Excess free-radical formation has been hypothesized to contribute to cancer, atherosclerosis, aging, and exercise-associated muscle damage. Antioxidant supplements such as vitamin C, vitamin E, and beta-carotene have been touted as beneficial for enhancing exercise performance and for preventing certain diseases. Before physicians routinely recommend supplements to prevent exercise-associated damage, more study will be required. Recommendations for the prevention of cardiovascular disease and cancer are more complex. Because study results have been contradictory, individual supplement recommendations must be offered with caution. Physicians must be cognizant of which supplements patients are taking and be prepared to discuss risks and benefits. The most beneficial prescription is probably a daily diet containing five to seven servings of fruits and vegetables..Muscular exercise promotes the production of radicals and other reactive oxygen species in the working muscle. Growing evidence indicates that reactive oxygen species are responsible for exercise-induced protein oxidation and contribute to muscle fatigue. To protect against exercise-induced oxidative injury, muscle cells contain complex endogenous cellular defence mechanisms (enzymatic and non-enzymatic antioxidants) to eliminate reactive oxygen species. Furthermore, exogenous dietary antioxidants interact with endogenous antioxidants to form a cooperative network of cellular antioxidants. Knowledge that exercise-induced oxidant formation can contribute to muscle fatigue has resulted in numerous investigations examining the effects of antioxidant supplementation on human exercise performance. To date, there is limited evidence that dietary supplementation with antioxidants will improve human performance. Furthermore, it is currently unclear whether regular vigorous exercise increases the need for dietary intake of antioxidants. Clearly, additional research that analyses the antioxidant requirements of individual athletes is needed

The objective of the study was to observe the various clinical features, histopathological and immunofluorescence findings in patients with autoimmune vesiculobullous disorders. The overall M: F ratio of autoimmune vesiculobullous disorders in the study was 1: 1.4. Trunk was the most common site of involvement in all types of autoimmune vesiculobullous disorders. Overall trunk was the most common site of onset of lesions in autoimmune vesiculobullous disorders but in pemphigus vulgaris mucosal onset is more common than trunk and extremities. Incidence of autoimmune vesiculobullous disorder was 0.11% of the total number of patients attending the skin OPD. Pemphigus vulgaris constituted the most common subtype of autoimmune vesiculobullous disorder in this study, followed by pemphigus foliaceus. Pemphigus group of diseases were most common in the 4th decade while bullous pemphigoid was most common in the 7th decade. Histopathological examination showed features typical of each subtype of autoimmune vesiculobullous disorder.

The purpose of the study was to establish the extent to which school feeding programmes influence performance of learners in primary school education in Baringo County. The study concludes that feeding programs enhance pupil’s participation in class assignment duties and discussion. There are only a few meals provided during the day hence pupil do not fully participate in class work rendering to low performance, the healthy pupils in the center are always active and perform well in the exam and a feeding program is important than other factors towards the improved performance. The findings of this study may be of use to the various primary schools for it would assist them understand better the issues related to school feeding programmes. This would see school managers in the various centres provide learners with balanced feeding programs and create awareness to parents on its importance to proper learning and holistic development of their children. The study would also go a long way to helping the government in making relevant policy to safeguard the wellbeing of primary school learners by providing well-balanced feeding programs to these centres as well as budgetary allocation to the same.

Abstract: The purpose of the study was to find out the effect of specific training on cholesterol among university hockey players. To achieve this purpose of the study, thirty men hockey players were selected as subjects who were from the various faculties, Annamalai University, Annamalainagar. The selected subjects were aged between 19 to 24 years. They were divided into two equal groups of fifteen each, Group I underwent specific training and Group II acted as control that did not participate in any special training apart from their regular sports and games practices. The subjects were tested on selected criterion variable such as cholesterol prior to any immediately after the training period. The selected criterion variable such as cholesterol was to assess body fat monitor. The analysis of covariance (ANCOVA) was used to find out the significant differences if any, between the experimental group and control group on selected criterion variable. The 0.05 level of confidence was fixed to test the significance, which was considered as an appropriate. The result of the present study has revealed that there was a significant difference among the experimental and control group on cholesterol.

India is a tropical country where skin diseases like fungal infections, pyoderma, acne, scabies etc. are very common. A large number of dermatological preparations are available in Indian market but studies on the price variation between commonly used topical brands are lacking. Hence the present study was carried out to obtain information on the price variation among different brands of anti-infective, anti-acne & analgesic topical preparations present in India. Information about dosage forms and prices of different brands of commonly used topical preparations was obtained from Current Index of Medical Specialties & Drug Update. Number of brands, percentage price variation, cost ratio etc for various drugs and combinations were calculated. There were total 206 brands manufactured by 52 different pharmaceutical companies of 35 drugs, out of which 24 showed more than 50% cost variation. Largest price variations were seen with mupirocin 2% cream (408.33 %), tazarotene 0.05% gel (183.8%) and diclofenac diethylammonium 1% gel (650 %) in single drug categories & gentamicin 0.1% + clobetasol 0.05% cream (308.82 %) among all fixed dose combinations. Least variation was observed for salicylic acid 2% foam (4.76 %) and terbinafine 1% + ofloxacin 0.75% + ornidazole 2% + clobetasol 0.05% cream (5.69 %). Cost of drugs play a crucial role in treatment outcome by directly influencing the patient compliance. Hence, it is essential to train physicians about cost variations among different brands available in the market so that they can reduce financial burden of patients without compromising the effectiveness of therapy.

A simple, precise and gradient RP- HPLC method has been developed and validated for Aciclovir raw and in tablet formulation. The proposed method was validated to obtain official requirements including accuracy, linearity, precision, selectivity and stability. The estimation was developed on C(18) column reversed-phase using the mobile phase composition as Phosphate buffer: methanol in the ratio (60:40 %. v/v). 1ml /minute was the flow rate and the maximum absorption were observed at 290 nm using Shimadzu SPD-20A Prominence UV-Vis detector. Aciclovir showed a precise and good linearity, the concentration range was 5-25 μg/mL. The RP-HPLC, assay showed the highest purity ranging 99.59 to 100.97% for Acyclovir tablet formulation. 100.19 % was the mean percentage purity. The Aciclovir retention time was found to be 3.01 minutes. The method accuracy was showed by statistical analysis.

We propose a non-monotone wedge trust region method for derivative-free optimization. Wedge trust region method based on traditional trust region is designed for derivative-free problems, and the non-monotone strategy is efficient to solve the trust region method. This paper combined the non-monotone strategy into wedge trust region methods, and the computational results proved the efficiency of the new composite strategy.

Medicated soaps for external uses are necessary to avoid related infections or diseases caused by some microorganisms. In the present study, four medicated soaps: Dettol, Protex, Dermoviva, and AB+ were investigated for their antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella sp and Candida albicans. Marseille soap was used as control. The antimicrobial effectiveness of selected medicated soaps was determined using paper disc and well methods. Soaps tested in the present research work showed varied levels of activity against the tested microbes. Among them, AB+ was the most active product, while Protex showed the lowest activity against the tested organisms’ species.

Calcitonin is a sensitive tumor marker for medullary thyroid cancer and is useful in preoperative diagnosis and postoperative surveillance for recurrent disease. Rare cases of medullary carcinomas with a normal or undetectable calcitonin levels have been reported in the literature. We present the case of a 46-year-old woman with a metastatic thyroid carcinoma non-secreting calcitonin

This study examines the pattern of stock returns in the Indonesian stock market. Using the GARCH (1, 1) model, the study investigates the effects of day-ofthe-week, month-of-the-year and monthly on the daily return series from January 2003 to August 2008. The study also examines the combined effect of the three anomalies. Overall, stock returns are found to be lower at the beginning of the week but closed higher by the end of the week. The stock returns are also found to be lower during the first quarter of the year but they register higher returns throughout the remaining months of the year, particularly towards the end of the year. The stock returns consistently produced significant positive returns on Wednesday throughout the month of April and May. Although evidence of significant positive returns is also found on other days within certain months, they do not prevail throughout the entire month. They are confined either to the first or second half of the month. The presence of seasonal effects in the Indonesian stock market indicates that market participants have the chance of making significant returns when trading on the specific days of the months. However, the abnormal gains are subject to the transaction cost which is not accounted for in this study.

The purpose of the study was to find out whether school feeding programme affect retention of learners in primary school education. The study was done in 10 primary schools in Mogotio Division. The unit of analysis constituted of 70 respondents (Head teacher/ Heads of school feeding program, Teachers, parent representatives and pupils). Purposive random sampling was used in this case whereby all the 70 respondents were picked to fill the questionnaire. Descriptive statistics analysis was used whereby the SPSS (Statistical Package for Social Sciences) programme is used. On retention, the study concludes that there were transfer cases in the center. Most parents take their children to private schools citing many reasons, which range from poor performance in public early childhood education centres, poor teaching methods, lack of skilled staff in public centres, and to a little extent due to poor feeding habits in the local primary schools. The findings of this study may be of use to the various primary schools for it would assist them understand better the issues related to school feeding programmes. This would see school managers in the various centres provide learners with balanced feeding programs and create awareness to parents on its importance to proper learning and holistic development of their children. The study would also go a long way to helping the government in making relevant policy to safeguard the wellbeing of primary school learners by providing well balanced feeding programs to these centres as well as budgetary allocation to the same.

Employees are the major drivers of any form of business and good employee performance is the most important need for the current competitive business environment to run successfully. Many organisations have started to attach a great emphasis towards the attitudes of workers towards the various instruments they use for performance appraisals. Performance Management and Performance Appraisal are very important tools; it helps to motivate employees to work hard and improves overall company’s productivity. The need to design instruments that motivate the employees through the entire of performance management process cannot be overemphasized.

Dermatoglyphics is the branch of science concerned with the study of prints on the fingers, palm, soles, and feet. This branch of science is an offshoot of anatomical sciences. Dermatoglyphics as an aspect of science has been studied widely by lots of ardent researchers and have been used to solve lots of problems relating to peoples’ identity and ancestry. Although, dermatoglyphics can be studied at three levels (1, 2, and 3) only level 1 (arches, loops, and whorls) have been explored. 99.9% of the works on dermatoglyphics is at level 1 but very few Nigerian indigenous works have been done at level 2 (bifurcations, trifurcations, bridges, ridge ending, enclosures, dots, opposed bifurcations, double bifurcations, island etc). This raises the question, what about level 2 and 3 study? Aim & Objectives: It is possible for one to think that the reason researchers have not dealt extensively on level 2 dermatoglyphics is lack of procedural knowledge and the understanding of the concept. Hence this study was done to explicitly showcase the procedures dermatoglyphics at level 2. Materials and Methods: Data Capture: The use of digital print scanner with very high resolution not less than 9000x4800 dpi (Hp G3110 Scanjet Scanner) which ensures the images are clear and visible. 2)Transfer of Prints: The captured prints are then transferred to a laptop system (computer) via a set of USB cords for examination. 3)Examination of Prints: The prints are assembled into the various categories following the objectives, each print intended to be studied will be zoomed and magnified using the magnification tool in the laptop (computer) for clarity and visibility. I) Make a straight horizontal and vertical line across the print on each finger or toe which divides it into quadrants. II) Examine each quadrant for digital patterns present. Taking note of the morphology of the patterns known. III) Identify and group the patterns seen for each finger or toe. IV) Summation- sum up the patterns for the left and right hands or foot, V) Compute into a statistical tool for analysis. Conclusion: There was marked difference between the males and females in the distribution of the patterns with the females having consistently higher values. Though the females had higher value of the Paul’s Index.

Family planning is widely acknowledged as an important intervention towards achieving Sustainable Development Goals (SDGs) three (4) and five (5) as it has proven to reduce maternal and child mortality. Family planning can prevent unwanted pregnancies and unsafe abortions. The aim of this study was to determine various factors that influence the uptake of modern family planning among women of reproductive age in South-eastern Nigeria. The study used data obtained from Nigeria Demographic and Health Survey (NDHS) 2013. Factors considered were drawn from the dataset. Analysis was carried out using Stata version 12.1. Multivariate logistic regression analysis was used to determine relationship between various factors and use of modern family planning methods. Level of significance was set at 0.05. The total number of participants in the study was 2,816. Twelve point fifty seven percent (12.57%) of the participants were currently using modern family planning methods. The highest proportion of use was 25.57% in Ebonyi State, while the lowest was 16.94 % in Imo State. The only identified predictor of use of modern family planning use was educational status. The women who had at least secondary education were almost twice (1.82 times) more likely to use modern family planning methods than those who had only primary education or less (OR=1.82, 95% CI: 1.4-2.4, P<0.001). Measures should be taken to increase female literacy, as this will most likely lead to improved uptake of modern family planning among the respondents.

Ankylosing spondylitis and rheumatoid arthritis are the most common chronic inflammatory rheumatism. Their localization at the level of the hip stresses severely the functional prognosis. We report a retrospective series of 40 total hip prostheses performed in 32 patients with inflammatory coxitis, collected in the Traumatology and Orthopedics Department at the Mohammed V Military Hospital in Rabat between 2008 and 2016. The average age at the time of the intervention was 42 years with a clear male predominance. All patients were followed in consultation with a clinical and paraclinical examination. Coxitis following ankylosing spondylitis is the most frequently encountered in our series (65.6%). The rating of Postel Merle d'Aubigné was used to assess the functional status of the hip before and after surgery. The total hip prosthesis was cementless in 37 cases and cemented in 03 cases. The clinical results for the 32 patients after a mean follow-up of 04 years were very satisfactory in (88%) of the cases. The objective of this study is to evaluate our functional results and to show the interest of total hip arthroplasty in this type of pathology, in order to improve the quality of life of these often young patients