Cefotaxime is a 3rd Generation Cephalosporin and mainly acts by binding to penicillin-binding proteins and inhibits final transpeptidation step of peptidoglycan synthesis, resulting in cell-wall death; resists degradation by beta-lactamase; proper dosing and appropriate route of administration are determined by condition of patient, severity of infection, and susceptibility of microorganism. Indicated in the various conditions like Gonococcal Urethritis/Cervicitis, Gonorrhea, Rectal, Infections Caused by Susceptible Organisms, Prophylaxis of surgical infection. A child of 5 years old of male patient came to pediatrics department with chief complaints of seizures and admitted in pediatrics department-II and his treatment chart was phenytoin 100mg PO BD and valproic acid 200mg – 200 mg – 300 mg Po OD. During his second of treatment child developed fever of 1020F and to reduce the condition physician prescribed cefotaxime 500mg BD IV on 4th day of treatment child developed macular rash all over the body. Better vigilance is necessary for implementation of safe and effective treatment for each individual patient.in order to prevent serious adverse drug reactions of this drug,close monitoring drug treatment course, creating awareness, recognition of the problem and careful management of all the patients who receive medication are essential, because use of cefotaxime causes Colitis, Diarrhea, Elevated blood urea nitrogen (BUN) and creatinine, Elevated hepatic transaminases, Eosinophilia, Fever, Injection site pain, Nausea, Pruritis, Rash, Thrombocytopenia, Transient neutropenia, Vomiting.

Education is a key component of a country’s developmental process. Inclusive education is a kind of education wherein all students including special needs (SN) learners attend and are welcomed by their neighborhood schools in age– appropriate regular classes and are supported to learn to contribute and participate in all aspects of life at school. Neighborhood public schools being at the heart of our communities are essential for quality inclusive education system. Special Needs learners who can benefit from public schools should not be denied the chance to access education nor be taken to special schools. However, inclusive education has been experiencing challenges which may undermine the program’s objectives if not well addressed. The extent to which these challenges could be impacting negatively on inclusive education policy in Kitale Township is however not clear. This is the gap to be filled. The Social Learning Theory guided the study. The study adopted descriptive research design. Questionnaires, interview schedules, and observation checklists were employed in data collection. The target population was 36 head teachers in the public primary schools in the township and 50 SN teachers. The sample size was 76 respondents selected using purposive and simple random sampling. Validity of data collection tools was determined through pilot study and assistance from supervisors. Reliability was tested using the test - retest method and the obtained value was .92. Hypotheses were tested using regression analysis at .05 level of significance. The study found that curriculum factors, teacher attitude, and social interaction had a significant influence on effective implementation of inclusive education policy. The study, therefore recommends more teachers to be employed to handle the large classes, the TSC to consider teachers handling SN learners in inclusive settings for special duty allowances being given to their counterparts in special schools and the curriculum to be evaluated to enhance effective implementation of inclusive education. In addition, review should be done on the part of funding to enable the acquisition of physical facilities and learning materials in public primary schools. Finally, parents, local communities and other education stakeholders should be educated on their roles in the implementation of inclusive education.

Hydroquinone (HQ) and clobetasol 17-propionate (17PC) are two medicinal agents commonly incorporated because of their skin bleaching properties into lightening cosmetics sold out in some sub-Saharan regions (Senegal, Togo, South Africa, Cameroon…). The aim of this study was to quantify these agents in lightening creams and body lotions marketed in Douala, the economic capital city of Cameroon. A preliminary investigation was carried out at the main cosmetics sales outlets (pharmacies, perfumeries and supermarkets) of the city, in order to come out the overall proportion of lightening cosmetics and to inventory the mainly bleaching agents listed as ingredients in these products. About forty lightening creams and body lotions were purchased and then analyzed in other to come out their respective hydroquinone and 17PC concentrations. The results have revealed a compliance rate of 79%, with 47.5% of the samples containing hydroquinone at a higher concentration than the one allowed in cosmetics (≤ 2%). Clobetasol 17-propionate, forbidden in cosmetics, has been identified in all the samples with 77.5% having a dosage above the 0.05% accepted medicinal creams, what may lead to systemic repercussions when used chronically.

In the recent days Internet has become an essential part of life. It has revolutionized communications, to the extent that it is now our preferred medium of everyday communication. In almost everything we do, we use the Internet. Chronic usage of internet affecting physical health conditions like weight gain etc., and this is causing the greatest problems among the young individuals. The main purpose of this study is to study the relationship between internet usage frequency in the University students on our GITAM University students with their BMI. The present study consists 100 Medicine students which were differentiated as males and females (43 Males and 50 Female students). Some of the students who are not responding for all the questionnaires are excluded (07 Students). Different questions were asked to the students in the class environment. A significant association was found between BMI and the intense internet usages (>5-7hrs/daily), with F value 3.55 and p value <0.05. Out of 93 students, 15 students with high internet usage (>5-7hrs) and 31 students with moderate internet usage (3-5hrs) showed positive correlation between increased internet use and obesity.

The deleterious association of non-bone consolidation and septic complication is a therapeutic challenge for orthopedic surgeons. Tibial fractures are a source of high rates of nonunion and septic and cutaneous complications. Here we present the case of a 56-year-old patient with a history of vascular, cardiac and obstructive post-smoking bronchopneumopathy who presented septic pseudarthrosis of the left tibial pilon with cutaneous complications and whose treatment consisted of , initially in an induced membrane technique, associated with a cutaneous cover by a lateral fasciocutaneous flap of the thigh and an osteosynthesis by a Hexapodal external fixator type True Lock. During the second stage, the bone graft was removed by endomedullary boring of the contralateral femur using the device named Reamer-Irrigator-Aspirator, and the stems of the external fixator were replaced by other rods allowing adjustment multiplicane and thus a gradual three-dimensional reduction as the consolidation progresses.

In reference to theNational Standards of Teaching Quality for Undergraduate Business English Majorsissued by the Chinese Ministry of Education, this article holds that the publishing of Business English Reading textbooks should emphasize the following five aspects: 1) reflecting the requirements for talent cultivation in theNational Standards; 2) compiling textbooksbased on the principleof "theme plus interaction"; 3) giving consideration to the "integration of course and certificates"; (4) building multi-modal and three-dimensional teaching materials; and 5) enhancing cooperation of publishers, schools and industries. This research result can also give reference to the publishing of other teaching materials.

The retro-lunar carpal dislocations are often under-diagnosed in the emergency services by the lack of knowledge of the pathology. The modalities of taking care of the lunations are still discussed; if the surgical treatment is now unanimous because it alone can limit residual carpal instability, bone necrosis or osteoarthritis. Many remedial techniques have been proposed, although controversial, the authors agree that a maximalist open-minded attitude gives the best results. Our work presents the results of a retrospective series of 12 cases of retro-lunar carpal dislocations. We will discuss the epidemiology of this condition, the different types of lesions, therapeutic modalities.

Being an embodiment of education philosophy and campus culture, university mottoes show the education objectives and school-running philosophy through their refined words and well-structured sentences. Present researches on E-C translation of mottoes help domestic university to go global. However, most of them are done from the perspective of linguistics, which, to some extent, weakens the importance of the functions of university mottoes. To view the translation of university mottoes from a different way and tackle problems that occur in the translation, this thesis, under the guidance of Skopos theory, makes an analysis on the features of Chinese university mottoes and overseas university mottoes and looks into translation techniques.

With an objective to develop some potent, novel and less side effect having antitubercular agents here we have synthesized a series of substituted/ unsubstituted 2-phenyl tetrahydroquinoline derivatives (IIa-g). These were obtained by the reaction between substituted 2-phenyl-1, 2, 3, 4- tetrahydroquinoline and sulphur in acetonitrile. Structure of the newly synthesized compounds were confirmed on the basis of physico-chemical and spectral data (IR, 1H NMR, 13C NMR and Mass). All the synthesized compounds were screened for their antitubercular activity using Microplate Alamar Blue Assay (MABA) method. Among the synthesized compounds II b, II e and II g have shown significant antitubercular activity.

This thesis deals with the merge operation in the four types of languages in the world, namely internal merge of displaced wh-words or wh-phrases in Single Filled Spec Languages, Multiply Filled Spec Languages, and Non-multiply Filled Spec Languages, and external merge of in situ wh-words and wh-phrases in Null Spec Languages. The universality of merge in the wh-questions proves that merge is a biologically based operation.

Normal-Phase High Performance Liquid Chromatography method was developed for determination of Rapamycin, Temsirolimus Regio isomer (monoester) and Temsirolimus diester in Temsirolimus drug and pharmaceutical formulations. The separation was accomplished on YMC Pack SIL (250 x 4.6 mm, particle size 5μm) column under isocratic mode. The column oven temperature was set at 35° C and Auto sampler temperature used at 5°C. The mobile phase is a mixer of n-hexane, ethanol and trifluoroacetic acid in the ratio of 90:10:0.01 and PDA detector set at 280 nm used for detection. The retention times of Rapamycin, Temsirolimus peak, Temsirolimus monoester and Temsirolimus diester peaks are 12.29, 21.24, 33.11 and 51.91 min. respectively. The method has been fully validated and is linear. Results of analysis are validated statistically and by recovery studies. During the process development of Temsirolimus, three process impurities (Rapamycin. Temsirolimus monoester and Temsirolimus diester) are detected by high performance liquid chromatography (HPLC). This method offers advantages over using photodiode-array UV detection (LC-PDA) for the determination of peak purity, namely components with similar UV spectra can be distinguished, the molecular mass of the impurity can be determined, and structural data can be obtained by using LC-MS. The result of studies shows that the proposed normal phase-HPLC method is found to be precise, linear, accurate, rugged, selective, specific, and robust. Hence this method may be used for the routine analysis in bulk drug and in its pharmaceutical dosage forms.

Teaching and learning of English vocabulary are the most basic parts in the whole process of English acquisition. Based on the result analysis of an extensive on-line questionnaire about the vocabulary teaching situation among some Chinese and foreign teachers, this paper points out the existing problems in college English vocabulary teaching and learning. The corresponding vocabulary learning strategies are proposed to stimulate students' interest in English vocabulary learning, enhance the flexibility of vocabulary learning and use, and thus improve the effect of English vocabulary teaching and learning.

The volatile compound composition of food provides an indication of the benefits that this food can provide to the consumer. Thus the present study aimed at identifying the bioactive compounds present in formulated fermented diet made from 20% red kidney bean (Phaseolus vulgaris L.), 60% mung bean (Vigna radiate), 10% irish potato (Solanum tuberosum), and 10% ripe fresh papaya (Carica papaya) fruits inoculated with different concentrations of Lactococcus lactis sp. (Lc. lactis sp.) strain using the Gas Chromatography- Mass Spectrophotometer (GC-MS). The formulated diet consisted the control diet containing no lactic bacteria, diet 1 (1 × 106 CFU/ml), and diet 2 (2 × 106 CFU/ml). The results of the GC-MS revealed the presence of twenty volatile compounds in each diet. Five compounds namely Benzyl Alcohol; 2-propyl-1-pentanol; 1,3-diethyl benzene; 1-Tridecyn-4-ol; Phthalic acid, and cyclobutyl isobutyl ester were identified in all diets. Three volatile compounds namely Benzyl alcohol, 2-propyl-1-pentanol, and 1,3-diethyl benzene were identified as the dominant compounds in control; whereas two (Phthalic acid, cyclobutyl isobutyl ester, (E)-9-Dodecenoic acid, methyl ester) and three more (9.12-Octadecadienoic acid, methyl ester; 9-Octadecenoic acid (Z) -, methyl ester, and Tetradecanoic acid, 10,13-dimethyl-, methyl ester) bioactive compounds were detected in diet 1 and diet 2 respectively. Benzyl alcohol was the principal dominant bioactive compound in all the diets. The present study indicates that inoculation and increasing in the concentration of lactic bacteria in diet led to the identification of 2 and 3 other major volatile compounds with biology activities which could be highly important in pharmacology and nutraceuticals.

This study was conducted to: 1) Conduct a feasibility test for developingaccounting learning through media and accounting teaching materials. 2) Implement or implement a model in accounting learning in class. 3) Evaluate accounting learning as a student performance measurement tool. This study uses "Research and development methods or R&D cycles, which are carried out in two years. Qualitative data methods use descriptive analysis. Based on observation results indicate that student-learning activities tend to only listen to lecturers' explanations, record and work on problems. For that diverse and innovative learning activities are needed. For this purpose, instructional materials and learning media are designed through 1) expert review 2) small group trials and 3) Field trials using experiment methods through initial test and final test. And the results of trials from small groups and field tests, will be made improvements in the design of teaching materials and learning media. The instruments used in this study are questionnaires. The targeted results are the implementation of accounting learning models with ADDIE models, with teaching materials, and learning media interesting and interactive accounting if to improve the quality of accounting learning. Therefore, the need for innovation in learning accounting through the ADDIE model to assist lecturers, in creating effective, efficient, and attractive learning programs so that the results of introductory learning accounting can be achieved.

A simple, precise, and rapid ultra-performance liquid chromatography (UPLC) method for the determination of fluoxetine level in human plasma using clomipramine as an internal standard (IS) was developed and validated. Plasma samples containing fluoxetine were spiked with the IS and extracted with hexane and iso-amyl alcohol (98:2,v:v) under alkaline condition. Extracted samples were kept at –80ºC for 10 minute then organic layers were transferred to clean tubes and dried under gentle steam of nitrogen at 40 °C. Residues were reconstituted in 200 µl of 0.05% phosphoric acid and 10 µl were injected in to the UPLC system. The compounds of interest were efficiently separated on 2.1 x 100 mm, Acuity UPLC, C18, steel column (at 30°C) and detected with a photodiode array detector set at 230 nm. The mobile phase consisted of water (pH= 2.4, adjusted with phosphoric acid) and acetonitrile (68:32, v:v) and was delivered at a flow rate of 0.3 ml/minute. No interference in blank plasma or by norfluoxetine or commonly used drugs was observed, and the detection limit of fluoxetine was 0.005 µg/ml. The relationship between fluoxetine concentration in plasma and peak height ratio of fluoxetine /IS was linear (R2 ≥ 0.985) in the range of 0.01 –1 µg/ml. Inter-day coefficient of variation and bias ≤ 13.0%, and < 9.4, respectively. Extraction recovery of fluoxetine and IS from plasma samples was ≥ 87%. Using the method, fluoxetine was found to be ≥ 85% and ≥ 89% stable in processed (24 hours at room temperature or 48 hours at -20 °C) and unprocessed (24 hours at room temperature or 23 weeks at -20 °C) samples, respectively.