In an effort to implement expansion of access to early childhood education, various policies have been issued by the government ranging from the statutory system to matters of a technical operational nature. One of the government policies in the education sector that supports lifelong education is the recognition of Early Childhood Education (PAUD). So far, the management of non-formal PAUD is still less professional, especially for the coaches or teachers, so that teachers who have the competence and certification are urgently needed as teachers of non-formal PAUD. This study aims to reveal the implementation of a child-friendly Child Care Park (TPA). The research method used is qualitative research (Qualitative Research) with a naturalistic phenomenological approach. This is expected to be a solution to gain a deep understanding of planning, implementation, monitoring, and evaluation of the meaning of phenomena that occur in the field.

COVID-19 and malaria share similar pathogenic pathways with the angiotensin converting enzyme 2 as a central initiator of signals to stimulate host cellular responses which in some instances result in multi-organ affectation. These signaling proteins are either upregulated or downregulated with the consequences of provoking immune responses with varying tissue damages. The similarities in clinical presentations, associated complications and therapeutic responses to the repurposed medications (anti-malarial drugs being used as anti-viral molecules) for the treatment of the novel disease COVID-19 have stimulated enormous interest in the recent past. The major objectives in this regard are to define the association between these two disease entities and possibly unveil options for interventions. This paper therefore aims at reviewing the molecular interactions which these diseases possibly share in their pathogenesis and phenotypic expressions and make projections for future interventions.

The main role of any Customs Union is to facilitate trade through three main pillars: the simplification and harmonization of Customs procedures, the faster release of goods, and the reduction of trade costs through the elimination of tariffs and non-tariffs barrier to trade. However, this is not the case within the CEMAC Customs union as the importation, exportation and the transits of goods is hampered by tariffs and non-tariffs barriers, costly and time consuming border procedures, coupled with excessive physical and documentary control, regulatory requirements that leads to excessive delays at the inland and border offices. The present situation has not created an enabling business environment for trade facilitation within the CEMAC sub-region. The relevance of this article is to examine the extent to which the adoption of the relevant international standards of the International Convention on the harmonization and simplification of Customs procedures, otherwise known as the Kyoto Convention, by the CEMAC Customs Union can create an enabling business environment within the CEMAC sub-region. In order to attain the above objectives, we employed doctrinal and analytical research methodology. From our findings, we therefore, recommend among others that the effective implementation of World Custom Organization regulations within the CEMAC Custom Union will depend largely on the political will of decision makers and capacity building of customs administrators and personnel. This paper therefore, conclude with a number of recommendations which if effectively implemented and enforced, will go a long way to improve on the regulatory frameworks of the World Customs Organization within the CEMAC Custom Union.

Background: Diagnosis of bloodstream infections in newborns is difficult due to a wide range of symptoms. Empirical therapy guided by a knowledge of the causative agents and their local antibiotic susceptibility profile is a crucial step in improving therapeutic results. As a result, we planned to investigate the bacteriological profile and antibiotic susceptibility pattern in neonatal sepsis. This was to compare the efficacy of a combination of ampicillin and gentamicin against 3rd generation cephalosporins for empirical antibiotic treatment of neonatal sepsis. Methods: It was a cross sectional observational study conducted over one and a half years.The period of study was from January 2019 to June 2020 in the Department of Paediatrics and Microbiology of a tertiary care Teaching hospital, Hydrabad. Blood culture samples of neonates suspected of having EOS or LOS were sent to the Microbiology department where they were inoculated into BACTEC TM Peds plus/F which was then inserted into the BD BACTEC fluorescent series instrument for incubation. Antibiotic sensitivity testing was done by disc diffusion as per CLSI guidelines. Zone sizes were measured and interpreted by BD PHOENIX AUTOMATED AST machine according to CLSI standards 2016. Results: 402 neonates were admitted to the neonatal unit of our hospital with suspected sepsis between January 2021 to June 2021. Out of which parents of 372 neonates consented to take part in the study. Out of which 196 were male and 176 were female neonates. Bacteria were isolated from 195 samples and 177 samples were negative out of listed 72 neonates. These 195 neonates were enrolled as cases in the study. Out of 195 cases, 75 cases were inborn and 120 were outborn. The blood culture isolation rate was 33.2 % and 56.5% in inborn and outborn respectively. There were 105 males and 90 females in the study. The culture positivity rate was 52.4%. Bacteria were isolated from 41 samples of suspected EOS neonates with a positivity rate of 33.8% and 154 samples of suspected LOS with a positivity rate of 34.5%. Gram-positive bacteria were isolated from the 107 cases and gram-negative bacteria were grown in 88 cases. The most common isolate was Staphylococcus aureus in 59(30.26%) followed by non- fermenters in 45(23.08%) cases. Conclusion: The prevalent pattern of causative etiological agents and their sensitivity pattern is critical because it aids in the selection of particular and effective antibiotic(s) for the index case's therapy. It also aids in the development of an institutional strategy for the selection of antibiotics for newborns admitted with suspected sepsis at the time of admission. This helps to avoid antibiotic abuse and the development of antibiotic resistance.

Non-cirrhotic portal vein thrombosis is a rare condition. Constitutional thrombophilia, alone or with other risk factors, predisposes to splanchnic thrombosis. Methylenetetrahydrofolate reductase (MTHFR) mutations are associated with vascular diseases. We report an observation of a 48-year-old patient who was diagnosed with MTHFR mutation during the etiological workup of a mesenteric venous thrombosis.

The objective of this study was to investigate the cost and return structures of white jute seed cultivation in Bangladesh. This study was conducted in two locations in three consecutive years 2013-15). The sample included 120 farmers selected using a purposive sampling method, consisting of 60 from each district. Sample size was same for three years. Survey questionnaires were used as the main instrument for data collection. Descriptive statistics and cost and return analysis were used for data analysis. The results indicate that the cost of production (99175 tkha-1) and output (123502 tkha-1) was higher in Tangail than Manikganj. Lowest cost of production (80252 tkha-1) was recorded in 2013 in Manikganj and maximum (102470 tkha-1) in 2014 in Tangail. Average BCR of white jute seed production of two locations was 1.25. Cost of production varies year to year and place to place due to variation in land rent value, labour wages, land preparation cost etc. This result indicates that profitability of jute seed production is almost same in two zones and by product yield is also important in case of white jute seed production.

The Covid-19 pandemic has affected the general population at different levels. In the context “prevention is better than cure” certain norms has been implemented by the government like maintaining social distancing and wearing masks. In this pandemic, individuals are facing numerous issues due to minimal availability to physical health and dental care. The solution to this problem of physical unavailability is telemedicine and teledentistry. Teledentistry is a means of virtual communication between patients and consultants which must be incorporated in general healthcare and dental care systems. Though with numerous advantages, this technology also posseses some disadvantages. Proper knowledge and application of this technology should be understood by the healthcare workers for it’s suitable implementation. If not fully replace, at least teledentistry can complement the existing compromised dental system during the current pandemic.

Introduction: Female stress urinary incontinence is a common affection that affects women in the general population. It can be improved by non-invasive medical techniques. Aims: To determine the value of perineal rehabilitation in the treatment of female stress urinary incontinence through the experience of the Department of Physical Medicine and Rehabilitation CHU Med VI of Marrakech. Patients and methods: This is a prospective, monocentric study that included 10 patients with stress urinary incontinence. They benefited from a multimodal rehabilitation protocol carried out in a minimum of 10 sessions. Results: The muscle tone of the pubococcygeal bundles of the elevator muscles of the anus was significantly improved after rehabilitation. The improvement in tone was correlated with the reduction in the frequency of leaks. The subjective satisfaction rate reached 80%. Conclusion: Perineal rehabilitation appears from the experience of our department to be effective for the treatment of stress urinary incontinence. It should be offered as a first-line option.

Background: GDM is a high risk factor in pregnancy & is associated with an increased risk of complications for both mother & baby during pregnancy as well as in postpartum periods. Screening & identifying these high risk women is important to improve short & long term maternal & fetal outcomes. Objective: To determine the fetal & maternal outcome and complications in pt presenting with GDM. Materials and Methods: The present cross-sectional observational study was performed at the Department of Obstetrics and Gynecology of the Jalalabad Ragib Rabeya Medical College Hospital, from June, 2018 to November, 2019. One hundren women who are diagnosed to have GDM were included in this study. Results: Complication of the maternal outcome during antenatal periods that 32(32.0%) patients had H/O GDM, 19(19.0%) had preterm delivery, 19(19.0%) had postpartum UTI, 18(18.0%) had pre-celapmsia, 16(16.0%) had UTI, 14(14.0%) had vulvovaginitis, 13(13.0%) had cervical tear, 12(12.0%) had polyhydramnios, 11(11.0%) had PROM and 11(11.0%) had postpartum hemorrhage. Complication of the fetus outcome during antenatal period showed that 19(19.0%) babies were NICU admission followed by 12(12.0%) had hyperbilirubinemia, 8(8.0%) had neonatal hypoglycaemia, 6(6.0%) had respiratory distress infection, 6(6.0%) had congenital anomalies, 5(5.0%) had prematurity, 5(5.0%) had polycythemia and 4(4.0%) had birth asphyxia. Conclusion: Maternal and perinatal morbidity and mortality is increased in women with GDM. Infections, preterm delivery, postpartum UTI, pre-celapmsia, UTI, vulvovaginitis, cervical tear, polyhydramnios, PROM and postpartum hemorrhage were the common maternal complications. Fetal complications include NICU admission, hyperbilirubinemia, neonatal hypoglycaemia, respiratory distress infection, congenital anomalies, prematurity, polycythemia and birth asphyxia most common cause.

Muscle mass loss or Sarcopenia is an important clinical problem that impacts every older population. The aim of this study was to observe the influence of planned exercise program on muscle mass and related selected variables. Total 40 elderly aged males (Experimental = 20, Control = 20) with the age ranging between 60-70 years were taken as subject. Age, height and weight were taken as personal data. Strength, flexibility, endurance and agility considered as physical functional fitness, BMI, chest, biceps (Relaxed and flexed), gluteus, thigh and calf circumference considered as anthropometric variable and percentage of muscle mass and myoglobin concentration considered as muscle mass component. Subjects were involved in 12 weeks, 65 minutes session (Warm up = 10 min, Training session = 45 min, cooling down = 10 min), 4 days/week planned multicomponent training protocol to fulfil the purpose of research work. The analysis and interpretation of the data was done by calculating mean, SD and paired sample t test. Result revealed significant improvement in physical functioning variables while anthropometric and muscle mass component variables remained unchanged. From this study it was understood that only 12 weeks training programme was not sufficient to develop quantitative parameters like selected circumference, muscle mass and myoglobin concentration but it was sufficient to develop physical functioning parameters which may influence muscle health and healthy lifestyle.

An ethnobotanical study of medicinal plants used by the communities in Wombera District, Benishangual Gumuz Regional State, and Western Ethiopia was carried out from 0ctober, 2019 to October, 2020. The purpose of the study was to document information of medicinal plants and indigenous knowledge on use and conservation of medicinal plants by the communities of Wombera District. A purposive sampling was designed and employed for selection of the study areas (6 sampling sites) and 200 informants (52 males and 18 females) aged between 18-85 years were randomly selected from 6 kebeles. Ethnobotanical data were collected using semi-structured questionnaires, interview and, group discussion s. A total of 91 medicinal plants were documented from the study area. Of these 60 were human, 7 veterinary and 24 both human and veterinary medicines. Data were analyzed quantitativelly. The highest number of medicinal plants was collected from wild habitat (64 %), while 33% was collected from home garden, 3% occurred both in wild habitat and home garden. The most plant parts used in treatment of human disease were leaves (34.6%) followed by roots (20.9%). The most frequently mentioned mode of administration was oral (54%) followed by dermal (27.5%) and the least was found to be application through eyes and ears (3%) each. The most common form of medicine preparation was crushing, pounding and homogenizing in water (43.07%) followed by boiling and Fumigating (16%), squeezing(15.45%), chewing(10.7) and the leasts were burning and cooking (5%) each. Deforestation for agriculture, over exploitation, firewood collection, and overgrazing were the main threats of medicinal plants in the study area. The biggest problem of traditional medicinal remedies is the accurate dosage, which sometimes may even kill. Moreover lack of awareness of cultivation in home garden resulted as threats of medicinal patient.

With inclining the speed of vehicle the cost will become low dominantly when the speed attains 750Km/h and crank length is 70mm. With increasing time the speed and force of vehicle will become periodic wave. When the crank length increases from 70mm to 100mm under 750r/m̖ 850r/m and 950r/m, the speed will increase and and the force will decrease. The force will decline with inclining rotation and crank force respectively. So it is chosen of the short crank and idling so as to maintain maximum force. The effect of crank length and rotation to force is about 20m/s and 70KN in this study. At the force with 750r/m and crank length with 100mm & 70KW it will be the lowest which is benefit for engine wear.

To evaluate the efficacy of uterine artery embolization (UAE) for the treatment of symptomatic uterine fibroids in patients treated at Al Ain Hospital, United Arab Emirates. Medical records and radiological images of all patients undergoing UAE in Al-Ain Hospital between 1 January 2012 and 31 December 2017 were retrospectively analysed. 141 patients aged 23-50 years were included in the study. Single femoral access technique was used in all patients. Clinical improvement was assessed by questioning patients regarding symptomatic improvement and follow up MRI to see the reduction in size of the dominant leiomyoma. Data was analyzed using SPSS 22. All 141 patients underwent technically successful UAE. 55 were lost follow up and were not included into the final analysis. Out of the remaining 85 patients, 55.3% were nulliparous and 44.7% were multiparous. A significant number of females that is 70.5% had multiple uterine fibroids compared to 30% who had only single uterine fibroid. 71.7% patients had menorrhagia pre-operatively, 98.4% had complete resolution at 6 months. As per the size reduction, paired t-Test showed statistically significant reduction in the mean leiomyoma size from 8 cm to 6cm and then further to 5 cm at 6 months and 1 year respectively. Almost 91.8% of the patients who underwent UAE were satisfied with the improvement in their symptoms as an outcome compared to 8.2% who were unsatisfied. Uterine fibroid embolization represents a promising method of treating fibroid-related menorrhagia and pelvic pain. Further studies with larger number of patients and long-term follow-up are needed.

The research of this article is motivated by the formulation in the Marriage Law No. 1 of 1974 where there are several articles that regulate the inheritance rights of illegitimate child, namely article 42 and article 43 that are not just as there is no attainment of justice in the inheritance rights of illegitimate child so that the child has not received welfare in his life therefore it need to be reconstructed to achieve justice. This research is a non doctrinal/ socio legal research which is descriptive analysis. With the constructivism paradigm. This research approach method is empirical, supported with normative and comparative approach. Primary data sources are interviews, observations, while secondary data sources are primary, secondary and tertiary legal materials which are then collected and analyzed using data triangulation. The result shows that the inheritance rights of illegitimate child is not yet fair because there is no attainment of justice in the inheritance rights of illegitimate child so that the child has not received welfare in his life, therefore, a reconstruction Inheritance rights of children outside of marriage based on the value of justice is needed by adding another paragraph in Article 43, that states that the civil position in the law gave no distinction between children outside of marriage and within marriage or gave one side a prioritize over other.

The novel coronavirus disease 2019 (COVID-19) has caused an outbreak and become a major public health issue and great concern from international community. Cardiac injuries were suspected and may even be considered as one of the leading causes for death of COVID-19 patients, especially for those with cardiovascular (CV) risk factors. The aim of this study is to investigate if cardiac injury (CI) in COVID-19, preexisting or acquired, is associated to increased mortality in these patients from intensive care unit (ICU) in Mohammed VI hospital in Marrakech, Morocco, from March 20, 2020 to May 20, 2020. Fifty-two patients with laboratory-confirmed COVID-19 were included. Demographic, clinical and laboratory data were extracted from electronic medical records (EMR). 22.7% patients had CI, all of them developed a HF during COVID-19 course and have died. Among these patients with HF, 44% had comorbidities (vs 7.3% of patients without HF p < 0.05). They were older (61.1 years old vs 50.5), 44% had hypertension and diabetes. Preexisting CV disease was reported in 44% (vs 1%). In terms of laboratory findings, Tn-T (med: 231; 422; 10.3; 8.87; 97.28; 41.86; 59.2; 39.27; 68 pg/mL), Nt-proBNP (553;152; 3166; 134; 306; 17900; 2524; 59000; 450 UI/L), levels of C-reactive protein (med: 147 [106.4-240] vs 162 [5-508.3] mg/L) and electrolyte disturbances: hypokalemia (88% vs 86%, p< 0. 05). Early evaluation and monitoring of cardiac damage with distinct attention to the elderly and highest CV risk factors may identify patients with HF and contributed to decreased COVID-19 mortality.