Water samples of River Gwagwarwa and River Rafin Malam were subjected to liquid-liquid extraction and analyzed for organic pollutants. The organic parameters were determined using the standard methods of America Public health Agency (APHA) and was extracted and analyzed using Gas chromatography-mass spectrometer (GC-MS). Ten different organic compounds were detected at different percentage values at River Gwagwarwa while only seven different compounds were detected in River Rafin Malam. The compounds fall within five classes of organic compounds, which include carboxylic acid, acid chloride, ester, aldehyde and acid anhydride. The distribution pattern of the organic pollutants at the two sampling stations depict the pattern; River Gwagwarwa > River Rafin Malam. The study shows that organochlorine was the predominant organic pollutant present in River Gwagwarwa sample which is a hazardous pollutant while River Rafin Malam has no toxic pollutant which is attributed to lack of activity of the River.

The traditional English teaching focuses on the grammar and sentence structure but ignores the relationship between the sentences and paragraphs thus causing students’ lack of awareness of using cohesive devices. This study aims to illustrate the cohesion and coherence problems in college students’ writing. As one of the four basic language skills, English writing skill is the most indispensable but complicated one for English learners to master. According to College English Curriculum Requirement and under the theoretical framework of Halliday and Hasan’s Cohesion Theory, this study finds out the misuse of reference, substitution, ellipsis, conjunction and lexical cohesion in students’ English writing. By illustrating the examples of the discourse errors in students’ English compositions, this study tries to put forward some suggestions to ameliorate traditional English teaching and improve students’ writing skill.

Gold is a safe haven asset especially in times of uncertainties and can provide long-term capital gain. The objective of this study is to investigate the causality relationship among the changes of the Malaysia stock price index (KLCI), US stock price index (DOJ), Malaysian currency exchange rate (EXR) and crude oil price (COP) on the gold price (POG) in the Malaysian Market. This study employs vector error correction method with co-integration analysis, Granger causality test, and model evaluation. Based on the findings, COP and the lagged of the gold price (POG) only have a significant short-term relationship, however, the KLCI, DOJ, EXR and COP has also a significant long-term relationship with the gold price. Moreover, POG granger causes KLCI and COP also granger causes POG, both are uni-directional causality. Furthermore, EXR granger causes POG with bi-directional causality. Evidently, EXR and COP changes are importantly affecting the gold price changes. Otherwise, the gold price changes are affecting also the changes of KLCI and EXR in the study. These findings are important for investors who are opportunities for investment in gold in Malaysia.

There is a need for a rapid and reliable test to predict dengue so that the patients are managed and monitored. Beckman Coulter LH series instruments provide data on leukocyte cell volume, V; conductivity, C; and light scatter, S which is useful in distinguishing viral and bacterial infections. This prospective study was undertaken in Chennai - India for a period of one and a half years. The cell population data for the dengue positive and negative patients were retrieved from the hematology analyzer Beckman Coulter LH780. Statistical analysis was performed using MedCalc for Windows version 15.0. Mann-Whitney test was used to compare the VCS indices between the different groups. Dengue positive, suspected and controls were 499, 493, 499 respectively. Male: female ratio is 1.4:1. The platelet count, standard deviation of volume and conductivity of monocytes, volume and percentage of lymphocytes and platelet counts were used to construct a tree model which distinguishes dengue from suspected cases with sensitivity, specificity and efficiency of 94.84%, 77.88% and 89.59% respectively. A classification tree was developed using changes in monocytes, lymphocytes and lymphocyte and platelet counts.

Brain tumors account for 85% to 90% of CNS tumors. In 20-40% of the patients suffering from brain tumor (BT), seizures are common during the commencement of the disease. The relationship between the onset of seizures and brain tumor is poorly understood. These patients show a complex therapeutic profile making selection of the drugs very tough. The quality of life of the patient is highly compromised due to brain tumor-related epilepsy (BTRE) as it is drug-resistant and poses the challenging risk factor for everlasting disability. Hence, there arise the need of unique and multidisciplinary approach of proper selection of medications with minimum side effects. Glioblastoma Multiforme is a grade IV highly malignant tumor attacking the glia, which provides nourishment and assist in signal transmission. Glioma cells secrete glutamate and choose neurotransmitter receptors for their invasive growth. Glutamate binds to ionotropic receptors, activate calcium release mediating excitatory neurotransmission. The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission and are critical for spread of epileptic activity. Glutamate is the main culprit for both the occurrence of seizures and glioma metastases. Hence there lies an opportunity to use the anti-epileptic drugs which targets calcium permeable AMPA receptors for the treatment of glioblastoma as well as BTRE. Topiramate (TPM), a derivative of D-fructose is a novel broad spectrum anti-epileptic drug which shows antagonistic effect on AMPA receptor. When treated with TPM a dose-dependent decrease in live cell number, increase in the number of apoptotic cells, decrease in the calcium influx, reduction in phosphorylation of Akt, Erk1/2 expression were observed. Also phosphorylation of AMPA receptor in presence of EGF was observed. The data suggests that topiramate lead to decrease in proliferation and survival by decreasing calcium influx and inhibiting mitogenic and survival signalling in U87MG cells.

The largest outbreak to date was the epidemic in West Africa, which occurred from December 2013 to January 2016 with 28,616 cases and 11,310 deaths. The aim of this work was to assess by a systematic literature review the impact of surveillance in health systems of Guinea, Liberia, Sierra Leone and Nigeria in combating Ebola Virus Disease outbreaks. Specific objectives include identifying the strength of their surveillance systems and exploring the impacts of surveillance on the containment of Ebola virus disease in the region. The PRISMA procedure was used in carrying out the study. The SPIDER tool was chosen and modified to establish the research question. Five databases were searched in this study viz., the Cochrane librarycentral, Medline, Google Scholar, PsycINFO and a grey literature called Open grey. Studies were critically analyzed and assessed using the Crowe critical appraisal Tool (CCAT). The search strategy generated a total of 30 articles, out of which 6 articles (5 studies and 1 report) were selected for data extraction. The need for professionalism and competence cannot be overemphasized in the healthcare and surveillance systems of West African countries, especially the ones under study.

In an attempt to maintain a stable exchange rate and price level in Thailand given shocks from the United States, China, Euro Area, and Japan; the top five trading partners of Thailand, this study employs the system equations of VAR model techniques. Results show that the interest rates, demand shocks, and foreign prices affect the stability of the Thailand exchange rates and price levels. More so, empirical evidences validate the existence of unidirectional causality between Thailand exchange rate and domestic (as well as foreign) price inflation.

River bank erosion has always been a challenging problem in Bangladesh. Conventional method of designing erosion protection structures are governed by the hydraulic loads resulting from currents and waves. In practice, toe protection elements are dumped into flowing water and settle somewhere on the river bed to form an apron. The present study has been undertaken to investigate experimentally the aspect of underwater threshold condition of toe protection elements. The experiments are conducted in the large tilting flume of the Hydraulics and River Engineering Laboratory of Water Resources Engineering Department, BUET. Cubeshaped Concrete Block (CC block) is considered as erosion resistant material. A geometrically similar undistorted scale factor of 20 has been selected to conduct the experiment. Hydraulic parameters and CC block are selected based on typical field condition and the experiment is designed according to the scale. Two different initial water level (set-up 1 and set-up 2) is deliberated for the same size of CC block to investigate the hydraulics of threshold characteristics. During experimentation various observations are made and the measured data are used to analyze various hydraulic features of threshold condition. Gradual smooth increment of flow is ensured to reach threshold condition. At this stage, water level is 0.212 m, section average velocity is 0.55 m/s and depth averaged velocity is 0.54 m/s for set-up 1. While for set-up 2, water level is 0.256 m, section average velocity is 0.54 m/s and depth averaged velocity is 0.53 m/s. Though the threshold velocity magnitude for setup 1 and set-up 2 are very close, the corresponding water level is quite different since initial depth of flow is different. It is expected that the results obtained here can be useful to develop predictive expression for estimating the threshold velocity of CC blocks. Scope of detailed analyses in this area of interest is in progress.

Rosuvastatin calcium is hypolipidemic drug and has low oral bioavailability of about 20% due to poor aqueous solubility and hepatic first-pass metabolism. These are major boundaries inefficient delivery of RC by oral route. Several delivery approaches are known to moderate the difficulties of solubility and increase the oral bioavailability of RC. Among numerous approaches, nanotechnology-based delivery of RC has prospective to overcome the challenges associated with the oral administration. This review focuses on various nano-based delivery systems such as nanoparticles, lipid nanoparticles, SEDDS and SNEDDS and tried for improving the aqueous solubility, dissolution and subsequently bioavailability of RC upon oral administration. Of all, solid lipid nanoparticles appear to be promising delivery system, based on current reported results, for delivery of RC, as this system improved the oral bioavailability and possessed prolonged pharmacodynamic effect.

This paper critically reviews methods applied in forecasting production of unconventional gas plays. The review focuses on methodologies suitable for shale gas plays, methodological ability to account for parameter and data uncertainty, as well as suitability for appraising undeveloped shale gas plays. The production analysis and forecast methods reviewed include empirical/decline curves, type curves and analytical/numerical methods applicable to unconventional gas production analysis and forecast. The review shows that most of the studies focus on developed shale gas plays, neither account for shale gas well reservoir heterogeneity nor account for below ground uncertainties-such as reservoir and source rock properties. This study concludes that significant research is needed to address the identified limitations of existing studies.

Ovarian cancer is one of the most important causes of pelvic masses and is the fifth leading cause of cancer related mortality. As in all cancers, method of early diagnosis for ovarian cancer should be easily applicable, economically, has high safety and specificity. Our study included 155 cases that were operated due to adnexial masses at Obstetrics and Gynaecology Clinic of Trakya University. Inclusion criteria for the study were decision of surgery due to an adnexal mass and presence of preoperative evaluation for parameters examined in this study such as age, serum CA125 value, Ultrasound score, menopausal score and thrombocyte count. Risk of Malignancy Index was calculated. Localization and amount of vascular flows in adnexial masses were evaluated using Color Doppler USG. Ages of the cases ranged between 17-75 years. Histopathologically 122 benign, 6 borderline, 27 malignant masses were detected. As surgical approach to malignant tumours is similar to borderline tumours, they were assessed within malignant tumour group. Malignancy was suspected in 27 of 155 cases which were evaluated with RMI. Malignancy was suspected in 33 patients evaluated with CDUS and malignancy was suspected in 26 cases evaluated with thrombocyte count. Evaluation of RMI according to histopathological results revealed that there was no difference between the two assessment methods. Specificity of the RMI evaluation was 98.4% and its sensitivity was 75.8%. Thrombocyte count demonstrated malignancy in 16.8% of the cases. Evaluation of CDUS findings revealed that 122 cases diagnosed as malignant in pathology were also diagnosed as malignant in CDUS and the other cases were detected to be benign with Doppler. CA125 values were below 35 U/mL in 86.8% of the cases with benign adnexal masses and above 35 U/mL in 72.7% of the malignant cases. Better preoperative benign-malignant differentiation will enable performance of optimal surgery in experienced centres. RMI which can be used for early detection and differentiation of malignancy has opened the way for objective evaluation of adnexal masses.With use of parameters such as CDUS, thrombocyte count, and age together with RMI benign-malignant differentiation of adnexal masses can be made more effectively.

This study aims to calculate the fishery economic value of Limboto Lake including aquaculture, catch, and bibilo fishery. The research was conducted in Limboto Lake area and using survey method that based on questionnaire in collecting data. Respondents were 100 people who determined randomly. The productivity method is an estimate of the ecosystem economic value for a product or service that contributes to the commercial goods production in the market. The results showed that the fishery economic value of Limboto Lake is 51.474.000. 000 IDR / year. More than 50% of the value is contributed by aquaculture fishery.

The experiment was carried out at the Regional Agricultural Research Station, Jamalpur under Bangladesh Agricultural Research Institute (BARI), Joydebpur, Gazipur-1701 during the period from December, 2015 to April, 2016 to observe the effect of nitrogen and zinc on the growth and yield of late sown wheat. The experiment comprised four nitrogen levels viz. (i) N0= Control (No nitrogen), (ii) N1=140 kg ha-1, (iii) N2=160 kg ha-1, (iv) N3=180 kg ha-1 and five zinc levels viz. (i) Zn0 = Control (No zinc), (ii) Zn1= 2 kg ha-1, (iii) Zn2 = 4 kg ha-1, (iv) Zn3=6 kg ha-1, and (v) Zn4=8 kg ha-1. The experiment was laid out in a split-plot design with three replications assigning N-levels in the main plots and Zn-levels in the sub-plots. The interaction effect of N and Zn levels showed significant variation regarding grain yield and the highest grain yield (1.96 t ha-1) was found in N2Zn3 combination ascribed to the highest number of tiller (376.33 plant-1), grain (37.07 spike-1) and 1000-grain weight (36.26 g) significantly different from other combinations. Grain yield decreased significantly beyond the levels N2 and Zn3 due to their either individual effect or interaction effect. The lowest level, N0 and Zn0 gave significantly the lowest grain yield due to their either individual effect or interaction effect (0.69, 1.24 and 0.61 t ha-1 respectively).

The research aimed to find out the difference in calcium concentration in breast milk between the good nutritional status and Chronic Energy deficiency in postpartum mothers. The research was the Cross Sectional design research type. The samples are 40 people who were chosen using the purposive sampling technique, and who met inclusive criteria. The samples were collected. Fourteen days after giving the researcher, they came to the respondent's house to measure BB, LILA and 24 hours foodrecall and milked 3 cc, done by the researcher, and will check their breast milk through laboratory test using Colorimetric Assay. The data with not normal distributed were tested using the statistical shapiro-wilk test with the resultof α> 0,05. The analytical test used Mann Whitney and Chi-Square test.The research indicated that there was a very significant difference of calcium concentration between postpartum the mothers with good nutrition status and the mother chronic energy deficiency with p value = 0.025 (p <0.05). The research also revealed thet postpartum mothers who experienced the decrease of low concentration (median 166.7 mg/L) 7.0 times more risk to experience the deficiency of cronic energy compared to the mother with postpartum good nutrition status.

Hand washing with soap is among the most effective and inexpensive ways to prevent diarrheal diseases and pneumonia, which together are responsible for the majority of child deaths. Routine Surveillance data shows increased morbidity from diseases of poor hygiene and environmental health in Kieni East sub-County, Nyeri County of Kenya. The objectives of the study were to assess hand hygiene, evaluate prevalence of diarrhea, find out relationship between socio-demographic characteristics and state of sanitation and evaluate relationship between hand washing practices and diarrhea diseases. A cross-sectional survey was conducted among 200 household selected randomly between October and November 2017. Additional data was obtained from key informant interviews with facility in-charges and community resource persons. It was found that majority (78%) of the respondents washed their hands after visiting the toilet while 20% washed their hands before preparing food. Whereas toilet facilities had a high coverage (97%), coverage of hand washing facilities was lower (60%). Coverage of hand washing facilities with soap was very low (27%). There was a significant relationship between level of education (p=0.025) and availability of hand washing facilities with soap. Similarly, there was a significant relationship between occupation (p=0.019) and availability of hand washing facilities with soap. There was a significant relationship between households with hand washing facilities with soap (p=0.00) and diarrhea cases reported in the previous 4 weeks. The study concluded that there is poor hand hygiene among residents of Kieni East sub-County. Although majority of respondents recognized the importance of hand hygiene, hand washing was not frequently observed. A sensitization program is urgently required in Kieni East sub-County on hand washing and hand hygiene.