In a preliminary research, the authors reported that solvents extracts of Alstonia boonei (Egbu) possess strong antimalarial activity against NK-65 Chloroquine sensitive Plasmodium berghei infected mice with aqueous extract having the highest decrease in mean percentage parasitaemia. This research is therefore aimed at evaluating the acute and sub-chronic toxicity of solvents extracts of the plant on kidney. The (LD50, oral) was conducted in two phases. In the first phase, oral doses of 10, 100 and 1000 mg/kg body weight of the extracts were administered and mice observed for sign of toxicity and death. In the second phase, 1600, 2900 and 5000 mg/kg body weight of the extracts were administered and signs accompanying toxicity and possible death of animals were also monitored. Sub-chronic toxicity studies were carried out to assess the effect of the solvents extracts on kidney function indices after 28 days of oral administration of the extracts at 150, 250 and 500 mg/kg body weight. The (LD50, oral) of all extracts was found to be greater than 5000mg/kg which is practically non- toxic according to standard scale of toxicity. The result of sub-chronic toxicity study showed a significant increase (P<0.05) in mean levels of creatinine, urea and serum electrolytes in all extracts administered groups in a dose dependent pattern compared to normal control. However, histopathological analysis of the kidney tissues shows no pathological changes between test groups and normal control. Thus, solvents extracts of Alstonia boonei modifies biochemical parameters (Crea, Urea and Electrolytes) but within the context of duration of this research, no significant pathology was observed in kidney tissues. Alstonia boonei stem bark should be used with caution

Primary Squamous cell carcinoma of the gallbladder is extremely rare and constitutes 0.5- 3% of all gall bladder malignancies. We report a 50-year-old female who presented with vague symptom of right upper quadrant pain. She was operated on a presumptive diagnosis of chronic cholecystitis according to clinical and ultrasonography findings. Histopathological examination showed an infiltrating mass of the gallbladder which revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluation revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is very rarely reported. Clinicians must be aware of its vague clinical presentations.

This study was designed to examine the relationship between organisation design and organisational effectiveness in the Nigerian construction industry. The population of this study was the entire managerial staff population of Julius Berger Nigeria Plc and Setraco Nigeria Limited, both construction companies in Nigeria. The study adopted the survey research design and copies of structured questionnaire were administered to a sample of 341 respondents. Proxies for organisation design were drawn from Kates and Galbriath “Star Model” of organisation design. Descriptive statistics were used to analyse the data, while simple linear regression analysis was used to test the hypotheses formulated for the study. The findings of this study indicate that the five elements under study have strong positive relationship with organisational performance. Consequently, it is recommended that management of organisations in the Nigerian construction industry should consider all five elements when designing or re-designing their organisation.

The scalp is a specific anatomic district, in which the most elevated density of pilo-sebaceous follicles is available and terminal hairs are concentrated. Scalp lesions are the most disregarded since they are not effortlessly seen with ensuing deferral in recognition and late treatment. This examination is expected to decide the histopathological investigation of Scalp Lesions. The present review think about assessed 65 instances of scalp lesions from the record of one of the tertiary care hospital of Uttar Pradesh over a span of three years. All the histopathologically demonstrated instances of scalp lesions were explored and clinical points of interest were gotten from the documents. Age, sex, and histology of the considerable number of examples were assessed. Among the 65 cases, 38 (58%)) cases were benign lesions. The male to female proportion was 1.5:1. Benign conditions were most conspicuous and small portion were malignant. Age appropriation in benign lesions was 20-40 years though malignant lesions were found in the elderly. Scalp injuries are uncommon, benign lesions are more common. For each situation of a scalp lesion a wide differential conclusion must be considered. Enhanced clinical experience and hospital participation with more thorough detailing would yield more illustrative information.

Tuberculosis (TB) is commonly associated with poverty and under-nutrition in both developed and developing countries. Being underweight has been associated with a higher risk of tuberculosis in several studies. A retrospective descriptive study was conducted to analyze TB surveillance data from the chest clinic teaching hospital Batticaloa, in SriLanka. Finally, 103 TB patient’s records were analyzed and available data were extracted. The prevalence of underweight among TB patients is 39(37.9%). Obesity and overweight were associated with a significantly lower risk of both clinically active and culture-confirmed tuberculosis

This study reports baseline information about melanocytic neoplasms in TUTH. The objective was to study the histological spectrum of melanocytic nevi and melanoma, and to make a clinicohistopathological correlation. 50 consecutive cases of melanocytic neoplasms were studied from December 2010 to December 2011.Of the 50 cases, 12 (24%) were malignant melanoma and 38 (76%) were melanocytic nevi. Cutaneous melanocytic nevi was the commonest, 30/38, (79%) followed by 8/38 (21%) conjunctival nevi. Head and neck was the commonest site (25/38) and the mean age at presentation was 32.66 +16.19 years, the female to male ratio being 5.3:1.In melanoma, 4 (33%) were extracutaneous, of the cutaneous, 2 (17%) were acral lentiginous, and 6 (50%) were nodular. Mean age was 50 + 16.99 years with an equal female to male ratio. Commonest site was extremities (6/8) in cutaneous and choroid in extracutaneous (2/4) lesions. Concordance between clinical and histopathological diagnosis were found in 30/50 (60%) cases. Melanocytic nevi are quite common in females, melanoma is rare, affecting men and women equally. In our context melanoma likely represents a sporadic disorder. Difference from the western societies is the common occurrence of nodular melanoma here and the topographical distribution.

Estimating a company’s sustainable profitability is a big challenge to investors. A profitable company yielding a steady revenue stream with modest capital expenditure has the ability to compound shareholder wealth at an attractive rate over time. Even though many studies have been conducted, most companies strive to provide competitive returns. The golden path of being profitable has not yet been revealed. Selected 15 Sensex Companies standing as leading players are expected to provide considerable support to empower the efforts of the Indian Government. On this backdrop, the present study aims at focussing and assessing the efficacy of the performance of the selected Sensex Companies with the help of the most appropriate accounting-based measure of profitability i.e. Return On Capital Employed (ROCE) from 2012 to 2017. The empirical study reveals that companies have not been able to increase revenue and ROCE simultaneously and they are not also compatible in comparison with the global capital market.

Trichomonas vaginalis amongst other STIs facilitate the natural history of HIV infection and may play an important role in the transmission dynamics of HIV. In this study we determined the prevalence of T. vaginalis infection and associated risk factors among HIV-1 infected women attending antiretroviral treatment Center at Jos University of Teaching Hospital. The study was a cross sectional survey of 168 HIV-1 infected women who presented to the STI clinic with symptoms and/or without symptoms of T. vaginalis infection from November 2015 to January 2016 after obtained informed consent. Demographic data and high vaginal swabs were collected by trained nurse. The samples were examined by light Microscope to identify T. vaginalis, Candida species and bacterial vaginosis. Of 168 HIV-1 infected women, 87 (51.8%) were positive for T. vaginalis infection. The rate of co-infection of T. vaginalis with bacterial vaginosis, Candidiasis was 44.8% and 5.7% respectively, both showed no statistical significance, P=0.360. The highest prevalence of T. vaginalis infection 29.8% was among individuals in the 30-41 years age group while the lowest 3.05% was among individuals in the 54-65 years age group. In the univariate analyses; age, occupation, educational status, marital status, previous history of STI, condom use, multiple sexual partners, pregnancy, ART status and symptoms manifestations showed no significant association, but in multivariate analyses, history of STI , symptoms manifestations showed significant association with p>0.05. The high prevalence of T. vaginalis highlights the need for routine screening among HIV-infected women.

The study investigated effects of Corporate Social Responsibility (CSR) on performance of organizations by focusing on its four fundamental components: economic, social, political and philanthropic. Using 8 sugar manufacturing firms, the study findings indicated that corporate social responsibility to have a predictive power and it could explain variations in firm performance. Ability to explain variations in company performance was realized through sales volume by 18% (R2 = 0.180), capacity utilization by 16% (R2 = 0.160) while profitability after tax by 20.3% (R2 = 0.203). Findings of CSR performance results show that though CSR activities have been viewed to contradict companies‟ ultimate mandate of profit making and sidetracking organization core activities, statistical results from this study shows positive performance outcomes especially profitability. This may be attributed to positive company image and brand as a result of CSR activities.

This research paper analyses the impact of knowledge creation process on Mauritian business from a case study perspective. The knowledge creation process is a dynamic one since it comes from diverse areas. Firstly, the university or any training institution develops business courses that would help students benefit from job opportunities in firms which expected them to apply their knowledge at work. On the other hand, the knowledge creation process might come from the firm that urges the graduate to develop his knowledge and capabilities that should directly impact on the business. There is also a new approach whereby the university develops courses by integrating the student with the industry in a programme tailor-made for the organisation. This paper states that knowledge creation process should be developed in a dynamic way that integrates and addresses business needs in today‟s fast changing environment. Through a case study approach in three selected situations, using Nanoko‟s Taxonomy of knowledge creation as a framework, it reveals that the knowledge creation process is a two-fold dynamic practice and that its success depends on the inter-relationship between tacit and explicit knowledge.

L-ornithine (L-Orn), is an intermediate metabolite in the urea cycle that plays an important role in the human beings and is used for the treatment of the liver diseases etc. Based on these versatile advantages, L-Orn is widely applied in the health care and pharmaceutical industries. In this study, l-arginase from Idiomarina sediminium was immobilized onto chitosan-hydroxyapatite. Effects of immobilization parameters including medium temperature and pH, enzyme concentration and coupling time was evaluated to obtain the best reaction conditions. The optimal immobilization pH was determined as pH 7.5 with the highest enzyme activity of 101.24 U chitosan-HAP beads and highest immobilization efficiency of 81.4%. Furthermore, the immobilized protein amount showed an increase with increasing enzyme concentration as expected. Characterization of immobilized enzyme was evaluated using l-arginine as a substrate. Immobilized enzyme exhibited better thermostability and higher stability at lower and higher pH values. Immobilization also resulted in a shift of 0.5 units in pH optimum for maximum enzyme activity. In contrast to optimum pH value, after immobilization no shift occurred in optimum temperature. Furthermore enzyme retained 81.8% of its initial activity during consecutive eight cycles. The results suggests that chitosan-HAP immobilized l-arginase can be employed on the large scale for industrial production of l-ornithine

Despite numerous studies have placed the emphasis on an examination of individual differences in humor styles, the investigation of this topic in Thai context has been overlooked and needs to be explored. As a consequence, the objective of this present study was to examine individual differences including gender, age, and body mass index (BMI) in humor style of Thai managers in real estate companies. Seventy-nine managers in all hierarchical levels of two real estate firms listed in Stock Exchange of Thailand were gathered for data collection by using Humor Style Questionnaire (HSQ) as the instrument. The result of independent sample t-test showed that male managers had a higher score on the use of self-defeating humor style than female managers (t = 2.806, p = 0.007). In addition, the result of KruskalWallis H test demonstrated that there was a statistically significant difference in selfenhancing humor between the different age groups (χ2 (3) = 8.731, p = .033). Nonetheless, results of Kruskal-Wallis H test indicated no statistically significant differences in all four humor styles between the different BMI groups. Discussion and recommendations for further studies were also discussed.

The Present study was carried out to analyse the prescribing pattern of drugs and appropriateness of antimicrobials use in gastroenteritis in hospitalized children. It was a prospective, observational, single centre study undertaken in gastroenteritis inpatients of paediatric department, aged one month to seventeen years, over a period of six months. Modified Kunin's criteria along with the guidelines set by the World Gastroenterology Organization were followed for assessing the appropriateness of the antimicrobials prescribed and prescribing patterns respectively. A total of 120 patients were enrolled, of whom 61% were in the age group below 5 years. Diarrhoea with mild dehydration was diagnosed in 53% patients followed by no dehydration (28%) and severe dehydration (19%). IV fluids (90.8%) and antimicrobials (86.6%) were the commonest drugs prescribed. 89% of antimicrobials were given in parenteral dosage form. 27.9% of antimicrobials were given for 3 days duration. Among the antimicrobials, ceftriaxone was frequently prescribed. Inappropriate antimicrobial therapy was given in 9.6% of the cases. Precise use of antimicrobials was preferred in 10.5% of cases. Microbiology report was missing in 79.9% of cases. No ADRs were observed during the study. Inappropriate use of antimicrobials was seen in the study. Emphasis on proper diagnosis, treatment, education and availability of effective guidelines may help in a judicious use of drugs in children.

In the present study an investigational work was performed to find out the effect of population density on the breeding of domesticated zebra finch. For the present experiment three different types of cages were used namely: type A, type B and type C cages. Type A cage was utilized for colonial breeding of zebra finch. Ten adult compatible pairs of zebra finches were kept in type A cage. Five type B cages were built for the study; two adult compatible pairs were kept in each type B cage. Ten type C cages were constructed for the present study; one adult compatible pair was released in each type C cage. In type A cage 5 pair produced eggs and only one pair hatched and reared chicks successfully. In type B cages none of the pairs produced eggs. In type C cages all pairs produced eggs, hatched eggs properly and reared chicks successfully.

Nurses are facing practice problems that causes disturbing and stressful situation. The most common and prevalent issue is moral distress. Moral distress is affecting performance of professional nurses at health care setting. Cross-sectional study design was used. Questionnaire consisted on 5 point Likert scale adopted was used to know the impact of moral distress on nurse’s performance with sample size 187 Nurses from Public Hospital Lahore. Finding of the study shows that there is a significant negative (reciprocal) impact of moral distress on performance of nurses The current study concludes that moral distress decrease the job performance of the nurser’s at hospital settng. This study revealed the negative relationship between moral distress and nurses’ performance. The study findings will enable the health care organizations to enhance the performance of staff nurses by minimizing the factors that are causing moral distress among nurses. Hospital can arrange workshops and education sessions to give awareness to deal moral distress situations