Psoriasis is a skin disease. It is rare growing disease around the world. Here in this investigation we have targeted a protein namely TRPV3 (Transient receptor potential cation channel, subfamily III) ion channel for the study of psoriasis, which is important factor of psoriasis. The medicinal plant namely Cassia fistula is selected for the in silico investigation. 39 phyto compounds as reported in various research papers are taken for study. Out of 39 phytochemicals, Chrysophanol compound showed highest binding affinity of -7.58kcal/mol having 3 conventional Hydrogen bonds with TRPV3 protein and is found to be a better natural compound as compared to other reported drugs generally used to for the psoriasis. This investigation will lead to more and better findings leading to drug discovery & use as functional food.

Bacterial antibiotic resistance is a type of drug resistance whereby some sub-populations of bacterial species are able to survive after exposure to one or more antibiotics. The study was aimed to determine the antibiotic susceptibility profile of some enterobacteria from respiratory tract infection (RTIs) patients attending some tertiary Hospital in Kano, Northern Nigeria. A total of one thousand and ninety six (1096) isolates were collected. Isolates were subjected to Gram staining, motility test, biochemical characterization and further examined using Microgen TM Gram negative Identification A (Microgen GN ID A) system. Susceptibility of the isolates to some commonly used antibiotics was determined using the disc diffusion method. The result showed that various Enterobacteriaceae isolates confirmed were Pantoae agglomerans 250 (53.53%) being the most occurring followed by Klebsiella spp 160 (34.26%) and then Escherichia coli 57 (12.21%) respectively. The antibiotic resistance pattern of the isolates showed that the highest resistance level was recorded for Ampicillin (78%), followed by Amoxycillin (72%), Ceftazidime (42%). There is also a significant level of resistance to Sulfamethoxazole trimethoprim (36%), Ceftriaxone (28%) and chloramphenicol (24%). Lower resistance levels were observed against Gentamicin (8%) and Ciprofloxacin (10%). It is concluded that there is significant level of antibiotic resistant of some isolates from respiratory tract infection (RTIs) patients.

Silver-conjugated magnetic iron oxide nanoparticles (Ag-MNPs) were successfully synthesized and characterized and its effect on certain bacteria was evaluated. The synthesized nanoparticles were tested against six isolates which include Serratia marcescens, Staphylococcus aureus, Escherichia coli, Enterobacter cloacae, Salmonella enterica and Acinetobacter baumannii. The result showed that antibacterial activity of the synthesized Ag-MNPs was found to be effective against Serratia marcescens and Staphylococcus aureus, while the compound was ineffective against some clinical bacterial isolates. The diameters of the zones of inhibition were found to be 20 mm and 27 mm for Serratia marcescens and Staphylococcus aureus, respectively. The Minimum Inhibitory Concentration (MIC) was 10 mg/ml for both organisms. Also, the Minimum Bactericidal Concentration MBC for the two organisms was found to be 20 mg/ml. Therefore, the synthesized compound has antibacterial activity and could be a reliable compound of choice for treating bacterial infections.

Background: The purpose of the study was to assess the association between job satisfaction and patient safety attitudes among nurses of Faisalabad, Pakistan. Materials and Methods: This is a cross-sectional study conducted in February to May 2021, on the nurses working in two Public hospitals in Faisalabad. A total of 300 nurses participated in the study. The main questionnaire based on the socio-demographic questionnaire comprises of the age, gender, qualification and work experience. Other than this, two questionaire were opted to collect data. One was on job satisfaction questionnaire was developed by Nicholas in 2007 the scale has the 6 dimensions including Coworkers, work demands, work content, work load, work skills and rewards. The other was patient safety attitude questionnaire comprised on six subscales, and additional items on demographic information (Kristensen, Sabroe, Bartels, Mainz & Christensen, 2015). Results: Majority of the nurses were having fatigue impairs while performing emergency situations. Very less participants shares that they were satisfies with the supervision offered to them during provision of the care. The mean score was towards poor conditions. The mean score of the components was less then 3.8 which is towards the dissatisfaction. There was a relationship between educational status and years of experience. Among the lower educational levels the nurses were more satisfied with the job and display more patient safety attitude. Additionally, nurses with more years of experience has less patient safety attitude than other groups of the participants. There was a strong positive relationship between the job satisfaction and patient safety attitudes among the nurses. Conclusions: There was a strong positive relationship between the job satisfaction and patient safety attitudes among the nurses. Hence, senior clinical nursing personals can significantly improve the patient safety implementation of nurses hence, it is suggested that they should take active part in the implementation of the patient safety protocols. Poor team work was the biggest issue in the low levels of job satisfaction. It is necessary to take steps in reducing the absenteeism and uplifting the image of nurses in the team work.

Introduction: Bloodborne exposures (BBEs) are of substantial concern throughout the clinical education of dental students. Developments in the incidence and type of BBEs should be thoroughly examined and assessed and suitable safety mechanisms and work practices be applied to decrease the frequency of BBEs. Materials and methods: This is a cross sectional study conducted among the dental students in Riyadh using an online survey. Dental universities in Riyadh were contacted and participants were requested to fill up the survey. 505 students from clinical levels were utilized in this study. Results: 66.5% had their Hep B vaccination done, 37.3% had their post HBV serology done, 65.5% had no previous exposure to bloodborne pathogen and 3.6% having more than 5 exposures previously. Conclusion: Knowledge seemed adequate, but the attitude and reporting protocol was lacking.

The experiment was conducted on three breeds the total 30 breeds of dairy cows and the number of animal of different breeds was 10 holistan, 10 garai and 10 Cross-bred (CB) during 2019 and 2020. The objective of this study was to know the impact of seasonal on milk production performance of Holistan, Garsi and CB or doragh. The average highest seasonal milk production of Garsi and CB was in spring and summer season, 9.22 and 9.02 liter, respectively and Holistan was highest in spring and summer season (8.261 liter), respectively. The overall average milk production of CB, Holistan and Garsi were 8.86, 7.98 and 7.37 respectively. The seasonal variation and milk production performance of all three breeds were found highly significant. Because the other season production was low. The average milk production of 2470 ± 37 L milk production in spring season followed by 2427 ± 41 L in summer and lowest in winter, as 2403 ± 82 L respectively. The average milk production of Garsi breed in different seasons was estimated and it was noticed that the highest average of 2460 ± 35 L milk production in spring season followed by 2434 ± 14 L in summer and lowest in winter, as 2413 ± 62 L respectively. The average milk production of CB Doragh breed in different seasons was estimated of 2540 ± 35 L milk production in spring season followed by 2457 ± 25 L in summer and lowest in winter, as 2432 ± 20 L respectively.

The telecommunication industry in India is rapidly growing and witnessing many developments. Globalisation has made telecommunication an integral part of the infrastructure of the Indian economy. India's telecommunication network is the second largest in the world based on the total number of telephone users (both fixed and mobile phone).It has gone through several transformations that has led to severe competition in the industry. This research studies the recent trends in the Indian telecommunication sector. The paper will provide a comprehensive knowledge on the recent developments in the sector and will help highlight the changes in the telecommunication industry. The study is based on secondary data. The paper describes the recent trends in Indian telecom sector.

It is well established that muscle activation regulates leg stiffness to optimize stretch shortening cycle (SSC) performance. There is a significant interaction between the surface properties, muscle activation and leg stiffness. The aim of this study was to examine the potentiating adjustments after drop jumps (DJs) executed on two surfaces with different elasticity. Twenty-two adults randomly performed 3 protocols: Protocols with three pre-conditioning DJs performed on a springboard (PSB), Protocol (PG) with three pre-conditioning DJs performed on a stiff ground surface and Protocol without any type of pre-conditioning (C). Vertical jump performance was evaluated at four time points: before (COND0), immediately after pre-conditioning (COND10), and after 1 (COND60) and 2 min (COND120) of rest. Dynamics, kinematics and electromyographic parameters of the ankle were evaluated. ANOVA with repeated measures revealed statistically significant increase in Hpeak, Ppeak and Kleg was observed (p<0.05), over split-intervals and rest periods for Protocol (PSB) while no differences were recorded in jump kinematics. Both protocols (PSB and PG) significantly decreased CI during the pre-activation and eccentric phase, whereas the CI was increased during the concentric phase. The positive effect observed in jump performance could not be attributed to co-activity of the ankle joint, indicating that jumping on an elastic surface, may be beneficial in cases where increased leg stiffness is a determining factor for final performance.

Background: Propofol is a commonly used intravenous (IV) induction agent. The induction dose of propofol is 1.5 to 2.5 mg/kg in healthy adults producing unconsciousness, depending upon concomitant medications (i.e. opoid analgesics), the patient’s age and physical status, and the extent of surgical stimulation. Objective: To assess the induction dose with ketamine and midazolam co-induction to propofola. Methods: This was a prospective, randomized, double-blind and interventional study conducted at Department of Anesthesiology, Sher-e-bangla Medical College Hospital, Barishal, Bangladesh from January to June 2019. Sixty adult patients undergoing elective surgery to be performed under general anesthesia were randomized to receive 0.3 mg/kg of Ketamine or 0.03 mg/ kg of Midazolam intravenously as co-induction agent. A minute after administration of co-induction agent, anesthesia was induced with Propofol 40 mg bolus then 10 mg every 10 seconds until the loss of verbal response. The hemodynamic response at 0, 1, 2, 5 minutes respectively and the induction dose of Propofol were noted. Results: The mean arterial pressure heart rates were significantly lower at 1, 2 and 5 minutes in midazolam group. However, mean arterial pressure and heart were within the physiological range in both the groups. Propofol dose requirement for induction between the two groups was similar (p>0.05) but co-induction significantly decreased the induction dose of Propofol as compared to standard recommended dose for induction. Conclusion: Our study showed that hemodynamic variables were maintained within the physiological range with midazolam and ketamine co-induction. However, lesser degree of decrease in mean arterial pressure was seen with ketamine but the heart rate was higher. A similar reduction of induction dose of propofol was achieved with both the drugs.

Objectives: To assess knowledge and attitude related to cervical cancer prevention, and screening among female students in the college of nursing in Kuwait. Subjects and Methods: This was a descriptive cross-sectional questionnaire-based survey in which 250 female students were recruited to answer the questionnaire. Results: Mean age of the students was 20.91 ±4.28 years. Ninety percent (n = 227) of them have heard of cervical cancer, but only 25.72 % (n = 65) recognized infection with the human papilloma virus as a risk factor. Only 23.33% (n=58) of the students studied are aware of the human papilloma virus (HPV) vaccination. Seventy-nine percent (n=198) of the students studied were aware of the Papanicolaou cervix smear (Pap smear), and 42% of them gave a positive response when asked about the test's necessity. When students with a history of marriage were compared to those without a history of marriage, they demonstrated a statistically significant increase in their intention to undergo cytological examination (61.5 % vs 38.5 %, p=0.036). Comparing students in years 3 and 4 of a bachelor's program to those in years 1 and 2 revealed that student in years 3 and 4 were more knowledgeable about the relationship between HPV infection and cancer cervix (23.7% Vs 16 %, p=0.003). Conclusion: Nursing students have a limited understanding of cervical cancer, HPV vaccination, and Pap smear screening as an early detection practice. Cervical cancer prevention and screening issues must be immediately integrated into nurses' existing teaching and training curricula.

Rationale: The usual metastases of breast cancer are mainly represented by the following organs: lymph nodes, bone, liver, lung, pleura and brain. While gastrointestinal involvement remains rare. Patient Concerns: A 67-year-old postmenopausal woman presented with abdominal pain and obstructive symptoms, she was diagnosed with duodenal metastasis of breast cancer with infiltration of the duodenal mucosa by lobular breast carcinoma. The patient had undergone the right breast mastectomy for infiltrating lobular carcinoma 6 years previously. Diagnosis: Metastatic infiltration of the duodenal mucosa by mammary lobular carcinoma was proven histologically and immunohistochemically. Lessons: The importance of thinking about metastases of the gastrointestinal tract in the presence of non-specific and vague symptoms and of clearly differentiating in this context these metastases from primary gastrointestinal tumors.

Despite medical advances, tuberculosis is responsible for over one billion deaths in the last 200 years. This study was carried out to determine interleukin 10 levels in serum of tuberculosis patients attending Aminu Kano Specialist Hospital, Kano (AKTH). A total of 330 subjects were enlisted for this study. The subjects were grouped into: Group A (30 control) and Group B (300 subjects). DNA sequences specific for Mycobacterium tuberculosis and rifampicin resistance were detected using Gene Xpert MTB/RIF assay. 5mls of blood were aseptically collected from subjects using standard venipuncture procedure into plain tubes for HIV and Interleukin 10 assay. TB patients co-infected with HIV were excluded from this study. The Interleukin 10 level was measured using commercial Sandwich ELISA kits. The result revealed that there was significant difference (p<0.05) between the interleukin 10 levels of the test (11.30±3.79) and control group (9.38±4.39). Furthermore, the result showed that there was no significant difference (p>0.05) between the interleukin-10 levels of rifampicin resistant (11.80±3.87) and non-rifampicin resistant patients (11.65±3.55). Interleukin 10 was also found to be higher among patients aged 30-39 (12.33±3.31) and female patients (11.95±3.50) than in male patients (11.45±3.65). Furthermore, Interleukin 10 level was found to be higher in TB patients before anti TB treatment (12.54±3.82) than in patients after treatment (9.86±3.59). The findings of the study showed that interleukin 10 is a viable biomarker in the pathogenesis of TB infection and can be used as prognostic marker for management of TB patients.

Skin is not only a protecting covering of our whole body but also it reflects the physical and mental health. Mukhdushika is the most common skin ailment in the teenage of youngsters, it disfigure the face. Acne vulgaris is chronic inflammatory condition of the pilosebacous follicles and caused by the Propionibacteriun acnes. It is correlated with Mukhdushika, a disease mention in Ayurveda. Microbial infections are the leading cause of diseases and disease related mortality. Non–judicious intake of antibiotic is the serious concern for antibiotic resistant strain of bacteria. Antimicrobial resistance (AMR) threatens the ability to successfully treat infectious diseases across the world. Among the most common skin pathogens Pseudomonas aeruginosa (gram-negative pathogen) has high antibiotic resistance rate and Staphylococcus aureus is another most common human pathogens that leads to many types of local infections such as wound, post-operative infection and also for prosthetic infections. S. aureus is also known for its ability to resist antibiotics such as penicillin, methicillin, tetracycline, erythromycin and vancomycin, so there is a need of different treatment to overcome the problem of AMR. Similar problem is also arises in the treatment of acne by antibiotics. Tarunyapidikahara Lepa is an Ayurvedic formulation consisting of equal amount of Lodhra (Symplocos racemosa Roxb), Dhanakya (Coriandrum sativum Linn.) and Vacha (Acorus calamus Linn) prescribed for topical application in Mukhdusika in renowned text Chakradatta, Kshudra Roga Chikitsa. This appraisal summarizes the antimicrobial potential of each ingredient present in the Tarunyapidikhara Lepa.

As different connecting means in Chinese and English, parataxis and hypotaxis have always been the focus of discussion and research by Chinese and foreign scholars. This pair of concepts has been studied for a long time, and after years of supplement and improvement, the concepts of parataxis and hypotaxis have been very mature and widely used in the translation practice of various styles. Therefore, the authors give an overview of the research on parataxis and hypotaxis from the aspects of the proposal, development and application of the concepts. Apart from that, the authors also analyze the reasons of parataxis and hypotaxis from the following two perspectives: (1) grammar and syntax, (2) culture and thinking modes. Through this study, the authors hope to further improve the accuracy and fluency of translation between Chinese and English based on theories of parataxis and hypotaxis, and also hope to find some reasonable explanations to the Chinese and Western cultural conflicts.

The Purpose of the present study was to find out the effects of circuit training and circuit weight training on Muscular strength endurance. To achieve this purpose, thirty men kabaddi players from Alagappa University College of physical education, karaikudi, were randomly selected as subjects. The age of the subjects ranged between 21 to 28 years. The selected subjects were divided into three groups of ten subjects each. The experimental group – 1(n=10 CT) underwent circuit training, the experimental group – 2 (n = 10 CWT) underwent circuit weight training and control group-3 (n= 10, CG) did not participate in any special training programme apart from their regular activities. The data was collected at prior to and after the training programme of nine weeks. Muscular strength endurance was chosen as a criterion variable. The analysis of co variance (ANCOVA) was used to analyze the data. The results of the study showed that the Muscular strength endurance was significantly improved due to the circuit and circuit weight training.