Backgrounds: Dengue viruses are transmitted to humans via mosquito bites from infected Aedes species (Aedesaegypti or Aedesalbopictus). Dengue fever affects over half of the world's population, or about 4 billion people. Dengue fever is a common cause of sickness in high-risk settings. Methods: In the current study two serotypes of Dengue viruses namely DENV1 and DENV2 taken for the study. Here two important compounds namely Ellagic acid and Ferric Carboxymaltose chosen for the targets to be inhibited. In silico docking approach performed to dock the two compounds against the DENV1 and DENV2 viruses of Dengue. Autodock 4.2 tool chosen for the docking purpose. Results: Dengue i.e., DENV-1 & 2 indicate excellent biding property with Ellagic Acid & Ferric Carboxymaltose of the order -6.02 kcal/mol& -6.9 kcal/mol, respectively. Either are hematinic; pregnancy safe; non-toxic; complete synergy between either vis-à-vis virus targets\binding sites; with supportive therapies; etc. Novel. It was found that, the Ellagic acid is more effective for DENV1 virus and Ferric kcal/mol, respectively. Conclusions: It can be stated that, these two drugs can be better approach for future study against the Dengue viruses and expected drug candidates.

Through the practice of synthesizing professional documents of domestic and foreign authors, the topic has interviewed experts and identified 34 specialized exercises to develop professional fitness for athletes of the Vovinam Truong team FPT University Ho Chi Minh City. This is the basis to continue to put into practice the exercises and confirm the effectiveness of these exercises.

The study’s purpose was to conduct a comparison of selected physiological measures among students who commute to school via three different modes of transportation (Bicycling, Walking, and Motor Vehicles). Initially, a total of 600 school-going boys (N = 600) were chosen as study participants. Class VIII to XII grade school male students aged 14 to 18 years were purposefully selected as study subjects from seven secondary schools in the Birbhum district of West Bengal, India. Each group had 200 participants: N = 200 for walking, N = 200 for bicycling, and N = 200 for motor vehicles. A category-wise number of subjects were selected from the different schools. The data was calculated by descriptive statistics. For all independent variables, which were computed by using SPSS, one way ANOVA test followed by t-tests were used. As a result, students traveling to school by motor vehicle, as non-active commuters, had a significantly higher Body Mass Index (21.81) and percent Body Fat (16.03) than the other two active commuters, namely the walking and bicycling groups. According to current researchers, students who commute from their homes to school each day may use walking as their main form of transportation. The researchers also concur that if the school is reasonably close to the home, walking is a great form of transportation for students.

The Attorney General's Office released AGO Regulation Number 15 of 2020 concerning the Termination of Prosecution Based on Restorative Justice. According to this regulation, the Public Prosecutor (JPU) has the right to stop the process of prosecuting the accused in some instances, if there is an amicable agreement between the victim and the defendant. The purpose of this study is to examine and analyze the weaknesses of the regulation of the position of the Prosecutor in the current settlement of general crimes by restorative justice and to reconstruct the regulation of the position of the Prosecutor in the settlement of general crimes by restorative justice based on the value of justice. This study uses a constructivist paradigm with a socio-legal by examining secondary data and primary data by finding the legal reality experienced in the field, as well as a qualitative descriptive method, namely where the data obtained, are then arranged systematically so that a comprehensive picture will be obtained, where later the data will be collected. will be presented descriptively. Based on the findings of this dissertation research, it is found that in principle criminal cases can be closed. Prosecutions terminated based on restorative justice limited to perpetrators who have recently committed a crime, not recidivists, and only to minor crimes. The Weakness of the Prosecutor in the settlement of general crimes in restorative justice is the legal substance (legal substance) Article 5 paragraph (5), Article 9 paragraph (5), PERJA NO 15 of 2020. Legal Structure, namely the expertise of the Public Prosecutor in providing the best offer or introducing a restorative concept to the parties. Legal culture (legal culture) assumes that what is done by the perpetrator must end with a criminal penalty. So it is necessary to reconstruct Article 3 paragraph (5), Article 5, Article 9, Article 12, the Regulation of the Attorney General of the Republic of Indonesia Number 15 of 2020 concerning Termination of Prosecution Based on Restorative Justice.

This article discusses the role of Collective Labor Agreements to create legal certainty for workers in the settlement of labor disputes at PT Panggung Jaya Indah Textile. This study aims to determine the legal protection obtained by workers listed in the collective labor agreement to create legal certainty. This study uses a normative juridical research method by examining and interpreting theoretical matters concerning principles, conceptions, doctrines and legal norms relating to civil case evidence. The results show that legal protection for workers listed in collective labor agreements to create legal certainty can be seen in subjective legal protection while other forms of protection can be seen in social protection, economic protection and technical protection in order to provide legal certainty, especially for all workers listed in the collective bargaining agreement. Furthermore, the fulfillment of labor rights in the settlement of labor disputes is regulated in Law Number 13 of 2003 concerning Manpower and Law Number 11 of 2020 concerning Job Creation in the form of the right to protection of job security, social security and compensation.

Background: IAC Yokohama system has 5 categories that may be stratified by their risk of malignancy (ROM) and supply guidance within a management algorithm for every category. The main objectives were to categorize the Breast FNAC samples according to new system of reporting and to assess the Risk of malignancy (ROM), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for all categories. Material and Methods: A total of 174 cases were prospectively studied over a period of one year from 1st November 2019 to 31st October 2020 in GMC, Jammu. All the FNAC received was reported routinely according to the newly proposed Yokohama system of reporting breast cytology. The ROM, sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and accuracy of Breast FNAC were calculated. Results: ROM is 0% for category 1, 2.27% for category 2, 50% for category 3, 50% for category 4 and 100% for category 5. Sensitivity, specificity, and diagnostic accuracy were, respectively, 100%, 100% and 99.11% for category A (only C5 category cases considered positive test results), 88.2%, 93.6%, and 93.6% for category B, (both C4 and C5 categories considered positive test results), and 94.1%, 91.48%, and 92.1% for category C (C3, C4, and C5 category cases grouped as positive test results). PPV and NPV were also calculated. Conclusion: Categorization of the Breast FNAB cytology according to IAC Yokohama system of reporting helps pathologist in the diagnostic clarity and guides clinician in the appropriate patient management.

Circumcision is the act of cutting to remove the entire foreskin from the penis. The frenulum of the penis can also be cut simultaneously in a procedure called a frenectomy. The word circumcision comes from the Latin circum meaning to twist and caedere meaning to cut (A Firmansyah et al,). The formulation of the problem in this study is to find out how the relationship between the influence of snakehead fish consumption on wound healing after circumcision. The research method used in this scientific paper is the grounded method, through a qualitative approach. The relationship between snakehead fish consumption and circumcision wound healing is because snakehead fish itself has a high protein content, namely albumin in snakehead fish (Nugroho, 2015). The conclusion of this study through direct observation on the sixth day is that the protein content in snakehead fish is higher than in other types of fish, the albumin content of snakehead fish reaches 6.22%.

Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods which are harmful to the individual or others. It is a form of substance-related disorder. Substance use disorders (SUD) are mental health conditions that arise from chronic drug use. There is an increased recognition of this problem in Saudi Arabia. Drugs of abuse testing is the detection of one or more illegal and/or prescribed substances in the urine, blood, saliva, hair, or sweat. Testing detects substances not normally found in the body. Drug abuse testing usually involves an initial screening test followed by a second test that identifies and/or confirms the presence of a drug or drugs. Initial screening is done by urine tests and confirmation is done by blood tests. Major drug class screened are Amphetamines, Barbiturates, Benzodiazapines, Cannibinoids, Cocaine, methadone and opiates. In this article we reviewed lab diagnosis of drug of abuse.

This research examines the influence of Narcissism, Board of Directors Bonus Scheme, Age, Gender and Term of Service with the moderating variable of Financial Reporting Quality on the tendency to commit fraud. Research respondents are CEOs of banks listed on the Indonesia Stock Exchange in 2015-2018 and the sampling technique uses the Purposive Sampling method. This study uses statistical regression analysis to see the effect of the independent variable on the dependent variable or the response to the moderating variable. The regression parameter test consists of the F test, to find out whether the independent variable has a simultaneous effect on the response variable or not. Then the t test, to test the effect of the independent variables one by one on the response variable. By using panel data regression modeling using an unweighted Fixed Effect Model and a weighted Fixed Effect Model, also using partial testing on the unweighted Fixed Effect model and the weighted Fixed Effect model. The results showed that panel data regression modeling using the unweighted Fixed Effect Model resulted in a significant simultaneous test, meaning that the variables of narcissism, directors' bonus scheme, age, gender and tenure affect the tendency to commit fraud simultaneously. Partial testing on the unweighted Fixed Effect model shows that individually only the tenure of service variable affects the tendency to commit fraud. The Fixed Effect Model with weights produces significant simultaneous tests, meaning that simultaneously the variables of narcissism, directors' bonus scheme, age, gender and years of service affect the tendency to commit fraud. And a partial test on the Fixed Effect model with weights shows that individually there are no independent variables that affect the tendency to commit fraud.

Background: The cytotoxic chemotherapy is the mainstay treatment of cancer and it is usually complicated with infections. Appropriate antibiotics and other supportive medications must be started immediately as bacterial infections may progress with the absence of granulocytes. Improved outcomes can be seen with empirical administration of broad-spectrum antibiotics and they remain as the standard of care. Patients with intermediate-risk for Febrile Nuetropenia (FN) (10%-20%) need to be evaluated for additional patient risk factors, after assessment, patients who present with at least one of the risk factors for FN is recommended for treatment with a G-CSF. Methodology: Our study was a retrospective cohort single centered observational study carried out randomly in 104 patients in the oncology department of Lourdes hospital, Cochin Data of the patients were collected from Mediware system, medical records and Statistical software SPSS were used for analysis of the data. Results: In our study febrile neutropenia was managed using antimicrobials, of which antibiotics and antifungals prescribed were 12.09% and 1.97% respectively and with granulocyte-colony stimulating factors (G-CSFs) (6.15%). Principally used empirical monotherapy was meropenem sulbactum / meropenem (n = 48) which was followed by piperacillin tazobactum (n=18) and cefoperazone sulbactum (n=15) This study had a leading prescription of Cyclophosphamide containing chemotherapy regimens which led to neutropenia. Breast cancer patients accounts the majority of febrile neutropenic episodes despite of receiving GCSF prophylaxis. The most common type of cancer patients who are suffering from neutropenia were breast cancer. The compliance with National Comprehensive Cancer Network (NCCN) guidelines were analyzed in that we can see 84.6% patients had partial compliance and 14.4% patients had full compliance. Conclusion: A total of 66 patients received both antibiotics and G-CSF treatment however 13 patients and 25 patients were managed only with G-CSF and antibiotic therapy respectively. This study had a leading prescription of Cyclophosphamide containing chemotherapy regimens which led to neutropenia. These regimens were used mainly in breast cancer patients. Breast cancer patients accounts the majority of febrile neutropenic episodes despite of receiving GCSF prophylaxis. The most common type of cancer patients who are suffering from neutropenia were breast cancer. The NCCN guidelines, majority of patients showed partial compliance(86.6%) and about (14.4%) showed full compliance.

The three decades following the fall of the Union of Soviet Socialist Republics, USSR, were marked by the Russian policies of catching up with Western countries. First, at the beginning of the decade that followed this fall, the restructuring of the economy was left to market forces, next there was an implementation of the policy of modernization of certain industrial sectors and the development of new technologies from the following decade. These policies have allowed investments by Western multinationals to access the Russian market, which thus fits into the global just-in-time management approach because of the economic and geopolitical arguments it presents. The war between Ukraine and the Russian Federation produced the opposite effect. That of dismantling these same multinational companies in a short time. It is this paradox that multinational companies established in Russia must resolve in order to participate in the remodeling of socio-economic relations with the Russian Federation. The question is: How do they do it? What risks do they run to achieve this? This article has deciphered the mechanisms of remodeling of socio-economic relations against the background of the risks incurred by these multinational companies in the light of the war between the Russian Federation and the West by the agency of Ukraine.

His association of mediastinal germ-cell tumours (MGCTs) with haematologic neoplasms is a rare though well known circumstance, and few cases are found in the literature. Most of these are non-seminomatous tumours in young males. The diagnosis of the haematological condition is usually either synchronic or metachronic with that of the germ-cell tumour. The prognosis is poor and basically determined by the haematologic neoplasia. Less than 20 cases of PMGCT with evolution into acute megakaryocytic leukemia have been reported in worldwide literature. Hematologic neoplasias associated with extragonadal germ cell tumors represent one of the most intriguing and biologically distinctive aspects of male germ cell cancers. The case report we present is that of a young 33 year old male with an initial diagnosis of both conditions which were detected synchronously. Despite timely intervention he succumbed to multiorgan failure following chemotherapy and an autopsy was performed.

Climate change is a threat not only to the affected country but to the entire world. Over the last few decades, incidents of climatic change have increased drastically, and these incidents have both direct and indirect impacts on the economy. The United Nations Environment Programme (UNEP) Adaptation Gap Report 2016 warns of the increasing impacts of climatic risks and, as a result, an increase in global adaptation costs. The prediction is that international costs will increase by two to three times by 2030 and four to five times by 2050. This study investigates the short-run and long-term impacts of climate change on economic growth across low-income countries from 2005 to 2018. The study uses the Panel Autoregressive Distributed Lag (PARDL) approach. This model allows us to study both the short-run and long-term effects of climate change on economic growth and capture the possible links in the short run. For the study purposes, twenty-two low-income countries were chosen from almost all continents on the basis of their income levels. The data for the GDP, as a proxy of a country's economic growth, is taken from the World Development Indicators (WDI), and for climate change, we use the global climatic risk index (CRI) developed by German watch (CRI) is used as an explanatory variable in the model. The empirical results show that climatic change, especially weather-related events, negatively impacts the economic growth of low-income countries during the studied period in the long run. But in the short run, climatic change does not significantly affect the economic growth of countries. Moreover, climate change has been severely affecting low-income countries over the last few decades, as reported in the study. As climatic risk increases, the vulnerability in these countries also increases, and this study supports the need for a global mitigation approach.

This paper reviewed the role of entrepreneurship and vocational education in sustainable development. Graduate unemployment is one of the greatest challenges that bedevil Nigeria, a nation endowed with enormous wealth in terms of human, mineral and natural resources. This paper stresses the importance of entrepreneurship and vocational education curriculum in solving unemployment problems and achieving sustainable development. This papers argues that entrepreneurship and vocational education will provide students who are leaders of tomorrow with skills with which they can be self-reliant because human resource through knowledge based capacity are the cornerstone for effective management and utilization of natural resources. The paper concludes that entrepreneurship and vocational education when engendered leads to employment generation, growth of the economy and promotes sustainable development. The paper recommended that educational institutions at all levels must inculcate and intensify the integration of entrepreneurship and vocational education into its curriculum systems.

We report a case of a 25-year-old female, with a history of gastrojejunal anastomosis 6 years ago for pyloric stenosis due to intentional corrosive ingestion, who was admitted for jaundice related to the common bile duct stones diagnosed at MRI. The patient had undergone Endoscopic retrograde cholangiopancreatography (ERCP) and upper endoscopy that allowed the diagnosis of afferent loop syndrome related to pyloric stenosis and duodenal stenosis. The afferent loop syndrome was related to hyper pressure in this afferent loop and was managed surgically by performing a jejuno-duodenal anastomosis.