and there was no visible vaginal opening. Faced with this clinical and paraclinical symptomatology, we made the diagnosis of vaginal agenesis. The ultrasound showed a uterus measuring about 92x71x62 mm, its parenchyma is homogeneous, its contours are regular. The presence in the uterine cavity at the corporeofundic level of a homogeneous echogenic collection of about 66.5 cc (69x35 mm). Note the congenital malformation of the cervix with agenesis). The Surgical Procedure Performed is vaginoplasty. Conclusion: Ultrasound of uterine malformation is difficult and requires some experience from the sonographer.

Background: Musculoskeletal pain and discomfort are common causes that influence most surgeons' performance and lifestyle. The purpose of this study is to investigate where surgeons experience the most musculoskeletal discomfort and suffering compared to non-surgical specialty doctors. Methodology: This descriptive case-control study included 156 participants from El Obeid, a city in Sudan's Northern Kordofan state. We randomly selected the volunteers between May and June 2024, irrespective of their age or gender. Results: This study included 156 doctors from diverse disciplines aged 27 to 70, with a mean age of 37. Male-to-female ratio: 2:1. Of the 156 participants, 104 (67%) were males and 52 (33%) were females. The bulk of participants were 31–35 (33%), 36–40 (30%), and under 30 (13%). Neck pain was experienced by 38% of participants, including 44% of surgeons and 25% of non-surgical specialists. Surgeons had a greater neck pain rate (RR = 0.420, 95% CI = 0.201–0.879). About 20% of participants, including 24% of surgeons and 13% of non-surgical specialists, reported shoulder pain. The study found a relative risk (RR) of 0.492 and a 95% confidence interval (CI) of 0.197–1.227 between shoulder pain and surgery. Additionally, 57% of participants—66% surgeons and 38% other specialties—reported lower back pain. With an RR of 0.317 (95% CI 0.159–0.633), surgeons are more likely to experience lower back pain. Foot discomfort affected 7% of participants, 9% of cases, and 4% of controls. Cases increased foot pain risk by 0.422 (95% CI 0.088–2.029). Conclusion: Surgeons in various specializations in Sudan, as well as doctors in non-surgical specialties, have a significant prevalence of musculoskeletal discomfort. The most often reported areas of pain were the lumbar region, cervical region, shoulder, and lower extremities.

This study examined financial sector development and original sin in Nigeria financial market. Time series data was sourced from Central Bank of Nigeria Statistical Bulletin from 1990-2023. Original sin measured by Nigeria external debt per exchange rate, Capital market development as market capitalization to gross domestic product, Foreign exchange market as variation in naira exchange rate per US Dollar, banking sector development as percentage total bank assets to gross domestic product, money market development as insurance total assets to gross domestic product, Money market development as value of money market instrument to gross domestic product. The study employed descriptive statistics and multiple regression models to estimate the relationship that exists between the dependent and independent variables. The null Hypotheses (H0) were tested at 0.05 level of significance, Ordinary Least Square (OLS), Augmented Dickey Fuller Test, Johansen Co-integration test, normalized co-integrating equations and parsimonious vector error correction model were used to conduct the investigations and analysis. The study found that 57.0% variation on original sin can be traced and explained by variation on the independent variables as formulated in the regression model. However, the F-Statistics and the F-probability justifies that the model is significant and adequate in explaining variation on the dependent variable. The β coefficient shows that capital market development have negative effect on original sin, foreign exchange market have positive effect on original sin, banking sector development have negative effect on original sin, insurance sector development and money market development have positive effect on original sin. From the findings, the study concludes that the independent variables determine positively and negatively original sin in Nigeria. We recommend that the need for policies to deepen the capital market as this can cushion the effect of the negative effect of external borrowing and domiciled in Nigeria currency rather than international currency. There should be institutionalized policies to enhance the value of the naira against other international currencies as this can reduce the pressure of exchange rate variation in international debt and international monetary environment. Public expenditure should be directed to the productive sector of the economy as this can enhance the productive capacity of the economy and reduce the negative effect on balance of payment and other macroeconomic variables. Policies should be advanced to reduce external borrowings; this can reduce the debt burden and reduce the incidence of original sin in the financial market.

This study, titled "Gyambon Ciki da Magungunansa a Bahaushiyar Al’ada (Ulcers and their Hausa Tradomedical Remedies)," was motivated by the researcher’s long-term observation of ulcers as a silent killer in Hausa and other African communities. The study is grounded in Talcott Parsons' "functionalism theory of culture," which views society as an interdependent system where each part contributes to the stability and functioning of the whole. Just as organs in the human body must work together for proper functioning, so must the interconnected parts of society. The research focuses on the meaning, nature, types, symptoms, and effects of ulcers, as well as preventive and curative measures from the perspective of Hausa culture. It is limited to the Hausa community in Kebbi State, Northern Nigeria. Using a qualitative approach, the researcher gathered data through interviews with experts in both traditional and orthodox medicine, as well as individuals affected by ulcers. The study's major findings include a comprehensive list of locally sourced food items, plants, herbs, and animals used in managing ulcer conditions among the Hausa. Additionally, the research reveals that some of the remedies are of Islamic origin.

Foreign Direct Investment (FDI) is a major force behind the integration of the global economy and has the potential to boost economic development in both investing and those receiving the investment. The majority of the study focuses on the influence of FDI on Bangladesh’s economic growth. A number of scholars have also looked at how FDI affects trade, domestic investment and other economic sectors. But surprisingly less research has been done on the effects of FDI on Bangladesh's export processing zones (EPZs). This study tries to investigate the impact of foreign and domestic investment on exports of EPZs between 2011-2022. To investigate EPZs export, this study used the Auto Regressive Distributed Lag (ARDL) approach. The Wald test was used to determine the direction of causation. The ARDL estimate shows that investment, GDP and FDI all have a positive correlation with rising EPZ export. The coefficient for FDI inflows is 0.15% which suggests that if FDI inflows raise by 1%, EPZ export will grow by 0.15% while all other factors stay constant. It also shows that a 1% increase in investment leads to 1.32% quicker growth in EPZ exports, assuming all other factors remain constant. The Wald test demonstrates the bilateral causal relationship between EPZ export & FDI and the unidirectional relationship between EPZ export & GDP. Therefore, Bangladesh must take immediate measures to protect potential foreign investors in order to provide a welcoming environment so that they can feel their contribution in the Bangladeshi business industry is respected.

The aim was to assess the frequency of fetal death in utero; to describe the sociodemographic and clinical characteristics of patients; to identify risk factors for IUD; to describe its management and to determine the maternal prognosis. Material and Method: This was a descriptive, cross-sectional, analytical study of the prospective case/control cohort type from June 2021 to May 2022, i.e. a period of 12 months in the maternity ward of the Koutiala reference health center. Results: Fetal death in utero concerned 85 deliveries out of a total of 3024 deliveries, i.e. a frequency of 28.11 ‰. The epidemiological profile is that of a poor person (37.6%) between 25 and 29 years of age (31.8%), with a pregnancy of 28 to 37 weeks of amenorrhea; they came on their own in (64.7%) of cases. If, in 5.9% of cases, the cause of fetal death was not known in the study; arterial hypertension was the most common etiology with 37.6% of cases. Patients gave birth vaginally in 89.4% and presented complications of infections (endometritis) in 10.6% of cases.

Presentation with a highly infiltrated malignant lesion often leads to unfavorable outcomes. This woman exhibited an advanced form of cervical cancer that had spread to the surrounding tissue, which might involve the urinary bladder. Due to the Sudan War in 2023, there was a lack of oncological therapy. In response, we implemented palliative surgery, which yielded positive results.

Nihilism is arguably the most misunderstood term in the history of philosophy. It is best understood as a risk inherent in the act of thinking itself, as noted by the 20th-century philosopher Hannah Arendt, rather than as a collection of "dangerous thoughts." Any notion, no matter how solid or widely accepted it initially appears to be, will eventually cause us to question its veracity if we give it enough thought. Additionally, we can start to question whether or not individuals who embrace the idea understand (or care) whether or not it is accurate. You can stop worrying about why there is so little agreement on so many topics and why other people seem to know so much about things that seem so uncertain to you. I believe that nihilism is beyond good and evil. But people in general have a predilection for negative nihilism. They ignore its positive counterpart out of ignorance. Nietzsche, for instance, had the latter in mind when he wrote those iconoclastic works. Baudrillard, in his most famous work on simulation and simulacra, also dedicates a whole chapter to nihilism. He also had the same in mind. The list is quite interminable. Some deconstructionists with American roots (Yale School of Critics) have also broached this topic to shed light on the modus operandi of deconstruction. I believe it was J. Hillis Miller who replaced the term with ‘parasite’ in his seminal essay The Critic as Host. He was defending ‘Deconstruction’ in the same vein as Philip Sidney did in the 16th century. The accusations levelled against poetry by Plato aeons ago seemed so rebarbative to him to have motivated him to write an ‘An Apology for Poetry’. The apology here was not an apology. It was a tirade against Plato’s Republic. Miller, on the other hand, was not only countering accusations but also explicating American deconstruction. The essay written way back in 1977 has so far received an astounding 935 citations. When I read the essay, I understood it made more sense and was less farfetched than its French counterpart.

This article aims to find solutions to accelerate the quality of physical education (PE) for students at universities of Vietnam based on theoretical and practical research on bettering the PE quality in the period of comprehensive educational reform and surveying the status quo’ of PE quality assessment of students at universities under the current curriculum. The study employs the methods of document analysis and synthesis, discussion interview, pedagogical test, sociological investigation and statistical mathematical on SPSS 22.0 software. The results obtained by research, case studies and surveys on 1268 students and 40 PE experts from 03 universities of Vietnam: Hanoi Pedagogical University 2, Tan Trao University and Hung Vuong University posit that students' PE performance is influenced by various subjective and objective factors, thereby emphasizing that to further the PE quality, learning outcomes and movement activities, universities are required to focus on innovative solutions in competency-centered approach for students. The article proposes 03 groups of solutions, including: Group 1: Solutions on extracurricular programs; Group 2: Solutions on innovation of teaching methods; Group 3: Solutions on mobilizing social capitals for facilities and equipment. These solutions gained great consensus and scientific significance on the research subjects.

Introduction: A successful endodontic treatment is ba¬sed on combination of adequate instrumentation, irrigation and obturation of canal system. The objectives of endodontic irrigants are lubrication of root canal, removal of microorganisms, pulp, dentinal remnants and dissolution of tissues. The objective of root-end filling is establishment of proper apical hermetic seal. Aim: To evaluate and compare the effect of various irrigating solutions on push-out bond strength of Biodentine and Mineral trioxide aggregate (MTA). Materials and Method: Sixty-four extracted human single rooted teeth were decoronated 1.5-2 mm coronal to cemento-enamel junction. The root canals were prepared and divided into four groups (n=16): Group I- Normal Saline (Control group), Group II- Triple antibiotic solution, Group III- 2% Chlorhexidine, Group IV- Morinda citrifolia solution. Mid root dentin was sectioned horizontally and irrigated further with respective irrigating solutions for 5 minutes and divided into 2 subgroups: Subgroup A- Biodentine and Subgroup B- MTA. The root-end filling material was incrementally placed and embedded in acrylic blocks. Samples were tested for push-out bond strength using universal testing machine. Results: The highest push-out bond strength was shown by 2% Chlorhexidine group when used with Biodentine and lowest when normal saline was used with Biodentine. Conclusion: All experimental irrigating solutions increased the push-out bond strength of MTA and Biodentine.

Aquaculture industry provides proteins and unsaturated fatty acids worldwide. Fresh water aquaculture is considered as the most prominent type of aquaculture in the world. Nile tilapia aquaculture is favored because it can adopt to wide range of environments and can tolerate various abiotic stresses. However, the success and profitability of aquaculture is significantly affected by type of feeds used in aquaculture system. An experiment was conducted to assess this important aspect of aquaculture. Nile tilapia fingerlings were fed on three different protein sources to assess the effects of these experimental diets on growth of fingerlings and on water quality. Three protein sources were freshwater shrimp meal (FSM), black soldier fly larvae (BSF) and soybean meal (SBM). Fingerlings were divided into groups based on their respective experimental diets and were arranged according to CRD with three replicates. Each replicate contained 30 fingerlings. Data was recorded for growth attributes of fingerlings and for water quality attributes. Analysis of data shows that BSF caused 32% increase in final weight of fingerlings followed by FSM, which caused 24% increase as compared to controlled. Net weight gain was also significantly enhanced by experimental diets. BSF caused 88% increase in weight gain as compared to controlled. BSF also increased 43% survival rate of Nile tilapia fingerlings as compared to fingerlings fed with controlled diet. Water quality was not much affected by all diets. Water quality parameters like DO, pH, temperature, ammonia and phosphorus all were in optimum range for tilapia culture. However, BSF provided 136% more phosphorus as compared to controlled. This study reveals the beneficial effects of BSF larvae protein source for Nile tilapia culture. So, from these findings, it can be suggested to partially replace fish meal with BSF larvae meal.

Accidents triggered by contact with winged adult forms of moths and accidents caused by contact with larvae. These accidents are caused by contact with the bristles on the abdomen of females of certain species, belonging to the genus Hylesia Hübner, 1820 (Family: Hemileucidae). Therefore, the simple fact of penetration of the bristles seems to be capable of causing intense inflammatory, popular, and pruritic reactions. Pararama (pararamose) is the common name for a stinging caterpillar found in the artificial rubber plantations of Pará, Brazil, the larval stage of the moth Premolis semirufa (Walker, 1856) (Famíly: Erebidae). Therefore, accidental contact with the small bristles of the caterpillars or with those of the cocoons causes a chronic inflammatory reaction in the interphalangeal joints that leads to ankylosis. The morbid condition mainly affects rubber tappers and is classified as an occupational disease. Eruca=larva; erucism is poisoning caused by a moth larva. The main families of Lepidoptera fireworms that cause erucism accidents are Megalopygidae, Saturniidae, and Arctiidae. The caterpillars of the Megalopygidae family have a body covered with long, harmless bristles that cover the smaller, sharp spines that carry poison glands this manuscript aims to report the biological characteristics of venomous Lepidoptera (Insecta) and their biological, clinical manifestations, treatment, prevention, and therapeutic possibilities. That paper is a narrative review of the literature, which is designed to explain and discuss a certain subject from a theoretical or contextual perspective, to allow the reader to acquire or update knowledge on a specific topic. The scientific articles that made up this review were searched on Google Scholar, Biological Abstract, HAL, Qeios, ResearchGate, Scielo, and SSRN. The following descriptors in Health Sciences (DeCS) were used: biological therapy, larva, wound, debridement, and healing. The following inclusion criteria were considered: original articles and reviews, published nationally and internationally in full, available electronically, and published in Portuguese, English, and Spanish. The exclusion criteria were dissertations, theses, monographs, and conclusion work, duplicates, and those that required payment to access the content in full.