Background: Sickle cell disease (SCD) is an autosomal recessive disease characterized by production of abnormal hemoglobin S. The aim of this study is to review the history of SCD adults patients who were admitted to inpatient ward in Al-Ahsa, Saudi Arabia. Method: A retrospective cross sectional study was conducted through medical records chart review in King Fahad Hospital (KFH) in Al Ahsa to detect all SCD adults patients who were admitted to inpatient ward during 2013 to 2015. A structured Self designed questionnaire was reviewed and used during data collection from patients files. Results: A total of 130 patients were admitted to inpatient ward, consanguinity reported in 96.2 %. In the last visit, 64.3 % had diagnosed with vaso-occlusive crises, 10.1 % had sequestration crises, 13/2 % had acute chest syndrome, and 12.4% had gall stone. Complications of SCD included spleen removed (46.4%), infection (93%), anemia (93%) and acute chest syndrome (40.6%). Conclusion: SCD is considered as a load in the secondary health care services. Further studies need to be conducted in this subject.

Excessive rainfall resulting to floods remain a thorny problem in developing countries including Cameroon. This follows the negative impacts of floods on the population, infrastructure and public services. This study examines rainfall variability, population vulnerability to floods and measures put in place by the population and other stakeholders to adapt to the situation in the Douala IV and V municipalities in Littoral Cameroon. The study exploits both primary and secondary sources data for its realization. Heads of households, quarter’s heads, municipal authorities and its personnel, and public administrative officials were contacted for data collection. The data focused on floods manifestation, their effects on the city, and adaptation strategies put in place to mitigate the negative outcomes. Data from semi structured interview conducted were analyzed using content analysis methods. Sociological and spatial data also collected were analyzed using remotely sensed techniques and statistical tools such as SPSS and Microsoft excel. Climatic data were collected from the urban council, the meteorological units in the town and the National Observatory on Climate Change of Cameroon. Sequential analyses (linear trend curves, standard deviations, and cumulative balances) were used to evaluate the evolution of rainfall and correlation to floods events. The result revealed that floods in Douala IV and V result from rainfall variability, characterized by deficit and excessive rains in the months of June, July, August and September. These heavy rains accompanied by human induced factors such as uncontrolled urbanization, anarchy in construction and occupation of wetlands, poor waste management, pollution of water ways and lack of drains for stagnant water evacuation leads to floods. Also, natural drivers such as the low relief of the area, a dense hydrographic network and contact with the Atlantic Ocean via the Wouri estuary result to floods. These floods are a problem to the health of the population, public services and infrastructure and sustainability of the city. Faced with the numerous damages caused by floods, remediation strategies such as: the construction of traditional dikes, solid house foundations, water embankments, and periodic weather forecasting by the National Observatory on Climate Change of Cameroon to reduce the negative outcomes of flooding has been ineffective in reduction of floods outcomes. Consequently, floods still remains a concern in Douala town. Good environmental practices such as civil education on hygiene and sanitation, periodic cleaning of drains, combats on deforestation of mangroves and afforestation campaigns, government investment on decentralization of waste collection and management will be productive in reducing the effects of floods in Douala. The implementation of all these remedial measures will not only ensure the safety of vulnerable civilian populations but the protection of their activities.

Background: Combined effects of pregnancy induced hypercoagulability and SARS-CoV-2 infection place pregnant women with COVID-19 disease at high risk of severe outcome. COVID-19 severity has also been associated with serum D-dimer, a biomarker reflecting coagulation and fibrin degradation, in general populations. Despite its prognostic value in pregnant women, the prognostic value of this finding particularly in maternal outcomes remains less understood. The aim of this study was to determine whether elevated serum D-dimer levels in pregnant COVID-19 positive women are of prognostic significance for severe maternal outcomes. Methods: This retrospective observational study included 62 third trimester COVID 19 positive pregnant women admitted to the Department of Obstetrics and Gynecology, BSMMU, Dhaka from March 2019 to February 2020. Serum D-dimer were measured at admission and day 7, 14. D-dimer levels were related to clinical outcomes and statistically evaluated using chi square tests and logistic regression at p < 0.05. Results: Significantly associated with higher risk of severe outcomes, all of which included ICU admission, respiratory complications and adverse pregnancy events is elevated D-dimer levels (≥1.5 mg/L). In logistic regression analysis, patients with D-dimer levels of ≥1.5 mg/L had 3.5-fold greater odds of severe outcomes (OR 3.486; 95% CI, 1.184 to 10.263; p = 0.023). D-dimer had a sensitivity of 64.29%, 67.55% specificity in predicting severe outcomes. Conclusion: Serum D-dimer is valuable prognostic marker of disease severity in pregnant COVID-19 positive women and may be used for early risk assessment and clinical decision making. Routine measurement may help identify early high risk cases in order to improve maternal outcomes.

This study aims to determine the analysis of the influence between the level of knowledge on the behavior of using paracetamol syrup in parents in the community and health care facilities in the city of Bandung. The research method used was analytic-correlation in a cross sectional approach. The sampling technique used was accidental sampling. Data collection was carried out using a questionnaire with data analysis using the Spearman Rank correlation test. The results showed that the level of knowledge of parents or guardians in the community (community) and three health care facilities in Bandung City (Pharmacy, Clinic, Puskesmas) the majority had high knowledge (65.13%). The behavior of using paracetamol syrup in parents or guardians in the community (community) and three health care facilities (Pharmacies, Clinics, Puskesmas) the majority had very good behavior (67.58%). In this study, the level of knowledge affects the behavior of paracetamol syrup use in the community (community) and three health care facilities in Bandung City (Pharmacies, Clinics, Puskesmas). So that the better the knowledge, the better the behavior of using paracetamol syrup.

This study aims to determine the analysis of the influence between the level of knowledge on the behavior of using paracetamol syrup in parents in the community and health care facilities in the city of Bandung. The research method used was analytic-correlation in a cross sectional approach. The sampling technique used was accidental sampling. Data collection was carried out using a questionnaire with data analysis using the Spearman Rank correlation test. The results showed that the level of knowledge of parents or guardians in the community (community) and three health care facilities in Bandung City (Pharmacy, Clinic, Puskesmas) the majority had high knowledge (65.13%). The behavior of using paracetamol syrup in parents or guardians in the community (community) and three health care facilities (Pharmacies, Clinics, Puskesmas) the majority had very good behavior (67.58%). In this study, the level of knowledge affects the behavior of paracetamol syrup use in the community (community) and three health care facilities in Bandung City (Pharmacies, Clinics, Puskesmas). So that the better the knowledge, the better the behavior of using paracetamol syrup.

Kiwifruit is a climacteric fruit that may decay rapidly and softens after harvest if not stored properly. How to expand the storage time of kiwifruit to maintain the quality, is a critical challenge for the kiwifruit industry development. Kiwifruit’s post-harvest life is tied closely to post-harvest management, such as scientific harvesting, green preservation, ethylene management, and low-temperature storage, as well as texture and quality. This study focuses on the advancement of related research from four perspectives and explores their impacts on kiwifruit storage in order to give a theoretical foundation for breeding varieties with superior storage capacity, and the development of storage and preservation technologies. Hayward and Hort16A varieties of kiwifruit had been cultivated largely in past but now, yellow-fleshed Sun Gold, Gold 3 and Gold 9, Hongyang, Maohua Cuixiang, Xuxiang, etc. are becoming significantly famous in international commerce. For the best postharvest quality, kiwifruit must be stored at low temperatures. Fruit quality, harvesting maturity, ethylene production, storage life, green preservation, and pathology are the priorities in breeding projects. To take advantage of adequate germplasm resources, reproductive biology understandings are needed.

This report analyzes the demand for language service professionals in Hebei’s energy and power industry from three key perspectives: enterprise requirements, translation education, and student employment planning. The 45 valid questionnaires cover four key aspects related to enterprises including the business scope, international business activity, language service team building and employment requirements. Despite the energy and power industry in Hebei Province have made significant strides in international collaboration, there is a gap between professional training and industry requirements. Enterprises demand language service personnel to maintain proficiency in terminology, have industry knowledge, master technical competence, and own international communication skills that most translation students lack. It can be seen that there are issues with the alignment between educational content and the actual need of enterprises. In addition, the results from teachers’ survey identified challenges in terms of aspects of teaching methods, curriculum setting, and the cooperation with enterprises. The report thus recommends to enhance the professional skills and industry knowledge of energy and power language services of translation students through various measures, including establishing professional knowledge bases and terminology bases of energy and power, designing relevant courses and practical projects, and strengthening school-enterprise cooperation. By performing these practices, it could better adapt to the future energy and power industry market demand. Furthermore, this report emphasizes that the education system needs to better adapt to the development of the industry, especially in the cultivation of interdisciplinary language service capabilities, and strengthen cooperation with energy and power companies to jointly develop language service talent training programs that meet the specific needs of the industry.

Acute myeloid leukemia (AML) is responsible for more than 40% of adult patients suffering from adverse effects leading to death around the world. The B-cell translocation gene 2 (BTG2) gene work as a tumor suppressor. In this study, a list of medicinal herb compounds and drugs was investigated for their pharmacokinetic properties and cytotoxicity by applying the SwissADME, pkCSM, and Molsoft LLC websites. The molecular docking between the medicinal herbs and AML-standard drugs against the human BTG2 gene was carried out by Auto-dock Vina. Furthermore, protein-protein interactions, gene ontology, and gene enrichment analysis were investigated to display the biological pathways related to BTG2. Also, molecular dynamics simulation was examined to study the behavior of the BTG2 protein and the protein-ligand complex. The present work exhibited that hesperidin displayed the highest binding affinity of −7.0 kcal/mol when interacting and docked against the BTG2 protein, while Cytarabinee and daunorubicin had binding affinity of 5.0 and 5.8 kcal/mol, respectively. The PPI highlighted 101 interactions with P-values less than 10 e-16., and the highest similarity score of 0.13 was found in P53 transcriptional gene network pathways. Interestingly, gene enrichment analysis illustrated that RNA degradation was the most significant enrichment pathway. Also, BTG2 contributes to the P53 signaling pathway in chronic myeloid leukemia. Via GADD45A gene. Molecular dynamics simulations were carried out for the highest binding docking (BTG2-hesperidin) complex, and the results revealed conformational alterations with more pronounced surface residue fluctuations in BTG2. The direct interaction of hesperidin with various crucial amino-acid residues like HIS 49, CYS 67, ARG 69, ASN 71, ASP 75, ARG 112, and THR 101 causes modifications in these residues, which ultimately attenuate the activity of the BTG-2 protein. The molecular dynamics determine the four numbers of H-bonds for executing the interaction between BTG2 and hesperidin. The best residue with high energy around all poses is Arg69. Finally, the present work highlighted that hesperidin was the highest phytochemical compound binding to BTG2 protein.

During a routine dissection of an adult male cadaver at the College of Medical Sciences in Bharatpur, Nepal, it was noted that the right median nerve was formed by three roots. This observation was made after a careful dissection of both upper limbs, including the axilla, arm, forearm, and palm. Of the three roots contributing to this anomalous median nerve, one originated from the lateral cord and two from the medial cord of the brachial plexus. Despite this atypical configuration, the distribution of the median nerve in the arm, forearm, and palm appeared normal, and the arterial pattern, including the axillary and brachial arteries, was also typical.

This study interrogates the interplay between board attributes and dividend payout policy amongst listed in Nigerian manufacturing firms. The research focuses on various board attributes, including board size, board independence, gender diversity, and board ownership, to determine their influence on the dividend decisions of firms. Using panel data from a sample of Nigerian manufacturing companies listed on the Nigerian Stock Exchange (NSE) from 2013 to 2022, the study employs multiple regression analysis to evaluate the effect of these variables on dividend per share. The results indicate that board independence positively influence dividend payouts, while board diversity and board ownership have negative non-significant effect on the criterion variable using t-statistics. These findings suggest that a well-structured board can enhance firm decision-making, leading to higher shareholder returns. The study recommends that policymakers and firm managers should consider the composition and governance of boards when devising strategies related to dividend payouts to optimize corporate performance and shareholder value.

Aquaculture is the fastest-growing food production sector, now contributing more to global fish biomass than capture fisheries. While much of this expansion has occurred over the past 50 years, it has been accompanied by numerous environmental challenges, including aquatic pollution driven by urbanization, industrialisation, harbour dredging, sand filling, pesticide runoff from agricultural activities, and land-use conflicts between aquaculture, industry, and tourism. These environmental concerns have heightened the focus on sustainability, particularly in relation to ecological preservation. This review explores the various types of waste generated by industries, households, and other establishments that are discharged into aquatic ecosystems, examining their potential impacts on aquaculture. In addition, it evaluates mitigation strategies aimed at reducing or eliminating these environmental threats. Increasing attention has been placed on raising awareness of environmental issues and adopting sustainable practices to minimise aquaculture's ecological footprint. While environmental degradation was not viewed as a critical issue in the early stages of the industry's development, it has now become a central concern across academic, governmental, industrial, and market sectors.

By analyzing the English translation of “Working Together for a China-Central Asia Community with a Shared Future, Featuring Mutual Assistance, Common Development, Universal Security, and Everlasting Friendship” delivered by President Xi Jinping, who presided over the first China-Central Asia Summit in Xi'an City, Shaanxi Province, on May 19, 2023, the article analyze how President Xi's keynote address used the attitude of evaluation theory system to promote China's joining hands with Central Asian countries to build the Belt and Road, and to lead the future in-depth cooperation between China and the Central Asian region.

This review article provides a thorough psychoanalytic exploration of David Lynch's Lost Highway, a film celebrated for its intricate narrative and surreal imagery. Utilizing Freudian and Lacanian theories, the analysis investigates the film's themes of identity, trauma, and the unconscious. The protagonist's disjointed journey through fragmented realities serves as a case study in the manifestation of repressed desires and fears. By examining the interplay of memory, perception, and selfhood, this article reveals the deeper psychological currents that drive the narrative and influence character motivations. Furthermore, the discussion situates Lost Highway within Lynch's broader oeuvre, highlighting the director's fascination with the subconscious and the complexities of human experience. Ultimately, this psychoanalytic reading positions Lost Highway as not merely a cinematic puzzle but also a profound commentary on the nature of reality and the psyche, inviting viewers to confront their own unconscious landscapes.

Sustainable tourism for Indian destinations is promoted and marketed by utilizing marketing strategies to gain interest from travelers. However, the promotion of sustainable tourism destinations is achieved in a manner that does not jeopardize the environment or community conservation. Sustainable tourism is promoted by increasing the destination's visibility, which includes social media marketing, search engine optimization, and content marketing, one such example is the scheme of Swadesh Darshan, which was launched by the Indian tourism and it aims for the development of sustainable tourism destinations. Furthermore, enhancing cultural and community features in marketing might help to attract and retain tourists' interest, thereby strengthening sustainable tourism. To entice people to visit sustainable tourist places, the tourism sector is focusing on proper selling factors, physical improvements to attractions and accessibility, and proximity to other tourist sites. Overall, the current study reveals that a comprehensive Destination Management action plan can help accelerate India's green tourism transition. This study aims to understand some of the marketing strategies employed by Indian Tourism Industry on environmentally sustainable vacation spots. The Indian travel industry is impacted by sustainable tourism, one of the topics discussed in this article. This study is descriptive and relies only on books and periodicals covering a wide range of topics that are relevant to sustainable tourism destinations in India. Moreover, the present study also highlights, the importance of online marketing strategies for marketing sustainable Indian travel destinations which is discussed to have a better understanding of the future of the tourism sector in India. The particulars of the study are emerging from the SWOT analysis model for the assessment as well as the scrutinization of the potential of the Indian tourism industry.

The purpose of the study was to find out the influence of different altitude training on VO2max and stress. Forty-five male middle distance runners studying in various colleges around Kodaikanal Town, Dindigul District, were selected and divided into three equal groups (n = 15), in which group - I underwent low altitude (sea level) training, five days per week for twelve weeks and group II underwent moderate level altitude training and group – III acted as control which did not participate any special training apart from their regular activities. The subjects were tested on selected criterion variables such as VO2max and stress at prior to and immediately after the training. For testing the VO2max, Cooper’s 12 minutes run/walk test result was taken and a formula recommended by Cooper was applied, and for stress, Girdano and Everly Stress Scale was used. The Analysis of Covariance (ANCOVA) was used as statistical tool to find the training effect difference between three groups. Since there were three groups involved in this study the ScheffẻS test was used as pos-hoc test. The result of the study shows that the VO2max was improved and stress level was decreased significantly for the training groups when compared with the control group. The result of the study also shown that there was no significant difference occurred between the experimental groups, such as, low altitude and moderate altitude training groups.