COVID-19 is a universal disaster that affects the global health, economy, and restricts population movements. In this study we suggest that minocycline; second generation of tetracycline antibiotic with platelets transfusion may cure COVID-19 patients. As we have no facilities and even no positively confirmed patients in Sudan, so we send my suggestions to save my brothers and sisters in humanity worldwide, and I hope that god bless my suggestions and gain fruitful results.

The first occurrence of the highly contagious Coronavirus was in 2003 when China was hit with the Severe Acute Respiratory Syndrome coronavirus (SARS-COV). SARS resulted in around 8,000 infections and 774 deaths worldwide not to mention the impact on world economy which saw declines in domestic and international travel and over 40 billion dollars in economic losses. Fast-forward to 2012, Saudi Arabia was hit with novel Middle East Respiratory Syndrome coronavirus (MERS COV) causing over 1611 active cases and 575 deaths worldwide. Since December 2019, our world succumbed to the rapid spread of COVID-19 now reaching 2,204,511 infections and 149,000 deaths worldwide. COVID-19 virus spreads through droplets of spittle or nose flow when an infected person coughs or sneezes. Effects vary between mild respiratory difficulties with average patients to severe illness with older people and those with underlying medical problems. Since vaccines are still unavailable, the world were to adopt extraordinary measure to control the outbreak such as flight suspensions, visa restrictions, border closures, social distancing and quarantine. The effects on world economy were severe with huge losses in tourism, travel, retail and service sectors and strains on the medical sector due to high demand and treatment costs.The circumstances surrounding COVID-19‘s spread makes many inquire about the motives of governments that are benefiting from the high infection and mortality rate of this virus to unproductive people, elderly and people with chronic illnesses forming a huge burden on welfare systems. Finally, with nothing confirmed, it is important to inquire about the invisible hands behind the epidemic and what would wait the world after COVID-19.

Communicative activities in ESL/EFL classroom contexts are productive when relevant linguistic devices are applied to literary texts. The literary effectiveness of George Bernard Shaw’s “Pygmalion”, an early twentieth-century play has been widely appreciated for its linguistic and literary effectiveness. The dialogic structures composed in the actions of the play reveal the varieties of spoken forms of English present during the Victorian period. After thorough scrutiny of the available research papers related to “Pygmalion” on the web, this study addressed the issues that were given less importance by the earlier studies. Considering the significance of “Pygmalion” as a prescribed coursebook in various universities across the world, this paper analysed the dialogic language of the play from a linguistic perspective. The existing literature on Pygmalion provides insights into thematic analysis from a literary and socio-linguistic perspective, referring to the class struggles and feminism. This paper examined the dialogues from a linguistic perspective. Weigand’s [1] dialogic principles were applied to the utterances of the characters, thereby providing insights into the metalinguistic aspects. The paper also presents the semantic effect of the communicative exchanges that the characters engage in when they meet at different settings in the play. Also, it provides resourceful ideas to the ESL/EFL teachers on various linguistic aspects that need to be focused while teaching a literary text. The findings of the study reveal the dialogic forms in “Pygmalion” can be useful to enhance the verbal, non-verbal and written communication of ESL/EFL students.

Aim: A comparative study to evaluate visual outcome in post-operative patients of Manual Small Incision Cataract Surgery and Phacoemulsification. Design: A prospective, comparative hospital based interventional study was conducted on 246 eyes having visually significant senile cataract undergoing cataract extraction surgery by either of two methods vis Manual Small Incision Cataract Surgery or Phacoemulsification at Regional Institute of Ophthalmology, Pt.B.D.Sharma PGIMS, Rohtak. A detailed post-operative examination was carried out on first post-operative day, then follow-up of patients of both the study groups regarding BCVA was carried out in Eye O.P.D. on 7th, I month. Results: Although the initial visual recovery on the 1st postoperative day was better in the patients who underwent phacoemulsification, with the uncorrected visual acuity better than or equal to 6/18 in 74% of the patients, whereas the percentage was 58.5 % in the SICS group. Similarly BCVA 6/18 or better on 7th post-operative was 100 % in the Phacoemulsification study group as compared to 87% SICS (p=0.010) group. Initial difference in visual outcome was nearly equalized within 1 month in both the study groups. There was no significant difference between the M-SICS & Phacoemulsification in terms of BCVA at Post-Operative 1 month, Post-Operative Spherical Refraction at 1 Week (p = 0.693) and 1 month (p = 0.640). But there was significant difference between two groups in terms of Cylindrical Refraction at Post-Operative 1 Week) (p=<0.001) and at 1 Month (p = <0.001) with the median Post-Operative Cylindrical Refraction higher in M-SICS group at 1 week & 1 Month. The median Post-Operative Cylindrical Refraction difference is all due to the fact that M-SICS had larger surgical incision causing higher surgically induced astigmatism. Conclusions: Phacoemulsification gives better uncorrected visual acuity (UCVA) at post-operative day 1 and better BCVA at 1week and Post-Operative Cylindrical Refraction at 1 Week and at 1 month. Whereas, BCVA at 1 month is similar in both the study groups MSICS and Phacoemulsification.

Photophysical techniques were employed as a tool to determine the binding interaction of an Intramolecular Charge Transfer (ICT) based dye 4- Dicyanomethylene-2,6-dimethyl-4H-pyran (DDP) with Bovine Serum Albumin (BSA) in water. Addition of BSA to DDP dye results no significant change in the ICT absorption maximum but a well-marked enhancement in the fluorescence quantum yield of the dye. The enhancement on the addition of BSA shows that the excited state characteristics of dye are influenced by the protein that comprises several hydrophilic and hydrophobic amino acid moieties. Fluorescence lifetime decay characteristics of DDP dye with BSA exhibits a tri-exponential decay with a large variation in the fluorescence lifetime and relative amplitude distribution. The dye is situated predominantly in the hydrophobic interior rather in the aqueous phase is established from time resolved fluorescence lifetime studies. The coexistence of three different fluorescence lifetime components of dye in the presence of BSA signifies the existence of dye in a heterogeneous micro environment with varying proportion. The existence of multi environment is authenticated by electrochemical impedance spectral studies (EIS). BSA markedly influences the redox potential properties of dye which reveals that the presence of charged species (zwitter ionic structure of amino acids), polar and non-polar moieties governs the electrochemical nature of DDP dye.

Teaching of health sciences courses is one of the most significant steps to develop the higher education sector. Integrated versus traditional teaching has been the area of discussion in many publications. In this paper, the authors will try to assess the influence of integrated teaching strategies on student outcomes in a clinical nutrition course in undergraduate level at Nutrition Department Faculty of Public Health; University of Benghazi. The exams results assessment showed that, exam scores for the blended teaching approach were statistically significantly higher than for the traditional teaching approach for both mid-year assessments and final exams.

Introduction: Although maternal mortality remains a public health issue, maternal death in actual number is less in community. As maternal death in itself is not sufficient to assess the level of health care concept of Near miss is introduced by WHO, though yet not widely adapted in reviews across our nation and being overcome by wide variety of high risk pregnancies. Objective: To determine frequency and nature of near miss events among pregnant women. 2. To compare nature of near miss pregnancies with high risk pregnancies. Methodology: A Case Control study of cases of near miss and high risk pregnancies which occurred over one year duration between 1st July 2018 to 30th June 2019 at Atal Bihari Vajpayee Govt. Medical College, Vidisha (M.P.). Near Miss definition was based on validated disease specific criteria comprising of diagnostic categories: haemorrhage, hypertensive disorder of pregnancy, anemia, sepsis, hepatic encephalopathy and other indirect causes. Near miss cases were determined for various disease processes and compared with high risk cases to assess the need for change in approaching these pregnancies. Result: There were 5993 deliveries and 7 maternal deaths. Significant difference was observed in characteristics of near miss and high risk pregnancies. Conclusion: Our review shows that beside the women who died due to pregnancy related complication, there were many additional women who received critical care during the same period and survived. Hospitals in India could benefit by including near miss investigations in their approach to all high risk pregnancies.

COVID-19 is a universal disaster that affects the global health, economy, and restricts population movements. In this study we introduce MNa theory to treat this viral crisis using triple therapy composed from combination of that minocycline, N-acetylcysteine and Aspirin. As we haven’t facilities and no confirmed cases of COVID-19 in Sudan up to date, so we send my suggestions to save my brothers and sisters in humanity worldwide, and I hope that god bless my suggestions and gain fruitful results through animal experimentation of triple combination therapy.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). It is affecting 213 countries and territories around the world. The disease causes respiratory illness (like the flu) with symptoms such as a cough, fever, and in more severe cases, difficulty breathing, cardiac problems were also observed in many COVID-19 patients.We theorize that COVID-19 induce mutation in chromosome 4 lead to 4p15.1-pter Duplication and a 4q35.1-qter Deletion , and the neurological and cardiac disorders observed among infected persons resulted from retrotransposition mechanism of gene duplication occur in the specified region of chromosome 4 mentioned above. Genetic studies to chromosome 4 of COVID -19 patients recommended to confirm MOA duplication and deletion theory (4p15.1-pter Duplication and a 4q35.1-qter Deletion).

We evaluated the prevalence of peripheral neuropathy in type 2 diabetes mellitus (T2DM) by clinical examination and nerve conduction study (NCS), and to correlate them with risk factors. 58 T2DM patients attending OPD in the department neurology of Jubilee mission medical college hospital, Thrissur were evaluated. Grading of signs and symptoms were assessed by Neuropathy symptoms score (NSS) and Neuropathy disability score (NDS) followed by nerve conduction studies. Diabetic status was evaluated by HbA1c levels and patients were categorized Group I -HbA1c<5 (No diabetes), Group II- HbA1c= 5-7(Long standing controlled diabetes), Group III HbA1c >7 (Uncontrolled diabetes). 58 T2DM patients of which 42(72%) were males and 16(28%) were females and their mean age were 52.1±8.8 and 48.6±5.3 respectively. Clinical findings showed abnormal deep tendon reflexes in male 37(88%) and female patients 11(66%). Deep sensory loss was highest among male 39(92%) and female patients 12(75%) respectively. Loss of pain and touch sensation male and female patients were found to be 24(57%), 9(56%) and 35(92%), 12(75%) respectively. Atrophy of the muscles in male and female patients were found to be 13(30%) and 4(25%) respectively. Electrophysiological assessment showed 34(58.6%) patients in the severe group and score was 8. However mild and moderate patients were 3(5.1%) and 21(36.2%) and there severity score was 5and 6 respectively.T2DM patients has high prevalence of diabetic neuropathy. Motor nerve conduction abnormalities were severe in males with diabetic peripheral neuropathy. Motor mononeuropathy reflects more severe involvement and peroneal and ulnar neuropathy is well marked in these patients.

The aim of the present essay is to present a literature review on the contribution of morphological awareness to reading and spelling ability of typically developing children and children with dyslexia. Inflectional morphological awareness is acquired early on children’s oral language. During course of written language acquisition morphological awareness contributes to reading and spelling ability of normally developing children in combination to phonological awareness. Several issues such as course of acquisition of inflection and derivational morphology in oral and written language are well documented in English language and presented in this paper.

Diagnosis of salivary gland tumours (SGTs) pose a challenge even to the experienced pathologist and immunohistochemistry may be a useful adjunct. Aim of this study is to assess the degree of differential expression of α-SMA among salivary gland tumours, and to evaluate the possible diagnostic benefits. Sections of formalin-fixed, paraffin embedded tissues blocks obtained from SGTs were stained using α-SMA monoclonal antibody. Immunoreactivity were scored based on Regezi method, with 0 indicating nonreactive, 1+ representing scattered spotty staining, 2+ indicating up to 25% of tumour cells positive, 3+ indicating between 25% to 50% tumour cells positive, and 4+ indicating more than 50%. Scores of 1+ and 2+ were regarded as low reactivity, 3+ was regarded as moderate reactivity, and 4+ was regarded as high reactivity. Data was analyzed and p-value <0.05 was regarded as significant. Out of the 42 cases of SGTs studied, 33 (78.6%) expressed α-SMA. The highest α-SMA score observed in adenoid cystic carcinoma, pleomorphic adenoma and basal cell adenoma was 4+, followed by peak score of 3+ observed in polymorphous adenocarcinoma, while 2+ was the highest score in mucoepidermoid carcinoma and epimyoepithelial carcinoma. Acinic cell carcinoma did not express α-SMA in all cases studied. There was significant differential expression of α-SMA between acinic cell carcinoma and adenoid cystic carcinoma (p=0.009); mucoepidermoid carcinoma and pleomorphic adenoma (p=0.048); mucoepidermoid and adenoid cystic carcinoma (p=0.004). In conclusion, α-SMA may be useful in the exclusion of acinic cell carcinoma and in the differential diagnosis between pleomorphic adenoma and mucoepidermoid carcinoma.

Multiple synchronous primary malignancies have been reported in colon carcinoma and studied for lynch syndrome or constitutional mismatch repair deficiency syndrome, however we present first case of co-occurance of colorectal adenocarcinoma and wilms tumor with mismatch repair deficiency. A 17 year old girl presented with pain in abdomen. A computerized tomography of whole abdomen revealed a large left sided renal mass along with mass lesion seen in the rectum Histopathology from both the mass revealed presence of colorectal adenocarcinoma and wilms tumor in renal mass. Immunohistochemistry for microsatellite instability was performed which showed loss of expression for MSH2/MSH6 and absence of BRAF mutation with presence of KRAS mutation. Diagnosis of wilms tumor with colorectal adenocarcinoma was made and possibility of constitutional mismatch repair deficiency was considered. A multidisciplinary approach is required for diagnosing synchronous malignancies and apart from clinical, radiological and histopathological studies, microsatellite instability testing in patients with colorectal carcinoma should also be considered to rule out Lynch syndrome or Constitutional Mismatch Repair Deficiency Syndrome. This report describes for the first time the coexistence of a colon carcinoma with Wilms tumor.

Agriculture is the backbone of the economic system declining its production due to overpopulation and urbanization, so there is a need of precision agriculture. Precision agriculture requires sensor integration, automatic control, and networking and data processing capabilities. With the implementation of rapidly growing IoT, challenges of based site-specific farming practice with the aim of maximizing the crop production along with the efficient usage of resources involved in farming process. It provides real time assessment of various crop and environment parameters by précising the observed farming land as well as the amount of required water, fertilizer and other input needs. This method enables our farmers to achieve efficiency with proper amount in the required time and therefore ensures growth of non-toxic safe and healthy crop. LPWAN is a wireless network technology, which can be inculcated in the agriculture farms for precision purpose. In this study Lora based technology is used to monitor the agriculture parameters i.e; temperature, humidity and soil moisture to realize timely monitoring of the crop growth parameters, which solves the problem of manually collecting the data and overcomes the problem of long distance communication and anti-interference of the intelligent systems. The hardware installation of reducing the sensor implementation is also represented in the study.

The objective of this paper is to defend the non-reductive thesis of phenomenal consciousness. This paper will give an overview of the arguments for the non-reductive explanation of phenomenal consciousness and justify why the reductionist approach is implausible in the context of explaining phenomenal subjective experience. The debate between reductionist and non-reductionist on the project of Demystifying and Mystifying phenomenal consciousness is driven by two fundamental assumptions-1) Reductive-Naturalistic Objectivism, 2) Phenomenal Realism. There are several arguments for the irreducibility of phenomenal consciousness; this paper will focus on the inverted spectrum argument, knowledge argument, and the conceivability argument.