The connecting factor formula is a distinctive concept in private international law and serves as a universal rule for resolving conflicts of laws. This paper examines the influence and role of private international law theories in the formation and development of connecting factor formulas by analyzing different stages of doctrinal evolution and representative scholarly perspectives. The study aims to provide a theoretical foundation for understanding and applying these formulas.

The area under castor oil cultivation in Iran has varied over the years. In 2019, the area under castor oil cultivation in Iran was about 11.02 thousand hectares, according to the FAO report (FAO, 2021). This is while in 1996, the area under castor oil cultivation was higher and then decreased. Castor oil can be extracted using a variety of methods, including cold pressing, solvent extraction, and screw pressing. These methods utilize different tools and techniques to separate the oil from the castor seeds. Deserts are often associated with areas of high atmospheric pressure, particularly subtropical high-pressure zones. This high pressure is due to sinking air, which warms and dries, leading to low rainfall and desert conditions. Conversely, low-pressure systems typically bring cloudy, rainy weather, not desert conditions. Chromosomes are string-like structures that store genetic information and are located in the cell nucleus. These structures are made up of DNA and protein and pass genetic information to new cells during cell division. The number of chromosomes in a castor bean seed is 20 (2n=20). This number means that each castor bean cell has 20 chromosomes, which are located in pairs (10 pairs) in the cell nucleus. Castor (Ricinus communis) is important in Iran as a valuable plant, both medicinally and industrially. Castor oil is traditionally used in traditional medicine for various treatments and is also known as an important source for oil production in industry. In this research we concluded that castor bean plants can be cultivated in desert environments, particularly in arid and semi-arid regions, due to their drought tolerance and adaptability to various soil types. While they prefer well-drained, fertile soil and a specific temperature range, castor beans can thrive with minimal rainfall and even tolerate slight soil acidity. Their deep-rooted nature allows them to draw moisture from deeper soil layers, making them suitable for water-scarce regions. In this research we concluded that the toxicity of raw castor beans depends on the percentage and size of the ricin toxin. Although the lethal dose for adults has been identified as about 4 to 8 seeds, reports of human poisoning from these seeds are very rare. In addition we concluded that Castor beans contain a highly toxic protein called ricin. During the oil extraction process, high heat inactivates and destroys this protein. After processing and purifying castor ricin, the final product is completely purified and becomes usable. Castor oil is one of the oldest medicinal plants in the world. Determining the genetic diversity of plants, including castor oil, plays an important role in identifying superior genotypes for use in plant breeding programs. For this purpose, the genetic diversity and relationship of castor oil ecotypes, resistance to salinity, and response to organic and mineral fertilizers were investigated in this study.

Without pigments, life would lack vibrancy. The natural world presents us with a kaleidoscope of colours from the lush green grass of home to the warm, ruddy hues of an autumn forest. These colours, with few exceptions, arise from natural pigments found in living organisms. Beyond providing visual appeal, pigments fulfil essential biological functions. Among the various classes of natural pigments, carotenoids stand out for their wide distribution and diverse roles in biological systems. Lycopene a red carotenoid pigment, is abundant in tomatoes, apricots, guavas, watermelons, papayas, and pink grapefruits, with tomatoes serving as the primary source in the human diet. Notably, lycopene demonstrates a strong ability to quench singlet oxygen, making it a powerful antioxidant. Its vivid colour and lack of toxicity also make it a valuable natural food colorant. In addition to its antioxidant properties and use as a natural colorant, lycopene demonstrates considerable potential in both medical and dental fields. It has been recognized as an effective adjunctive, non-invasive therapeutic agent in the management of several oral diseases, including leukoplakia, oral submucous fibrosis, lichen planus, and oral squamous cell carcinoma. Furthermore, lycopene contributes to the preservation of periodontal health by preventing the breakdown of supporting tissues. This review highlights the mechanism of action, multifaceted role of lycopene, particularly emphasizing its preventative and therapeutic potential in managing a range of oral health conditions.

Coronaviruses are a large family of viruses that cause a variety of illnesses, from the common cold to severe acute respiratory syndrome. The SARS–COV–2 outbreak was first reported by the World Health Organization in China and has now become an epidemic, reflecting the extremely high transmissibility of the virus, which has caused great concern and stress among people around the world. Research suggests that prevention, risk education, and promotion of self–care behaviors can slow the spread of the disease in communities, and identifying sources of transmission can be effective in controlling it. The mortality rate of this virus is significantly higher in the elderly and people with underlying diseases compared to healthy people. Coronavirus is a challenging disease and can be easily transmitted in public places, and the number of people infected with this virus is increasing exponentially across all ages and groups. Therefore, increasing public awareness of this disease and providing positive psychological programs and teaching prevention methods in the media can reduce mental problems in society, in addition to reducing mortality and the number of patients.

Background: Cancer cachexia, often referred to as cancer wasting, is a multifactorial syndrome characterized by involuntary weight loss, muscle wasting, and systemic inflammation. It affects up to 80% of patients with advanced malignancy and is a major cause of morbidity and mortality. Despite increasing recognition, it remains underdiagnosed and inadequately treated. Objective: This meta-analysis aimed to evaluate the prevalence, clinical consequences, and effectiveness of interventions for cancer cachexia across malignancies. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library up to December 2024. Randomized controlled trials (RCTs), cohort studies, and meta-analyses reporting prevalence, outcomes, or interventions in adult cancer patients were included. Studies were pooled using a random-effects model. Primary outcomes were prevalence and overall survival; secondary outcomes included treatment tolerance, quality of life, and intervention efficacy. Results: Forty-eight studies comprising 23,400 patients were analyzed. The pooled prevalence of cachexia was 49.2% (95% CI 43.1–54.8), highest in pancreatic (74%) and lung cancer (63%) populations. Cachexia was associated with a 41% higher risk of mortality (HR 1.41; 95% CI 1.23–1.61) and reduced chemotherapy tolerance (RR 1.38). Nutritional interventions alone were insufficient, whereas multimodal approaches (nutrition, pharmacologic agents, exercise) improved weight stabilization and quality of life. Anamorelin drug showed moderate efficacy in increasing lean body mass, though survival benefit remained unproven. Conclusion: Cancer cachexia is highly prevalent and clinically significant, yet interventions remain suboptimal. Early identification and multimodal treatment should be integrated into oncology practice. Future research must focus on biomarkers, standardization of diagnostic criteria, and novel therapeutic targets.

Late blight, caused by Phytophthora infestans, is a devastating disease of tomato, primarily driven by asexual reproduction through sporangia and zoospores. This study presents the first confirmed report of self-fertile P. infestans isolates in Northeast India, capable of producing sexual oospores, signifying a major shift in the pathogen's survival strategy. Infected tomato plants collected between November and December were cultured on rye agar at 18 ± 1°C. Oospore initiation occurred after 28 days, with mature oospores averaging 35 µm in diameter. These self-fertile isolates formed oospores independently and exhibited pathogenicity as confirmed by Koch's postulates. Field observations over five years in semi-temperate conditions (10–17°C, high humidity) confirmed oospore formation in senescing tissues. This discovery suggests that P. infestans may now overwinter in soil via oospores, increasing its persistence and genetic diversity, and possibly resulting in earlier and more severe outbreaks. These findings highlight the urgent need for integrated management strategies targeting both asexual and sexual propagules.

Diabetes mellitus (DM) is a significant public health and economic concern in Saudi Arabia, affecting more than 20% of adults. Insulin remains a cornerstone in DM management, but the country relies significantly on imported products. Hence, this results in high healthcare expenditures and variable availability. In line with Vision 2030, Saudi Arabia has prioritized the localization of insulin manufacturing to ensure sustainable access, reduce import dependency, and enhance national health security. This paper explores the clinical, economic, and policy implications of localizing insulin production in the Kingdom. The current work used a case study methodology to assess the feasibility, challenges, and strategic opportunities for the domestic production of innovative insulins, such as Degludec and IDegAsp. The study supports the development of public-private partnerships, investment in biotechnology infrastructure, and regulatory reform to foster a robust local biopharmaceutical ecosystem. By 2027, Saudi Arabia aims to meet 50% of its insulin demand through local production, making it the first country in the GCC region to produce innovative insulin. This initiative is expected to promote affordability and position the Kingdom as a leader in insulin innovation.

This research analyzes the impact of Financial Constraints, Income Shifting, and Sustainability Reporting on tax avoidance, with Institutional Ownership as a moderating variable. The sample consists of 34 manufacturing companies listed on the Indonesia Stock Exchange from 2021 to 2023, using purposive sampling methods. Data were analyzed using panel data regression with EViews 12. The results indicate that Income Shifting and Sustainability Reporting significantly affect Tax Avoidance, while Financial Constraints do not impact Tax Avoidance. Additionally, Institutional Ownership moderates the effect of Income Shifting on Tax Avoidance but does not moderate the effects of Financial Constraints and Sustainability Reporting on Tax Avoidance. This study meets classical assumption tests and found no issues with multicollinearity, heteroscedasticity, or autocorrelation. The findings highlight the importance of Institutional Ownership in monitoring tax avoidance and the need for transparency in sustainability reporting.

The inadequate supply of educational teaching aids and truly functional laboratories to aid teaching and learning of sciences across Nigeria, particularly Zamfara State, due to high cost incurred in acquiring them has necessitated the invention of a multifunctional mobile teaching aid and intervention laboratory for schools. The invention is a home-grown, purpose-built game changer to positively leverage the educational sector to enhance quality and effective Science, Technology. Engineering and Mathematics (STEM) education in Nigeria. Thus, the article x-rays banditry activities in Zamfara State and feasibility of integrating mobile-laboratory-intervention for skills acquisition in Zamfara State. The study adopted a mixed method research design using both qualitative and quantitative data. Four research questions and hypotheses were formulated to guide the study. The population consisted of 280 principals selected from three educational zones in Zamfara State using multi-stage sampling technique. A self-designed instrument was used for data collection. The questionnaire was subjected to face-and content validity by experts in education and gave a reliability coefficient of 0.85 using Cronbach Alpha reliability test. Mean and standard deviation were used for answering the research questions while t-test analysis was used in testing the hypotheses for the study at 0.05 level of significance. The findings revealed no significant difference in the opinion of the respondents on the impact of banditry activities on STEM education for skills acquisition in Zamfara State. The study recommended among others that the provision of multifunctional mobile laboratory intervention, organization of workshops and conferences on the significance of STEM education should be encouraged at all levels.

The integration of neuroanatomophysiology and neuropsychopharmacology links the structural and functional organization of the nervous system with the pharmacological modulation of neural processes, cognition, mood, and behavior, creating an interdisciplinary bridge between neuroscience and clinical practice. Differentiating neurodivergence, understood as natural variations in brain structure and function, from neurological disorders, involving impairments or degenerative processes, is essential for diagnostic accuracy and social inclusivity. Advances in neuroimaging, biomarkers, and targeted pharmacotherapies have enabled earlier detection, better characterization, and personalized interventions. This study aimed to analyze how these fields interact in understanding, diagnosing, and treating neurodivergence and neurological disorders through an integrative bibliographic review. Searches in SciELO, LILACS, BVSMS, and Google Scholar used controlled descriptors and free-text terms, with inclusion of qualitative review articles in Portuguese, English, or Spanish. Data extraction emphasized objectives, methods, and findings, prioritizing methodological rigor to integrate theoretical and applied perspectives for improved clinical outcomes.

Stereotactic lesioning has re-emerged as a feasible option to deep brain stimulation (DBS) for severe Parkinson's disease (PD), especially in individuals with restricted access to device-based therapy. Although single-target lesioning of the ventral intermediate nucleus (Vim) or globes pallidus internus (GPi) effectively addresses certain motor disorders, dual-target lesioning within the same hemisphere is yet little investigated. To assess the effectiveness and safety of dual-target stereotactic lesioning (Vim + GPi) against single-target lesioning (Vim or GPi alone) in individuals with advanced Parkinson's disease and medication-resistant motor symptoms. A prospective observational research with 450 consecutive patients with advanced Parkinson's disease was carried out at two neurosurgical centers in Iraq. Patients underwent either single-target (n = 321) or dual-target (n = 129) radiofrequency lesioning. Outcomes were assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS-III) and complication rates over a follow-up period of 1–2 years. Statistical comparisons were made using t-tests and p-values < 0.05 were considered significant. Dual-target lesioning yielded significantly greater improvement in tremor (↓ 85.7%), rigidity (↓ 75.7%), and bradykinesia (↓ 82.4%) compared to single-target approaches (all p < 0.0001). However, complication rates were higher in the dual-target group, particularly for speech (27.1% vs. 13.1%, p = 0.0016) and balance disturbances (37.2% vs. 17.1%, p < 0.0001). No notable variations were detected in age, illness duration, or baseline LEDD across the groups. In comparison to single-target ablation, dual-target stereotactic lesioning is associated with a higher incidence of adverse effects; nevertheless, it is significantly more successful in managing motor symptoms in advanced Parkinson's disease (PD). The meticulous selection of patients and the adjustment of lesion characteristics are essential to enhance benefits while concurrently limiting issues. In individuals unsuitable for deep brain stimulation (DBS) or seeking more comprehensive symptom relief, these findings advocate for the targeted application of dual-target approaches.

Beta-thalassemia major (β-TM) is a prevalent hereditary condition. Because they are highly prone to infection, the patients will have higher rates of infection-related death and morbidity. Meteorin-like protein (METRNL) a minor secreted protein and weighs about 28 kDa, which comprise 311 amino acids. This study aimed to evaluation immune inflammatory markers METRNL in sera patients with β-TM groups. Thalassemia Unit" at the "Al Zahra Teaching Hospital" in Najaf, Iraq, registered 60 patients with β-TM, including children and adolescents. They were 28 females and 32 males, ages 7 to 20. during the January–March 2022 timeframe. In the current study, it is found a significant increase in serum levels of FSG, insulin, and HOMA-IR, as well showed significantly lowered in BMI, HOMA-β, and METRNL in patients with β-TM as compared with control group. The linear regression analysis showed that the levels of FSG, insulin and HOMA-IR were significantly negative correlation with METRNL. ROC curve form METRNL that might be diagnosis of patients with β-TM with an AUC (0.748), the cut-off value was 29.0025 (ng/mL) for serum METRNL (95% CI: 0.585-0.911; p=0.003), a sensitivity of 73.3% and a specificity of 78% were acquired for METRNL in β-TM patients. The lower serum METRNL levels in β-TM patients than the healthy group, may be used potential risk indicator of the patients' worse prognosis, for induces endothelial dysfunction and lead to inflammation in most organs tissues could be later outcome to heme induce damage.

Background: Telehealth or telemedicine primarily focuses on patient benefits and safety including improved accessibility, enhanced patient satisfaction, and establishing and maintaining continuity of care. The John Hopkins Aramco Healthcare (JHAH) pharmacy aimed at establishing the pharmacist-led medication management clinics (MMC) clinics as a model of medication management and patient counseling. Objectives: To describe and compare the outcome of implementing telehealth services managed via a pharmacist-led medication management clinic (MMC) to confer person-centered patient care services at JHAH. Methodology: The retrospective observational study was conducted in a single-centered tertiary care institution, John Hopkins Aramco Healthcare, Saudi Arabia for a duration of six months from June 2021 to December 2021 among ambulatory care patients. Results: There were few significant differences between the gender distribution between patients of tele MMC and MMC that TELEMMC were more preferable choice for the age group 61-70 years compared to MMC, where as in MMC age group 51-60 years were more preferable. Both TELEMMC and MMC demonstrated a high level of satisfaction with general medicine department with 63% of patients. Conclusion: The present study demonstrates the impact of TELEMMC on clinics, indicating a substantial increase in the number of individuals, particularly geriatric patients, opting for telemedicine consultations. The widespread acceptance of this new method reflects the positive impact it has had on healthcare delivery and patient outcomes

The world financial system is growing more volatile, and it is questionable whether the conventional reserve currencies will remain as strong as ever. This paper examines whether the euro can meaningfully challenge the U.S. dollar's dominance as increasing economic volatility and the appearance of new competitors like the Chinese Yuan raise this question. This study applies a qualitative and descriptive-quantitative study design. The analysis in this paper draws on empirical data from institutions including the IMF and the BIS. To guide the analysis, this paper uses three key theories: hegemonic stability theory, network effects, and institutional trust. While the U.S. dollar is still the main global currency, it's losing ground. Its share used to be above 70%, but now it's decreased to 53.6%. The euro, on the other hand, has maintained a consistent 20% share and has been remarkably stable. The euro gets its strength from the EU's reliable banking policies and a strong legal system. However, internal division stalls its growth as a global heavyweight. Specifically, the lack of a common fiscal policy and constant political disagreements among member states act as a drag on its overall performance. The Yuan is growing, but it still only accounts for about 2% of the world’s reserves. Despite China's massive economy, the currency is held back by 'red tape' and trust issues specifically, strict controls on moving money, government intervention in its value, and a general lack of transparency. This paper concludes that no single currency will take the lead in the future. Rather, the world is moving toward a multipolar reserve system where the dollar, euro, Yuan, and selected digital currencies will coexist.

The paper examines the impact of mobile health applications on patient adherence through a literature-based research approach. Key questions explored include the impact of mHealth on treatment compliance, the efficacy of app-based interventions, and barriers to adoption. The study aims to assess mHealth’s influence on adherence, identify success factors, and evaluate its potential to address healthcare gaps. The methodology involved a systematic literature review of peer-reviewed articles, clinical trials, and case studies from 2015 to 2023, utilizing qualitative and quantitative analysis to synthesize findings. Data were collected on app features, user engagement metrics, and adherence outcomes from databases like PubMed, IEEE Xplore, and Google Scholar. Results show that mHealth apps significantly improve adherence through reminders, educational content, and personalized feedback, with a notable impact on chronic disease management. Challenges such as low digital literacy and privacy concerns hinder efficacy. The study concludes that mHealth has transformative potential but depends on user-centered design, robust data security, and healthcare system integration. Contributions include a framework for optimizing app-based interventions and policy recommendations to support digital health adoption. Practical applications include reduced treatment gaps and healthcare costs, while limitations like sample bias and technological evolution highlight the need for longitudinal research. Future directions include investigating AI-driven personalization and cross-cultural adaptability.