Immune checkpoint inhibitors (ICIs) are a new group of drugs that have been recently used as part of antineoplastic therapy targeting the immune system to activate the anti-tumor effect. However, as a result of this immune activity adverse events usually occur that can affect different body parts known as immune related adverse events (irAEs). In the oral and maxillofacial area, irAEs mimic many immune-mediated conditions, including oral lichen planus, mucous membrane pemphigoid, and Sjögren syndrome, among others. The aim of this review is to summarize the irAEs in oral and maxillofacial areas and to enlighten oral healthcare professionals on how to recognize these events and to be a part of the care team for patients treated with ICIs.

The calophyllum inophyllum is a potential source of non-edible vegetable oil for producing biodiesel because of its ability to grow in a wide range of climate conditions, easy cultivation, high fruit production rate, and the high oil content in the seed. The biodiesel is extracted through transesterification process with methanol and NaOH as catalyst. The biodiesel was blended with diesel by various percentages such as B0, B25, B50, B75 and B100. The blends were prepared on a volume basis. Density, kinematic viscosity, flash point and fire point, these are the four main fuel properties that were investigated. The results showed that the density, viscosity, flash point and fire point of diesel fuels (B0) are lower than the calophyllum inophyllum biodiesel (B100). Therefore, the density, viscosity, flash point and fire point of the blend increases with the increase of biodiesel concentration.

Plants' reliance on molecular epigenetic control reflects their developmental, lifestyles, and the evolutionary histories. Plants grows by continually developing new parts from the self-sufficing stem cells population, termed as meristem, as opposed to mammals, whose tissues and organs formation is primarily determined during the embryo development. The interest in different medically active products has been developed to improve their pharmacokinetic and biological properties for utilizing glycosyl-conjugation. The conjugation of various drugs with various mono, di, or polysaccharides has boosted the therapeutic potentials of these drugs that is also manifested by a significant number of research papers. The current review article encapsulates extremely important and the up-to-date example of this conjugation, specially associated to enhancing antitumor activities of original glycoconjugates. The given examples along projected mechanisms of activities enhancement may guide to design, synthesize and evaluate new glycosyl conjugates for improved therapeutics.

When workplace stress arises, intuition often guides our perception and assessment of its significance. This is because it's clear that when a substantial portion of the adult population is actively involved in the workforce, there's a corresponding recognition of how workplace responsibilities can influence the well-being of working individuals. However, this perception is only partially accurate. Despite a common understanding, we argue that a more profound comprehension of workplace stress's psychological, mental, and physical repercussions is both advantageous and essential. This deeper understanding is critical for understanding how stress can affect productivity and overall well- being, challenging the prevailing misconception. Tanisha Srivastava, a twelfth-grade student, conducted a survey involving healthcare experts such as doctors and practitioners. The survey findings illuminate the widespread presence of workplace stress across diverse professions, emphasizing its significant impact on overall well-being and productivity. Organizations must lead in implementing supportive measures and fostering work environments, prioritizing mental and physical health to combat this challenge. This report reveals that workplace stress is a shared concern among various medical specialties, necessitating proactive efforts to address and reduce it effectively. Encouraging anti-stress initiatives and prioritizing productivity management can lead to a more nurturing and supportive workplace. Much like other sectors, the medical field stands to gain by placing employee well-being at the forefront, ensuring professional success, personal satisfaction, and mental health. In conclusion, the survey responses underscore the pervasive influence of stress on diverse aspects of health, from physical conditions to mental well-being, underscoring the imperative of addressing stress and promoting a balanced work-life dynamic to mitigate its detrimental effects.

Background: Healthcare workers are physically and mentally burdened due to frequent work shifts rotation, demanding tasks, together with family-related issues which limit their participation in planned physical activity program. Objective: The aim of the present study was to investigate healthcare workers’ levels of Physical activity and their Quality of Life. Methods: 62 healthcare workers from Federal Medical Center, Owo, Nigeria participated in this study. Ethical approval was obtained from the Institution’s Health Research Ethics Committee before the commencement of the study. Data was Obtained using the International Physical Activity Questionnaire (IPAQ) and the WHOQoL-BREF. Analysis was done using descriptive statistics of percentages and frequency while inferential statistics Chi square test and Mann Whiteney U test was used for the test of significance. Alpha level was set at 0.05. Results: High prevalence (51.5%) of low level of physical activity was observed among health care workers. There was no significant difference between age (X2 =0.404, p>0.05); gender (X2= 0.554, p>0.05); work category (X2=0.841, p>0.05) BMI (X2= 0.632, p>0.05) and the three categories of physical activity. A significant difference was observed in the overall QoL between male and female respondents (U= 249.500, p=0.002). Similarly, there was a significant difference in Overall QoL between workers in clinical department and workers in administration department (U=260.000, p=0.002). Conclusion: There is high prevalence of low level of physical activity among health workers. The increase clinical workload among health workers probably contributed to low level of physical activity and QoL among health workers in core clinical departments.

Physical health is the foundation for the comprehensive development of college students, and with the development of social economy and changes in lifestyle, the physical health level of college students is facing various challenges and problems. Therefore, conducting a comprehensive analysis of the current situation of college students' physical health level and proposing corresponding improvement strategies has important theoretical and practical significance. Using various research methods such as literature review, mathematical statistics, and measurement, this study focuses on the physical health test data of students from Liaoning University of International Business and Economics from 2020 to 2022. The study aims to conduct statistical analysis on five aspects of students' grades, overall results, body shape, physical function, and physical fitness. The research results show that the body shape level of school girls shows a "two headed bias, and the middle is equivalent"; The overall respiratory system function of female students is slightly better than that of male students; The explosive strength and flexibility of male lower limbs are higher than the "pass or above" level specified in the National Student Physical Health Standards. Based on this, a causal analysis was conducted on the problems existing in students' physical health, and corresponding improvement measures were further proposed: to improve physical monitoring work and play the role of physical testing; Accelerate the reform of physical education teaching and implement the "four year consistent system" teaching; Strengthen extracurricular physical exercise and set up extracurricular physical education credits; Relying on sports associations to carry out various forms of sports activities; Guided by the construction of high-level sports teams, we aim to create a school sports brand.

Background: Relationship between obesity and hypertension is well established and hypertension shows positive relationship with all obesity indices. Objective: To determine the obesity indicator with the greatest sensitivity in predicting hypertension. Method: A cross-sectional community-based descriptive survey was carried out in Enugu Metropolis. Multistage sampling procedures were used to select participants using the World Health Organization STEPS instrument. Height, weight, waist circumference; hip circumference and blood pressure were measured and recorded. Results: A total of 482 participants were recruited; of which 160 (33.2%) and 322 (66.8%) were males and females respectively. 89 (18.5%) participants have high systolic blood pressure, 117(24.3%) have high diastolic blood pressure, while the overall hypertension prevalence is seen in 123 participants (25.5%). The blood pressure was noticed to increase as obesity increases regardless of the index of obesity used and that at WHR≥1 all the 15 participants (M:8, F:7m) that crossed that threshold were hypertensive regardless of age and sex demonstrating the sensitivity of WHR in predicting hypertension and associated cardiometabolic risks. Conclusion: obesity and hypertension are interrelated and common in our environment, all the indices of obesity show positive correlation with hypertension but WHR offers a simple index that can be used to detect occult hypertension in our clinics due its 100% correlation at the WHR threshold of ≥1.

Artificial Intelligence (AI) has emerged as a disruptive force, transforming industries and revolutionizing business processes. Among the domains significantly impacted, project management holds immense potential for transformation. AI’s integration promises intelligent automation, data-driven decision-making, and predictive capabilities, addressing challenges in traditional project management methodologies. Successful AI implementations have revolutionized project management, improving forecasting, resource allocation, and risk assessment. Despite the benefits, challenges hinder AI adoption, including data quality, investment uncertainties, workforce readiness, and change management. However, AI’s potential to address gaps in project management is substantial, enabling data-driven decisions, real-time monitoring, resource optimization, and enhanced agility. This research examines AI’s evolution, successful implementations, challenges, and potential implications, providing insights for effective AI integration in project management. Key Takeaways: • Project management is one domain that stands out as highly impacted by artificial intelligence, offering immense potential for transformation through AI integration. • AI-driven solutions in project management promise intelligent automation, data-driven decision-making, and enhanced predictive capabilities, addressing traditional methodological limitations. • Despite challenges, AI holds substantial potential to address existing gaps in project management practices.

Objective: The aim of the study was to assess the peak power and relative peak power output between raiders and defenders in professional kabaddi players using the counter movement jump test. Method: A total of 16 professional male kabaddi players, evenly split into 8 raiders, and 8 defenders with an average kabaddi experience of 6 years (aged 22.5 ± 3.1 years, height 175.1 ± 6.3cm and weight 78.7 ± 0.5kg) participated in this study. A counter movement jump test on a force platform was performed to determine their power output values along with their whole-body composition analysis. All players have played in national, international, or pro league competitions. During their 8-week pre-season camp in September–October 2022, these athletes trained and were tested at Inspire Institute of Sport in Bellary, India. Results: The results indicated that there is no significant difference in peak power output with respect to a Kabaddi player’s playing position or training age. But a significant positive correlation (p=0.039) was established between lean body mass and relative peak power output. Conclusion: The current study suggests that peak power production from the countermovement leap test may be a good way to measure explosive leg power in kabaddi athletes. Kabaddi raiders and defenders have similar vertical jump height, peak power, and relative peak power. Years of kabaddi experience did not affect countermovement jump test variables. According to the study, all kabaddi players have similar physiological demands.

Artificial Intelligence (AI) is already here, and is speedily transforming industries. This paper examines the impact of AI on the socio-political rights of the people globally, particularly in the area of job loss. Automation is not a new concept. It can be traced to the introduction of machines into industries back in the Second and Third Industrial Revolutions. However, the automation introduced by artificial intelligence is of a higher level. Artificial Intelligence is taking risks for humans in the manufacturing industry, mining industry, and even in the Military. It is versatile, that is, it is capable of being used in every sector of the world, and with the rate of technological unemployment, (caused by automation), the significance of Artificial Intelligence has become subject to controversy. This research adopts a desk based doctrinal research methodology to examine the issue of socio-economic human rights in era of automation. This research discovers that AI will create jobs, but an analysis of research studies on job loss due to automation reveals the large margin between jobs created by AI and jobs lost due to AI, thus posing threats to socio-economic human rights. It also discovers that the jobs created by AI require only persons with technical skills and knowledge for employment in the nearest future. AI will cause deskilling and falling wages. This research work recommends that legislations must be put in place to ensure that the use of AI technologies are controlled in order to give the government enough time to balance the inequality created by AI technologies. Technical skills acquisition and robot tax can be adopted by nations to enable them cope with the speed of AI.

Scrub typhus is not a recent disease. This was prominent before the era of World War II. However, the disease is primarily prevalent in the Pacific Islands and southeast Asia. The symptoms begin with fever, eschar development, and a rash. As a result, diagnosing the disease has become more complex because comparable symptoms can be observed in a variety of other conditions. Therefore, proper diagnostic tests are required to diagnose the condition. Scrub typhus infections are increasing in India every year, and several states are reporting an increase in cases. The disease mostly affects the gastrointestinal system, nervous system, renal systems, and respiratory systems; however, mortality can be minimized with early diagnosis and adequate treatment. As many people in India are unaware of the condition, raising awareness will help in the saving of many lives.

An organisation's ability to evolve for them to remain current in today's ever changing technological marketplace is paramount to the sustainability and viability of an organisation. Agility is perceived as a key attribute that aids an organisation in this endeavour. The concept of agile and agility has been around for a couple of decades now. Initially coming into existence through the Agile Manifesto, starting out as a predominantly technology focused paradigm. It has slowly but steadily moved into a mindset shift within projects and now more recently within organisations. The ability of an organisation to embrace agility and an agile mindset has been one of the core factors impacting the viability of an organisation and its place in the globalised marketplace.

Menstrual period is a monthly activity that every woman who has attained the age of puberty experienced. It is a natural process and when it does not show or come, the woman in question will be worried and until the root cause of the delayed or stoppage is known and if possible, rectify the cause of the abnormally, the woman will not be happy. The aim of the study is Ascertaining the Level of Psychological Effects of Delayed Menstrual Period Among Female Students in Tertiary Institutions in South South, Nigeria. The study was a cross-sectional study and a total of 250 female students within participated in the study. A well-structured questionnaire was distributed to each participant by the research assistant after consent was granted by the participants. The study was carried out in the six States that make up South-South Geopolitical Zones and it lasted for a period of 3 months. The findings revealed that 243(97.20%) of the participants affirmed being depressed as a result of delayed menstrual period while 7(2.80%) disagreed being depressed due to delayed menstrual period. Also, 240(96.00%) of the respondents isolated themselves due to delayed menstrual period. The results shows that 238(95.20%) of the respondents were ashamed due to delayed menstrual period and 239(95.60%) were deeply thinking. The research revealed that 240(96.00%) of the participants agreed that delayed menstrual period affects their academic performance and 243(97.20%) of the respondents worried about the delayed in their menstrual period. The data were analysed using SPSS version 23 and P < 0.05 was said to be significant.

Introduction: Allergic rhinitis is one of the most common chronic conditions affecting all age group and it is characterized by sneezing, nasal congestion, and rhinorrhea. In some cases, conjunctivitis also occurs up on expose to a variety of irritants like pollen, duct, perfumes, and weather changes. Aim: This study evaluates the impact of COVID19 pandemic and quarantine on patients with allergic rhinitis sign and symptoms. Results: The study was conducted in the Kingdome of Saudi Arabia and 740 participants returned the online questionnaire. of those, 596 (80.5%) identified dust and weather changes as the main irritants to their symptoms, and 440 (59.5%) experienced sneezing as the main symptoms before COVID-19 pandemic. Only 89 (12%) reported symptoms relief by 90-100% during lockdowns and curfew periods. There was a significantly lower rate of medication use during the pandemic (28.32%) compared to the time before the pandemic (50.93%). During the COVID-19 pandemic, of the respondents 271 (36%) reported no improvement, 179 (23.8%) had mild improvements, 131 (17.4%) reported a moderate improvement, and 171 (22.7%) reported a significant improvement. Conclusion: The study showed that 40% of the participants had moderate to significant symptomatic relief during the periods of lockdowns and curfew of the COVID-19.

Providing medical knowledge and ability to give high-quality patient care, physicians are long acknowledged as crucial players in the healthcare system. To address the challenges and challenges within contemporary healthcare systems, however, physicians' roles as healthcare leaders are becoming more and more important. This manuscript addresses the challenges and opportunities that physicians encounter in their leadership positions and emphasizes how crucial it is for them to lead effectively to transform the course of healthcare. The first section of the paper examines the difficulties faced by physicians in their roles as healthcare executives. These difficulties include limited opportunities for leadership training and development, resistance to change, balancing clinical responsibilities with leadership obligation, navigating complex organizational structures, managing conflicts of interest, and time constrain. Additionally, the manuscript emphasizes how important it is for physicians to embrace technology improvements and the shift to a digital healthcare system while protecting patient privacy and data security. In contrast, the manuscript also presents various opportunities that physicians can seize to enhance their leadership effectiveness. These opportunities include; enhancing patient safety and quality of care, driving interdisciplinary collaboration, advocating for healthcare policy reform, value-based care, organizational support, and technological advancements. A lead physician can shape the healthcare organization by properly understanding these issues and avail opportunities.