The aim of the present investigation was to develop controlled release tablet of Abacavir sulphate using. Azadirachta indica (Neem gum) and comparison with official guar gum (BP). Additionally, physiochemical properties of the gum were evaluated. Totally five batches abacavir containing extended release tablets were designed using neem gum / guargum characterized for preliminary trial. Best formulation was selected for optimization by 22 central composite design. In this Input variable were Neem gum/Guargum (X1) and Microcrystalline cellulose (X2). The output variables were Hardness (Y1) friability (Y2) swelling index (Y3) and in vitro release (Y4). The optimized formulations were subjected for inviro-invivo correlation. The study results revealed optimized batch A2 showed hardness of 5.8 kg / cm2, friability 0.63 %, swelling index 84.3% and in vitro release of 90% over the period of 12 h. A higher similarity between optimized tablets and Abamune tablets (Cipla) was established with similarity factors f2 was 50 .7.pH 6. 8 phosphate buffer. Also the in virtro in vivo correlation coefficient obtain from point –point analysis of optimized tablets was 0.98. The optimized tablets exhibit super case 11 mechanism.

The studywas to evaluate the relationshipbetween performance appraisal system and staff retention in Enugu Electricity Distribution Company of Nigeria. The specific objectives include to; examine the relationship between employee’s rate of output produced and employee training. Examine the relationship between employee recognition and achievement of organizational goals. The population consists of 983 staff of Enugu Electricity Distribution Company of Nigeria (EEDC).The study used the survey approach. The primary sources used were the administration of questionnaire to staff. The 274 sample size of the study, the study used the Freund and Williams’s formula. 261 staff returned the questionnaire and accurately filled. The validity of the instrument was tested using content analysis and the result was good. The reliability was tested using the Pearson correlation coefficient (r). It gave a reliability co-efficient of 0.82 which was also good. The hypotheses were analyzed using f-statistics (ANOVA) tool. The findings indicated that there is positive effect relationship between employee’s rates of output produced and employee training F(95,n= 274)= 827.372,P<0.05;This indicates that there is positive effect relationship between employee recognition and achievement of organizational goals F(95,n=274)= 367.439,P<0.05.The study concluded that appropriate training and development programmes would be designed to correct deficiencies through performance appraisal. The study recommended that Performance appraisal should be encouraged in organizations to assists workers and management meets their expected target and Recognition of employees by the management should be a top issue in organization to enable workers gives out their best.

The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in the gastrointestinal tract. The purpose of the research work is to formulate and optimize the gastro retensive film (GRF) containing Propranolol hydrochloride in order to prolong the release time and improve the bioavailability. Five basic gastroretensive films were developed by solvent casting method for preliminary trial . The best formulation was subjected for two factor two level design approach. Independent variables selected were concentrations of Eudragit S 100 (X1) and Eudrajit RL 100 (X2) and dependent variables were Folding Endurance (Y1) Tensile strength (Y2) Elongation at break (Y3) and in vitro drug release (Y4). The results of the study indicate optimized formulation (P2) exhibit folding endurance 114, tensile strength 1.3 kg mm2, Elongation at break 22% and in vitro release 46.5 % for 12h. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion mechanism. The gastro retensive formulations can be used in diseases where an extended release of propranolol is required.

Over the past two decades, gulf cities have been rapidly growing, mainly after the discovery of oil. Large-scale urban projects have been constructed as a result of globalization, which has affected the built environment and the urban fabric of gulf cities. Doha, the capital city of the State of Qatar, has been substantially influenced by globalization. The city has experienced great transformation in its environment since the 1950s, after the discovery of oil. Therefore, Doha has faced the challenge of keeping pace with urban developments that have been increasing and taking over the existing heritage embedded in buildings and traditional neighborhoods. Al-Hitmi is one of the neighborhoods affected by urbanization and sprawling. This research study investigates Al-Hitmi neighborhood and its features, opportunities, constraints, and relationship with the surrounding areas, specifically Qatar National Museum and the Museum Metro Station. The research design is based on the review of the literature, site analysis of the selected case, and surrounding context in order to (1) find opportunities and challenges and (2) to propose a strategy for the urban regeneration of the neighborhood of AlHitmi.

Laryngeal tuberculosis is an extra pulmonary form of tuberculosis and is found in about 2% of all tuberculosis cases. A retrospective analysis of 31 cases of laryngeal tuberculosis was done in the present study extending for 30 years in three Medical Colleges of West Bengal, India. Out of these 31 cases in the study, 20 patients were male and 11 were female with an M: F Ratio of 1.8:1. The age of the patients ranged from 31 years to 59 years. The highest incidence of 45.2% was observed in the age group of 51 to 60 years, followed by 35.5% in the age group of 41 to 50 years and 19.4% in the age group of 31 to 40 years. All the patients presented with hoarseness of voice and cough was the second common symptom. Out of the 31 patients, 9 patients complained of pain in the throat and seven of those had referred earache also. In majority of the cases, the lesions were limited to the vocal cords, arytenoids, and posterior commissure. False cord was involved in 15 cases and ulcer over the arytenoid was found in 14 cases. Patients with lesions involving only the vocal cords, presented with hoarseness of voice, whereas lesions involving the other areas of the larynx, such as arytenoid and aryepiglottic fold presented with odynophagia. Enlargement of the regional lymph nodes was observed in 5 cases out of the total 31 cases. Most of the cases were found during the first 20 years of the study whereas only 4 cases were found during the last 10 years, which could be attributed to the successful implementation of the Revised National Tuberculosis Control Programme in India. However, the emergence of multi drug resistant strain of the causative bacillus and tuberculosis-HIV co infection has complicated the scenario at present. On histopathological examination, tubercular granuloma with stromal hyperplasia, large number of phagocytes and giant cells, epitheloid cells, Langhans cells and typical necrosis with caseation were found. Confirmation of the diagnosis utilizing a proper diagnostic algorithm and treatment with specific Anti Tubercular Drugs (ATDs) are most important in the management of laryngeal tuberculosis.

Over the past three decades, rapid urban sprawl, a changing economy, and shifting demographics have caused rapid developments, which included the urban regeneration of existing neighborhoods. In the 1940s, after oil and natural gas discoveries in the State of Qatar, Doha experienced massive transformations on social, economic, cultural and environmental levels. These transformations have created (A) the need for creating sustainable neighborhoods and (B) raised questions related to how existing neighborhoods can be more sustainable in the future. This study investigates the neighborhood of Msheireb Downtown Doha and the reasons which have caused its urban regeneration. The study investigates (1) practical forms of sustainable urbanism principles by analyzing the Msheireb project and (2) how this urban project can be enhanced according to these principles. The research design encompasses a summary of the literature, the site analysis, structured interviews and a resultant vision of a sustainable concept for Msheireb to define the actions needed to implement the sustainable neighborhood concept. The findings reveal that, comparing the image of old Msheireb with the current regenerated one, the later neighborhood is compact, pedestrian-friendly and mixed use, which in turn encourage people to engage and promote a higher level of social interaction and therefore, contribute to enhancing the urban livability of the neighborhood.

Thymomas are among the most common anterior mediastinal tumors that can uncommonly present with respiratory failure. This case – A 62 year old lady who presented with complaints of limb weakness and the development of type II respiratory failure, discusses in detail the problem posed and the workup leading to the diagnosis. Surgery was performed based on the radiological findings. The tumor was completely resected and the diagnosis given as Masoka classification‑Type B2-predominantly cortical thymoma

Anacyclus pyrethrum L. root is one among the ingredients of polyherbal formulation frequently employed for the treatment of stress by Ayurvedic practioners. So, the objective of this study was to scientifically validate its use. Animals were administered graded doses of ethanolic extract of Anacyclus pyrethrum root and subjected for anoxia stress tolerance test, swimming endurance test and acetic acid induced writhing test models and its adaptogenic potential was assessed by estimating various parameters. Stressed animals demonstrated altered values of these parameters. Ethanolic extract of Anacyclus pyrethrum root exhibited significant anti-stress activity by restoration of all the altered values. Present findings validate its use in Aurvedic system of medicine.

This study’s aim was to establish the relationship between peer pressure and high-risk sexual behavior among high school students in Kenya. Twenty-eight students were sampled per school from form 1 to 4, which summed to 138 students in Nakuru East Sub County. Primary data was gathered from the 138 students through a structured questionnaire. Interviews were conducted to the school head teacher. Only 120 respondents were able to fill in the questionnaires.This meant that the response rate was 87.6%. The focus group discussions were done successfully as well as the interviews scheduled with the head teachers. Quantitative data was analyzed through statistical package for social sciences (SPSS) using cross tabulation and chi-square to determine response frequency and percentage. Cross tabulation was used to analyze the variables using tables and was supported by qualitative data. The Pearson Chi Square was 0.00 indicating that peer pressure influenced high-risk sexual behavior among high school students in Nakuru East Sub County, Kenya. The study found that peer pressure influenced the students’ decisions on sex and relationships. The study concluded that peer pressure was an influence to high-risk sexual behaviour among high school students and the youth in general. It influenced the decisions they made on dating, sexual relationships, and sex. The study recommended that sex education should be included in the curriculum in order to help the students on gaining knowledge on life skills.

This study aims to analyze Corporate Social Responsibility (CSR) policy implementation on Semen Bosowa Maros (SBM) Ltd. in promoting community empowerment in Baruga village. The study took place in the area of operation of SBM Ltd. in Baruga village applying qualitative research with a case study approach. Sources of data in the study consisted of primary and secondary data. The result of analyzed CSR policy implementation research SBM Ltd. in the village Baruga based on the content and context of the policy suggests that the implementation of CSR policies SBM Ltd. still dominantly implemented in the form of charity and humanitarian assistance (charity and philanthropy) But in the form of a sustainable community empowerment must increasingly be made enterprising and enhanced to promote to be more capable of establishing communities’ independency, welfare, and empowerment around the company's operations, in particular Baruga village community.

Access to justice suffers a number of challenges and results to ineffective functioning of the justice system. Despite the existence of empirical studies on strategy implementation and strategic planning in the Judiciary, no research has been carried out on the effect of case management on access to justice. The population of the study comprised one hundred and thirty five respondents being magistrates, Judicial staff, Office of the Director of Public Prosecutions (ODPP) counsels, advocates, police and prison services, children and probation officers based in Molo Law courts. The study used the descriptive research design. Stratified proportional sampling was used to categorize various stakeholders into strata and determine the number of participants that would be selected from each stratum. Simple random sampling was used to select individual respondents from each stratum. Primary data was collected by use of questionnaires, where quantitative data was analyzed using both descriptive and inferential statistics specifically Spearman correlation analysis, while qualitative data was analyzed using thematic analysis. The study targeted to collected data from 94 individual but only 72 were able to complete and return their questionnaires to the researcher. From the study findings, the values of Spearman correlation coefficient were r = 0.735 for case management. This implies that the way case management is handled is an important determinant of whether there will be access to justice or not.

This study assessed the influence of outbound logistics on retail marketing at Naivas Supermarket. The purpose of the study was to rate and appraise the success of company’s outbound logistics process by rating the success of transport logistic activity based on the supermarket retail marketing. The objective of the study was to assess how transportation affects outbound logistics of retail marketing at Naivas Supermarket. The study was informed by the organizational theory. The study utilized the descriptive research design. Purposive sampling was used to get a sample of 45 respondents who included the regional managers, branch managers, stock co-coordinators, floor supervisors and shelf stockers out of which 39 completed the study. The study collected both quantitative and qualitative data using both questionnaires and interviews. The research will collect and analyze both qualitative then quantitative data to get results of this research. Quantitative data was analyzed using descriptive statistics mainly frequencies, percentages, and the Pearson chi-square while qualitative data was analyzed using the thematic technique. Findings reveal that Naivas Supermarket generally employs a centralized transportation where the company is directly involved in managing logistic services rather than outsourcing this function to third parties. The analysis of outbound logistics transportation had an effect (mean=8.9667). The chi-square test established that outbound logistics transportation (X2= 12.208, p= 0.043). The study recommends that to improve retail marketing, the supermarket should automate the process of loading and offloading goods before and after transportation.

Teh Botol Sosro, produced by PT. Sinar Sosro, is the first brand of ready-to-drink tea in Indonesia that has been developed and maintained for decades. The number of competitors make Teh Botol Sosro remains firm in fighting in the ready to drink tea market. This study aims to analyze the effect of product quality on partial purchase decisions, price on partial purchase decisions, promotion on partial purchase decision, brand awareness on partial purchase decisions, and product quality, price, promotion and brand awareness simultaneously. The population of this research is visitor of Giant Mall Permata Tangerang. While the sample is the respondents who buy Teh Botol Sosro. The average visitor who bought Teh Botol Sosro at Giant Mall Permata Tangerang was 1,200. Thus obtained respondents to be observed with the Slovin formula is 100 respondents. Quantitative analysis method using multiple linear regression analysis, followed by determination analysis (R Square), partial hypothesis testing (t test) and simultaneous (F test) with alpha 5 percent (0,05). Prior to further analysis, data quality and classical assumption test are done. Analytical tool using SPSS version 23.0 for windows. The result of this research shows that product quality has partially influence on Purchase Decision, price has partially influence on Purchase Decision, promotion has partially influence on Purchase Decision, brand awareness has partially influence on Purchase Decision, and product quality, price, promotion and brand awareness have simultaneously influence on Purchase Decision of Teh Botol Sosro product at Giant Mall Permata Tangerang. There are still other factors that affect the Purchase Decision, therefore it still needs further research.

This study aims to examine and analyze the influence of motivational leadership and compensation on employee performance of PT XYZ. The sampling method used is a saturated sample. The population is 47 employees and the samples are all employees. The method of analysis used in this study is multiple linear regression. The results showed that leadership, motivation and compensation simultaneously have a significant effect on employee performance. Partially, leadership and motivation have a significant positive effect on performance. Motivation and compensation have a significant positive effect on performance.

The oropharyngeal aerobic gram-negative bacillary carriage, uncommon in healthy people, is high in patients with head and neck cancer. A marked increase in oral Gram-negative enterobacteria and pseudomonads has particularly been shown during the period of radiation therapy. The aim of the study was to determine whether these bacteria could play a role in the causation of irradiation mucositis. The current study demonstrated that aerobic and facultatively anaerobic gram-negative rods and cocci and Gram-positive bacteria showed a marked increase in head and neck–irradiated subjects. There was a weak but non-significant correlation between the bacterial flora and oral mucositis.