Chemotherapy induced peripheral neuropathy is a disabling pain condition resulting from cancer therapy. However, no scientific data available for many herbal drugs which are locally used and evaluating these drugs would be worth to have scientific approach of using them. In this study an indigenous plant called Clerodendrum viscosum leaves have been used to evaluate the effect of plant in vincristine induced peripheral neuropathy in rat model. Vincristine sulfate was administered to Male sprague dawley rats to induce neuropathy. Pain behavior was assessed by Hot plate, Cold plate, sciatic function index and formalin test were also estimated. Animals were sacrificed and the sciatic nerve excised for histopathological studies. The whole preclinical studies revealed that the aforementioned plant extract exhibited less neuronal damage. The study concluded that methanolic extract of Cleodendrum Viscosum leaves can used against chemotherapy induced peripheral neuropathy.

Background: Magnesium plays an import role in the physiology of parturition. Decrease of Magnesium in plasma may be responsible for a decrease of the same in myometrium and this might have a considerable influence on the preterm labour. A Hypomagnesaemia leads to neuromuscular irritability leading to uterine hyperactivity which leads to cervical dilation. Objective: To find out the association between serum magnesium and preterm level. Methods: This was a cross sectional study, conducted in 100 women in labour, of them 50 were diagnosed case of preterm labour and 50 women were in labour at term attended in Gynaecology and Obstetrics department of Dhaka Medical College, Dhaka, from January 2015 to December 2015.5ml fasting blood sample was collected and was analyzed for serum magnesium using a standard enzymatic method. The mean value of serum magnesium was compared between two groups by student unpaired t-test and serum magnesium level was correlated with BMI, Gravita and gestational age in preterm labour patients by Pearson’s correlation coefficient test. A p-value was considered to be statistically significant at 0.05 at a 95% confidence interval. Results: The mean age was found 28.2±4.5 years in group I and 26.7±4.1 years in group II. The mean age difference was not statistically significant (p>0.05) between two groups. A majority (80.0%) of the patients came from a middle-class family in group I and 29(58.0%) in group II. The mean BMI was found 23.0±3.8 kg/m2 in group I and 26.4±2.4 kg/m2 in group II. The socioeconomic status and BMI were statistically significant (p<0.05) between two groups. The mean serum magnesium was found 1.64±0.13 mg/dl in group I and 2.05±0.11 mg/dl in group II. The mean serum magnesium level was significantly (p<0.05) lesser in group I. Serum magnesium had an area under curve 0.974, which gave a cut-off value < 1.8 mg/dl, with 98.0% sensitivity and 88.0% specificity for prediction of preterm labour. Conclusion: Most of the patients were belonged to age 21-30 years in both groups are not associated. A negligible correlation was found with BMI, gravid, through serum magnesium in preterm labour. Low serum magnesium level was significantly higher in preterm labour.

In the making of the United States of America, rights related to life, liberty and pursuit of happiness hits blocs prejudices and society-based realities. Unlike whites, blacks witness cases of highly-ranked socio-economic hardships in settling families, providing the minimum possible for stable households and assuring well-mannered children from one generation to another. Failure to pass on a legacy of well-indicated morals, mores, attitudes and patterns is abundantly highlighted in Fences by August Wilson, with Troy Maxson the main character who definitely misses the point the same way his own father does with consequences on kids, wives and the whole living society. Psychoanalysis and Marxist literary theories help to denote and decode how generations of fathers as bread-winners pass on to extended families, principles for living which members of the same family accept or reject through manners in which they choose to live their own lives: unfulfilled responsibilities and generation gaps at stake.

This study examines the social and economic conditions of handloom weavers in Uttar Pradesh state of India. This study is primarily based on secondary data, and the data were evaluated using a simple percentage, an annual growth rate, and a compound annual growth rate. They were also shown in a pie chart and a bar chart. This study is based on the following key aspects such as location, age, gender, religion, social group, educational qualifications, type and size of family, employment status, type and ownership of dwelling units, ration card, source of loan and purpose of the loan, monthly household income from handloom-related activities, and ownership of looms. The study results indicated that most workers are men, and the number of women workers is not good. Most weavers in Uttar Pradesh are members of the Muslim religion or the OBC (Other Backward Class) social group. Most workers live in kutcha houses, especially in rural areas. In cities, more households live in pucca and semi-pucca houses than in rural areas. It was also found that most handloom workers (97.3%) have their own homes in rural areas. There aren't enough educated handloom weavers, and a study shows that most weavers have never been to school. It can be said that most of the weavers, or about 55 per cent, worked as independent weavers. About 40 per cent worked as master weavers. It was found that most, or 59.5 per cent, of weaver households, have an income of less than Rs. 5,000. It can be said that most (53.2% of the weaver households) have taken out a loan for handloom purposes. The study found that most (25.5%) handloom households got loans from the government, followed by commercial banks (21.9 per cent). It found that most weaver households (73.5% of them) work with looms and that 26.5 % of weaver household’s work without looms. The study found that more male weavers (66.1%) have bank accounts than female weavers (only 33.7%). The study found that more male weavers (66.1%) have bank accounts than female weavers (only 33.7%). It found that 62.4 per cent of male weavers and 37.5 per cent of female weavers have aadhar cards. Only two transgender people have Aadhar cards. Most households (60%) have a monthly household income of less than Rs. 5,000, but the monthly household income in cities is higher than in rural areas. It also shows that most of the sales of their main products come from the local market (46.1%) and master weaver (43.3 per cent).

The purpose of this research study was to investigate the effects of ethanolic stem bark extract of Persea americana on some reproductive parameters of female Wistar rats. In this study, female Wistar rats were randomly assigned into three (3) groups of 5 rats each. The control group (Group 1) was given distilled water. Group 2 received 200mg/kg of the extract and group 3 received 400mg/kg of the extract daily for a period of 21 days following acclimatization. The female rats were cohabited with males in the ratio 2:1 (M:F) for 10 days. Blood samples were collected and some tissues harvested at sacrifice. The statistical analysis was done using Statistical Package for Social Sciences (SPSS). One-way analysis of variance (ANOVA) test was used to compare groups followed by post-hoc testing to determine whether there were significant differences between the control and treatment groups. P-value less than 0.05 was considered significant and result presented as Mean±SEM. The result showed that the extract of Persea americana caused stimulatory effect on anterior pituitary synthesis of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and may have also caused changes in the gonads leading to decreased gonadal hormone synthesis (estrogen and progesterone). The percentage fertility of the female Wistar rats was significantly reduced suggesting that the stem bark extract of Persea americana possess antifertility effects.

Objectives of the study: the metabolic syndrome (MS) consists of a group of metabolic alterations that have insulin resistance as their common denominator and identifies a pathophysiological condition at high risk of developing cardiovascular disease and type 2 diabetes. 20% and 30% of the adult population is affected by MS Design and method: in this article the authors try to make a scientific contribution regarding the problems of some patient populations often having to necessarily take drugs with an important metabolic impact while developing an iatrogenic-based MS (IMS) and propose to further investigate the aspects and the clinical pharmacological problems of the population of psychiatric patients at risk of MS. Results: Although the prevalence of MS has been observed to be often higher in the urban population of some developing countries, there are patient populations who develop MS due to the extensive use of certain drugs with obesogenic-metabolic adverse effects, in particular some generations of antidepressant and neuroleptic drugs (NL) used in mental disorders and antiretroviral drugs, such as integrase inhibitors used in HIV infection. Conclusions: Populations at risk of IMS should be at the center of the search for an individualized precision medicine with the careful choice of pharmacological therapies and appropriate lifestyle. Unfortunately, precision medicine in the psychiatric field seems to be stopping its growth due to the lack of identification of biomarkers and indicators of psychopathology.

Bacterial and viral therapies have gained enough success and attention for biological cancer treatments. There is a need to protect the living tissues of the body that are helpful for activating the immune responses. Many failures are associated with the conservational therapies that render them for the current era of medical sciences. Viral and bacterial genomes have been used for targeting the initial basis of metastasis and inhibiting the growth of cancerous cells. S. pyogenes OK-432 strain showed action against cancerous cells with intact bindings to the proliferative tissues. Phenazine 1-carboxylic acids have anticancer nature and pose a high level of cytotoxicity against the. Salmonella strain (KST0650) showed maximum potential against CT26 cancer cells. Oncolytic biologically and virologically group of the controlled viruses that have been used for tumor treatment. Some critical cancers under medications such as hormone therapy- induced helpful for prolonged life span. Pro-active drugs and combinations of probiotics also prevent the bacteria from synthesizing the protective layer of peptidoglycan.

Background: Hypertensive disorder is the most common medical problem encountered in pregnancy with a high perinatal and maternal mortality & morbidity. Worldwide about 76,000 pregnant women die each year from preeclampsia and related hypertensive disorders. Objective: To assess the relation between labetalol and methyldopa in treatment of pregnancy induced hypertension. Methods: This study was hospital based comparative prospective study was conducted at Dept. of Obstetrics & Gynaecology, Dhaka Medical College Hospital, Dhaka, Bangladesh from January to June 2021. The study consisted of 100 patients with pregnancy induced hypertension attending outpatient department and admitted in ANW, or who directly came to labour room. These patients were randomly selected on lottery basis after they fulfilled the inclusion criteria. Total patients were taken for the study and divided into 2 groups of 50 patients in each group. Results: A total 100 patients were included. The mean age in Group I was 24.4±4.55 years and in Group-II, 23.95±4.28 years. Maximum number of patients was between 19- 24 years in both the groups. In Group-I, 26 (52%) patients and in Group-II, 25 (50%) patients were in this age group. The maximum age in the Group I was 34 years and 35 years in the Group-II. The minimum age was 17 years in both the groups. The inter group difference was not statistically significant (p>0.05) thus the two groups were comparable by age. At baseline no significant difference was seen in SBP in both treatment groups. However after 8 days post testament SBP of women was significantly lower in Group-I patients as that of Group-II patients. i.e. Group-I: 123.41 vs. Group-II: 126.62, p- value=0.009. At baseline no significant difference was seen in DBP in both treatment groups. However at 8th day post treatment DBP of patients was significantly lower in Group-I patients. i.e. 77.18 vs. Group-II 79.64, p-value=0.005. For SBP more effective control was seen in women whose parity was 3-4 and for DBP notable difference was seen in women whose parity was 1-2. The control of systolic blood pressure was more effective in patients with normal body mass index and for Diastolic blood pressure (DBP) more effective control was seen in patients who were obese. On comparison methyldopa significantly causes more drowsiness, headache and nasal congestion and the incidence of Postural hypotension and dysponea in both groups were not significantly different. The patient who required additional drugs to control the uncontrolled hypertension. In Group I, 2 (4%) patients and in Group II, 3 (6%) patients did not respond with starting drug. The inter group difference was not statistically significant (p>0.05). Conclusion: Labetalol had less maternal adverse effect compared to methyldopa but fetal outcome was not observed in this study. Labetalol and methyldopa are equally efficacious in controlling blood pressure in new onset hypertension in pregnancy. This study is just a step in this long way. Therefore, labetalol can be considered positively in the treatment of pregnancy induced hypertension.

Production of environmentally amenable silver nanoparticles (AgNPs) has earned the interest of the scientific community owing to their broad applications, primarily in the field of optronics, sensing, and extensively in pharmaceuticals as promising antioxidant, antimicrobial and anticancer agents. Conventionally silver nanoparticles are synthesized by a chemical method using chemicals as reducing agents which later become accountable for various biological risks due to their general toxicity; engendering the serious concern to develop environment-friendly processes. This study explored the production of eco-friendly AgNPs and the investigation of their antibacterial activity using ethanolic leaf extract of Jatropha curcas (LEJC) as the reducing agent and aqueous silver nitrate as the precursor. The characteristics of the synthesized LEJC-AgNPs were studied by ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform Infrared (FTIR) and Scanning Electron Microscope (SEM). The LEJC-AgNPs formation was observed from the colour change of the mixture from dark-yellow to colloidal brown. A distinctive absorption maximum with surface Plasmon resonance at 425 nm confirmed the formation of LEJC-AgNPs and data on SEM analysis have shown that the synthesized nanoparticles were in the nano range and predominantly irregular and spherical in shape. FTIR identified the functional groups present in the extract for the formation of the LEJC-AgNPs. This green synthesis provides an economic, eco-friendly, and clean synthetic route to AgNPs. The assessed antibacterial activity of the LEJC-AgNPs obtained depicts activity against Staphylococcus aureus (Gram-positive), Escherichia coli and Klebsiella Pneumonia (Gram-negative) at 20, 40, and 80 mg/mL respectively. This data is reflective of the role of LEJC-AgNPs as a potential and promising antimicrobial agent against bacterial infections.

The purpose of the study was to investigate the impacts of pressure training with yogic practices on ability of kicking and self-confidence among football players. Forty out of handball players were randomly selected from Coimbatore district, selected players were divided into two groups consisting of 20 football players. No attempt was made equate the groups. The age of the subjects ranged between 18 to 23 years. The influence of the pressure training with yogic practice was assessed on fitness. The training load was increased from the maximum working capacity of the subject doing pilot study. The study was formulated as pre and post-test random group design, in which forty were divided into two equal groups. The experimental group-1(n=20) underwent Pressure training and group -2 served as control group (n=20). In this study, only one training program were adopted as independent variables and ability of kicking and self-confidence was selected as dependent variable and it was tested by warner soccer skill test, performance was recorded in points and self-confidence was tested by CSAI-II Inventory was recorded in scoring. The training period of this intervention 6 days in a week for twelve weeks. The collected pre and post data was critically analyzed with dependent‘t’ test. The level of significance was fixed at 0.05 levels for all the cases in order to find out the significance. The result clearly proved that the pressure training demonstrated better improvement on ability of kicking and self-confidence and self-confidence.

The positive diagnosis of autoimmune pancreatitis (AIP) can be challenging and poses a problem of differential diagnosis with pancreatic cancer. It’s most sensitive and specific biological marker is the serum IgG4 level. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) plays a key role in the positive and differential diagnosis. Treatment is based on corticosteroid therapy. We report the case of a 43-year-old female patient admitted for cholestatic jaundice with a cephalic pancreatic mass on imaging simulating pancreatic cancer.

This article provides the conceptual framework for earnings management, which begins by presenting the concept of earnings management, then the actions, motives, techniques, measurement, and then the consequences of this practice. This article also presented studies that dealt with earnings management in the Saudi context. This is because the Kingdom of Saudi Arabia has recently witnessed a clear development in companies and changes in accounting systems which in turn provides an opportunity for more research on earnings management in Saudi Arabia. Several studies provide evidence that EM occurs in Saudi companies, and there are many motivations to practice earnings management in Saudi companies.

Background: Adhesive Capsulitis is a frequent issue that can cause serious impairment. There have been many different treatments explored, with encouraging outcomes, but the effectiveness of these interventions is not well supported by the available data. Anecdotally, pulsed radiofrequency (PRF) to the suprascapular nerve (SSN) has been described as a safe and effective procedure. In addition to the PRF SSN, this study provides evidence of therapeutic motor and sensory stimulation. Methods: 110 patients with adhesive capsulitis underwent percutaneous PRF to the SSN under ultrasound guidance, and the results were prospectively evaluated. Patients were split into two groups. The SSN was demonstrated by the first group (60) in the suprascapular region. A second group of 50 people used a radio frequency equipment to apply motor and sensory stimulation (MSS) cycles to the proximal SSN in the supraclavicular area in addition to the PRF. At 2, 8, and 12 weeks, respectively, the pain was monitored using the Visual Analog Scale and active range of motion (AROM) in the shoulder. Results: Patients in both groups reported significantly substantial reductions in pain scores and improved movement all-time points as compared to pre-procedure scores (P<0.001). Supraclavicular pRF with stimulation significantly reduced pain scores and improved shoulder motions at 2 and 4 weeks compared to suprascapular PRF with stimulation (p<0.05). Regarded 12-month follow-up group showed a substantial improvement in shoulder motions (p<0.05), but there was no discernible difference in pain level. Conclusion Proximal PRF SSN with MSS demonstrated encouraging outcomes for early pain relief and enhancement of shoulder functioning. There are financial advantages. Without the need for hospitalization or extended physical therapy sessions, return to work sooner. However, the sample size was too tiny to allow for any significant interpretation.

City publicity video spreads city images with strong visual impact, and high-quality subtitle translation builds a bridge for cultural exchange. So this paper takes the short video City For Life of Xiong'an as an example and bases on its stylistic features to discuss the strategies of sound and picture synchronization, discourse coherence strategies, and cultural value principles applied by translators in the process of subtitle translation. The translator should strive to achieve textual coherence and cultural transmission on the basis of the inherent characteristics of subtitles.

Background: Excess aromatase activity is common in males with severely impaired sperm production, as shown by low Semen testosterone and somewhat increased estradiol levels. Elevated estrogen levels cause inhibitory effects of the hypothalamic-pituitary-gonadal axis, resulting in a reduction in LH required for testosterone production and FSH to maximize sperm motility. The main objective of this study was to see how an aromatase inhibitor to Improve Semen Quality in Case of Eugonadotropic Hypogonadism. Methods: This Prospective study was conducted in the Department of obstetrics and gynecology, Dhaka Medical College Hospital, Dhaka, Bangladesh during the period from June 2020 to May 2021. The sample size was 40 subfertile men with oligospermia. (≤ 10 million/ml), low semen testosterone level (<300 ng/dl) and low testosterone to estradiol ratio (<10). All patients were treated with Aromatase Inhibitor 2.5 mg daily for 4 months. At the end of the 4 months the semen analysis was performed. Statistical analysis was carried out by using IBM Statistical Package for Social Sciences version 25 for windows (SPSS version 25.0). Results: The sperm concentration, sperm motility and total motile sperm count significantly increased after Aromatase Inhibitor treatment. The side effects were mild and well tolerated. Conclusions: According to the findings of this study, some men with oligospermia, low Semen testosterone levels, and normal gonadotropin levels may have curable endocrinopathy. In infertile males with a low Semen testosterone to estradiol ratio, Aromatase Inhibitor may be administered to enhance sperm parameters.