Background: Benign Prostate Hyperplasia (BPH) is an age associated prostate gland enlargement in men that can lead to urination difficulty. The exact etiology of BPH is unknown. However, inflammation is a critical factor in the development of BPH. Soursop as a traditional medicine has anti-inflammatory properties. This study investigated the anti-inflammatory potentials of soursop pulp extracts on induced benign prostatic hyperplasia (BPH) in adult male wistar rats. Materials and methods: Twenty-four adult male rats grouped into five were used for the study. BPH was induced subcutaneously in the inguinal region with testosterone propionate 3mg/kg/day. Acute toxicity test was carried out to determine the safety of the extract. The rats in group A served as the control group. Rats in group B, C and D were administered 200mg, 400mg, and 600mg of aqueous soursop extract per kg body weight/day. Biochemical analyses of the protein specific antigen, albumin, white blood cell count, testosterone, and C-reactive protein were performed after the trial. Statistical analysis was done using SPSS version 23. Results: Aqueous soursop pulp extract significantly decreased (p<0.05) the protein specific antigen by 58.87%. The extract at 400mg resulted in a percentage decrease in white blood cell count by 35.37% and albumin by 31.23 %. The extract at 600mg significantly decreased the testosterone and C- Reactive Protein by 59.88% and 69.47% respectively. Conclusion: The inflammatory bio-markers (prostate specific antigen, albumin, white blood cell count, testosterone, and C-reactive protein) studied after treatment revealed that aqueous soursop pulp extract is promising in the management of benign prostate hyperplasia.

Introduction: The present study was conducted to identify factors associated with late recourse to prenatal consultation in the city of Mbandaka. Method: This study was based on a case-control survey. A total of 650 pregnant women (325 cases and 325 controls) responded to a structured questionnaire. Cases were pregnant women seen late in the ANC service and each was paired with a control who came to the first antenatal visit in the first trimester. The data were analysed using SPSS 22 software where multivariate analyses based on the logistic regression model allowed the research objectives to be met. The risk of error considered was 0.05. Results: The factors associated with late recourse to ANC were: cost of ANC (p<0.01); lack of financial means (p<0.01); lack of motivation (p<0.01); shame (p<0.01); unavailability of the pregnant woman (p<0.01); traditional practice before performing ANC (p<0.01); parity (p<0.05) and marital status (p<0.05). Conclusion: The use of ANC remains late in Mbandaka. Any action aimed at encouraging pregnant women to start ANC in the first trimester of pregnancy should focus on improving the socio-familial environment, the service offer, socio-economic characteristics, socio-cultural characteristics and socio-demographic characteristics.

Occupational Health and Safety (OHS) risk management is an effort made to manage the risks of work accidents to minimize the risk of work accidents in a company. The aim and target of OHS risk management is to create an OHS system in the work environment that involves all parties, so as to reduce the number of workplace accidents and create a safe workplace. Therefore, it is necessary to conduct further research on the implementation of the OHS risk management system in the company. In this research, identification and analysis of accident risk have been successfully carried out, as well as making suggestions for risk mitigation in a company in the corrugated carton box sector. In addition, work accident investigations have also been carried out to determine the cause of a work accident and detect latent sources of hazards that were not detected in the risk identification process.

General academic English has become a new trend during the transitional period of college English reform in China. This paper introduces its construction practice in North China Electric Power University（Baoding）from the following aspects: need analysis, course objectives, course content, course arrangement, course evaluation and course implementation effect. This paper aims to provide theoretical basis and practical experience for the construction of general academic English curriculum and the reform of College English.

Background: This study was carried out to investigate the effectiveness of 1.2% Simvastatin gel and 1% Metformin gel in chronic periodontitis pockets. The rationale behind using Statins is that this class of drugs has a potential anti-inflammatory effect on oral epithelial cells, blocking the intermediate metabolites of the mevalonate pathway. Statins also modulate bone formation by increasing the expression of bone morphogenetic protein-2 providing a new direction in the field of periodontal therapy. Statin administration decreases GCF levels of pro-inflammatory mediators which are responsible for much of the host tissue destruction seen in periodontitis. Metformin acts at molecular level via both AMPK (5’adenosine monophosphate activated protein kinase) dependent & AMPK independent pathways. It shows effects on Nuclear Factor-κB (NF-κB), differentiation of monocytes into macrophages as well as suppressing IL-2, interferon (IFN)-γ and TNF-α from these macrophages which thereby improved the periodontal clinical parameters. There is no evidence of literature till now comparing the clinical efficacy of 1.2% Simvastatin gel with 1% Metformin gel in patients with chronic periodontitis. Method: The study population consisted of 48 sites from chronic periodontitis patients, divided into 3 groups which received sub gingival irrigation with Scaling and root planning alone, SRP with 1.2% Simvastatin gel and SRP with1% Metformin gel. Results: 1.2% Simvastatin gel and 1% Metformin gel improve the periodontal health with statistically significant improvement in the PPD, RAL, RGML values as compared to SRP alone. Conclusion: LDD systems using gel formulations are advantageous because of their sustainability, prolonged release, stability in the pockets, clinical effect of 1.2% Simvastatin gel and 1% Metformin gel improves the periodontal health compared to SRP alone.

Background: The effects of cholesterol and statin therapy on serum uric acid (SUA) concentration are poorly known, and the latter's effects are even less clear. A mean atorvastatin dosage of 24 mg/dl satisfies the American Cardiovascular Assessment Campaign management objectives and dramatically lowers prevalence of chronic in individuals with cardiovascular events, according to the Greek Drug and Cardiovascular Evaluation research. We compare the temporal evolution of SUA levels in patients receiving standard treatment who received insufficient statin therapy (12 percent received statins) to patients receiving formalised care who received atorvastatin therapy almost exclusively (98 percent). Methods: In this study 160 individuals with abnormal lipid profiles in their blood were enrolled to investigate the connection between lipid profile and uric acid in dyslipidemic patients (dyslipidemia). It was a 5-month cross-sectional study conducted at Dr Abdul Sattar Lab Sialkot using a convenient sampling method. The uric acid, total cholesterol, triglycerides, LDL, and HDL cholesterol levels of enrolled participants were measured. In short, we performed uric acid and lipid profile tests on under-observation samples to investigate the association between uric acid and lipid profile parameters in the enrolled (dyslipidemic) individuals. Result: This research looks at people between the ages of 20 and 60. The Graph shows that (15) patients are between the ages of 20 and 30, (46) patients are between the ages of 31 and 40, (74) patients are between the ages of 41 and 50, and (25) patients are between the ages of 51 and 60.Patients of both sexes are covered. It was found that there exist significant positive relationship between uric acid and lipid profile in dyslipidemic patients. This study shows a positive correlation between LDL, triglycerides, total cholesterol and uric acid whereas a negative correlation was observed between HDL and uric acid. According to the current results, when uric acid rises, Total Cholesterol, Triglycerides, and Low Density Lipoproteins (LDL) rise as well. But High Density Lipoproteins (HDL) falls with the increase in uric acid levels. As a result, this study may be useful in reducing the incidence of related cardiovascular morbidities, and we will be able to predict dyslipidemia more accurately, which may further leads to CVDs. As the rate of CVDs rises in Pakistan, it is becoming increasingly necessary to investigate the factors that are directly linked to the disease. Conclusion: This article's objective was to investigate any connections between Uric Acid and Lipid Profile. Because dyslipidemia predicts the risk of coronary artery disease, so uric acid levels should be considered in these individuals for more complete risk factor prediction and treatment. Increased levels of lipid profile parameters can lead to serious heart diseases, and the only way to avoid this is to get a quick diagnosis of the disease.

This study examines the effect of monetary policy on the financial performance of Flour Mills Nigeria plc using an annual dataset from 1990 to 2021. The financial performance is measured as return on assets while monetary policy is a proxy by monetary policy rate. Other control variables in the model are exchange rate, inflation rate and managerial efficiency. In the estimation, this study employed the autoregressive distributed lag (ARDL) model. The results of this study reveal that monetary policy has a significant negative effect on the financial performance of flour mills plc while the exchange rate and inflation rate have no significant influence on the financial performance of the company. The result further suggested that managerial efficiency has a significant positive effect on the financial performance of the sampled firm. According to the results, this study recommended that monetary authorities should cut down the monetary policy rate. The foregoing will serve as an incentive for the company to increase its production operation and in the long will help to boost output and financial performance. Finally, the study recommends the need for the company to strengthen its efforts in improving managerial efficiency because of its positive influence on financial performance.

Introduction: Ganglioneuroma is a rare, benign neurogenic tumor that develops from sympathetic ganglionic cells. It is mainly located in the retroperitoneal region. Observation: This is a 39-year-old patient with no pathological history who has been seen for right back pain. Abdominal CT showed a right adrenal tumor with diameters of 40mm×22.5mm, a spontaneous density of >10 HU before injection, and > 31.5 HU after injection with a wash-out at late time < 40%. The hormonal balance reversed the secreting character of the mass, surgical treatment was indicated, histological analysis came back in favor of adrenal ganglioneuroma. Conclusion: Although benign, the ganglioneuroma may present malignant aspects, including scanographic that can mislead the clinician. Therefore, histology remains the examination of choice to make the diagnosis.

Infectious pathologic changes caused by pathogens, which are harmful that enter the body by bacteria, fungus, viruses, and parasites. Infectious-diseases can range in severity from very mild to very dangerous. Numerous human diseases are caused by bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris and Bacillus subtilis. Capparis spp. that have anti-bacterial, anti-oxidant and anti-inflammatory properties, including spermidine, carotenoids, quercetin, tocopherol, and rutin by the anti-bacterial, anti-fungal, and anti-leishmanial action. Carrot seed oil (Daucus carota) and tea tree oil (Melaleuca alternifolia) both exhibit antibacterial action respectively. Curcumin and its derivatives were found to have more potent anti-bacterial activity against several strains of S. pneumonia. Oregano oil and carvacrol has revealed that they have anti-viral properties against respiratory-syncytial-virus (RSV), that causes respiratory disease, rotavirus, a frequent condition of diarrhea in theng children, and herpes simplex virus type 1 (HSV-1). Sweet basil extract, which contain ingredients like ursolic acid and apigenin, have powerful antiviral properties against hepatitis B, herpes and enterovirus. Candida infections have fewer severe side effects and less cost load than chemical medications, can be treated with new pharmaceuticals, plant, and herbal items.

This paper examined health sector readiness and COVID-19 containment in Rivers State, Nigeria. The study concerned itself with the responses from the health sector, which determines its readiness to contain the COVID-19 pandemic as a health emergency. The study was guided by contingency theory. Contingency theory argues that there is no specific and best way of solving problems affecting society and therefore lays emphasis on solutions to problems. Data was collected from secondary sources using content analysis. The analysis indicated that the post-epidemic level of preparedness was poor due to decades of neglect arising from leadership ineptitude, underfunding, and inadequate training in the health sector. However, post-epidemic response and containment efforts, which have kept the fatality rate at 1.3%, demonstrate the importance of prioritization of needs under resource constraint. The drastic contingency measures of sit-at-home, lockdown, and border closure, together with emergency purchase, donor and stakeholder funding, and assistance in the provision of required medical facilities, were an apt product of resilience and courage under fire. The study recommends, among other things, increased budgetary allocation for overall health sector development in line with international best practices. This must be driven by a visionary and pragmatic leader.

Idan dai mutum ma’abocin karatun rubutattun labaran Hausa ne, ko mai sha’awar sauraro ko karatun tatsuniyoyin Hausa ne, babu shakka zai riƙa ganin wasu kamannu tsakanin wasu rubutatttun labaran Hausa da kuma tsatsuniyoyi na Hausa. Wannan dalili ne ya sa wannan takarda ta yi tsokaci a kan kyakkyawar dangantakar da ke tsakanin rubutattun labaran Hausa da tatsuniyoyin Hausa. Taken wannan takarda shi ne, “Dangantakar Jigogin Wasu Labaran Magana Jari Ce da Na Tatsuniyoyin Hausa.” Manufar takardar ita ce, kwatanta dangantakar da ke akwai tsakanin wasu labaran da ke cikin Magana Jari Ce I - III da tatsuniyoyin Hausa ta fuskar jigogi, wato saƙonnin da suke ɗauke da su. An karanta wasu ayyukan masana da suka yi a kan fagagen tatsuniyoyi da rubutattun labaran Hausa. An kuma karanta littafin Magana Jari Ce I-III a matsayin dabaru da hanyoyin gudanar da bincike. An ɗora wannan bincike a kan Ra’in Tsarin Adabi (Structural Theory) na Propp (1928). Bayan an ƙare binciken, sai aka gano cewa, akwai kyakkyawar alaƙa ta fuskar jigogi tsakanin wasu labaran Magana Jari Ce I-III da tatsuniyoyin Hausa. Wannan alaƙa kamar yadda aka gano ta samu ne saboda rubutattun labaran Hausa sun tusgo gyauronsu ne daga tatsuniyoyin Hausa. Haka kuma, mawallafin littafin Magana Jari Ce I-III wato Abubakar Imam ya daɗe yana sauraron tsatsunoyin Hausa daga bakin kakanninsa tun yana yaro ƙarami kamar yadda kowane yaro ke tashi da sauraron su a ƙasar Hausa. Wannan babu shakka ya tasiranci tunanin Abubakar Imam wajen gina littafin Magana Jari Ce I-III.

Objectives: The benefits of topical drug delivery systems, which have been used for centuries, include the ability to deliver medications both quickly to the affected area where they are most effective and over an extended period of time. These systems lengthen the drug's mean resident time and contact time. The design and characterization of an antibiotic emulgel for topical medication administration is a goal of the current investigation. Methods: Cefpodoxime Proxetil emulgel were prepared using different concentration of Carbopol 934, HPMC K4M and xanthan gum as gelling agents and evaluated the relevant parameters such as physical examinations, pH, extrudability, spreadability, viscosity, swelling index, drug content, in-vitro diffusion studies and microbiology activities. Results: All formulations are neutral and viscosity of emulgel was found in the acceptable limits. On physical evaluations were found to be optimum in terms spreadability, swelling index and extrudability. Drug content of all formulations were found in the ranges 69.73% to 97.58% and CEF4 emulgel exhibiting the highest drug concentration and the lowest percentage drug release due to its controlled release pattern and proven non-fickian diffusion mechanism release. The results found that, the selected formulations proven better bacterial activities against both gram positive and gram negative organisms. Conclusions: Type and concentration of polymers can have an impact on the drug permeability studies and physical-chemical characteristics of the developed antibiotic emulgel, which had excellent results and was suitable for possible therapeutic purposes.

Gastrointestinal tuberculosis accounts for nearly 3 % of the total extra pulmonary cases. Tuberculous appendicitis is a rare type of gastro intestinal tuberculosis, seen only in 0.1 to 0.3% of cases. Here we present a tuberculous appendicitis case in a 20 year old female.

Once the novel molecule is planted, preformulation study is one of the fractions that is started. In a larger sense, it covers with research on a molecule's physical, chemical, analytical, and medicinal properties and offers suggestions for effective modifications that could be made to improve performance. The study of preformulation factors can contribute to the development of pharmaceutical formulations that are dependable, safe, stable, and efficacious. Pantoprazole is an irreversible proton pump inhibitor (PPI) that reduces gastric acid secretion. PPIs, pantoprazole binds to the proton pump (H+,K+ -adenosine triphosphatase) in the parietal cells to exercise its pharmacodynamic effects; however, in comparison to other PPIs, its binding may be more specific for the proton pump. When given as an enteric-coated, delayed-release tablet, pantoprazole is well absorbed and has a 77 % oral bioavailability. It is metabolized by the liver's cytochrome P2C19 into the inactive metabolite hydroxypantoprazole, which is then subjected to sulphate conjugation. Independent of dose, the elimination half-life ranges from 0.9 to 1.9 hours. Similar to other PPIs, pantoprazole is effective in promoting the healing of gastric and duodenal ulcers. In the present works overall objective of preformulation studies of Pantoprazole is to engender information useful in developing stable and Bioavailable dosage forms.

Introduction: Paraneoplastic hypoglycemia unrelated to insulinoma is a rare cause of hypoglycemia and is due to paraneoplastic secretion of either IGFI, IGFII, or more rarely insulin Observation: We report a case of paraneoplastic hypoglycemia in a patient with metastases of an unknown primary. This is a 60-year-old patient admitted to the ward for recurrent hypoglycemia, the first of which was discovered following an apyretic coma. He has a history of hepatic and gluteal metastases from an undifferentiated carcinoma, the primary of which is unknown, followed in the oncology department and treated by chemotherapy. The biological assessment shows microcytic hypochromic anemia, hypoinsulinism <0.1mIU / l associated with a collapsed C peptide <0.15ng / ml (RV: 1.1- 4.4) with a concomitant glycemia of 21 mg/l. In view of the clinical context and the paraclinical explorations, the diagnosis of paraneoplastic hypoglycemia was retained after the elimination of the factitious origin and the insulinoma. The patient was put on diet, infusion of 5% glucose serum from which he was weaned after the introduction of prednisolone corticosteroid therapy: 60 mg per day with good tolerance and disappearance of hypoglycemia. Discussion/Conclusion: Paraneoplastic hypoglycemia is hypoglycemia most commonly caused by the overproduction of insulin-like growth factor 2 (IGF-2) and its precursors which can activate the insulin receptor. In general, large mesenchymal and epithelial tumors may be the cause. The diagnosis is confirmed by the discovery of an elevated IGF-2 / IGF-1 ratio. The basic treatment is surgical excision. Glucocorticoids are among the drugs that can be used in cases where surgery is not possible as a first line followed by other alternatives in case of failure.