Background: Pain is a significant and possibly debilitating symptom for children and it can affect the quality of life. Poorly relieved pain has been associated with negative outcomes including delayed recovery and increased likelihood of early death. The study aimed to assess nurses’ knowledge and attitudes towards managing Paediatric pain in Jouf region. Methods: This study adopted the quantitative research approach through conducting across-sectional survey. Results: The results showed that nurses’ had a moderate level of knowledge about pain management of Paediatric patients (15.15±4.3), and had neutral attitudes towards pain management among Paediatric patients (2.67±0.62) Conclusion: Educational and training programs should be conducted for nurses in the field of Paediatric Pain Management in Jouf region hospitals.