The objectives of this study are to analyze and find weaknesses in the Regional Notary Assembly Supervisor Authority in Indonesia currently and how to reconstruct the law to realize a better Regional Notary Assembly Supervisor Authority based on justice value. The method used in this study uses an empirical juridical approach supported by a normative approach with the paradigm used by the constructivism paradigm. The results of the research show that there are that the regulation of the authority of the notary regional supervisory board in the context of supervising notaries is currently not optimal based on the value of justice as there are weaknesses in the regulation of the authority of the notary regional supervisory board in the framework of supervising notaries at this time as the board don't have the authority to impose sanctions on a notary. Therefore, there is a need for reconstruction of the authority of the regional notary supervisory board as stated in article 70 of Law No. 30 of 2004 concerning the position of a notary, in which the notary regional supervisory board must have the authority to impose sanctions on a notary.

Background: The challenges in healthcare continuously evolve. Patient flow, on time coordination of right care and at the same time utilization of hospital resources are all equally important to manage day to day scenarios in a hospital. Purpose: The purpose of this phenomenological study is to explore the perception of Emergency Department (ED) nursing staff about the implementation of the Urgent Care Clinic (UCC). Methods: The Phenomenological-Transcendental approach was conducted in the ED of Security Forces Hospital, Riyadh, Saudi Arabia. The target study population were ED nurses. The purposive sampling technique was used to select 15 samples, who underwent interviews. The inclusion criteria for the participants included full- time Registered Nurses with more than 1 year of experience in the ED, having a diploma or a degree in nursing and participation willingness. Exclusion criteria included newly registered nurses or those nurses holding senior management positions. Results: The interview tapes were transcribed verbatim by a transcriptionist who was knowledgeable with research data confidentiality. Colaizzi's (1978) seven stages of phenomenological technique was used to analyze the data and refine emergent information into themes. Conclusion: This research explored the perception of the ED nursing staff about the implementation of the UCC utilizing Colaizzi's process of phenomenological data analysis to achieve the description of lived experience of the ED nurses.

Nursing research has become increasingly important in health care environment. This paper explores the barriers to research among nurses at the Ministry of National Guard-Health Affairs in Saudi Arabia. This cross-sectional quantitative study was conducted between November and December 2020. The study has utilized a questionnaire comprising of demographic data and a set of perceived barriers categorized into groups, i.e. nurse, institutional and educational barriers. 482 questionnaires were analyzed. The strongest barrier in the nurse category was not knowing how to get involved at 43.1% (n=208; Agree), not having access to mentors with research experience, 45% (n=217; Agree) in the institutional category, and lack of training in research, 46.7% (n=225; Agree) in the educational preparation category. The study showed that multiple factors contributed to lack of engagement in research among this nursing cohort. Therefore, any interventions require a systematic and multiple-pronged approach to support nursing research.

Anaemia is a public health problem that affect both the rich and poor, and it possess a serious challenge to the health care profession, consequently this research is therefore aim at investigating the anti - anaemic potentials of Tigernut (C. esculentus) extract administered to albino wistar rats exposed to Phenylhydrazine induced toxicity. Forty (40) male albino Wistar rats weighing between 180- 250g were used for this study. They were randomly divided into four (4) groups of ten (10) rats each. Control group received normal feed and drinking water. Extract group received 600mg/kg bw of aqueous extract of Tigernut orally, PHZ group received PHZ induction and PHZ + Extract group received PHZ induction + 600mg/kg bw of aqueous extract of Tigernut. The feeding regimens lasted for 4 weeks, after which blood samples were collected via cardiac puncture for estimation of different parameters. Results showed that ingestion of aqueous extract of C. esculentus was able to reverse the significant decrease in RBC (p<0.01), HB (p<0.001), PCV (p<0.001) and Fe+ (p<0.01) values occasion by PHZ induction, back to appreciable level. In conclusion ingestion of C. esculentus extract is capable of reversing the derogatory effect imposed on hemopoietic processes following PHZ induction. Since C. esculentus is cheap and readily available it can therefore be recommended for the management of anaemic condition pending the availability of a viable health facility.

The aim of this research is to find and analyze the weaknesses of the judge's decision on the obscure lawsuit exception in Indonesia and how to reconstruct it based on justice value. This study uses the constructivism paradigm, the approach method is sociological research, the research specifications are analytical descriptive, the data used are primary data and secondary data, primary data is obtained by interview while secondary data is obtained by means of literature study, data analyzed qualitatively by using the Dignified Justice Theory, Legal System Theory, and Progressive Legal Theory. The results of the study show that the Weaknesses include weaknesses in legal substance, namely weaknesses in the provisions of Article 136 HIR. Weaknesses in Legal Culture are that positivism is still the mainstream of judges therefore the Panel of Judges often does not read and study cases together from the start and the Chairperson of the Panel of Judges as a senior judge is still decisive in making decisions, next, the weaknesses in the Legal Structure including the acceptance stage, where, after starting their career as a judge, they must submit themselves to the supervision of judges and structures outside the court. Therefore, the legal Reconstruction intended by the author is related to the values of Pancasila, as the Reconstruction of the Norm is an exception to the obscure lawsuit being considered and decided before the examination of the main case.

The objectives of this research are to analyze and find legal weaknesses of Victim's Protection Regulations through Claims for Damages Case Combination and how to reconstruct the Victim's Protection Regulations through Claims for Damages Case Combination based on justice value. The method used in this study uses an empirical approach and a normative juridical approach with the paradigm used by the constructivism paradigm. This study uses the constructivism paradigm. The approach method used is sociological juridical, with descriptive-analytical research specifications. The data used are primary data and secondary data, which are then analyzed. The results of the study show that the weaknesses in merging cases for compensation claims include: a) Lawsuits can only be filed at the first level; b) The public prosecutor who enters the request for compensation in the case file; c) The decision on compensation demands is very dependent on the criminal case, therefore, Based on the foregoing, the legal reconstruction as intended by the author is by adding a new article, namely article 98 paragraph (3) which reads: "That the Public Prosecutor is obliged to ask the victim whether he wants to make a claim for compensation" and also revises Article 100 paragraph ( 2) so that it reads: "If a criminal case is not filed for an appeal, then an appeal regarding the decision for compensation is still permitted."

This research article presents a numerical simulation of the extensive severe cyclonic storm Fani and its impact along the coast of Bangladesh, which made landfall in the coastal region of Odisha, India, on May 3, 2019. A semi-implicit finite difference method in Cartesian coordinates was employed in this study to solve vertically integrated shallow water equations. The approach allowed for effective forecasting of the storm Fani's impact on the region of choice. Our considered physical domain is discretized with high-resolution gird to cover all the big and small offshore islands. The model predicted water levels for a total of sixteen coastal stations of the Bay of Bengal along the coast of Bangladesh (from 2 May to 03 May 2019, at 3-h interval). Simulated water levels are found closely co-related to the reported data. The simulation results demonstrate that the semi-implicit finite difference method is an effective tool for simulating the storm surge and flooding caused by any severe cyclonic storm. The study also shows that the storm surge and flooding caused by Fani were significant, with a maximum surge height of over 5 meters in some areas. The simulated results provide insights into the spatial and temporal evolution of the storm surge and flooding, which can be useful for designing and implementing appropriate disaster management strategies in the affected regions. Overall, this research article contributes to the scientific understanding of the behavior of severe cyclonic storms and the associated storm surge and flooding, and provides a valuable tool for policymakers and stakeholders to develop and implement effective disaster management strategies in cyclone vulnerable coastal regions.

Basaloid squamous carcinoma of the uterine cervix is a rare tumor type characterized by an ulcerated, infiltrating growth pattern; nests or cords of small basaloid cells; prominent peripheral palisading of cells in the tumor cell nests; and the absence of significant stromal reaction. The characteristic microscopic features are nests, lobules, trabeculae and groups of round to oval basaloid tumor cells. These tumor cells are small with high nuclear cytoplasmic ratio and shows peripheral palisading. There may be areas of comedo type necrosis and areas showing typical squamous cell carcinoma differentiation.

As a follow-up to an earlier report on the antihyperlipidaemic activity guided fractionation study on the chloroform extract from the sclerotia of the edible mushroom Pleurotus tuber regium, this present study is reporting the isolation of a sesquiterpene enol carboxylic from the active chromatography fraction of the chloroform extract of this edible mushroom. The purity of the compound was confirmed from TLC and Melting point determination. The chemical structure was elucidated using spectroscopic techniques (Mass spectrometry, 1&2D Nuclear magnetic resonance and Infra red spectroscopy). The isolated compound coded as compound P, exhibited molecular mass of 256 with molecular formular of C14H24O4 and from the 1 &2D NMR and IR analyses, the compound P was identified as a sesquiterpene enol carboxylic acid with a sytemic name of 2,3-dihydroxy-10-propylcyclodec-2-ene-1-carboxylic acid.

Background: Type 2 diabetes mellitus is a prevalent hereditary condition that has multiple genetic risk factors as well as environmental influences. Aim: The Work aimed to find if there is an association between the presence of Single Nucleotide Polymorphism of the Adiponectin gene & its association with type II diabetes in Egyptian patients. Material & Techniques: This case-control research had been conducted at Molecular Biology and Biochemistry, Genetic Engineering & biotechnology institute, university of Sadat city. This research had been conducted on eighty patients; separated into 2 groups diabetic group and the control group. Results: significant reduction in adiponectin level in type II diabetes studied cases compared to normal control subjects (p <0.001). GG genotype is significantly more predominant in type 2 diabetes (54%) while the GT genotype is more predominant in control (60%) (p-value =0.04)., while no variation in allele distribution among both groups (p value=0.6). Conclusion: In studied cases with type 2 diabetes, there was a significant reduction in adiponectin levels in type II diabetes patients. GG genotype is significantly more predominant in type 2 diabetes. The genotype GG significantly rises the risk of occurrence of type 2 diabetes.

Pulmonary Tuberculosis is caused by bacilli mycobacterium tuberculosis and known to infect human race since the dawn of history and archaeological evidence has traced its association in neolithic times. Tuberculosis is the most common infectious lung diseases in India with significant mortality and morbidity. Tuberculosis can cause diverse thoracic presentations ranging from nodules, consolidations & cavitation, mediastinal adenopathy, pleural effusion to diffuse endobronchial disease presenting like bronchial asthma. Due to diverse presentations, diagnosis is many times delayed due to lack of suspicion by treating general physicians and rational treatment many not offered in time. In spite of awareness by government organizations and considered as ‘global health issue of concern’ by World Health organization, tuberculosis is still considered as social stigma. Destroyed lung is described in literature and known complication of pulmonary tuberculosis. Destroyed lung is defined as combination of pleural and parenchymal lung destruction with cavitation, bronchiectasis, loss of lung volume and mediastinal herniation to diseased side. In this case series, we have reported two cases with history of pulmonary tuberculosis in past and received adequate anti-tuberculosis treatment. Both were having residual chronic lung disease and symptoms causing significant impact on quality of life with recurrent hospitalization, hospital visits and cost of care. One patient has history of delayed diagnosis and ATT was started after maximum lung destruction due to tuberculous process has already occurred. In this patient tuberculosis was cured but residual lung damage or sequel presenting as destroyed lung. In second case, tuberculosis was diagnosed in adequate time but patient has defaulted due to adverse events of ATT and he has taken medications as per his own tolerance. Neither adherence nor compliance was acceptable in second case and resulted into partially treated case of pulmonary tuberculosis. Ongoing lung destruction inn second case would be cause for destroyed lung in absence of irrational medicines in today’s era of good quality ATT. Destroyed lung is preventable with early diagnosis, prompt evaluation with microscopy and nucleic acid amplification tests and treatment with universally available, acceptable and affordable free ATT as National guidelines. Destroyed lung is having significant impact on quality of life and health expenditure and considered as ‘radiological stigma’ of Tuberculosis.

Background: Effective root canal treatment involves cleaning and shaping root canals using a range of instrumentation procedures and techniques. The aim of this review was to provide an update on root canal hand instrumentation techniques and how to overcome iatrogenic errors. Purpose: Purpose of this review was to provide an update on root canal hand instrumentation techniques commonly used in endodontics, including how to overcome iatrogenic errors and optimize the quality of endodontic treatment outcomes. Methods: A comprehensive search was carried out using multiple databases, PubMed, Medline, Google scholar, and Scopus, to identify relevant studies addressing the objective of this study and to summarize the current evidence to readers. Results: The hybrid technique is a commonly used approach that combines the benefits of both the crown-down and step-back techniques and was reported to be one of the best techniques to produce an optimal root canal preparation outcome. Hand-instrument manipulation using the balanced forced technique is also favored as it rapidly and safely permits removal of canal contents allowing irritants and medications to reach deep inside canal spaces. Conclusion: The use of hand files is still recommended for initial canal negotiation and preparation and is essential for the correction of procedural errors. This study provided an update on several hand instrumentation techniques commonly used in endodontics. The correct and safe application of these techniques can prevent iatrogenic procedural errors from occurring which optimizes the quality of treatment outcome.

In the present research, the level of cancer antigen 125 (CA125) significantly increased in DMBA experimental groups (group II) compared to normal control group. However the level of CA125 decreased in dose dependent manner with 10% carbohydrate ketogenic diet having the most significant effect. Also, the 7,12-Dimethylbenz(α) anthracene (DMBA) caused significant increase in liver enzymes (Alanine amino transferase, Aspartate amino transferase and Bilirubin) of 41±1.06, 40±1.16, 20.80 ±1.47 and 25±1.34, 27±143, 12.17±1.08 compared to normal control at P<0.05 respectively. Furthermore, with the group treatment 10%, 20% and 30% carbohydrate ketogenic diets also elevated the liver enzymes. More so, a significant decrease was observed in total protein, albumin, RBC, Hb, PCV, MCH superoxide dismutase, glutathione reductase and glutathione peroxidase with a corresponding increase in white blood cells. Interestingly, ketogenic diets significantly increase total protein, albumin, superoxide dismutase, glutathione reductase, and glutathione peroxidase with a decrease in white blood cells, total cholesterol, triglyceride, low density lipoprotein bilirubin concentration. It can therefore be concluded that, the administration of ketogenic diets slows the progression of breast cancer through inhibiting the downstream of insulin receptors of both mammalian target of rapamycin signal cascade and motogen activator protein kinase pathways.

Monthly All Share Index data from 1985M01-2021M12 was sourced from the Central Bank of Nigeria and the Central Securities Clearing System of the Nigerian Stock Exchange; to analyze multiple bubble periods. The supremum Augmented Dickey Fuller (SADF) and Generalized supremum Augmented Dickey Fuller (GSADF) quantitative model with 1000 repetitions along with a window size of 42 was selected to carry out the Monte Carlo simulation at the 95% confidence level. From the Backward SADF estimation, three periods of explosive pricing and collapses were detected. The study therefore recommends that market regulators should promote market information and support regular training of market participants to stem speculations and reduce arbitrage. Overall, well-informed risk management practices should be established to guard against market losses.

Medication mistakes continue to be one of the most serious issues in hospitals. Such mistakes can occur during the prescription, distribution, or administration of medications. Lipid emulsions are commonly utilized in whole or partial parenteral feeding initially, Following convincing results from animal models and effective case reports in humans, the use of intravenous lipid emulsions (ILEs) as an antidote in local anesthetic systemic toxicity has acquired considerable acceptance. Although intravenous lipid emulsion (ILE) was initially employed to treat life-threatening local anesthetic (LA) toxicity, its application has broadened to cover non-LA poisoning and less severe symptoms of toxicity. However, in recent years, the function of lipid emulsions in the treatment of lipophilic chemical toxicity and overdose has been established. In addition to typical poisoning treatment, lipid emulsion therapy was employed. The observed sequence of events provides substantial support for the importance of ILE treatment in the effective management of both instances. However, further study is needed in this area to provide definite guidelines for the use of intravenous lipid emulsions in pediatric lipophilic agent poisoning. The body of data supporting the use of ILEs in acute drug intoxication is growing. The current data supports the use of ILEs only when there is an imminent threat to life from local anesthetic systemic toxicity or lipophilic cardio-toxin poisoning. Lipid emulsion therapy is a potential and less expensive alternative in cases of acute lipophilic poisoning where a specific antidote is unavailable.