Introduction: Anemia is a common disorder in dialysis patients. The use of high doses of erythropoiesis stimulating agents is associated with poor outcomes in this population. The aim of this study, was to describe the response of ESA treatment in hemodialysis patients and determine the factors that can influence this response. Materials and Methods: We compared the effectiveness of erythropoietin treatment using the erythropoietin resistance index (ERI). The patients were divided into two groups according to their ERI: group 1 with ERI>10 UI/kg/week/g/100 ml and group 2 ERI 10 UI/kg/week/g/100 ml. We evaluated the effects of the anthropometric, demographic, clinical, laboratory and dialytic factors on ERI. Results: We found that low BMI, low serum albumin, high C-reactive protein, high serum ferritin and high predialysis serum 2 microglobulin levels were associated with high ERI and a hyporesponsiveness to erythropoietin. A multivariate analysis was showed significant association between high ERI and low serum albumin (OR=0.56; p=0.02). Conclusion: This may provide new contribution into anemia management in Hemodialysis patients. However, more prospective studies with a larger sample population are needed to generalize our results.

Introduction: Thyroid hormone resistance (RTHβ) is a rare disorder characterized by reduced tissue responsiveness to thyroid hormones (THs). It is primarily caused by mutations in the thyroid hormone receptor beta (THRB) gene. This case describes a two-year-old boy diagnosed with RTHβ following the incidental detection of elevated thyroid hormones during a routine checkup. The clinical presentation, laboratory findings, genetic analysis, and implications for management are discussed, highlighting the complexities of this rare condition. Patient concern and Clinical Finding: A two-year-old boy was referred to the Pediatric Endocrinology Department due to elevated FT4 and FT3 levels with normal TSH identified in routine blood tests. Born at 36 weeks after an uneventful pregnancy to non-consanguineous parents, the child had normal growth and development until subtle symptoms, such as reduced physical activity, weight loss despite adequate nutrition, and warm, sweaty skin, were observed. Physical examination showed no goiter or ophthalmopathy, with neurological development appropriate for age and weight and height within normal percentiles. Laboratory tests revealed elevated thyroid hormone levels, negative thyroid antibodies, and normal thyroid ultrasound findings. Diagnosis/Intervention/Outcomes: The diagnosis of resistance to thyroid hormone beta (RTHβ) was confirmed through whole exome sequencing, which identified a heterozygous missense mutation in the THRB gene (c.1313G>A; p.R438H). This de novo mutation ruled out inheritance and suggested a sporadic origin. Regular monitoring of thyroid function tests and clinical follow-ups ensured biochemical stability and vigilance for potential symptoms of thyroid dysfunction. The child remained clinically euthyroid with normal growth and development, showing peripheral adaptation to altered thyroid hormone signaling. Long-term surveillance was recommended to monitor for any late-onset complications or thyroid-related symptoms, with an overall favorable prognosis. Conclusion: This case illustrates the complexities of diagnosing and managing RTHβ in a pediatric patient. The identification of a THRB mutation provided a definitive diagnosis and emphasized the utility of genetic testing. Long-term follow-up is essential to monitor the clinical course and adjust management as needed. Further studies are required to elucidate the genotype-phenotype correlations in RTHβ and optimize treatment strategies.

The integration of technology into curriculum delivery has revolutionized the landscape of education, particularly in teacher education. This paper explores the implications of technology-driven methods for teaching the Islamic Studies curriculum in the preparation of trainee teachers. The study examines the impact of incorporating digital methods such as digital storytelling, virtual field trips, simulations, and digital drills and practice in teaching specific topics in Islamic Studies. These methods enhance learner-centered approaches, critical thinking, and student engagement. Additionally, the paper addresses the challenges and opportunities associated with implementing these techniques. By understanding the transformative potential of technology, teacher education programs can equip educators with the necessary skills to navigate the evolving educational landscape and prepare Islamic Studies student-teachers to meet the demands of the 21st century.

This paper presents a Discrete Wavelet Transform (DWT)-based approach for medical image fusion, implemented using Verilog HDL and verified with Xilinx ISE. The methodology involves fusing CT and MRI images using the Haar wavelet transform and validating the results through simulation and synthesis. Tools such as MATLAB are used for cross-verification. The objective is to enhance diagnostic accuracy and support medical imaging applications through efficient hardware design.

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous group of malignancies arising from the mucosal linings of the oral cavity, pharynx, and larynx. Locally advanced HNSCC (LA-HNSCC), encompassing stages III and IV, involves large tumors and regional lymph node metastases without distant spread, contributing to high morbidity and mortality. Understanding the clinical features of LA-HNSCC is crucial for improving treatment strategies and patient outcomes. Objective: To evaluate the clinical characteristics of patients with LA-HNSCC and their impact on treatment outcomes, specifically comparing the TPLF and LFP regimens. Methods: An experimental study was conducted at Khwaja Yunus Ali Medical College & Hospital from January to December 2015, involving 60 patients with LA-HNSCC. Patients were treated with neoadjuvant chemotherapy (TPLF or LFP regimens) followed by concurrent chemoradiation. Data was collected through patient interviews, clinical evaluations, and laboratory tests. The primary outcome measures were tumor regression, clinical response, and acute toxicities. Statistical analysis was performed using SPSS, with significance set at p < 0.05. Results: The majority of patients were male (80% in Arm A and 77% in Arm B) and over 50 years old. Smoking prevalence was high (83.3% in Arm A and 80% in Arm B). The most common primary tumor sites were the oral cavity (Arm A: 30%, Arm B: 33.3%) and oropharynx (Arm A: 23.3%, Arm B: 26.7%). Neck node swelling, pain, dysphagia, and weight loss were the most frequent clinical complaints. No statistically significant differences were found between the two treatment arms in terms of age, smoking, occupation, ECOG performance status, or histological grading. Conclusion: Both TPLF and LFP regimens provided similar outcomes in terms of clinical characteristics and treatment response in patients with LA-HNSCC. These results suggest that the choice between TPLF and LFP regimens may not significantly influence treatment outcomes. Further research is needed to explore additional factors affecting treatment efficacy and refine therapeutic strategies for LA-HNSCC.

This project introduces a cutting-edge solar-powered rover designed to revolutionize environmental analysis and boost agricultural productivity. Featuring advanced monitoring and control systems, the rover incorporates high-performance solar panels, a sophisticated battery management system, and adaptable operational modes to maintain optimal performance in varying conditions. Outfitted with precise sensors for analyzing water quality (pH, turbidity, TDS), soil moisture, and weather metrics (temperature, humidity), it provides an extensive suite of environmental monitoring capabilities, complemented by real-time data recording. A sleek, user-centric web dashboard and mobile app facilitate effortless interaction, offering customizable interfaces, remote management, and Bluetooth connectivity. The integration of machine learning enhances predictive analytics and dynamic decision-making, while autonomous navigation with obstacle avoidance ensures smooth traversal across challenging terrains. This pioneering solution redefines agricultural efficiency, fostering sustainable practices through intelligent automation and actionable insights.

This thesis's motive is to recognize the challenges that university students face while trying to speak English because of the effect of their educational background and it aims to uphold the role of teachers to assist students in overcoming those challenges using motivation and teaching strategies according to social-psychological aspects of Applied Linguistics. The data are collected from Army-governed universities, Schools, and Colleges from a sub-district and a renowned education consultant center in Bangladesh. There were 100 participants, and it used a mixed method. The failure of students to speak English at the tertiary level, this research identifies the possible barriers and suggests some solutions that will be effective for all English speakers. In most cases, the highest obstacles are anxiety, inferiority, lack of self-motivation, and dependency on the native language in academics. It also finds that the focus is mostly given to writing skills in the mentioned institutions as well as motivation, co-curricular activities, building a friendly and interactive environment in the classroom, improving the assessment policy, and equal facilities in educational institutions can overcome these challenges. It indicates the social, economic, and psychological obstacles that may block students from Speaking English in a public place and offers some methods to build student-friendly classrooms where students' both extrinsic and intrinsic motivation can be boosted.

This study aims to analyse the effect of intrinsic motivation and work discipline on employee performance with organisational commitment as an intervening variable at Puskesmas Siwalan, Pekalongan Regency. The research sample consisted of 58 employees, and the data were analysed using the Structural Equation Modeling (SEM) method with the Smart PLS tool. The results showed that intrinsic motivation and work discipline had a positive and significant effect on employee performance. Organisational commitment also proved to be a variable that mediates the relationship significantly. The findings underscore the importance of strengthening intrinsic motivation and work discipline as key factors for improving performance in the healthcare work environment. This study provides practical implications for health centre management to develop performance improvement strategies through strengthening employee motivation and commitment.

Bangladesh is a Muslim dominated country. Many of the Muslims are practicing Muslims. Islam has influence on the life of Muslims and many aspects of women human rights are influenced by Islam. Marriages, divorce, maintenance of wife, inheritance are regulated by Islamic laws. Some other aspects are regulated by secular laws. Bangladesh is signatory to many International conventions and declarations regarding women human rights. So Bangladesh women human rights are emanated from Islamic sharia laws, Bangladesh constitution, policies of the government and international declarations and conventions. In many respects women human rights in Islam and the rights emanate from secular sources are consistent with minor inconsistency where Bangladesh has made reservation. But the problem is that these rights are not observed properly. Local cultures have significant influence on the non-observance of women human rights in Bangladesh. As many of us are Muslims and we observe women human rights in Islam, it will uphold women rights in Bangladesh.

Brain hemorrhage is a critical condition that needs quick and precise response and diagnosis for timely treatment. Traditional methods like CT and MRI scans depend on expert interpretation, which can be time-consuming and prone to errors. This study introduces an automated framework with deep learning to detect and classify brain hemorrhages. By utilizing convolutional neural networks (CNNs), the system recognizes important features in medical images and classifies hemorrhages into types such as intracerebral, subarachnoid, subdural, and epidural. Trained and tested on brain scan datasets, the framework depicts the potential of deep learning to deliver quick and accurate diagnoses, avoiding delays and enhancing patient outcomes significantly.

The purpose of this study was to analyze the effect of competency development and compensation through motivation on the performance of health workers at the Karanganyar and Kajen District Health Centers. The sample of this study was midwives and nurses at each health center in Karanganyar and Kajen Districts totaling 84 respondents. With SEM PLS analysis tools. The findings of this study are that there is a positive and significant influence between competency and performance; there is a positive and significant influence between compensation and performance and there is a significant positive influence between motivation and performance.

The present study investigates the teaching of the English language in some Chadian educational institutions of science and technology, with the aim of bringing out the specificities in the teaching and learning processes in the concerned institutions. The study is thus informed by Morley’s (2000) perspective on Halliday’s (1985) Systemic Functional Linguistics, and makes use of a quali-quantitative method. Informants randomly sampled from a population constituted of teachers, students and government officials were subjected to questionnaires as main research tool. The findings reveal that common teaching and learning practices in the institutions under inquiry rather fall under general English instead of ESP. Thus, need is to revisit syllabuses and teaching methods so as to meet the communicative needs of the learners.

The aim of this research is to analyze efforts to improve employee performance by using IT, work discipline with organizational commitment as an intervening case study at the Central Java Province BKKBN office. The sample for this research is the Pekalongan Residency Family Planning Counselor with a total of 90 respondents, using the SEM PLS analysis tool. The findings of this research are that there is a positive and significant influence between the use of IT on employee performance; There is a positive and significant influence between work discipline on employee performance and there is a significant positive influence between organizational commitment on employee performance.

Objective study This is for analyze influence communication and cooperation team to performance employee with motivation Work as intervening variable, Sample study This is Apparatus State Civil Servants (ASN) in Organizations Regional Apparatus (OPD) in the environment Government Regency Pekalongan. Totaling 100 respondents, with tool analysis Partial Least Square Structural Equation Model (PLS-SEM) Smart PLS 3.0. Findings from study this show that communication influential positive and significant to performance employees, while cooperation the team also has an influence positive and significant to performance employee. Besides that, motivation Work show influence positive and significant to performance employee. More continue, communication influential positive and significant to motivation work and cooperation the team also has an influence positive and significant to motivation work. Can observed that motivation Work play a role as a mediator variable communication and cooperation team in influence performance employee.

Human action of ethical worth is free and voluntary one. And ethical judgement concerning human action carries with it particular inference about the nature of man: the fact that s/he is a responsible being. This derives from man’s ontological status as reasonably acting being of care and accountability to and for one’s self and others. This qualitative research critically analyses the place of responsibility in ethical life of man. It discloses that free responsible human action is in fact deliberately rational action, and that in lived experience there is a unique logical relationship between responsibility and the quality of human society and environment. It emphasizes that maturity is an index of developed existence. It then makes the submission that the inevitability of responsibility in human existence is part and parcel of what we may call the ethical cost implicational character of our moral consciousness and freedom.