Introduction: Oral candidiasis is a common fungal infection caused by various yeast species, including Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis, and Candida glabrata. Clove, a well-known plant in traditional medicine, has been used as an antiseptic remedy for diverse infections, including those affecting the oral cavity induced by yeasts and bacteria. The emergence of resistance to numerous antifungal agents among Candida species necessitates exploring alternative treatments. Hence, this study aims to evaluate the antimicrobial activities of clove extract and develop a suitable pharmaceutical formulation containing clove extract for managing oral candidiasis. Method: The antimicrobial culture and sensitivity test were conducted using the agar-well diffusion assay, evaluating different concentrations of clove extract against Candida albicans. The minimum effective concentration was then formulated into a gel dosage form, and its antimicrobial activity was assessed, comparing it with miconazole oral gel. Result: The results showed that the prepared clove extract gel had antifungal effects on Candida albicans that were similar to those of the miconazole oral gel. The zone of inhibition for the clove extract gel was measured at 25 mm, while the miconazole gel showed a zone of inhibition of 27 mm. Conclusion: The results of this study show that clove extract gel may be an effective antifungal agent, especially against Candida albicans. This suggests that it may be a promising herbal alternative to conventional medicines for treating oral candidiasis.

Objective: Ovarian cancer is a leading cause of gynecological cancer death among women worldwide. Silent growth of the tumor and challenges associated with preoperative evaluation of an ovarian mass are responsible for late presentation. The aim of this study was to evaluate the association between preoperative neutrophil to lymphocyte ratio (NLR) and epithelial ovarian tumor. Methods: A total of 60 patients diagnosed with ovarian tumor who fulfilled the selection criteria were recruited as study population. The ovarian tumor was subsequently diagnosed by histopathological analysis as either malignant epithelial ovarian tumor or benign epithelial ovarian tumor. Preoperative demographic and laboratory variables are reviewed in all patients. Association of preoperative NLR was assessed in benign and malignant epithelial ovarian tumor using unpaired t test. Receiver operating characteristics curve was used to calculate optimal cut off value for NLR to predict ovarian cancer preoperatively. A p-value of <0.05 was considered to indicate statistically significant differences. Results: There was statistically significant difference between the groups in terms of age, menopausal status, and NLR (all p=0.001, except for menopausal status p=0.007). NLR value was significantly higher (3.47±1.52) in patients with malignant ovarian tumor (p=0.001) than that of benign ovarian tumor. Higher NLR value predicted ovarian cancer at the cut-off value of 2.78, with 75.6% sensitivity and 78.9% specificity (95% CI, 0.97-1.0). Conclusion: Malignant epithelial ovarian tumor is associated with higher NLR. Preoperative NLR may be helpful for prediction of malignant ovarian tumor.

Regulations on religious freedom vary widely from country to country. Several factors, including country history, culture, and religious demographics, can influence these different approaches to religious freedom. Considering all these aspects, this paper explores the differences in regulating freedom of religion between Indonesia and Canada by applying normative legal research methods. The studies concluded that the difference in regulating religious freedom between Indonesia and Canada lies in how they officially recognize religion, restrict the construction of places of worship, provide legal protection, prohibit discrimination, and approach multiculturalism. Although Indonesia recognizes several official religions, its legal application and protection may need to be clarified and more potent than in Canada, which has a more comprehensive and robust legal framework protecting religious freedom and respecting religious diversity.

Background: Worldwide, diabetes mellitus (DM) is a leading cause of death and disability. Iron overload is increasingly being connected to insulin resistance in patients with type 2 diabetes mellitus (T2DM). Free iron causes the assembly of reactive oxygen species that invariably steer the body’s homeostasis toward oxidative stress-mediated diabetic complications. We have very limited research-based data regarding the total iron binding capacities in type 2 diabetes mellitus patients. Aim of the study: The aim of the study was to compare the total iron binding capacities (TIBC) between type 2 diabetes mellitus patients and healthy individuals. Methods: This cross-sectional study was conducted in the Department of Biochemistry, Dhaka Medical College (DMC), Dhaka, Bangladesh from July 2015 to June 2016. In total 100 participants were enrolled in 2 groups as the study subjects. In group A, in total 50 diagnosed patients with type 2 diabetes mellitus (T2DM) were included. On the other hand, in group B, 50 age and sex-matched healthy individuals were included. Properly written consent was taken from all the participants before data collection. All the demographic and clinical information of the participants was recorded. All data were processed, analyzed and disseminated by using MS Excel and SPSS version 23.0 program as per necessity. Results: In this study, the mean serum iron in group A and group B were 112.7 μg/dl and 87.6 μg/dl respectively. The mean serum ferritin concentration in group A and group B were 199.3 μg/dl and 107.0 μg/dl respectively. There was a statistically significant increase in serum iron and serum ferritin concentrations in group A compared to group B. Both serum ferritin and serum iron levels showed strong positive correlations with HbA1C ((r=0.724, p<0.001, r=0.724, p<0.001) and FPG (r=0.724, p<0.001, r= 0.724, p<0.001). The mean TIBC level was found 184 μg/dl in group A and 318.8 μg/dl in group B. In analyzing the total iron binding capacities (TIBC) between the groups we observe that the TIBC (µg/dl) levels in group A and group B were 184.0±79.5 and 318.8 ± 14.0 µg/dl respectively. The TIBC levels were significantly lower in group A than in group B (<0.001). Conclusion: The total iron binding capacity level is significantly lower in type 2 diabetes mellitus (T2DM) patients than that in healthy individuals. Routine screening for iron status along with glycemic control in diabetic patients might help prevent complications in such patients.

Enhancing facial aesthetics is a primary motivation for individuals with class II division 1 malocclusion seeking orthodontic treatment. Among the different techniques available to treat Class II malocclusions, a two-phase approach involving functional jaw orthopedics and fixed orthodontic treatment is commonly employed. In this case report, we present the treatment of a young male patient with a Class II Division 1 malocclusion. In the initial phase, the patient underwent growth modification and correction of overjet, overbite, and profile using the Andresen activator. Subsequently, a fixed orthodontic appliance was utilized in the second phase to achieve well-aligned arches and enhance both aesthetics and functionality.

The continuing spread of drug-resistant tuberculosis (TB) is one of the most urgent and difficult challenges facing global TB control. Patients who are infected with strains resistant to isoniazid and rifampicin, called multidrug-resistant (MDR) TB, are practically incurable by standard first-line treatment. In 2012, there were approximately 450,000 new cases and 170,000 deaths because of MDR-TB. Extensively drug-resistant (XDR) TB refers to MDR-TB strains that are resistant to fluoroquinolones and second-line injectable drugs. The main causes of the spread of resistant TB are weak medical systems, amplification of resistance patterns through incorrect treatment, and transmission in communities and facilities. Although patients harboring MDR and XDR strains present a formidable challenge for treatment, cure is often possible with early identification of resistance and use of a properly designed regimen.

Inflation targeting (IT) is practised in many countries and the real effects of strict inflation targeting were investigated on several occasions and less on other variants of IT. The study investigates the effects of inflation targeting lite on output. In particular, the compatibility of inflation targeting lite with managed exchange rate regime on output stabilization. The inflation targeting regime, the operating environment and exchange rate regimes were reviewed for Zimbabwe. An ARDL model was adopted as the empirical strategy to investigate the compatibility problem and the real effects of IT lite. Modelling output as output gap, inflation targeting lite and the exchange rate regimes were found to be inconsistent with output stabilization. IT lite and exchange rate premium increased the output gap, however the interaction between IT lite and exchange rate premium had negative effects on output. These results hold for both the short run and long run. However, considering the official rate and parallel rate separately, parallel rate has a negative effect but its interaction with IT has positive effects. The study recommends that developing countries should consider the exchange rate systems before the adoption of IT as a monetary policy framework. A floating exchange rate seemed to be compatible with IT lite.

Introduction: The pharmacologic agents currently used routinely to prevent postpartum hemorrhage are mainly oxytocin, syntometrine (a combination of oxytocin and ergometrine), and carbetocin. Syntometrine is associated with a statistically significant reduction in the risk of postpartum hemorrhage when compared with oxytocin alone. So, this study aimed to assess the adverse effects of carbetocin administration in the third stage of labor. This study aimed to analyze the adverse effects of carbetocin administration in the third stage of labor. Methods: This cross-sectional observational study was conducted at the Department of Obstetrics and Gynaecology, Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh. The study period was from May 2016 to October 2016. 100 women undergoing normal vaginal delivery were the study subject. A convenient sampling technique was used in this study. Necessary data was collected in the data collection sheet. Women received a bolus of 100 microgram carbetocin IV at delivery of the anterior shoulder. A standardized deliver mat (Quaiyum's mat) was used before placental removal for measuring blood loss. Statistical analysis was carried out by using the Statistical Package for Social Sciences version 19.0 for Windows (SPSS Inc., Chicago, Illinois, USA). The mean values were calculated by frequencies and percentages. Result: In this study, the majority (54, 54.0%) of patients belonged to age 20-25 years, followed by (30, 30.0%) >25 years. It was observed that the majority 93(93.0%) patients had regular menstrual history. Concerning the clinical indices, anaemia was found 69(69.0%), jaundice 08(8.0%) and edema 24(24.0%). Additional uterotonices was used in 15(15.0%) and blood transfusion 07(7.0%) patients. Mean blood loss before the use of the weight of Q-mat was found 74.81±1.23 gram, mean blood loss after the use of the weight of Q-mat was 246.28±99.98 gram, and mean net blood loss was 141.61±59.93 gram. Majority 61(61.0%) babies had birth weight ≥2.5 kg. Majority 68(68.0%) patients had Hb% <10.5. The mean Hb% before delivery was 10.3±0.47 gm/dl with a range from 9.40 to 11.20 gm/dl The mean birth weight was found 2.57±0.41 kg with a range from 2.3 to 3.10 kg. Conclusion: Carbetocin appears to be an effective new drug in the active management of third-stage labor. Carbetocin has associated with a lower risk of various adverse effects and preventing postpartum hemorrhage in women undergoing vaginal delivery.

Introduction: Induced abortions are those terminated by deliberate action undertaken to terminate a pregnancy. Information on the incidence of induced abortion is crucial for identifying policy and programmatic needs aimed at reducing unintended pregnancy. Because unsafe abortion is a cause of maternal morbidity and mortality, measures of its incidence are also important. This study aimed to analyze the sociodemographic characteristics of induced abortion. Methods: A descriptive cross-sectional study was conducted at the Department of Obstetrics and Gynaecology, Dhaka Medical College Hospital, Dhaka, Bangladesh. The sample was composed of 50 women who underwent induced abortion in this hospital, between January 2022 and January 2023. A simple random sampling technique was used in this study. Data were collected using a data collection sheet, processed, and analyzed by SPSS. version 22. Data were presented in tables and pie charts. The study was approved by the Ethics Committee of Dhaka Medical College Hospital. Informed written consent was taken from the respondents. Result: In this study, most of the patients (25, 50%) were in the 25-30 years age group, followed by (18, 36%) 31-35 years age group, and (7, 14%) the rest were in >35 years age group, most people (30, 60%) resided in the urban areas and most of them (35, 70%) had a monthly income of <15000 BDT, followed by (10, 20%) 15000-20000 BDT. Respondents were mostly (25, 50%) uneducated, some of them (15, 30%) passed secondary school, and (10, 20%) higher secondary school. Most of the patients (18, 36%) in this study used the barrier method for contraception, followed by (16, 32%) withdrawal method. Regarding the cause of induced abortion, unplanned pregnancy was the prominent cause (16, 32%), followed by, inadequate income (12, 24%), and contraception failure (12, 24%). Conclusion: This study concluded that most of the patients aged between 25 to 30 years and most of them resided in urban areas having a low monthly income, and poor education level. Some prominent causes of induced abortion were unplanned pregnancy, inadequate income, and contraceptive failure.

Rungia repens is a common Acanthaceae member growing mostly in agricultural wastelands. This plant is noted to have febrifuge, antitussive, and vermifuge properties. The qualitative phytochemical study of the leaves and stem of R. repens showed that the plant is rich in phytochemical composition. The chemical analysis showed the presence of alkaloids, phenolics, cardiac glycosides, and steroids in the methanolic extract of this plant. The DPPH and FRAP assay showed that the plant parts have significant antioxidant potential. The disc diffusion of the methanolic extract of this plant reveals its antimicrobial activity. Thus, it is stated that the plant has significant antioxidant and antimicrobial potential.

Ankyloglossia is defined as a developmental anomaly of the tongue characterized by an abnormally short, thick lingual frenulum resulting in limitation of tongue movement or in simple terms, tongue tie. In this condition there is difficulty lifting the tongue to the upper teeth or moving the tongue from side to side, tongue appears notched or heart shaped when stuck out. Adult tongue-tie may result in mouth breathing, inability to speak clearly, difficulty kissing, jaw pain and tongue thrust. We hereby report case of tongue-tie of two siblings and its management by electrocautery, this technique was simple, easier as well as less time consuming, unlike conventional surgery. There is little damage to adjacent tissue and no blood in the operating field when using the electrocautery.

The paper discuss the meaning and origin of continuing Education and highlighting the challenges Faced by Women Attending Continuing Education in North-West Nigeria, Continuing education is meant for those who had left early the formal school system. It is aimed at helping these sets of people to continue their education in a less rigid formation than what formal school system provides, and probably help them to go further In Nigeria presently, the practice of continuing education has been broadened to include the provision of educational activities that will meet the needs of illiterates, the drop-out. The underprivileged. Educationally disadvantaged, oppressed, the unnerved different categories of professionals, the down-trodden and the backwards. Thus, continuing education offers a wide range of training or education meeting needs of all shades of people. It therefore serves as the best means or instrument of democratizing education or equalizing access to education irrespective of age sex or social affiliation. Women education faced the following challenges even as they continuing the Education: Cost of schooling Marital instability, Children/husband, Gender discrimination, Conflict and crisis, Class struggle, Cultural and religious Imitations, Povertty, Illiteracy. The paper suggested among other that other obstacles, like social cost to education, personal interest and commitment to education distance-related barriers to education, re-entry policies for young mothers, and hygiene management in schools.

Cerebral thrombophlebitis gravidopuerperale is a rare but serious pathology that can engage the maternal-fetal prognosis. It requires early diagnosis and treatment fast. Indeed, much rarer than arterial thromboses, thrombophlebitis are a significant cause of death and stroke. They can occur during pregnancy but most often they occur within a few days to a few months following postpartum. The frequency of peripartum cerebral thrombophlebitis is on average 1/3000 to 1/10000 births, but recently the number of cases recognized seems higher partly because of the more widespread knowledge of the variability of different forms of clinical presentations of cerebral venous thrombosis allowing a diagnosis, and on the other hand the wider use of imaging means more and more effective, in particular MRI. The objective of this study is to describe the epidemiological, clinical, paraclinical, therapeutic and evolutionary gravido -puerperal cerebral thrombophlebitis.

This study examines and presents gender analysis model on the influence of tax audits, tax amnesty and e-filling implementation on individual taxpayer compliance (an empirical study on MSMEs DKI Jakarta). This study uses multiple linear regression analysis using a quantitative approach to the method of collecting data using primary data. Data collection was carried out by distributing questionnaires in online form via Google form to individual taxpayers of MSMEs in DKI Jakarta using the convenience sampling method, so the total data in this study were 400. The results of this study indicate Tax Audit, Tax Amnesty and Implementation of E-Filling have a significant positive effect on Taxpayer Compliance. Male respondents thought that tax audit and implementation of e-filling had more effect on their tax compliance than according to female respondents, while female respondents thought that tax amnesty had more effect on their tax compliance than according to male respondents.

Globally, undernutrition is the single biggest contributor to disease. Undernutrition is of particular concern in young children as it can compromise their physical and intellectual development. Current study formulated and evaluation of supplementary food from tiger nut (Cyperus esculentus), date palm (Phoenix dactylifera), moringa (Moringa oleifera), groundnut (Arachis hypogaea) and milk. The formulated supplementary food were designated S1, S2 and S3. Nutritional composition, selected minerals and anti-nutritional factors were investigated using standard analytical methods of Association of Official Analytical Chemist. Data was analyzed by ANOVA and results expressed as mean and standard deviation. Result of proximate composition indicates that ash ranged from (4.0 - 7.5), moisture (2.5 - 5.5) and protein (9.3 - 15.0). The result also revealed that the formulations contain appreciable amount of all essential amino acids. Anti- nutritional factor indicate that oxalate ranged from (7.0 - 14.0) and phytate (6.5 - 7.0). Selected micro-nutrient estimated suggested that the composite blends are good sources of minerals like Zn, Ca and Fe which are of public health importance. Based on the results of this study, it can be concluded that with proper blending of local foodstuff, it is possible to prepare nutritionally adequate supplementary food.