The presence of the sports can historically contribute international understanding and cooperation. Olympic and Paralympic Games in Tokyo will be scheduled, and “Exercise is Medicine” has been known widely by American College of Sports Medicine (ACSM). Authors et al. have continued clinical practice and research on pole exercise for years. The methods include various movements in frontal, horizontal and sagittal planes. The pole consists of aluminum with 60-160 cm in length. Moriyasu pole training would be clinically effective, which can simultaneously increase the flexibility of thorax, vertebrae and pelvis, and the functioning ability of joint movement and posture control.

This research aims to analyse the influence of return on equity, debt to asset ratio, working capital turnover and dividend payout ratio to stock return and to know the factors of return on stock. The data source used is the secondary data obtained from the annual report of the food and beverage sub-sector manufacturing company listed on the Indonesia Stock Exchange (BEI) in 2014-2018. This research uses causal research design, the method used in this research is the purposive sampling method. The data analysis methods in this study used multiple linear regression analyses and their data processing using version 21 programs. Based on purposive sampling method, there are 65 final samples this research. The method of analysis used is statistical analysis in multiple linear regression test forms. Overall, the results of the study revealed that Return on Equity (X1) has no significant effect on the stock return, Debt to Asset Ratio (X2) has no significant effect on the stock return, Working Capital Turnover (X3) has a significant influence on the stock return, Devidend Payout Ratio (X4) has no significant effect on the stock return.

Introduction: Laboratory tests are important for the confirmation of the diagnosis of the disorders and also they are required to see the prognosis or to monitor the effects of the treatment of diseases. Many laboratory tests are ordered inappropriately, some of the ordered tests reports have not been utilized neither for the diagnosis nor for the assessing the prognosis of the disorders. Methodology: Source of data was obtained by documentation maintained in the inpatient registers for routine and emergency tests. Study type and design is Descriptive Cross Sectional study. Results: The percentage of total number of investigations increased was calculated from the year 2007 to till 2016. In our study we found that there was more than 1000% increase in the laboratory workload over a period of 10years both for elective and emergency (around 742%) sample analysis. Discussion: There is an increase in the workload of both routine and emergency tests which were done in Central Biochemistry laboratory and found out the normal value reports in some samples, which were required neither for the diagnosis nor for the prognostic purpose of the disorders. Conclusion: The study revealed gross overuse of laboratory; the ordered tests were required neither for the diagnosis nor to see the prognosis or to monitor the treatment of the disorders. This inturn affect the patients and organization in terms of direct cost & indirect cost. Inappropriate tests may increase the laboratory overload which affects laboratory results adversely in terms of the quality and availability of the laboratory resources.

Breast cancer is the most common occurring cancer among women worldwide. Risk factors included drinking lot of alcohol, lack of physical exercise, family history, ionizing radiations and hormones replacement therapy during menupuase. BRAC1 gene play important role in biochemical processes occurring in cells of the breast cancer. It is highly abundant in tumor cells as compared to the normal cells of human body. It makes it strong and ideal candidate for biochemical and functional characterization at molecular level. The molecular pathways associated with tumor formation and progression of breast cancer not completely discovered yet. There is need to design such potential target or drugs that can target the cells of breast cancer and regulate the epithelial mesenchymal transition as well as reduces the number of cases due to breast cancer. Information regarding genes involved molecular pathways remains unclear. There is need to identify genes involved inthe development of breast cancer as well as prognosis. GEO database of NCBI especially used for breast cancer datasets searching.Cytohubba is used to identify the DEGs. Functional enrichment software that is used for classification and characterization of genes at functional level. Biological database such as STRING that designed for to construct PPI networks of DEGs. MCODE in Cytoscape-Intergerated plug in experimentally applied to check the interactions in PPI network. Cytohubba also used to check out the either hub genes functional or target newly drug for the breast cancer treatment. Kaplan–Meier is biological software that is used to check out the survival of individual hub genes subjected to breast cancer. X2K (Expression2Kinases) used to check out the expression of hub genes. The between hub gene and drug especially be designed in database of drug bank.

The cytogenic study included 20 mentally retarded children within the age group of 1 to 16 years, were evaluated for numerical chromosomal abnormalities. Out of 20 subjects, the first 11 samples were taken from the children of the school of the Mentally Retarded People, university road, Rajkot and the rest 09 samples were collected from the patients visited to Psychiatric OPD at the Government Civil Hospital, Rajkot. 15% female subject while 85% male subjects were evaluated for the present study. The selection criteria were children of the age between 1 and 16 years and the confirmation of mental retardation. The severity of category of mental retardation has not been focused. Chromosome preparation from peripheral blood cultures was done using standard techniques and cytogenic analysis was performed using GTG-Banding technique. 10% Karyotype were observed with numerical chromosomal abnormalities and that is Trisomy of 21st pair of chromosome. The study concluded that chromosomal abnormalities are thought to be the most common cause of mental retardation. However, apart from a few selected types with typical aneuploidy, like Down’s syndrome, the frequency of detectable chromosomal abnormalities in association with idiopathic mental retardation is very low.

In Ayurveda, ahara (food), swapna (sleep) and brahmacharya (celibacy) are considered as tryo-upasthambhas or sub-supporting pillars of life. Food is critical for the sustenance of life; it is the first of the three, followed by sleep and brahmacharya. Foods are any substances containing nutrients, such as carbohydrate, proteins and fats that can be ingested by a living organism and metabolized into energy and bodily tissues. Digestion is the process of breakdown of complex form of food into simplest monomers through enzymatic process in gastrointestinal tract. In Ayurveda, conversion of hetrogenous panchbhautic ahara (complex food) into its basic homogenous panchmahabhuta (simplest monomers) is directed by the synchronization of three sets of agni; jathragni, dhatwagni and bhutagni. The process of digestion, metabolism and assimilation is mainly accomplished by agni. The site of jathragni is grahani or pakvamashaya better known as pittadhara kala. Samana vayu, Pachaka pitta and kledaka kapha helps in digestion. Samana vayu which is present near the vicinity of agni stimulate the pachakagni for the digestion and separation of food. Kledaka kapha is present in the stomach which softens the food materials. Ayurvedic classics explains the whole process of digestion that starts with the intake of food, takes place in three stages called as Avastha paka, these are Madhur avastha paka, Amla avastha paka and katu avastha paka. Few works have been mentioned on conceptual features of avastha paka in relation to modern physiology. In this article correlation of the physiological concept of avastha paka with modern medical science has been stated. For this study, the basic materials have been collected from the Ayurvedic classics with the available commentaries, as well as Text books of modern medical science better understanding of the concept and its comparison with contemporary science.

Throughout a long time, green chemistry (GC) reviled how a basic scientific methodology and advanced practice can enhance the safe output to human life and the environment without compromising the desired outcomes. For this, advancements in scientific processes have been made in the field of designing safer reagents and solvents, advancement in catalysis and possible development of the renewable feedstock. From the chapters of the past, future chemists are being taught and trained to a wider concept of green chemistry to practice and increase awareness towards human as well as environmental impact. Green Chemistry practice is in high demand and the adherence to the 12 principles of the Green Chemistry concept is growing rapidly. A need for great change in policy, rules and regulations that will force industries, research institutes, academics, and others are still needed more than ever. Moreover, better encouragement, awareness and making an individual person responsible to adapting to a Green Chemistry concept in a real practical way, are needed. Green actions are always louder than green words.

Background: The present study is undertaken with limited available facilities to find out the efficacy of two oral antihypertensive drugs namely labetalol and methyldopa in management of pregnancy induced hypertension. Methods: The study consisted of 150 patients with pregnancy induced hypertension attending outpatient department and admitted in ANW, or who directly came to labour room. These patients were randomly selected on lottery basis after they fulfilled the inclusion criteria. Total 150 patients were taken for the study and divided into 2 groups of 75 patients in each group. Results: The mean SBP before treatment in methyldopa group was161.33 ± 8.97 mmHg and 160.03 ± 8.23 mmHg in labetalol group which showed a fall to 138.61 ± 6.67 mmHg (methyldopa group) and 138.08 ± 5.37 mmHg (labetalol groups) after treatment. Fall of SBP was significant in both the groups. But inter group difference was not significant (p > 0.05). The mean DBP before treatment was 106.85 ± 4.33 mmHg in methyldopa group and 105.63 ± 5.23 mmHg in labetalol group which decreased to 89.31 ± 6.51 mmHg and 89.68 ± 5.26 mmHg respectively after treatment. Fall of DBP was significant in both the groups. But inter group difference was not significant (p > 0.05). Fall of MAP was significant in Group A and Group B. But inter group difference was not significant (p > 0.05). Conclusion: Labetalol and methyldopa are equally efficacious in controlling blood pressure in new onset hypertension in pregnancy.

The purpose of this study is to analyze the effects of Profitability, Leverage, and Liquidity on Financial Distress which is proxied using Z-scores. The object of research is the sub-sector of property and real estate companies listed on the Indonesia Stock Exchange in 2016-2018. This research was conducted using a sample of 47 companies listed on the Indonesia Stock Exchange. Determination of the sample using a purposive sampling method with criteria by researchers using a causal relationship design. The analysis of data use statistical analysis in the form of multiple linear regression tests. The result of this study is that profitability, and liquidity variables have significant effects and positive on financial distress. The Leverage variable has a significant effect and negative on financial distress. While The Audit Committee has no effect on financial distress.

A group of neoplasms that share the characteristic light microscopic appearance of being composed of relatively small, round to round-spindled, monotonous, seemingly undifferentiated cells. It comprises all significant categories of neoplasms- carcinomas, sarcomas, lymphomas, and neuroendocrine- neuroectodermal tumors. Hence microscopic similarity between them and the diagnosis in routine histologic examination extremely difficult. This heterogeneous group of lesions becomes a diagnostic challenge. The diagnosis depends on clinical, radiological, pathological and genetic features. Each lesion has its own has distinctive features but histopathologically termed as ‘round cell tumors’. This article provides an insight into this group of intriguing round cell lesions, which are characterized by varied histopathological features and their associated confirmatory immuno-histochemical markers for a reliable and a consistent diagnosis.

Confidence is an important aspect of one’s personality and a confident smile makes the picture complete. With the increased awareness and changing times people seeking dental treatment for aesthetic purpose has significantly increased. One of the commonest cause for unaesthetic smile is the presence of discolored teeth. Though there are various reasons for the discoloration of the teeth, Flourosis which is endemic in various parts of world is one of the major causes of the discoloration. Various treatment options are available to conceal the discoloration. This case report represents one such modality of smile makeover using ceramic laminate veneers.

During pregnancy there is a physiological hypercoagulability which may be increased by genetic risk factors and / or acquired thrombosis. This increases the risk of thromboembolism and the risk of thrombosis in placental vessels and thus termination of pregnancy. Among genetic risk factors for thrombosis, factor V Leiden and mutated factor II are responsible for spontaneous miscarriages, which are essentially late. The rare deficits in antithrombin, protein C and protein S are also involved. Factor V Leiden is a thrombophilic condition that can lead to serious thromboembolic events and in pregnant women recurrent miscarriages. We report the case of a 36-year-old woman who presented 6 miscarriages that led to the diagnosis of thrombophilia by resistance to activated protein C and whose last 4 pregnancies were well followed by anticoagulant treatment with low molecular weight heparin aspirin.

Background: Hyponatremia, which is defined as plasma sodium concentration of less than 135meq/L, occurs primarily due to imbalance in water homeostasis, antidiuretic hormone (ADH) regulation and renal handling of filtered sodium. The two most common causes are effective circulating volume depletion causing non-osmotic release of ADH and the syndrome of inappropriate ADH secretion, disorders in which ADH secretion is not suppressed despite decrease in plasma osmolality. Methods: Observational Study conducted at Medicine wards and, Medicine OPD of SMS hospital, Jaipur. Patients were interviewed for demographic data such as age and sex. History of other comorbid conditions along with presenting complaints was noted. Further these patients were subjected to a physical examination for clinical signs. These findings were recorded on a predesigned and pretested proforma. Results: In our study, lethargy(50.4%), headache(42.3%) and anxiety(31.7%) were most common symptoms. Majority of the cases were admitted and treated in the ward i.e. 249(87.7%), while few patients were treated in ICU i.e.35 (12.3%). Conclusion: Based on the findings of this study it may be concluded that, hyponatremia can present with protean clinical manifestations. The presentation can vary from mild symptoms such as vomiting, lethargy, malaise to severe forms such as confusion, seizure and coma.

Cases of leptospirosis in Indonesia increased dramatically in 2018 by 895 cases with 148 death cases due to leptospirosis in 2018. Risk factors were found in more than half of leptospirosis events including environmental conditions, the presence of rodents, waste water disposal, waste disposal facilities, history of contact with rats, presence of rivers, and history of flooding. Previous research has reported the finding of mice containing Leptospira in post-flood areas in Indonesia. Therefore this study aimed to determine the relationship of environmental conditions with the presence of Leptospira bacteria in rats in flood-prone areas. This research is an analytic study with cross sectional approach. Data obtained by observing the type of rat, the process of surgery and taking rats, rats calculation of success traps and observation of environmental conditions. The polymerase chain reaction (PCR) test was carried out in the Microbiology Laboratory of Hasanuddin University Hospital. Statistical tests with fisher exact were used to determine the relationship of environmental conditions with the presence of Leptospira bacteria in rats. The results of this study found 100% Mus musculus, 53.3% Rattus norvegicus, 22.2% Rattus tanezumi infected with Leptospira bacteria. The results showed the presence of sewers with stagnant water (0,000), presence of standing water other than sewers (0,026), presence of sewage waste (0,005), presence of waste other than ditches (0,007), smell of rat urine (0,049) and pH of stagnant water the optimum (0.001) with a p-value < 0,05. We recommend to the Paccerakkang inhabitants who reside in flood-prone areas, to always maintain environmental conditions such as cleaning the environment suspected of being a habitat for rats.

Works on risk analysis focused on activity in the operating room or in intensive care is rare. In fact, the operating room remains one of the units where the patient's medication management process is complex, which tends to increase the risk of ME as well as the severity of its consequences. In anesthesia, attention should be paid more specifically to errors during the preparation and administration of drugs, because these are actions that are performed many times every day. The analysis of this adverse event in our patient made it possible to classify this adverse event in the category of administrative errors. The administration of vancomycin should be done by slow infusion when it has been administered to our patient by direct intravenous route, this type of error is part of the volume or flow errors. Medication administration error can be prevented by providing coaching and continuing education for practitioners. It is also necessary to label the medication storage compartments of the anesthesia cart; the correct identification of drug ampoules and to ensure that there is only one packaging of the same product.