CHKV is a re-emerging arboviral disease. Increase incidence is seen in many parts of India. This study was done to see the trends over a period of 10years. A total of 3676 samples were studied. Their demographic data and CHIK antibody detection was detected. This data was analyzed in 2 half’s of 5 years each. Over 10 years, 368 were positive for CHIK IgM ELSIA. Majority were females. Age group affected was middle age. Over the 10 years the disease was seen in all seasons of the year. There were no deaths seen due to CHKV infection. CHKV infection has high morbidity but is a self limiting disease and vector control is the only prevention.

Helicobacter pylori (H. pylori) is a gram negative bacterium that naturally colonizes the gastric epithelium, which causes chronic gastritis and peptic ulcer disease. Recent studies have shown that it may interfere with many biological processes and influence the occurrence of many diseases outside the stomach. Many studies have proposed a link between H. pylori infection and atherosclerosis. Atherogenic Index of Plasma (AIP) has been considered as a strong marker to predict the risk of atherosclerosis. The present study was done to assess the correlation between AIP and other lipid indices with H. pylori infection. The study comprised of 50 biopsy proven H. pylori cases and 50 age-sex matched controls. Blood samples were collected in fasting state and analyzed for total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL) and LDL-cholesterol and the lipid indices were calculated. Lipid indices like AIP, CRI 1 & 2 & AC were significantly higher in H. pylori infected cases compared to controls. Hence these lipid indices can be used for identifying individuals at higher risk of cardiovascular diseases in H. pylori infected patients.

Background: Malnutrition is a general term and often refers to under nutrition resulting from inadequate consumption, poor absorption, or excessive loss of nutrients, but the term also encompasses over nutrition. Aim of the Study: Aim of the study was to find out the clinical profile and major co-morbidities among hospitalized children with severe acute malnutrition at a tertiary care hospital. Methods: A prospective observational study was conducted in the Department of Pediatrics, Khulna Medical College and Hospital, Khulna, Bangladesh, over one year from January 2019 to December 2019. Result: A total of 1810 children were enrolled and analyzed in this study. Table 1 shows the baseline data of our study. Most 59.67% of patients were from the age group 1-12 months, 588(32.49%) patients were from the age group 13-24 months, and 142(7.85%) patients were from the age group 25-59 months. Conclusion: Determinants of severe malnutrition include faulty feeding practices, ignorance about nutritional needs, repeated infections, large family size, and low socioeconomic status. The weight-height ratio is one of the best among the criteria for identifying SAM, and hence, every child should be screened adequately on presentation.

Statelessness is the absence of the right to have a legal connection between Nationality and State. The State of Nationality is an identity to enjoy a ‘right to have rights’. Statelessness disrupts the enjoyment of all the rights which are generally perceived or purported to have been granted for all including inter alia the right to work, the right to vote, the right to health, the right to welfare benefits or welfare and a child’s right to education. Statelessness precludes people from relocating and increases their chances of arbitrary arrest, confinement or detention with no adequate answers. In short, Statelessness demotes and generates a state of irrelevance among the people with no hope of their condition ever improving, no possibility for a better future for themselves or their posterity. The state of Statelessness dismantles the idea of cohesive human existence in a civilized world. Therefore, Statelessness is a deprivation of a range of rights and benefits that bestow upon individuals Constitutional identity, National security and State protection popularly known as Nationality or Citizenship. Statelessness may be imputed to a catena of causes including Administrative practices, Conflict of Laws, Discrimination, Denationalization, Matrimonial litigation, Non-registration of births, Persecution, Renunciation, Transfer of territories, Re-demarcation of new boundaries, State succession, Terrorism, Climate change and forced displacement and Migration. But its magnitude and scale still remain to be mapped because the problem of Statelessness is a new predicament for International Law and its offshoots. It has emerged as an ordeal for the International Community that has to attend to the plight of 10 million Stateless persons Worldwide. United Nations High Commissioner for Refugees’ (UNHCR) mandate is well founded in light of the sheer amount of Stateless persons. Furthermore, there are also at least 1.5 million stateless refugees and around 3.5 million Stateles

Introduction: Sickle cell anaemia is a monogeneic hereditary disease that manifests as a lifelong multisystemic disorder characterized by periods of relatively stable health punctuated by periods of acute ill health, mostly possibly reversible and an accumulation of chronic complications, mostly irreversible affecting various organ systems with an outcome of persistent morbidity, and the risk of premature mortality. The aim of this study is to identify electrocardiographic changes typical to patients with Sickle cell anaemia (SCA). Method: Fifty three SCA patients and fifty three apparently healthy, age and sex matched adults HbAA subjects were recruited in this case control study. Individuals with other cardiovascular risk factors were excluded from the study. All recruited individuals were evaluated using electrocardiography. Result: There was left and right atrial abnormality in 7.4% and 3.8% of the SCA patients respectively while shortened PR interval was identified in 1.9%. First degree atrioventricular block was noted in 3.8% while features of Right bundle branch block (RBBB) and left bundle branch block (LBBB) were found in 3.8% and 1.9% of SCA patients respectively. Both Left and Right Ventricular hypertrophy with significant ST-T wave changes in the anterior and inferior leads were also observed in the SCA patients (p=0.001). Prolonged QTc was also identified in 20.8% SCA patients (p=0.02).CONCLUSION: Varied ECG abnormalities are common in SCA patients which may contribute to sudden death. Early ECG findings make for timely intervention towards prevention of disease progression.

Objective: The endometrium plays a key role in the fertility and endometrial pathology and gains great importance in the female reproductive system. It is important in terms of fertility and endometrial pathology with its mechanism and regulatory factors. Aim: This study highlights the complex process of endometrial regeneration and the researchs aimed at explaining the ability of endometrial stem cells to new remedy to the treatment of infertility as well as some diseases. Conclusion: There is no doubt that the endometrium has unlimited ability to regenerate any tissue. Today, they are in the various stages of experimentation in cell-based therapies of the regenerative medicine and will open hopeful avenues in treating heavy or fatal diseases by using stem cells. Beside endometrial diseases and infertility, an extensive range of clinical practices have included tests of stem cells in the endometrium. Furthermore, this study summarizes the identification of stem cells and regeneration properties in the endometrium.

Corticosteroids have proved to be extremely effective in the treatment of acute inflammation and chronic inflammatory diseases. Drug utilization review (DUR) is an on-going, systematic, criteria-based program of medicine evaluations that will help ensure appropriate medicine use. The present study aim was to evaluate the drug utilization of Corticosteroids in the various department of a tertiary care teaching hospital, Khammam. A prospective observational study was conducted to evaluate drug utilization pattern of corticosteroids. Total 249 corticosteroids were prescribed Prednisolone was prescribed in 39.5% prescription followed by hydrocortisone in 27%, budesonide in 19%, methylprednisolone in 15.5%, Dexamethasone in 9.5%, Deltazacort in 7.5%, Prednisone in 4.5% and Fluhydrocortisone in 2% respectively. 34 ADRs were detected in the study due to corticosteroid use, facial puffiness was detected in 12.50%, headache in 14.70%, Hypernatremia in 14.70%, Hyperglycemia in 17.64%, hypertension in 26.47% and osteoporosis in 14.70%. 72.6% of the drugs were prescribed from the NELM list. Clinical pharmacists interact directly with patients in several different ways. Hence, the clinical pharmacist can perform potential role in health care system in assisting physician in altering the number of medications taken, the number of doses taken, improving the patient medication adherence, detect the adverse drug reactions, drug interactions, in patient counselling, improve the health related quality of life and decreasing the health care cost of the patient.

Nelsonia canescens is a small perennial herb widely used in Burkina Faso traditional medicine for the treatment of any diseases. In the present study, the purpose was to investigate the potential cytotoxicity and selectivity of different extracts from N. canescens on human cervical cancer HeLa and SiHa cell lines. MTT assay revealed higher cytotoxic activity of methanol extract in a dose-dependent manner against both HeLa and SiHa cells with respective IC50 values of 21.72 ± 0.08 𝜇g/mL and 25.30 ± 0.44 𝜇g/mL. Methanol extract (ME) showed the best selectivity index value of 7.93 ± 0.03 with HeLa cell line and Ethyl acetate extract (EAE) showed the best selectivity index value of 7.48 ± 0.05 with SiHa. The potential cytotoxicity and selectivity of N. canescens extracts against HeLa and SiHa cells line suggest that this species could be exploited further as a potential lead in cervical cancer treatment.

Language teaching is inseparable from culture teaching. As one of the basic elements of classroom teaching, this paper analyzes the cultural content of the New Standard College English Integrated Course 3 with the quantitative discussion. The results show that this course is still dominated by British and American culture, and the proportion of Chinese culture and other cultures is limited. The results of the analysis provide some references for publishing houses and Chinese English teaching.

This study aims to determine the effect of the effectiveness of internal control, good governance and ethics on budgetary discipline. The object of this study is the Supervisor, Corporate Governance Manager, Budget Manager, Internal Auditor, Head of Internal Auditors in companies in the automotive category and automotive spare parts located in the KIIC Industrial Zone, Karawang, West Java. This research was conducted by sending questionnaires to 89 respondents. Therefore, the data analysis used is PLS SEM. The results showed that the effectiveness of internal control variables had a negative but significant effect on budgetary discipline, good governance and ethics had a positive and significant effect on budgetary discipline.

Introduction: Breast cancer in women, and especially in young women, represents a real public health issue given its frequency and severity. The objective of our study is to specify the epidemiological profile; anatomo-clinical; therapy and prognosis of breast cancer in young women. Methods: Descriptive retrospective study spread over a period of 5 years (2013-2017), collecting all the patients followed for breast cancer aged 40 years or less, within the cancer department of CHU Med VI in Marrakech. Results: The average age was 34.2 years (19-40 years). The average age at puberty was 12 years old (9 and 16 years old). Nulliparity was noted in 22% of the cases. Clinically, the T classification in the cases specified was: T1 (n = 48), T2 (n = 128), T3 (n = 52), T4 (n = 42). Clinical lymph node involvement was found in 44% of the cases. Histologically, infiltrating ductal carcinoma was the most common (n = 283). SBR II grade was the most frequent with a rate of 66%, Thirty Fifty percent of all patients had an over-expression of HER2 , Sixty-three percent had lymph node invasion, including 42% with capsular rupture and 31% of patients were metastatic in appearance. Therapeutically, fifty patients had neo-adjuvant chemotherapy. The surgery was conservative in 66% of the cases. Adjuvant chemotherapy was sequential in 61% of the cases. 180 patients had adjuvant radiation therapy. Of the 96 patients with HER2 over expression, 82 received treatment with trastuzumab. Hormone therapy was prescribed in 156 patients or 49% of cases with expression of hormone receptors. In our series, the median follow-up was 8.1 months. The course was marked by a locoregional relapse in fifty-eight patients, and a metastatic relapse in sixty patients. Conclusion: Since screening in our country does not include young women, it would be interesting to reconsider its indications, especially given the growing frequency of this cancer in young women as well as its poor prognosis.

The purpose of this study was to test the hypotheses of the influence of the head of the Study Program Competence, and Organizational Commitment in Islamic Higher Education in Jambi Province. This research is quantitative research with a survey method. The sampling technique used probability sampling with a sample size of 60 respondences. Path analysis was applied for hypothesis testing with a significance level ɑ=0.05. The results of this study revealed that both partially and simultaneously there were influences: 1). There is a direct influence on the competency of the Head of the study Program (X1) on organizational commitment (X2). Based on the results of the analysis calculation, the value of t obtained (9.14) > t table (1.987), so that H0 is rejected and H1 is accepted. It means that the competency of the head of the study program that developed in the institution had a significant influence on organizational commitment. This study implied that the results obtained from this study provide information that Organizational Commitment can be improved by providing an increase in each variable supporting the organizational commitment under study, it could not be done simply by ignoring the other variables in the path of the variable under study.

Backgroup: Pregnancy is a diabeto-genic condition, which is why pregnancy with diabetes is one of the common medical and endocrinological disorder encountered in obstetrics. Diabetes Mellitus complications during pregnancy has become more common worldwide. About 0-4% of all pregnancies are complicated by diabetes mellitus and 90% of those are GDM. Aim of the study: This study was conducted to find out the maternal and fetal outcome of the pregnancies complicated by pre-gestational and gestational diabetes mellitus. Material & methods: This was a cross-sectional analytical study which was conducted in the Department of Obstetrics and Gynecology Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. In this study, a total of 225 patients were selected using purposive sampling technique. There were three groups of pre-gestational diabetic, gestational diabetic and non-diabetic control, designated as Group A, Group B, Group C accordingly; and each consists of 75 patients. Duration of data collection was one year (July 2016 to June 2017). Information collected from all pregnant women (After 28 weeks of gestation) using a questionnaire made for recoding all relevant parameters under study, after proper counseling and taking written consent of the patient or her legal guardian. Results: History of GDM was significantly more common among patients with pre-GDM (38%) and GDM (18%) compared to controls. History of abortion, IUFD and congenital anomaly were significantly higher among pre-GDM mothers than GDM mothers and controls (p<0.05). History of deliveries with macrosomia and still birth was distributed similarly across the groups (p>0.05). Pre–GDM and GDM patients had significantly higher number of patients with HbA1C >6.5% than controls. Mean FBS and PPBS was significantly higher in pre-GDM & GDM patients than control (p<0.05). APGAR score was <7 in significantly higher number of pre–GDM and GDM babies than controls (p <0.05). Mean Weight of the babies was significantly lower among pre–GDM patients than GDM patients (p <0.05). Among pre–GDM patients and GDM patient’s cases of birth asphyxia, Hypoglycemia, hyperbilirubinemia and congenital anomalies were significantly higher than controls (p< 0.05). Conclusion: Interventions such as preconception care for women with pre-gestational diabetes, screening for early diagnosis, patient education, multidisciplinary approach and good metabolic control maintained throughout the pregnancy is the key to successful fetomaternal outcome.

The purpose of the study was to determine the availability and utilization of vocational and guidance counselling services in technical colleges in Taraba State. The study adopted descriptive research design. The area of the study was Taraba state, located in north-eastern part of Nigeria. The population of the study comprises of 743 final year students in the eight technical colleges in the state. The sample size for the study was 223 which represent 30% of the population. Observation checklist and questionnaire were used as an instrument for data collection. The instrument was validated by five experts, three from the department of guidance and counselling and two from the department of technology and vocational education in Nnamdi Azikiwe University, Awka. The questionnaire was trial tested on 20 teachers at Government Technical College Numan, Adamawa state; Cronbach alpha was used to analyze the data generated from the trial and a reliability coefficient of 0.84 was obtained. Frequency count and percentage and percentage were used to analyze data to answer research question one and two. Mean was used to analyze data to answer research question three. Findings from the study indicated that in Technical colleges in Taraba state, there is only one Vocational guidance and counsellor, nine Para-counsellors, and one support staff; there are 10 vocational guidance and counselling services available; and only four vocational guidance services are utilized. It is recommended that technical college proprietors in the state should hire and post more vocational guidance and counsellors for their respective schools and technical college managers should ensure that more vocational guidance and counselling services are initiated and made available to students.

Euphorbia cyathophora Linn (Euphorbiaceae) is commonly known as Wild poinsettia, fireplant, fire on the mountain, milkweed, widely used for the treatment of constipation, bacterial and inflammatory disease conditions like arthritis and rheumatism. Colourful plants are very dangerous like Daffodil, Lantana, Foxglove and such plants are conserved as a genetic resource and used as food, fibre, fertilizer, fuel and in used in diversely way. Euphorbia cyathophora is one such plant. This review highlights the systematic position, vernacular names, vegetative characters, ecology and distribution, phytochemistry and the economical values of the Euphorbia cyathophora are well discussed.