Different factors involved in increasing the risk of infectious diseases caused by genetic and environmental changes. Due to high risk of infectious diseases such as chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, advances have been made in the fields of molecular sciences and engineering technology for highly effective tools and high-throughput omics technologies. Ebola virus is the most contagious as compared to the other viruses colds, influenza, or measles. Pathogenic bacteria are involved in causing of infectious diseases. Hib disease is the serious public health concern disease caused by Haemophilus influenza. Norwalk virus also causes serious abnormalities in the digestive system that ultimately leads to muscle cramp. Antimicrobial resistance have been challenging in the fields of biomedical sciences. Sequencing of bacterial genomes helpful for track the different status of fates of mutations that rise and fall through indication of multiple replicates. Genetic engineering based biomedical therapies needed to understand the target microbial cell, protein factory that secreted the variety of products.

Legal education has changed very little over the last century. At the same time, there have been significant advances in the field of education leading to several theories. The following will examine the five leading theories of education: connectivism, humanism, constructivism, cognitivism, and behaviorism. Each of these will be evaluated next to the Socratic Method, which is the primary method employed by law school instructors. Specific examples of how some of these theories have surfaced in law school and how the Socratic Method embodies other theories will be noted. The effect of technology on law school instruction will also be addressed. The overall goal of this article is to reveal how these theories can be utilized in the law school setting to produce highly competent graduates who will improve the efficacy of the field as a whole. Anecdotal example from North American and African law schools will underscore the notions put forth in this article.

This study aims to determine and analyze the effects of leadership and organizational culture on employee performance and customer satisfaction variables as an intervening at PT. Sukaputra Graha Cemerlang Sentul City. Quantitative descriptive method with a causal relationship approach is the method used in this study. The population selected in this study were all employees of PT. Sukaputra Graha Cemerlang in Sentul City with a population of 217 people. Of all the population samples taken based on the Slovin formula are 141 samples. Data analysis using Structural Equation Model (SEM) with SmartPLS (Partial Least Square) 3.0. The results showed that leadership style had a positive and significant effect on customer satisfaction, organizational culture had a positive and significant influence on customer satisfaction, leadership style and organizational culture had a positive and significant influence on customer satisfaction, and customer satisfaction had a positive and significant effect on performance. employees of PT. Sukaputra Graha Cemerlang in Sentul City. Customer satisfaction can mediate the influence between leadership style and organizational culture with the performance of employees of PT. Sukaputra Graha Cemerlang in Sentul City.

Background: Pregnancy is associated with anatomic, physiological and metabolic adaptations to accommodate the fetus and prepare the mother for delivery. These adjustments are mediated by the hormonal influences of the placenta. The study is aimed at evaluating the pattern of changes of serum growth hormone and cortisol in normal pregnancy to access the possible effect of gestational age and parity on these parameters. Methods: A cross sectional study involving a total of 300 apparently healthy females (21-50yrs) with 200 and 100 pregnant females and non-pregnant controls respectively. The age of the subjects, last menstrual period, gestational age and parity were obtained using a simple questionnaire while the weight and height were obtained following standard protocols. Blood samples were obtained from the subjects and serum growth hormone and cortisol were analyzed using standard laboratory methods. Results: Serum growth hormone was found to reduce in pregnant subjects compared to the non-pregnant control with the lowest decrease observed in the second trimester (p<0.05). Conversely, serum cortisol increased among pregnant subjects compared to the non-pregnant control, showing a gestational age-dependent increase (p<0.05). Conclusion: Our findings suggest that serum growth hormone and cortisol vary with gestational age with growth hormone decreasing while cortisol increases. The present study also highlights that parity appears not to have any influence on serum growth hormone and cortisol during normal pregnancy.

Everyone is stressed to some extent. The way you respond to stress, on the other hand, has a significant impact on your overall well-being. Stress is defined as any type of change that causes physical, emotional, or psychological strain. Stress is your body's reaction to anything that requires your attention or action. Students are exposed to a wide range of potentially stressful situations in their daily academic lives, which can have a negative impact on both their academic achievement and their health. Among the factors that may be weakened by academic stress are self-efficacy expectations, which are regarded as one of the most important determinants of student engagement, persistence, and academic success. Sometimes the best way to deal with stress is to change your situation. Other times, changing your response to a situation is the best strategy. Short-term and long-term stress are both possible. Both can cause a variety of symptoms, but chronic stress can take a serious toll on the body and have long-term health consequences. As a result, they must be educated on healthy coping strategies. Counselling sessions and other student support systems must be better organized to address issues such as career guidance, healthy coping behaviors, time management, and improving self-esteem among those affected. It is also important to pay attention to making the study environment in the classroom less stressful and free of excessive academic load (Joseph, 2021). This would accomplish the aim of reducing academic stress, improving academic performance, and minimizing anxiety. This review article aims to discuss the causes and coping strategies for adolescents dealing with academic stress.

The chemical compounds extracted from medicinal plants have potential to evoke mental and social sensations in addition to maintain physical health. . Species of Asteraceae and Liliaceae play significant cardiovascular roles irrespective of exploring their toxicological aspects. Carbohydrates, proteins, lipids, nucleotides, fats, and steroids are the primary organic compounds which are involved in metabolism of essential developmental and growth functions of plants. The detrimental effects of environmental stress factors are suppressed by the gene expressions of ion transporters and water channel proteins present in the cell membranes incorporated with the up or downregulation of osmo-proctant osmolytes and essential proteins such as HSP and chaperones. Sunflower (Helianthus annuus L.) is an important crop known for its food, forage, and silage constituents. It is a prominent specie in Asteraceae family. Its seeds are enriched with edible oil-world’s fourth largest oil source. The mineral elements, dietary fibers, and secondary metabolites such as carotenoids, flavonoids, tocopherols, saponins, tannins, alkaloids, chlorogenic acid, caffeic acid, peptides, phytosterols, triterpene glycosides, and vitamins contribute towards nutraceutical roles. Pot marigold (Calendula officinalis) possesses antibiotic, anti-inflammatory, and antifungal properties which allow its applications in preventing muscle spasms, treating sore throat and ulcers of duodenum and stomach, soothing eczema, healing wounds, and relieving rashes.

Diffuse sclerosing papillary thyroid carcinoma (DS PTC) is a relatively rare variant of papillary thyroid carcinoma. It is characterized by distinct histological features like scattered microscopic tumor islands, diffuse sclerosis, lymphocytic infiltration, numerous psammoma bodies, radiological features like snowstorm appearance and biologically aggressive behavior in the form of invasion and metastasis. A preoperative diagnosis is often challenging in the absence of nodules and scanty fine needle aspiration cytology sample. We describe a case of multifocal diffuse sclerosing variant of papillary thyroid carcinoma in a 29 year old young male who presented with a swelling in the right side of neck of 2 month duration in the absence of a visible thyroid swelling. Neck swelling was non tender, well defined, firm, not moving with deglutition. Laboratory studies showed normal thyroid function, neck ultrasound revealed heteroechoic right lobe with multiple punctate echogenic foci and enlarged right sided cervical nodes with echogenic foci, fine needle aspiration cytology of which was consistent with metastasis from papillary adenocarcinoma. Based on the above investigations, a total thyroidectomy with central compartment lymph node dissection and modified radical neck dissection of right side was performed. Histological analysis revealed Multifocal Diffuse Sclerosing variant of papillary Thyroid Carcinoma. Clinical and histological challenges usually occur when DS PTC present as diffuse thyroid enlargement, dispersed microscopic tumor islands, extensive fibrosis, abundant lymphocytic infiltration mimicking thyroiditis and when the fine needle aspiration cytology sample is non representative.

Intimate Partner Violence (IPV) has been identified as a global public health problem of human rights concern. It is a global issue with far reaching consequences for the physical, reproductive, and mental health of women, regardless of social, economic, religious or cultural group. Most of the times, IPV is usually perpetrated by a husband or an intimate male partner of a woman or girl and this is often due to the emotional attachment with or economic dependency of the women on the perpetrators of violence. The outbreak of the COVID-19 pandemic and the lockdown measure, although effective in reducing the disease spread has led to unintended negative consequences. The social, economic and financial distress experienced during the COVID-19 lockdown period has increased the prevalence of Intimate Partner Violence. The financial difficulty associated with the lock-down period has been known to precipitate stress and frustration, and subsequent negative coping mechanisms such as substance abuse and depression; all of which are baseline triggers for intimate partner violence. This has been labelled the silent pandemic. This article examines the rise in incidences of Intimate Partner violence in Nigeria during the COVID-19 Pandemic and contends that Individual Risk Factors, Financial Dependence on the Abuser, Poor Implementation of the rights of women, Cultural Perception of Women, Poor Governance and Resource Management, Lack of Adequate Social Welfare Palliative Schemes, in addition to the complications arising from dealing with COVID-19 pandemic are major factors that have resulted in the surge of Intimate Partner Violence in Nigeria. This work underscores recommendations to curb Intimate Partner violence in Nigeria during and beyond the COVID-19 pandemic, and ensure better realization of the rights and welfare of women and girls such as Legal Framework Reform, Socio Economic Empowerment of Women and girls, Community Mobilization and Behaviour Change Communication, Awareness Creation, and establishment of Sexual Assault Referral and Counselling Centres.

To integrate with the jawbone and gum tissues, a prosthetic dental material must be appealing, long-lasting, repairable, cleanable, and bio-compatible. In terms of new prosthetic materials, prosthodontics is rapidly evolving. Despite the fact that all artificial materials emit compounds into the oral environment, side effects and unpleasant responses are possible. We utilized Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to conduct an automated and manual search to find clinical studies that looked at the relationship between prosthetic materials and biohazards. A 'ideal' material will have properties that are equal to or very close to those of the material being replaced. One of the most important properties for any material used in the human body is biocompatibility, or more specifically bioactivity. Unlike other implanted materials, the biocompatibility of dental materials varies depending on their structure and state.

The classical theory is that before being biologically active, proteins are assembled into a unique three-dimensional structure in terms of quality. These Intrinsically Disordered Proteins (IDPs) are very common in many genomes, including humans and play a key role in central cell processes such as transcription and translation, cell cycle, and cell signaling regulation. In addition, the proportion of proteins associated with various diseases such as cancer and neurodegenerative diseases is very high in IDPs. Therefore, considerable efforts have been made to elucidate the molecular mechanisms supporting the role of IDPs in Biology and disease through the use of experimental and computational methods. Animal models are needed for human genetic anatomy and better treatment options. Genetic disease Although some animals are used key models in academic and industrial research .There is a lot of stress in the anatomy of genetic diseases. The Genetic resemblance of rats and the humans from which is naturally occurring genetic disease, unique population. The availability of structure and complete genomic sequencing has made purebred dogs a powerful model. Used for disease research. The main advantage of dogs is that they suffer from about 450 genetic diseases, of which about half show significant medical symptoms, Similar to the same human disease. Therefore, these two facts make dogs an ideal medical practice, and a genetic model. This review sheds light on some of them, common genetic disease, in dog model. In this article plays an important role in identifying the genes responsible for the disease and / or the use of new genes, treatment of interest for dogs and humans.

Intimate Partner Violence (IPV) has been identified as a global public health problem of human rights concern. It is a global issue with far reaching consequences for the physical, reproductive, and mental health of women, regardless of social, economic, religious or cultural group. Most of the times, IPV is usually perpetrated by a husband or an intimate male partner of a woman or girl and this is often due to the emotional attachment with or economic dependency of the women on the perpetrators of violence. The outbreak of the COVID-19 pandemic and the lockdown measure, although effective in reducing the disease spread has led to unintended negative consequences. The social, economic and financial distress experienced during the COVID-19 lockdown period has increased the prevalence of Intimate Partner Violence. The financial difficulty associated with the lock-down period has been known to precipitate stress and frustration, and subsequent negative coping mechanisms such as substance abuse and depression; all of which are baseline triggers for intimate partner violence. This has been labelled the silent pandemic. This article examines the rise in incidences of Intimate Partner violence in Nigeria during the COVID-19 Pandemic and contends that Individual Risk Factors, Financial Dependence on the Abuser, Poor Implementation of the rights of women, Cultural Perception of Women, Poor Governance and Resource Management, Lack of Adequate Social Welfare Palliative Schemes, in addition to the complications arising from dealing with COVID-19 pandemic are major factors that have resulted in the surge of Intimate Partner Violence in Nigeria. This work underscores recommendations to curb Intimate Partner violence in Nigeria during and beyond the COVID-19 pandemic, and ensure better realization of the rights and welfare of women and girls such as Legal Framework Reform, Socio Economic Empowerment of Women and girls, Community Mobilization and Behaviour Change Communication, Awareness Creation, and establishment of Sexual Assault Referral and Counselling Centres.

Ever since Ken Saro-Wiwa published his novel Sozaboy in 1985, it has attracted and received tremendous critical attention. However, literary scholars and critics mostly explore either the author’s use of language or his representation of the Nigerian Civil War in Sozaboy. Deploying theories of ecocriticism and regionalism, this paper shifts that focus by examining certain ways Saro-Wiwa articulates his sense of place in Sozaboy and the place, as is well-known, is Dukana – his narrative locus. At the centre of this paper is the contention that Dukana, Saro-Wiwa’s fictional world, is replete with certain characteristics which shape a writer’s vision of place and these include the landscape, culture, beliefs, habits and mannerisms or ethos of a place. Accordingly, I shall analyse Saro-Wiwa’s sense of place in Sozaboy in terms of his perceptions of these characteristics of Dukana. In this way, I propose to locate Saro-Wiwa in the regionalist or place-sense writer’s tradition. I shall further argue that Saro-Wiwa derives his sense of place from what he has seen and known about the Niger Delta region and its people in lived experience. The paper finds that in addition to Saro-Wiwa’s experimentation with language and his concern with the civil war, what also informs his writing of Sozaboy is his desire to articulate rural sensibilities. Drawing from his preoccupation with regional life and events that live on in the pages of his fictional works, the paper concludes that Saro-Wiwa is, for the most part, a regionalist or place-sense writer.

This paper examines the dynamics surrounding enrolment interventions that have been put in place by key stakeholders in promotion of the 100% enrolment rates in primary schools. The study was guided by the following objective: to determine enrolment dynamics of primary schools in Eldoret West Sub County, Kenya. The study was based on the social demand approach, a model which when applied to education, refers to the aggregate/total demand for school places in a nation (Zimmer, 1985). The researcher adopted a survey research design which aimed at obtaining complete and accurate findings. The design was appropriate for the study since the researcher intended to critically examine enrolment dynamics in Eldoret West, Kenya. From the 177 primary schools in the sub county, a total of 53 schools were sampled. All the 53 Headteachers and all the 5 Quality Assurance Officers in the Education sub county office participated in the study. Data was collected by use of questionnaires, interviews and documents analysis. It was established that there was a significant growth in enrolment due to current government policies. The stakeholders should be mobilized to provide resources needed to expand primary school facilities to ensure equal access to education opportunities for all.

Covid-19 pandemic has resulted in death of millions of people across the world. The impact of the disease on human health and the economic hardship on the affected countries have been severe. The public must routinely practice precautionary measures to control the spread of the disease, as no antiviral treatments are currently available. However, the level of awareness and practice of these preventive measures against Covid-19 infection among pregnant women, which constitute vulnerable groups have not been evaluated in our environment. The aim of the study was to determine the awareness and knowledge of pregnant women on Covid-19, its preventive measures and the practice of those preventive measures. It was a cross-sectional study among pregnant women attending antenatal care clinic at Usmanu Danfodiyo University Teaching Hospital, Sokoto. An interviewer administered questionnaire was used to obtain relevant information on sociodemographic characteristics and also their knowledge and practice of Covid-19 preventive measures. All the respondents were aware of Covid-19 infection and the source of information was from Television. All the respondents were aware of the various preventive measures of Covid-19 and the knowledge was good among 98.7% of the respondents. However, only 19.1% had good practice of the preventive measures. Educational status of the respondents was found to have significant association with knowledge of preventive measures (χ2= 9.5, p = 0.014).

This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1indicate the formation of complex which is assign toV(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide(DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compound was tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.