Background: Dengue fever, a major public health challenge in tropical regions, shows increasing incidence and severity worldwide, with frequent outbreaks in Bangladesh. Vitamin D, known for its immune-modulating properties, has been suggested to influence outcomes in viral infections, including dengue. This study aimed to evaluate the vitamin D status among dengue patients and examine its association with disease severity and recovery outcomes. Methods: This hospital-based cross-sectional study was conducted from January 2022 to December 2022 in the Dengue cell of Bangabandhu Shekh Mujib Medical University, Dhaka, Bangladesh. Vitamin D was measured in the Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. A total of 130 dengue patients, aged 18 to 60, were enrolled. Serum vitamin D levels were measured and analyzed alongside demographic, clinical, and biochemical parameters to assess the correlation between vitamin D status and dengue severity. Results: The mean age of patients was 35.6 years, with a predominance of males (57.7%). Vitamin D deficiency (levels <20 ng/mL) was observed in 69.2% of patients, with mean levels significantly decreasing with increased dengue severity (18.5 ng/mL in mild cases vs. 9.8 ng/mL in severe cases, p < 0.01). Patients with lower vitamin D levels had prolonged hospital stays and recovery times. A significant decrease in vitamin D levels from pre- to post-diagnosis (20.0 ng/mL to 15.2 ng/mL) was also noted, underscoring the potential impact of dengue infection on vitamin D status. Conclusions: This study highlights a high prevalence of vitamin D deficiency among dengue patients, with lower levels associated with increased disease severity and slower recovery. Targeted interventions, including vitamin D supplementation, may improve patient outcomes and warrant further investigation.

Introduction: Clinical trials are essential in the advancement of global scientific knowledge. The role of nurses at SQCCCRC-UMC has become more significant because of their direct role in caring for clinical trial participants. This necessitated building their capacity through training to care for trial participants as per the International Council of Harmonization- Good Clinical Practice (ICH- GCP). Objectives: This study aims to investigate the effect of a capacity-building initiative that includes conducting Clinical Trial Workshops (CTW) and getting nurses certified in online ICH-GCP. Method: 21 CTW were conducted. Pretest and posttest scores to check knowledge were collected from 2022 to 2024 and analyzed using paired t-tests to compare averages. Nurses were also asked to submit ICH-GCP certification to the clinical trials department (CTD) for record keeping. Results: CTW had a total of 171 participants composing of 96% of nurses (n=165). Those nurses accounted for 50.6% of the total nursing workforce (n=326). 88.5% (n=146) of those nurses completed both the pretest and posttest. The mean posttest score (87.2%) was compared with the mean pretest score (68.5%) showing an average increase of 19 %, which indicated statistical significance. (CI=95%, t=0.05). 86 nurses have completed ICH-GCP certification during the same period. (26.4 % of all nurses, n=326). Conclusion: The capacity building approach significantly improved nurses’ knowledge about clinical trials which can potentially aid in caring for patients in clinical trials. Additional research is needed to assess the long-term impact of this approach on nurses’ attitude in caring for those patients.

Background: Acne Conglobata (AC) is a rare and severe form of nodulocystic acne, primarily affecting adolescents and young adults. Characterized by deep nodules, abscesses, and interconnected sinus tracts, AC often leads to significant scarring and psychological distress. Despite its rarity, it presents a unique challenge in resource-limited settings like Bangladesh, where awareness and specialized dermatological care are insufficient. The multifactorial etiology includes hormonal imbalances, genetic predisposition, and environmental factors, complicating both diagnosis and treatment. Objective: This study aims to provide comprehensive insights into the clinical characteristics, risk factors, comorbidities, and treatment outcomes of Acne Conglobata in Bangladesh, with a focus on emerging therapeutic modalities. Methods: A cross-sectional observational study was conducted at a tertiary hospital in Dhaka, Bangladesh, from January to December 2024. A total of 50 patients diagnosed with Acne Conglobata were included, with data collected through clinical evaluations, patient interviews, and medical records. Descriptive statistics were employed to analyze demographic variables, risk factors, comorbidities, and treatment outcomes. Results: The majority of patients were aged 17-30 years, with a higher prevalence in males (70%). Hormonal imbalances (especially during puberty) and a family history of acne were the most common risk factors. Comorbidities such as depression/anxiety (40%), obesity (30%), and insulin resistance (20%) were prevalent. Treatment regimens primarily involved oral isotretinoin (80%), oral antibiotics (60%), and steroids (50%). Scar revision procedures were used in 30% of cases. Conclusion: Acne Conglobata significantly impacts young adults in Bangladesh, with genetic, hormonal, and environmental factors playing key roles in its pathogenesis. Depression, obesity, and insulin resistance were common comorbidities. Oral isotretinoin remains the most effective treatment, but a multimodal approach, including psychological support and scar revision, is essential. This study highlights the need for increased awareness and access to advanced therapies, especially in resource-limited settings like Bangladesh.

During the period between 1933 and 1945 the racial theory of National Socialism underwent enormous variations. It is possible to observe four different phases, some of which overlap in time. The first of these is based on the existence of a superior 'Aryan' race and defined by Hitler in Mein Kampf. This second stage, which ended around 1934, was characterized by the uncritical acceptance of Hans Günther's theses. Günther idea is centered on the Nordic breed: a tall, long-legged, thin, with average height, among males, about 1.74 m. Hair color is blonde. The stream of thought emanating from Hans Günther is known as Nordicism. The fact that about 95% of the German population, as well as almost the entire top leadership of the NSDAP, qualified as 'bastards-à-la-Günther', the Party was unable to accept such a conclusion. This was the generator of the third stage of NS racial theory. This phase is defined by an entire rejection of Günther's Nordicism. In Nuremberg, on the Day of the Party of 1933, Hitler declared: 'We do not conclude from the physical type of a man his ability, but from his achievements his race’. The fourth stage of the NS racial theory is fully demonstrated when the Waffen SS begins to welcome non-Nordic elements into its ranks. Since this fourth stage of National Socialist Racial Theory was interrupted in 1945, it is very difficult to predict what its end would have been.

Study aims to evaluate the evolution of anthropometric and hematological parameters in anemic rats treated with an aqueous extract of Moringa oleifera leaves. Seventy rats aged 8 to 16 weeks were divided into seven groups of ten rats each, including five males and five females. Various doses of the aqueous extract (200 mg/kg, 400 mg/kg, 800 mg/kg, and 1600 mg/kg) were administered in comparison with a positive control group and a group treated with Ranferon®. Treatments were administered from day 3 to day 14, with blood samples taken on days 1, 3, 7, and 14. Anemia was induced by injecting 40 mg/kg of phenylhydrazine twice a day for two days. The samples allowed for the determination of red blood cell count, hemoglobin levels, hematocrit levels, mean corpuscular volume, mean corpuscular hemoglobin concentration, and platelet count. The results showed a correction of anemia by the aqueous extract of Moringa oleifera leaves from the seventh day of the experiment, unlike the positive control group.

Annickia affinis is a medicinal plant traditionally used in Africa against several diseases including peptic ulcers. We conducted this study to evaluate the antiulcer and gastroprotective activities of the ethanolic extract of the stem bark of this plant. The antiulcer activity was evaluated on Wistar rats using 95% ethanol and then administering to them as treatment solutions, the ethanolic extract of the stem bark of the plant and other referenced anti-ulcer drugs over periods of 7 and 14 days. The gastroprotective activity was carried out following the opposite path, the different batches of rats first received one of the treating solutions and an hour later, the ulcer was induced on them and they were finally sacrificed an hour after administring the ulcerogenic solution for the macroscopic and microscopic analysis of their stomachs. Phytochemical screening revealed the presence of alkaloids, saponins, reducing sugars, coumarins, anthocyanins, anthraquinones. UPLC-MS analysis revealed the presence of 16 compounds, notably berberine, berberrubine, canadine, palmatine, jatrorrhizine, columbamine, pseudocolumbamine, 7,8-dihydro-8-hydroxypalmatine, atherosperminine, argentinine, 7-hydroxydehydronuciferine, 7-hydroxydehydronornucierine, Caryophyllene oxide, 1,5-epoxysalvial-4(14)-ene, humulene epoxide II and spathalenol. The administration of the ethanolic extract of the stem bark of Annickia affinis at doses of 2000 mg/kg and 5000 mg/kg showed no acute toxicity. The results obtained from the evaluation of pharmacological activities revealed that the ethanolic extract of the stem bark of Annickia affinis would have antiulcer and gastroprotective properties comparable to omeprazole and sucralfate at the dose of 150 mg/kg. It appears from this study that the stem bark Annickia affinis could be used both in the prevention and in the treatment of gastric ulcers which would justify its use in the traditional pharmacopoeia.

Background: Preeclampsia is a major public health problem especially in low- and middle-income countries. It is associated with a serious burden on the health care system and the economy of the family. This study aimed to determine the prevalence of preeclampsia and feto - maternal outcome of women diagnosed with preeclampsia in a secondary health facility in North central Nigeria. Materials and Methods: This was a retrospective cross-sectional study carried out among women diagnosed with preeclampsia at Nigeria Customs Hospital KaruAbujaover a seven-month period from 1st of January 2022 to 31st July 2022.Case notes were identified from records in the labour ward, antenatal clinic, theatre, gynaecological emergency and the intensive care unit. The case notes were retrieved from the Central Medical Record’s library. Data was entered and analyzed using the IBM Statistical Product and Service Solutions (SPSS Statistics) Version 27. Armonk, NY: IBM CorpA. Results: The total of 420 deliveries were reported during the study period of which 56 cases developed preeclampsia and only 47 has the complete information and were included in the statistical analysis. The retrieval rate was 83.9%. The prevalence of preeclampsia among the study participants was 13.0%. The mean age of the study participants were 31.04 (5.01) years, The mean gestational age at the booking was 23.86 (4.73) weeks. The mean gestational age at the diagnosis preeclampsia was 35.60(4.87) Only12 (25.5%) participants had severe preeclampsia. Perinatal mortality was 8.5 per 1000, Thirty-three (77.0%) of the neonate were born prematurely, and 2 (4.6%) had birth asphyxia. No maternal death or stroke were reported among the study participants. Only six (12,8) of the women sustained acute kidney injury. Conclusion: The prevalence of preeclampsia was high in the rural community of Karu Abuja. No maternal death was reported among the study participants. The perinatal mortality was 8.5 per 1000 birth.

Applying natural fibre-reinforced polymer composites for automobile body parts has not gained much attention in Nigeria. Natural fibres appear to be a good alternative to non-biodegradable synthetic fibres. This work aimed to develop natural fibres obtained from plantain pseudo-stem for reinforcement with polyester composites for automobile bumper fascia application. The plantain fibres were manually extracted and treated using the mercerization process. Compressive and impact tests were carried out on the laminates which were prepared according to the ASTM D695 and ASTM D256 standards, respectively. The plantain fibre-reinforced composite automobile bumper was then constructed using the hand lay-up technique. Laminates with volume fractions 0.3 and 0.4 are produced and analysed for impact and compression tests. From the experimental results, it was observed that the Impact strength for a volume fraction 0.3 and 0.4 was 12.22 kJ/m2 and 13.83 kJ/m2, respectively and compressive strength for a volume fraction 0.3 and 0.4 was 65.3x103 kN/mm2 and 67.4x103 kN/mm2, respectively. The study shows that plantain fibre-reinforced polyester composites could be an alternate candidate for automotive bumper fascia.

Japanese encephalitis (JE) is the leading form of mosquito borne viral encephalitis in Asia, with about 100,000 annual cases in which children are more dominant. The causative agent of JE is Japanese encephalitis virus (JEV) which is transmitted by Culex mosquitoes particularly Culex Tritaeniorhynchus. Mostly JE infections in humans are asymptomatic while severe JEV infection occurred in only few cases characterized by high grade fever, headache, seizures and unusual behavior, lesion and paralysis. The specific treatment of JEV is not available so far but the supportive care is effective. Many antiviral drugs have been investigated, but none of these have shown to improve the effect of JE except minocycline. The objective of gathering information and performing review is to asses JEV emergence possibility in Pakistan and to define some mitigation measure. In this review, the current knowledge of the prevalence and the pathogenesis of the JEV have been summarized. Furthermore, the current scenario of JEV, challenges and possible way forward in Pakistan has been discussed.

Wheat is a critical staple crop in Pakistan, contributing significantly to food security and the national economy. However, the adoption of modern sustainable wheat production practices (SWPP) remains low, leading to suboptimal yields and persistent food insecurity. Therefore, this study is conducted to investigate the socio-economic factors influencing the adoption of sustainable wheat production practices among smallholder farmers in Khyber-Pakhtunkhwa, Pakistan. Using a multistage sampling technique, data were collected from 268 farm households in the Charsadda district. Descriptive statistics and econometric models were employed to analyze the data, with an adoption index constructed to measure the extent of SWPP. The results reveal that education, farm size, farming experience, income, and access to extension services are significant determinants of SWPP adoption. Older farmers and those with larger families also showed a propensity to adopt SWPP, though to a lesser extent. The regression model explained 65.1% of the variation in adoption, highlighting the importance of these factors in enhancing wheat productivity. Barriers to adoption include limited access to credit, inadequate extension services, and low education levels. The study concludes that targeted interventions are needed to promote the adoption of SWPP. Recommendations include enhancing farmer education and training, strengthening extension services, improving access to credit, and implementing policies that support SWPP.

This research investigates the empirical linkage between trade openness and poverty in India through a comprehensive three-stage model approach. In first stage descriptive statistics, correlation matrix analysis and unit root tests are used to analyse the characteristics, nature and stationarity of the selected variables. Further, in the study Autoregressive Distributed Lag (ARDL) co-integration model to explore both long-run and short-run relationships between trade openness and poverty. Some post estimation test including the Breusch-Godfrey LM test, White heteroskedasticity test, and the Ramsey RESET test in the last stage. The empirical findings of the study show that there is positive correlation between trade openness and poverty (HDI). In the long run, trade openness, foreign direct investment (FDI), and exchange rate have significant impacts on poverty reduction, while inflation rate and GDP per capita exhibit mixed effects. Impact of FDI and Trade Openness (TO) is positive on poverty reduction, while exchange rate, inflation rate, and GDP per capita show varying impact on poverty. The study suggests that policymakers should consider fostering trade openness and addressing other economic factors to effectively reduce poverty in the country.

Technologies such as Artificial Intelligence and Automation are shifting the human workforce to new roles, creating the need for new skills. This research aimed to understand the expectations of companies in Chihuahua, Mexico, regarding the skills required for the future of work and compare them with the results presented by the World Economic Forum in its 2018 Future of Jobs Report. A survey was conducted among 359 companies on this topic. The main findings reveal a 60% match between the top 10 skill groups prioritized globally and locally. However, skills such as "Technology Design and Programming," "Emotional Intelligence," "Reasoning, Problem-Solving, and Ideation," and "System Analysis and Evaluation" are considered crucial globally but not locally.

Abū Bakr Moḥammad Ibn Zakriyā Al-Rāzī, a distinguished physician of the 9th–10th centuries, made ground-breaking contributions that significantly shaped the discipline of paediatrics and advanced the knowledge and treatment of infectious diseases. His scholarly works, which include the renowned texts Kitāb al-Hāwi and Kitāb al-Judri wa al-Hasbā, underscore the critical importance of preventive health measures, stringent hygiene practices, and the necessity of implementing age-appropriate treatments tailored specifically for children. Al-Rāzī made a significant distinction between the illnesses that affect children and those that are prevalent in adults, advocating for a therapeutic approach that is uniquely tailored to the specific health needs of the younger population. His ground-breaking monograph, titled Kitāb al-Tibb al-Atfāl, systematically addressed the various aspects of paediatric care, offering insights that were revolutionary for his time. Furthermore, Al-Rāzī's meticulous and detailed descriptions of diseases such as smallpox and measles enhanced the precision of diagnostics, thereby improving the understanding of these conditions and their management. His insightful contributions laid the essential foundations for the evolution of modern paediatrics as well as for the contemporary approach to infectious disease management, influencing several generations of medical practitioners and researchers in subsequent eras.

Background: Endometrial cancer (EC) is a leading gynecological malignancy worldwide, with rising incidence in developing countries. Prognostic factors play a critical role in guiding management, especially in resource-limited settings where molecular testing is not routinely available. Aim of the study: To evaluate clinicopathological prognostic factors influencing recurrence in patients with endometrial cancer treated at a tertiary care hospital in Bangladesh. Methods: A retrospective observational study was conducted on 45 histologically confirmed EC patients who underwent hysterectomy-based surgery. Demographic, clinical, pathological, and treatment-related data were analyzed using SPSS version 26.0. Univariate analysis was performed with Chi-square or Fisher’s exact test, and multivariate Cox regression was used to determine independent predictors of recurrence. Hazard ratios (HR) with 95% confidence intervals (CI) were reported, and a p-value <0.05 was considered statistically significant. Result: The mean age was 54.9±12.4 years; 55.6% were postmenopausal. Most patients presented with stage I disease (77.8%). Significant independent predictors of recurrence included tumor grade 3 (HR 2.75; p=0.039), myometrial invasion ≥50% (HR 3.80; p=0.023), LVSI presence (HR 4.25; p=0.007), advanced FIGO stage III–IV (HR 5.67; p=0.004), and lymph node positivity (HR 3.92; p=0.032). Surgical approach and adjuvant therapy were not significantly associated with recurrence. Conclusion: Advanced stage, high tumor grade, deep myometrial invasion, LVSI, and lymph node involvement are key prognostic factors for recurrence in EC. In low-resource settings, reliance on these clinicopathological predictors is essential for risk stratification and optimizing treatment strategies.

Diabetic foot ulcers (DFUs) are a significant global health burden, exacerbated by the rise in multidrug-resistant (MDR) bacterial infections. This study evaluated the antibacterial effects of Sansevieria zeylanica (S. zeylanica) leaf and root extracts against MDR Proteus mirabilis isolated from diabetic patients with DFUs at a teaching hospital in Nigeria. Antimicrobial susceptibility testing of clinical isolates of MDR P. mirabilis was conducted using the Kirby-Bauer disc diffusion method. The antibacterial activity of S. zeylanica extracts was evaluated using the agar well diffusion method. Additionally, the synergistic/antagonistic effect of the extracts with Ofloxacin was assessed. Antimicrobial susceptibility testing revealed high resistance to conventional antibiotics, with 61.5% of isolates identified as MDR. Methanolic extracts of S. zeylanica demonstrated moderate antibacterial activity, with root extracts exhibiting greater inhibition zones (10-17 mm) compared to leaf extracts (8-13 mm). However, co-administration with Ofloxacin revealed an antagonistic effect. These findings suggest that S. zeylanica root extracts hold promise as an alternative therapeutic agent for DFU management. Further research is needed to optimize extract formulations and explore their clinical applications.