Optimal management sequence for the primary tumor and the liver in synchronous colorectal liver metastases (SCLM) is still controversial. Except reviews, studies comparing the 3 surgical approaches are infrequent. The present study aimed to describe the surgical management of patients operated of SCLM. In particular, we compared short-term outcomes and survival according to the surgical strategy. A multicentric retrospective study was conducted on 125 patients with SCLM. Surgical strategy was defined as classic (colorectal first approach), combined and reverse (liver-first approach). Between 2008 and 2013, 87 patients completed the classic strategy, 24 combined strategy and 14 reverse strategy. The 3 groups were comparable regarding pre-operative data. Liver metastases involvement was significantly higher in reverse group. Severe cumulative postoperative morbidity was 39.2%, similar between the 3 strategies. Ninety-day mortality was higher in combined group (12.5%, p>0.05). Failure rate of liver first approach was 17%. The 3-year overall survival (OS) was 73% in classic group, 78% in combined group and 93% in reverse group. The 3-year disease free survival (DFS) was 29%, 30% and 19% for classic, combined and reverse strategy respectively. There was no significant difference with regard to OS and DFS between 3 groups. We demonstrated that liver first approach is safe and feasible with acceptable perioperative and survival outcomes despite initially worse prognostic criteria. Reverse strategy can be applied to a vast majority of patients independently to the liver tumor burden and should be considered progressively as a reference in the management of SCLM

Ocular diseases have been documented as the most common health problems universally. Most of the chemicals and synthetic drugs currently in use have marked side effects. Hence, there has been an ideal shift from the use of modern drugs to the age old herbs. Randia dumetorum Lamk is one such important plant with various established medicinal properties. The aim of the present study was to evaluate the preliminary antibacterial activity of methanolic extract of Randia dumetorum Lamk. (Xeromphis spinosa Thumb) Against common ocular pathogens such as Serratia marcescens, S. agalactiae, Corynebacterium macbinleys and Propionibacterium acnes. Methanolic extract of the dried fruits of the plant was prepared. Different concentrations of the dried fruit extracts (R. dumetorum) were transferred to the nutrient agar plates, which had been previously inoculated with the test microorganisms. The plates were incubated at 37°C for 24 h in an incubator and the zones of inhibition were measured using well diffusion method. The extract showed potential antibacterial properties comparable with that of the standard streptomycin against the organisms tested. The methanol extract of R. dumetorum displayed a concentration related antibacterial activity. The results showed that the inhibition of the bacterial growth was more pronounced on Corynebacterium macbinleys as compared to the other tested organisms

The current clinical study was planned to assess the efficiency of Jeemootakaphala Avapeedaka and Pradhamana Nasya in Kosthashakhashrita kamala. The study was completed on 30 patients diagnosed with Kosthashakashrita kamala of either sex, among the age faction of 20 to 60 years who were arbitrarily chosen. The patients were categorized into 2 groups i.e Group A & group B. Jeemootaka phala Avapeedaka Nasya was given to group A, while Jeemootaka phala Pradhamana Nasya was administered in group B. The dosage of Nasya was -1.5 ml in every nostril in group A, 65 mg in every nostril in group B. The evaluation was made before the treatment and after treatment. Patients were followed up after 7 days of Nasya. Hence whole study period was 15 days. Both Nasya showed considerable improvement in Kosthashakhashrita kamala. Clinical efficiency of group A was better than to group B however statistically both groups showed similar efficacy.

The aim of this study was to examine the effect of leadership style, organizational culture, and achievement motivation toward qari’ (man reciter of al-Qur’an) and qari'a (woman reciter of al-Qur’an) organizational commitment at LPTQ (The Institution for the Development of Tilawatil Qur'an) in Riau islands area. This research particularly was conducted separately on three parts of region namely; in the center, Province of Riau Islands (City of Batam); in the western region (Karimun Regency); and in the eastern region (Tanjung Pinang City). Survey method applied in this study along with path analysis used in hypothesis testing. The total of respondents amounted to 204, but only 186 in a number of respondents who returned the sheet of questionnaires. The total respondents for trials were as many as 30 participants. Each region was represented by 10 respondents, Alpha Cronbach formula used in these trials. The results revealed that there were a positive influence and significant: 1) Leadership style on qari' and qari's Organizational Commitment. 2) Organizational Culture on qari' and qari's Organizational Commitment. 3) Significant Leadership style on Achievement Motivation. 4) Leadership style, Organizational Culture on Achievement Motivation. 5) Leadership style, Organizational Culture and Achievement Motivation towards qari’ and qari'a Organizational Commitment in Riau Islands. The study concluded that: There were direct influences of leadership style, organizational culture and achievement motivation towards the organizational commitment of qari’ and qaria’. Based on the calculation of path analysis obtained Fobtained (24,69) > Ftable (2.67). So H0 was rejected and Hi was accepted. It meant that the style of leadership, organizational culture, and achievement motivation gave a significant influence on the commitment of the qari and qari’a organization.

Taking the position that writing can be an important skill to foster knowledge building pedagogy; this article explores reading news through mobile applications as a supportive tool for this purpose. Fifteen language learners as participants of the experimental group used two popular news applications on their mobile phones for reading as a pre-task activity that made them outperform their counterparts in the control group in terms of using facts in essays. No significant difference, however, was observed in the overall writing ability of two groups despite considerable progress of the variable content in the experimental group’s favor.

Calcitonin is a sensitive tumor marker for medullary thyroid cancer and is useful in preoperative diagnosis and postoperative surveillance for recurrent disease. Rare cases of medullary carcinomas with a normal or undetectable calcitonin levels have been reported in the literature. We present the case of a 46-year-old woman with a metastatic thyroid carcinoma non-secreting calcitonin

This research investigates the impact of the global financial crisis on the performance of Nigerian stock market from 2004 to 2013. The main aim of the research was to examine the impact of global financial crisis on the performance of the N.S.E. Data for this research was sourced from a secondary source. The data were statistically analyzed using descriptive analysis and Kruskal-Wallis H test statistical tools. The analysis showed that Global Financial Crisis has no significant effect on Market Capitalization, value and volume of shares traded on the floor of the N.S.E. From the analysis, the researcher concludes that Global Financial Crisis has no significant effect on market capitalization, value of shares traded and the volume of shares traded in Nigerian stock exchange.

Solid lipid nanoparticles (SLNs) are at the rapidly developed field of nanotechnology with a few potential applications in drug delivery, clinical medication and research, and additionally in other distorted sciences. Because of their small size-subordinate properties, lipid nanoparticles offer the likelihood to grow new therapeutics. The capacity to loaded drugs into nanocarriers offers another model in drug delivery that could be utilized for optional and tertiary levels of drug targeting on. Consequently, SLNs hold extraordinary advantage for achieving the objective of controlled and site specific drug delivery and henceforth have pulled in wide consideration of analysts. The current review describes the role of solid lipid nanoparticles on the pharmacokinetics of poorly soluble antihypertensive drugs. In the event that suitably examined, solid lipid nanoparticles may open new areas in treatment of hypertension with improved oral delivery

The objective of the study was to observe the various clinical features, histopathological and immunofluorescence findings in patients with autoimmune vesiculobullous disorders. The overall M: F ratio of autoimmune vesiculobullous disorders in the study was 1: 1.4. Trunk was the most common site of involvement in all types of autoimmune vesiculobullous disorders. Overall trunk was the most common site of onset of lesions in autoimmune vesiculobullous disorders but in pemphigus vulgaris mucosal onset is more common than trunk and extremities. Incidence of autoimmune vesiculobullous disorder was 0.11% of the total number of patients attending the skin OPD. Pemphigus vulgaris constituted the most common subtype of autoimmune vesiculobullous disorder in this study, followed by pemphigus foliaceus. Pemphigus group of diseases were most common in the 4th decade while bullous pemphigoid was most common in the 7th decade. Histopathological examination showed features typical of each subtype of autoimmune vesiculobullous disorder.

Ankylosing spondylitis and rheumatoid arthritis are the most common chronic inflammatory rheumatism. Their localization at the level of the hip stresses severely the functional prognosis. We report a retrospective series of 40 total hip prostheses performed in 32 patients with inflammatory coxitis, collected in the Traumatology and Orthopedics Department at the Mohammed V Military Hospital in Rabat between 2008 and 2016. The average age at the time of the intervention was 42 years with a clear male predominance. All patients were followed in consultation with a clinical and paraclinical examination. Coxitis following ankylosing spondylitis is the most frequently encountered in our series (65.6%). The rating of Postel Merle d'Aubigné was used to assess the functional status of the hip before and after surgery. The total hip prosthesis was cementless in 37 cases and cemented in 03 cases. The clinical results for the 32 patients after a mean follow-up of 04 years were very satisfactory in (88%) of the cases. The objective of this study is to evaluate our functional results and to show the interest of total hip arthroplasty in this type of pathology, in order to improve the quality of life of these often young patients

Employees are the major drivers of any form of business and good employee performance is the most important need for the current competitive business environment to run successfully. Many organisations have started to attach a great emphasis towards the attitudes of workers towards the various instruments they use for performance appraisals. Performance Management and Performance Appraisal are very important tools; it helps to motivate employees to work hard and improves overall company’s productivity. The need to design instruments that motivate the employees through the entire of performance management process cannot be overemphasized.

This complete enumeration, cross-sectional comparative record-based study was conducted at a municipal medical college in Maharashtra state, India. First-year MBBS students undergo formative assessment (one terminal examination and one preliminary examination) before they appear for First MBBS University examinations (summative assessment). Marks scored by the First-year MBBS students in terminal and preliminary practical examinations during the seven year period (2011-2017) were statistically analysed. In the terminal practical examination, the gender difference in the average marks scored in terminal practical examinations was statistically significant (Z=2.226; p=0.026) only for Batch 2013, while in the preliminary practical examination the gender difference was statistically significant for Batch 2011 (Z=2.094; p=0.036) and Batch 2017 (Z=2.139; p=0.032). The marks obtained in preliminary practical examination exhibited less variability as compared to that in the terminal practical examination. This study may serve as a springboard towards further research on student assessment in the subject of Physiology

Abstract: The purpose of the study was to find out the effect of specific training on cholesterol among university hockey players. To achieve this purpose of the study, thirty men hockey players were selected as subjects who were from the various faculties, Annamalai University, Annamalainagar. The selected subjects were aged between 19 to 24 years. They were divided into two equal groups of fifteen each, Group I underwent specific training and Group II acted as control that did not participate in any special training apart from their regular sports and games practices. The subjects were tested on selected criterion variable such as cholesterol prior to any immediately after the training period. The selected criterion variable such as cholesterol was to assess body fat monitor. The analysis of covariance (ANCOVA) was used to find out the significant differences if any, between the experimental group and control group on selected criterion variable. The 0.05 level of confidence was fixed to test the significance, which was considered as an appropriate. The result of the present study has revealed that there was a significant difference among the experimental and control group on cholesterol.

A combination of ethinylestradiol and drospirenone is used as an oral contraceptive and also for the treatment of premenstrual dysphoric disorders, acne and hirsutism. In this study, a derivative spectrophotometric method has been developed and validated for the simultaneous determination of drospirenone and ethinylestradiol. First order derivative spectrum was used for the determination of ethinylestradiol at 211 nm and drospirenone at 298 and 302 nm. The developed method was linear over the concentration range of 0.25-2.5 μg/mL and 20-200 μg/mL for ethinylestradiol and drospirenone, respectively. The within-day and between-day precision and accuracy were acceptable for both compounds (CV<2.5% and error<2.4%). The proposed method was used for simultaneous determination of ethinylestradiol and drospirenone without any separation before analysis

This research aims to determine the effect of emotional intelligence, complaining behavior and job satisfaction on the performance of employees. The object of this research is the employee at the office of Dinas Penanaman Pelayanan Modal Terpadu Satu Pintu Kota Tangerang Selatan. This research was conducted on 86 respondents by using quantitative descriptive approach. So the data analysis used is statistical analysis in the form of multiple linear regression test. The results of this study indicate that partially and simultaneously, emotional intelligence, complaining and job satisfaction have significant effect on employee performance at the office of Dinas Penanaman Pelayanan Modal Terpadu Satu Pintu Kota Tangerang Selatan.