Abstract: We present the case of 30 year old male patient of Apert Syndrome with cryptorchidism and recurrent life threatening hemoptysis. Subsequent investigations revealed bronchiectasis. We would like to highlight the fact that complications secondary to congenital anomalies, if not addressed early, lead to medical, financial and social burdens that are otherwise avoidable.

Regular environmental monitoring (EM) system is indispensable routine activity in assessing the microbiological quality of the manufacturing environment surfaces for the production of medicinal products. However, the release of the full potential of such regular activity will not be achieved nor the elucidation for points of defects and improvements cannot be appropriately investigated unless systematic analysis of the results can be ensured and performed periodically. In the current study, statistical process control (SPC) and six sigma tools were used in the study of the quality of microbiological surface cleanliness in clean rooms in pharmaceutical manufacturing plant during ten months period on weekly basis using contact plates. Initial evaluation of data distribution showed that ten out of 11 partitions of the manufacturing area followed distributions other than the Gaussian ones which required logarithmic transformation to approach normalization for further statistical analysis. When control charts were constructed for transformed data, material followed by personnel airlocks showed the greatest risk of microbial excursions then the corridor with the overall risk of failure 99.5% suggesting that there was a state of significant imbalance between cleaning program and its frequency with the work type and load in these sections. The present work provided insight for the area of defects that could not be observed using conventional data trending and provided focus on defined sections that could impact the overall microbiological quality. This analysis provided a promising mean for designing quantitative risk assessment for microbiological quality control in pharmaceutical, human consumables manufacturing and other healthcare industries.

Abstract: Preconception care is any intervention provided to women and couples of childbearing age, regardless of pregnancy status or desire, before pregnancy, to improve health outcomes for women, newborns and children. Preconception care mainly focuses on health promotion, screening and interventions for women of reproductive age to reduce risk factors that might affect future pregnancies. A descriptive research design was used for this study. Non- probability purposive sampling technique was used to select the respondents. Two hundred twenty-seven reproductive age women were interviewed face to face using structured questionnaires. Most of the respondents 99 (43.61%) were in between the age group of 21-25 years. Majority of respondents 218(96.03%) belonged to Hindu religion. Most of the respondents 152(66.96%) belonged to nuclear family. Only 65(28.63%) had information regarding preconception care. Majority of respondents 192(84.58%) had average level of knowledge. Highest knowledge score was in the area of reproductive health risk factors, and lowest in the area of health promotion. The overall mean percentage was 57.39. There was significant association of Reproductive age women had average level of knowledge on preconception care. Highest knowledge was in the area of reproductive health risk factors where lowest was in the area of health promotion. Awareness program is required to improve the different aspects of knowledge regarding preconception care.

A stroke is the rapid loss of brain functions due to disturbance in the blood supply to the brain. In the last few years a great deal of research has been carried out to find the effectiveness of herbal drug for the treatment of stroke. Both thrombolytic and neuro-protective properties of herbal drugs may be a novel strategy for effective stroke therapeutics. The animals were divided into five groups of six each. Except the normal and control groups, all other test groups received different doses of aqueous extract of Hugonia mystax orally for 45 days as per the treatment schedule.Animals were observed for behavioral parameters after 24 hours of surgery in three different areas, neuromuscular function, vestibule motor function, and complex neuromotor function which consists of various subtests such as forelimb flexion, twisting, resistance to lateral push, circling, hind limb placement, forelimb placement, pinna reflexes and corneal reflexes.The remaining animals in each group were also sacrificed after 72 hours post-surgery by cervical decapitation. The brains were excised and used for the estimation of Lipid peroxidation, Superoxide Dismutase and Catalase.Hugonia mystax, a rich source of antioxidant consists of dietary fibers, flavonoids, proteins, vitamins like vitamin B1 and minerals like iron, copper, magnesium and potassium. It is also an excellent source of molybdenum and folate. The present study results support that Hugonia mystax has dose dependent stroke preventive activity in common carotid artery occlusion along with ferric chloride induced thrombosis model.

Abstract: Opsoclonus-myoclonus syndrome is a rare neurological disorder, usually found in children and associated with neuroblastoma. In adults it is rare and associated with malignancies, toxic medications, metabolic disorders, brain anoxia or autoimmune causes. Here we present a case of post infectious opsoclonus-myoclonus-ataxia syndrome who recovered completely after immunotherapy.

Chemoinformatics or Cheminformatics is an important interdisciplinary field that integrate the domain of chemistry and information science with computer science. In other words, it is the application and integration of Informatics with chemical Science. This concept originated some years back but gained popularity as a knowledge domain in the domain of chemical sciences very recently. It plays a vital role in storing large data sets related to chemical science and converting or transforming it into knowledge to make better and faster decision. Here, the methods or algorithm incorporated into it,assist the professionals to identify the better and appropriate chemical compound to also meet the need of medical and allied domain as they are the ultimate end users of the end product of chemical science. Inspite of having several benefits, there are so many misconceptions are still there with Chemoinformatics. This paper explains the general role of Chemoinformatics, its application, brief evaluation and future potentials.

Abstract: We present the case of 30 year old male patient of Apert Syndrome with cryptorchidism and recurrent life threatening hemoptysis. Subsequent investigations revealed bronchiectasis. We would like to highlight the fact that complications secondary to congenital anomalies, if not addressed early, lead to medical, financial and social burdens that are otherwise avoidable.

The construction of roads on soft clay soils is a challenging task and therefore considered as one of the biggest concerns in geotechnical engineering. The utilization of soft soils in tropical regions is currently low, although construction on them has become increasingly necessary due to economic reasons. Recent developments in nanoscience and nanotechnology opened fundamental and applied new frontiers in science and materials engineering. Advanced materials are being developed with enhanced chemical and physical properties with unique characteristics. The properties of these materials are determined not only by their composition and chemical bonds, but also by size and morphology. However, the traditional cementitious stabilizers like cement are under discussion, not only for their negative environmental effects during manufacture but also for their cost.

Abstract: Polycythemia Vera a myeloproliferative disorder sometimes associated with vascular complications like stroke. The clinical course may be complicated by deep vein thrombosis at multiple sites if the underlying hematological disorder is not corrected. We present 3 cases of cerebrovascular disease complicated by polycythemia and the problems that came up during their management. All three cases could be managed successfully and are on follow up as outpatients.

Abstract: The Junggar basin in Jimsar depression X group’s lithology give priority to fine siltstone, micritic dolomite and transition rocks, the average porosity is 9.17%, the average permeability is 0.15 mD, belongs to low porosity, low permeability reservoir. With the method of conventional high pressure mercury injection experiment we find out that, Reservoir microscopic pore structure change is poor; with the method of Constant velocity mercury injection experiment learned that, Reservoir percolation ability is mainly composed of throat radius distribution and pore throat radius ratio distribution.

African literature projects deeply embedded and enduring patterns of thoughts alongside the feelings and behavior of the society from which it is drawn. In so doing, it recounts the struggles and challenges of the communities for which it is written. The Nigerian writer as an African, probes and responds to the yearning of his nation. This paper is set to focus on the northern Nigerian woman/writer because, the African woman both as a writer and character in the society is surrounded by societal issues that affects her directly or indirectly. As such, the writer is faced with the task of voicing out these issues, projecting female characters that bear the burden of womanhood and the effect of this burden, using the two northern Nigeria writers in the texts, The Hound and Habiba in examining the societal burden placed on the northern woman and the effect of this burden on her and the nation. An effect that turns out to instill a negative personality and perception in these characters as the struggle for self- actualization and the challenges of being women or are destroyed by these impediments.

Abstract: Retail environment in Malaysia was changed especially in food and grocery segment when hypermarket format was introduced by foreign retailer in 1993. In this paper we tried to understand consumer decision during shopping food and grocery either hypermarket is a main location or not. An empirical study, which was carried out in Shah Alam with 400 grocery shopper as respondent showed no significant relationship between shopping decisions and demographic characteristic except marital status. On the other hand, only two out of five trips characteristic showed significant relationship namely trip frequency and companion during shopping in hypermarket.

Abstract: Depositional system analysis is an important part of basin analysis,also, it is the foundation of sequence stratigraphic research, and of important significance for understanding the evolution of the basin. It plays an important role in studying distribution of sedimentary facies, reservoir evaluation and hydrocarbon accumulation. According to the well logging data and core data analysis, the sedimentary system is a complete and typical contraction system domain, the sedmentary microfacies it mainly develops are underwater distributary channel, debouch bar and sheet sand. Combined with the north provenance, the northern sedimentary system decided that the sand bodies in the north region of the study area are more developing. Also, the area that river flowed has a great scale.

Abstract: Interlayers commonly found in the river sand inside, by studying how it is formed, for the restoration of river sand deposition process，reservoir genetic mechanism has an irreplaceable role. Based on the principle of sedimentology analysis, interlayers and sand body is the product of a certain deposition, both closely integrated into a unified whole, by studying the causes interlayers can be assisted genesis of reservoir sand bodies. Different types of channel sand bodies have different internal configuration, the underground reservoir sands internal structure is difficult to directly study, such as changes in its occurrence is difficult to identify, and interlayer is relatively easy to study. Thus, the sand can be studied by studying the interior configuration thin interlayer. Because of its low permeability or permeable, interlayer flooding on oil displacement agent has a certain shielding effect, interlayer internal fluid reservoir seepage can play spoiler, limiting the role. Channel sand reservoir characteristics can be changed according to their internal Interlayer displacement path, influence displacement efficiency, thereby affecting the inner layer of remaining oil distribution, especially for high water cut stage remaining oil distribution in complicated situations, interlayer study can effectively guide field development.

Abstract: Women’s health status is affected by complex biological, social and cultural factors, which are interrelated and only can be addressed in a comprehensive manner. Reproductive health is determined not only by the quality and availability of health care, but also by socio-economic development levels, lifestyles and women’s position in society. Women health is compromised not by lack of medical knowledge, but by infringement on women’s human rights including reproductive health rights. Poor women, who lack adequate food, basic health care, or modern contraception, suffer grave consequences for reproductive health. A woman who is malnourished and in poor health runs much greater risks in reproductive health issues and usually suffers without proper treatment and dies in most of cases. The aim of the present study to find out the factors affecting women’s reproductive health in Punjab. Multistage sampling techniques were used for data collection. At the first stage two Districts i.e. Faisalabad and Multan of Punjab province were selected randomly. At the second stage four tehsils, two from each district (Tehsil Faisalabad and Tehsil Jaranwala from District Faisalabad and Tehsil Multan and Tehsil Shujabad from District Multan) were selected randomly from the selected districts, than 12 localities, three from each tehsil (Chak No. 59/JB, 30/JB & 31/JB from Tehsil Faisalabad, Chak No. 60/GB, 55/GB & 54/GB from Tehsil Jaranwala and Khokhran, Mithal Shah and Gondian from Tehsil Shujabad and Ghalu, Sanhbai and Hasnabad from Tehsil Multan) were selected randomly. A sample of 300 respondents (25 from each locality) selected purposively. It was found that majority of the respondents were eating vegetables and less than a half of them were drinking milk on daily basis. It is clear from the findings that the respondents had many health problems i.e. headache (61.7%), high blood pressure (60.3%), back pain (54.7%), swelling on different body parts (41.3%), irregular menses (33.0%), hand, facial swelling (32.7%), urinary complications (28.3%), cramps and abdominal pain (26.7%), vaginal bleeding (25.0%) and some of them had anemia and heavy bleeding. Less than a half of the respondents (45.0%) used any contraceptive method and one-fourth of them were observed its side effects. Bi-variate analysis shows that education, income and age at marriage were positively associated with reproductive health status and age and total no. of pregnancies were negatively associated with reproductive health status. There is a dire need to improve the health facilities available at government Health Centers especially at BHUs to address the reproductive health problems that will surely improve women’s health status.