Background: The FOXP3 gene provides instructions for producing the forkhead box P3 (FOXP3) protein. The FOXP3 protein attaches (binds) to specific regions of DNA and helps control the activity of genes that are involved in regulating the immune system. Aim: This study intended to analyze SNPs in FOXP3 gene in the coding region, 5`UTR and 3`UTR using bioinformatics tools and visualizing the 3D structure of the gene. Methods: SNPs were retrieved from NCBI, and the protein sequences were retrieved from UniprotKB. SIFT and Provean software was used to predict whether the nsSNPs were tolerated or deleterious. Polyphen- 2 for nsSNPs function prediction on the produced protein.I-mutant and Mupro software to check the protein stability, finally PHD software to see whether the nsSNPs were related to a disease or not.Regulomedb to predict the regulatory element for 5`UTR region. For the 3`UTR PolymiRTs database to predict the variation in microRNA (miRNA). FuncPred software to show the unknown function for the selected SNPs.TheI-TASSER to visualize the 3D structure. Results: A total of 205 SNPs were retrieved, 180 SNPs in the CDS region, 20 in 3`UTR, 5in 5`UTR. SIFT prediction resulted in 93 deleterious and 87 toleratednsSNPs, Proveanrevealed60 deleterious and 120 tolerated,Polyphen-2 resulted in 29 probably damaging,11 possiblydamaging, 3 benign and 2 no result. I-mutant showed 12nsSNPs increasing, and 25 decreasing the protein stability, MUpro resulted in 3nsSNPs increasing the protein stability and 42 decreasing the protein stability, PHD resulted in 17 nsSNPs as disease related and 28 as neutral. For noncoding SNPs, Regulomedb resulted in 11 SNPs, PolymiRTs result in 11, and FuncPred result. Conclusion: The analysis of FOXP3 gene showed that from 205 nsSNPs only 11 SNPs are highly damaging and 20 SNPs found in the 3UTR region which predicts its function using different methods. Still bioinformatics software have their limitations, the results from this study may be convenient in future for further population based research activities and towards development of perfect medicines.

Food insecurity caused by decline in food production due to shortage of workforce, has necessitated the automation of the various agricultural operations. The study was aimed at the design and development of a prototype drip irrigation robotic system, which used the internet services for its operation (Internet of Things). The robot has a microcontroller, soil moisture and temperature sensors and a water pump. During operation, the robot received the input commands through the soil temperature and moisture sensors. It had the ability to deter the water requirement of the targeted crop, before irrigating it autonomously with the right volume of water. Performance evaluation of the robotic system revealed that it had an efficiency of about 90% and accuracy of about 95% when controlled through the internet. This prototype will help in the production of automated drip irrigation robots, that will preformed effectively in the field.

Unilateral termination of a contract means the termination of the labor contract by the employer or the employee without the consent of the other party. Accordingly, when terminating the labor contract, there will be two cases, one is unilaterally terminating the labor contract in accordance with the law or unilaterally terminating the labor contract illegally. Although the law has a mechanism for one of the parties to unilaterally terminate the labor contract (hereinafter referred to as unilateral termination), to ensure benefits for the other party, the Labor Code also stipulates it is very clear which cases can be terminated, which cases cannot be terminated. Most of the cases that the law that allows unilateral termination may arise from other objective or subjective reasons, but in general, doing unilateral work will significantly reduce the significant damage to the party who is doing the job. This study focuses on analyzing the contents related to the termination of illegal labor contracts of both employers and employees, thereby pointing out the shortcomings in the Law, specifically the Ministry Labor Code 2019.

Autoimmunity simply stated is one's immune system responding to self. The occurrence of infectious disease is affected by interaction between microorganisms. The link between certain bacterial infections and autoimmunity is particularly compelling, and molecular mimicry is often implicated in autoimmune disease pathogenesis. The role of microorganisms in the spreading of diseases has undergone significant modification in the past few decades with new observations from clinical, epidemiologic, and basic science research. Primary bacterial colonizers are Staphylococcus epidermidis and other coagulase-negative Staphylococci. Other microorganisms that are generally regarded as skin colonizers are species of Corynebacterium, Propionibacterium and Brevibacterium. Adenovirus, herpesvirus, and poxvirus are all examples of large DNA viruses that infect humans. Adenoviruses, of which there are many types, cause gastroenteritis and respiratory disease in humans. Notable human diseases caused by RNA viruses include the common cold, influenza, SARS, MERS, COVID-19, Dengue Virus, hepatitis C, hepatitis E, West Nile fever, Ebola virus disease, rabies, polio, mumps, and measles. Parasitic diseases that can be blood borne include African trypanosomiasis, babesiosis, Chagas disease, leishmaniasis, malaria, and toxoplasmosis. Vaccinations are generally the cheapest and most effective trusted Source way to prevent viruses. Some vaccines have succeeded in eliminating diseases, such as smallpox.

Acute myocardial infarction is the leading cause of death. Streptokinase is the most commonly used thrombolytic agent. This study was conducted to compare in-hospital outcome of patients with acute myocardial infarction receiving streptokinase with those not receiving it. About 340 patients having acute MI were included in the study. Two groups were formed. Group 1 (SK Group) receiving streptokinase and Group 2(Non SK) not receiving streptokinase. For the patient condition assessment In-hospital mortality was the primary end while mechanical and electrical complications were the secondary end points. Among 340 patients, 255(75%) were males and 85(25%) females. Out of those 218 received streptokinase, while 122 did not receive the drug The mean age of group 1 was 53.1 ±10.3 years and group 2 age was 60.5 ± 16years. Mean time of arrival to the hospital after symptom onset was 10.4 ± 9.97 h. SK group patients reached in 5.9 ± 4.7 hours while group 2 in 19.4 ± 10.5 h. In-hospital mortality in group 1 and group 2 was 19(8.7%) and 25(20.5%) respectively, (p=0.002). Complication rate was significantly higher in non-streptokinase group. Patients of acute myocardial infarction receiving streptokinase have significantly lesser in hospital mortality and complications as compared to patients not receiving it.

Stealing, generally, has been recognised as a criminal offence and worldwide it has been viewed as the permanent deprivation of a person's ownership in a property by another. The concept of property has often been limited to material things which can be transferred to or inherited by another. This paper seeks to shed light on those other things that are not but should be considered property for the sake of defining the offence of stealing. In doing this, the effect of technology on the concept of stealing in Nigeria will be examined. A comparative analysis of the Nigerian status and the status of a few select jurisdictions, as regards the subject matter, will be done. It is believed that at the end of this paper, the concept of stealing will be viewed broader than it is seen now and that what the average person would normally see as fraud or "419" (using the Nigerian slang), will be clearly classified as stealing.

Since the outbreak of coronavirus disease 2019 (COVID-19) in late December 2019, it has brought significant harm and challenges to over 200 countries and geographic regions around the world. COVID-19 affects people in different ways, with patients exhibiting a range of symptoms and severity. Risk factors such as age, gender and comorbidities have been highlighted as increasing the risk of complications and mortality. These risk factors, however, do not account for the other 52% of deaths arising from COVID-19 in seemingly healthy individuals. This review examines the interplay between periodontal disease and development of severe complications of COVID 19. Periodontal infections alter the natural course of systemic conditions, due to the presence of a constant low grade systemic inflammatory state in the body. Correlating these two entities is the main focus of this review and how maintaining good oral health may reduce the risk of complications of COVID-19.

The aim of the research work is to assess the Purnus amygdalus gum for the potentiality of tablets binder / disintegrant excipient and potato starch was used as standard excipients. The gum was assessed for various tests. Ibuprofen was used as a model drug for the preparation of tablets. Totally eight batches were developed using various compositions. Pre-formulation and post formulation study were performed for the tablets. Also the tablets qualities were compared with innovator tablet. FTIR studies ruled out the drug excipient interaction. The hardness of the tablets were in the acceptable range. Disintegration time was ~4 minutes. Dissolution were between 70 – 89%. The results of the study describe that the Purnus amygdalus gum (PA ) could be alternative tablet excipients for potato starch.

This study aims to determine the weaknesses of regulations regarding child protection for persons with intellectual disabilities who are victims of sexual violence in Indonesia and to reconstruct the meaning of children in order to protect the rights of persons with intellectual disabilities who are victims of sexual violence in Indonesia. This study uses a constructivism paradigm based on literature review with juridical research methods. The results showed that the laws and regulations on child protection regarding the age limit of children are that it only refers to international conventions, without paying attention to the existing living laws in Indonesia, namely Customary Law and Islamic Law. Third, the reconstruction of mental age norms in the Child Protection Law can be further developed by making norms in the form of the draft of Article 1 point 1a that states that a child is someone whose mental age is under 18 (eighteen) years old according to a psychological expert's examination, for a person with intellectual disabilities as a victim of violence, the basis for the application of this norm is juridically existed in Article 28H paragraph 2 of the 1945 Constitution and socio-philosophically, through the theory of social justice developed by John Rawls with the principle of fair equality of opportunity.

vital not only to provide comprehensive care but also to enhance and promote competence. This study is a comparison between a general and a specialized hospital. Objectives: Measure knowledge, and skills among nurses in two different hospitals. Methods: A cross sectional survey questionnaire used for collecting data, 60 nurses from each hospital. Statistical analysis: Descriptive statistics, chi-square test used to compute association among variables, the p-value of <0.05 was considered as statistically different. Result: There is no difference in skills and knowledge in most procedures except for some specific procedures. In addition, the load of work varies from hospital to others. Conclusion: Nursing, in both hospitals; showed having the required level skills and knowledge. However, continuous cross training directed to enhance some specific nursing procedures, regardless of the working hospital.

This is a quasi-experimental study to determine the internal administration of Acalypha indica leaves powder in management of cough. Cough is a natural reflex expulsive defense mechanism of the body, for clearing excess secretions or mucous or inhaled irritants or toxins or foreign substance in the respiratory tract it is the commonest symptom of respiratory diseases. Productive cough means a sudden, noisy expulsion of air from the lungs that effectively removes sputum from the respiratory tract and helps clear the airways, permitting air to reach the alveoli. The treatment of coughs is one area where the use of certain herbal remedies remains common today. In the Siddha system Acalypha indica herb is considered to be effective medicine for cough. This is an annual herb belongs to Family Euphorbiaceae. The researcher administered questionnaire was used to collect data. Fifty (50) clinically diagnosed productive cough patients were randomly selected at District Siddha Ayurveda Hospital, Kopalapura and symptoms were evaluated based on scoring system. Evaluation visit were made baseline on 7th, 14th, 21st , 40th day interval, after final assessment were observed after one week for getting information about recurrence of disease. The effect of treatment was evaluated on basis of changes of degree of symptoms after treatment.Statically highly significant improvement (p<0.000) in reduce of bouts of cough, sputum expulsion, throat irritation and nasal discharge.

Background: The incidence of caesarean section varies from hospital to hospital and from community to community and it is much more in tertiary care hospital because of referral from other centres. Objective: The objective of this study was to investigate the caesarean section rates by evaluating the indications as per modified Robsons criteria and to determine the area of concern that requires maximum focus to decrease the overall caesarean section rate. Methodology: This cross-sectional retrospective study was conducted over a period of one year from January 2019 to December 2019 in the department of Obstetrics and Gynecology at Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh. Result: Total number of deliveries for one year was 891. Out of them 162 were normal vaginal delivery and 729 were by caesarean section. Overall maximum caesarean section was contributed by group five Robsons criteria. Conclusion: Robsons ten group classification provides an easy way in collecting information about the indication of C/S and there by caesarean section rate. It is important that efforts to reduce the overall caesarean section rate should focus on reducing the primary caesarean section and increasing vaginal birth after the caesarean section.

Viruses as pathogens have ability to replicate in the particular host in order to damage their organs. Some bacterial pathogens cause lethal diseases associated with metabolisms. Bacteria also increase the rate of infection due to antibiotic resistance. There is need to design such drugs that control the specific targets of bacterial strains. Streptococcus type also causes the diseases associated with medical conditions such as pneumonia. Shigella as well as Salmonella also causing the diseases in food and food products. Pseudomonas syringae as one of the bacterial pathogens that attacks on the leaves as well as different parts of plants that finally damaged to whole plant. S. pneumoniae is the pathogenic bacterial strain that causes severe inflammation in the lungs by damaging to the lungs. E. coli as the type of bacterial pathogen that enter into the intestine of the human. It particularly stays here and multiplies to increase its infection to damage the specific parts of intestine. Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and joint pain. The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three structural proteins. At present, CYD-TDV or Dengvaxia® is the only approved vaccine, but potent inhibitors are currently under development.

Chondroidsyringoma is a rare benign skin tumor whose preferential location remains the craniofacial region. It is characterized by a double component; epithelial and mesenchymal. We report the case of a 72-year-old female patient with a polypoid-like tumor located in the middle thirds of the free edge of the right nostril wing. After surgical excision, the histology is in favor of a chondroidsyringoma. No recurrence was noted after a follow-up of 20 months.

The purpose of this study is to provide empirical evidence regarding the influence of management characteristics and GCG on earnings quality, in the midst of the urgency of earnings quality information that is prone to conflict of interest, especially in state-owned companies today. This research is a quantitative research where the population is all state- owned companies in Indonesia which are listed on the website of State-Owned Entreprises (SOE) in 2016-2018. The sampling technique used a purposive sampling, and obtained 67 companies that meet the standards. The technique of collecting data is by taking information from the company's annual report so that the data source used is secondary data. The analysis method used is Eviews. The results showed that educational background, gender, and GCG had a positive effect on earnings quality. Meanwhile, tenure has a negative effect on earnings quality.