Introduction: A relatively new type of ectopic pregnancy is cesarean scar pregnancy (CSP). This is related to the increasing number of cesarean deliveries and to the advances in imaging. There are 2 types of CSP; CSP with progression to cervicoisthmic space or uterine cavity (type I, endogenic type) or with deep invasion of scar defect with progression towards bladder and abdominal cavity (type II, exogenic type). The endogenic type of CSP could result in a viable pregnancy; yet with a high risk of bleeding at the placental site. The exogenic type could be complicated with uterine rupture and bleeding early in pregnancy. As early diagnosis and treatment is important for the best outcome, every pregnant woman with history of cesarean delivery should be screened early in the first trimester of pregnancy. Diagnosis can be achieved with ultrasound and Doppler imaging. To date there have been only 5 randomized studies on CSP and evidence based management remains unclear. Until then, treatment should be individualized according to many factors including clinical presentation, β-hCG levels, imaging features, and the surgeon’s skill. We report a case of cesarean scar pregnancy successfully managed in our university hospital center.

Collision tumors of the thyroid gland are a rare entity. Primary squamous cell carcinoma of the thyroid (PSCCT) is a malignant epithelial tumor, composed entirely of cells with squamous differentiation and accounting for less than 1% of all malignancies of the thyroid gland. PSCCT arises from other thyroid diseases such as Hashimoto’s thyroiditis, tall cell variant papillary carcinoma, follicular carcinoma, and anaplastic carcinoma1. We describe a patient with the combination of a well-differentiated squamous cell carcinoma and follicular carcinoma of the thyroid.

Introduction: The neutrophil-lymphocyte ratio (NLR) is an economically accessible tool useful in cases of Type II Diabetes Mellitus (T2DM). It can be utilized as a laboratory index, indicating systemic inflammation. The sensitivity of NLR to HbA1c must be validated to utilize for its prognostic potential. Correlation of HbA1c with NLR and other parameters have been analyzed to assess the utility of NLR in chronic cases of T2DM, thereby evaluating the utility of NLR as a marker of systemic inflammation in diabetes. Place and Duration of study: Department of Pathology, Saveetha Medical College, Chennai, One year. Objectives: 1. To compare levels of NLR and other parameters in diabetics with those of healthy people and observe the nature of correlation between HbA1c and other parameters.2. To find the linear relationship between HbA1c and other parameters in the diabetic population. Material and methods: An observational study conducted at our Institute from January to October 2020. Blood profiles of 240 T2DM patients and 100 healthy controls were recorded. Results: The NLR (5.35) of T2DM group was significantly elevated (p 0.001) compared to NLR of control group (2.16). Urea and creatinine levels had positive regression coefficients with HbA1c indicating susceptibility of diabetic patients to diabetic nephropathy. Conclusion: NLR showed significance in T2DM. Increased NLR is associated with elevated HbA1c and poor glycemic control in patients with T2DM. It can be used as a prognostic tool during the follow up of diabetic patients.

Aim: To evaluate the platelet indices in differentiating reactive and clonal thrombocytosis. Study Design: Observational study Place and Duration of Study: Department of Pathology, Saveetha Medical College, Chennai, and the duration of study is one year. Methods: This is an observational study conducted at our college for a one-year duration. A total of 100 patients with thrombocytosis of platelet count over 4.5 lakhs/mm3 will be included in the study. The study sample consists of cases with thrombocytosis of over 4.5 lakhs. The utility of platelet indices Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) for the differential diagnosis of thrombocytosis were analysed and assessed. Results: Out of the total 100 cases, 94 were reactive thrombocytosis, and 6 were confirmed to be clonal in origin. Infectious and reactive aetiology was significantly more compared to clonal thrombocytosis. Patients with reactive thrombocytosis showed a lower mean platelet volume and platelet distribution width compared to primary thrombocytosis. In reactive thrombocytosis, MPV ranged from 8.0 - 9.0 fl with mean MPV of 10.6 fl and PDW ranged from 8.4 – 10.1 % with mean PDW of 10.26 %. In clonal thrombocytosis, MPV ranged from 8.2 –1 1.1 fl with mean MPV of 9.5 fl and PDW range was 8.9 – 11.2 % with mean PDW of 10∙1%. Conclusions: The findings of our study favour a reactive cause in thrombocytosis when MPV and PDW are in the lower range and clonal causes had a high MPV and PDW in comparison to reactive causes.

Pre-pregnancy mother's body mass index plays a role in increasing or decreasing maternal weight. Maternal body mass index is a prominent indicator for the nutritional status of pregnant women who can be at risk of increasing the occurrence of births with low birth weight babies. This study aims to analyze the relationship between pre-pregnancy body mass index and the occurrence of low birth weight babies at Abdul Moeloek General Hospital Bandar Lampung, Indonesia. This study uses an observational analytic research design with a cross sectional approach. The population in this study were all post-partum mothers who gave birth at the Abdul Moeloek Regional Hospital in Bandar Lampung and involved a sample of 79 respondents who were taken using the consecutive sampling technique. Sampling was carried out based on inclusion and exclusion criteria that met the research criteria until the desired number of samples was met. Analysis of the research data is the chi-square test and logistic regression test. The results showed that the two independent variables, namely the pre-pregnant mother's body mass index and weight gain during pregnancy, had a significant relationship to the baby's birth weight. The significance of body mass index is p-value=0.004 and the significance of weight gain during pregnancy is p-value=0.000. Thus the body mass index of pre-pregnant women and weight gain during pregnancy can affect low birth weight babies at Abdul Moeloek Hospital Bandar Lampung.

Background: Orthodontic treatment involves the use of appliances such as braces or aligners to straighten teeth and improve bite. Maintaining good oral hygiene during treatment is crucial to prevent the development of dental caries and periodontal disease. Methods: A literature search was conducted using PubMed, Cochrane Library, and Google Scholar for studies published between 2018 and 2022. The search terms used included "orthodontic treatment," "oral hygiene," "dental caries," and "periodontal disease." Inclusion criteria for studies were: (1) written in English, (2) published in peer-reviewed journals, (3) focused on orthodontic treatment and oral hygiene, and (4) included original research. Exclusion criteria were: (1) case reports, (2) reviews or meta-analyses, (3) not focused on orthodontic treatment or oral hygiene. Results: A total of 28 studies were included in the systematic review. The majority of the studies were observational in nature and conducted on adolescent patients. The studies consistently demonstrated that poor oral hygiene during orthodontic treatment is associated with an increased risk of dental caries and periodontal disease. Specifically, a poor oral hygiene status was found to be associated with a higher incidence of white spot lesions, gingivitis, and periodontitis during treatment with fixed appliances. Conclusion: The results of this systematic review demonstrate the importance of oral hygiene in orthodontic treatment. Patients undergoing orthodontic treatment should be educated about the importance of maintaining good oral hygiene to prevent the development of dental caries and periodontal disease. Dentists and orthodontists should closely monitor the oral hygiene status of their patients during treatment and provide appropriate interventions to improve oral hygiene and prevent the development of oral health complications.

This study was conducted to evaluate the presence and concentration of Oxytetracycline and Penicillin G residues in raw cow and Fermented milk consumed in Maiduguri, Northeastern Nigeria. A total of 172 (86 raw and 86 fermented) milk samples were randomly collected from different milk selling points in Maiduguri. A Spectrophotometer ultraviolet visible spectrum machine was used to detect and quantify the oxytetracycline and penicillin G residues in the milk samples. All samples (raw and fermented milk) tested positive for oxytetracycline and penicillin G residues with a mean residual concentration of 36 µg/L and 20 µg/L in raw and fermented milk respectively for oxytetracycline while the mean residue concentration of penicillin G is 649 µg/L and 397 µg/L in raw and fermented milk respectively. However, the oxytetracycline residues detected were all below the Maximum Residue Level (MRL) standards of 100 µg/L, while the penicillin G residue detected were all above the maximum residue standard of 5 µg/L. The maximum and minimum residue for oxytetracycline detected in raw milk was 79 and 10 (µg/L) respectively while the maximum and minimum residue detected in fermented milk was 42 and 9 (µg/L) respectively. The maximum and minimum residue detected for penicillin G residue in raw milk was 1993 and 767 (µg/L) respectively while the maximum and minimum residue detected in fermented milk was 288 and 164 (µg/L). This study revealed the presence of both oxytetracycline and penicillin G residues in raw and fermented milk consumed in Maiduguri. However, oxytetracycline residues detected in this study were found to be within the acceptable limits, while the penicillin G residues were highly above the MRL standard set by CODEX.

Background: The liver has a vital role in the hemostatic system. It is the site of synthesis of proteins responsible for clotting factors and their inhibitors. Liver infections/ diseases pose the effective functioning of the liver enzymes and clotting profiles. Objective of Study: This retrospective study aims to determine the plasma level of APTT, PT, in patients with chronic disease state in the University of Abuja Teaching Hospital, Gwagwalada, Nigeria. Materials and Methods: A total of 144 participants were enrolled for this study; both PT and APTT were analyzed using Quick and kaolin methods, respectively. Results: 144 candidates who met the inclusion criteria were recruited for this study. table 1.0 and 2.0 showed relationship between PT and APTT in liver infections/ diseases respectively, among the subjects, 81 subjects had Asymptomatic HBV Infection with mean ± SD of 15.3704± 3.0391, 18 Asymptomatic HCV infection, 2 HBV and HCV coinfection, 34 Chronic HBV, 6 Chronic HCV, 1 HCV/HIV coinfection, 1 Chronic HCV /HIV coinfection, 1 HBV/HIV coinfection, and Liver cirrhosis. They was non-statistically significant decrease in the level of PT among patients with both asymptomatic and chronic HBV, HCV, HBV and HCV co-infection, HBV co-infection with HIV, HCV co-infection with HIV and patients with liver cirrhosis with P-value of 0.229. Conclusion: Findings from this study demonstrated that coagulation profile has an association with liver disease.

This study looked into pension assets investments and its impact in the Nigerian economy. The investments includes quarterly reports of corporate debt securities, government bond securities, mutual funds’ investments, money market instruments, private equity funds and real estate securities from 2004 – 2020, and was sourced from the statistics database of the National Pension Commission, the Central Bank of Nigeria and the World data bank. The statistical measures used to analyze the data are the descriptive test, Unit root test, Co-integration test, Vector error correction, Causality and Impulse response function. The outcome of the analysis show that the variables were stationary after first differences were taken; and were also co-integrated at 2 lags indicating that both short and long run equilibrium relationship exist among the variables. From the vector error correction model, previous years’ deviations from long run equilibrium had a 0.09% speed of adjustment; leading to a short run equilibrium. The Causality test reveal that changes in government bond securities lead to changes in real estate securities and changes in money market investments leads to changes in government bond securities. In addition, the impulse response demonstrates that a shock to the system produces more negative responses than positive ones. The study thus recommends that the pension industry should vigorously create more awareness on the importance of employee pension plan; develop more e-channels to help rake in investible funds as well as develop more innovative products to support diversification of pension fund in different assets classes among others.

Background: Intellectual disability is a disability characterized by limitations in the intellectual functioning and resulting in the need for extraordinary supports for the person to participate in activities involved with typical human functioning (Wehmeyer, Schalock, Verdugo et al., 2008). Rehabilitation is therefore an essential aspect in the life of the person with a disability. According to the World Health Organization (WHO, 2011), rehabilitation is a process that is aimed at enabling disabled persons reach and maintain their optimal physical, sensory, intellectual, psychological and social functional levels. Special schools provide the rehabilitation needs by encompassing educational needs, rehabilitation services and integrated education (Kuyini 2014). Special education has proven to be instrumental in the provision of activities that will foster social development and to the maximum extent possible assimilation into regular schools and community activities (Smith 2007). Aim: To investigate the activities undertaken to rehabilitate children with intellectual disabilities in selected schools in the Kumasi metropolis. Methods: The study was undertaken at the Garden City Special School and Community Special Vocational School and employed the use of the descriptive design with a qualitative approach. A sample size of fifteen respondents were used, out of which nine (9) were teachers and six (6) were parents. The study made use of two sampling techniques to select the respondents. The sampling technique employed in the selection of teachers was the non-probable purposive sampling whereas the technique for selecting parents was the convenience sampling. Research data was collected by the use of an interview guide and the data collected was analysed using thematic content analysis. Findings: The study found out that the activities undertaken to rehabilitate the students with intellectual disabilities in the selected schools, had the underlying basis of promoting independent living and improving the social skills of children with intellectual disabilities relationships with people. Teachers therefore ensured that students were trained in the activities of daily living, communication skills, social skills, fine and gross motor skills, functional arithmetic, vocational skills and the concept of money. The study revealed that children with intellectual disabilities gained a substantial increase in their social interactions and their health. However, it was noted that the special schools faced some challenges that hindered their rehabilitation efforts and these included inadequate teaching and learning materials, lack of new facilities and inadequate and unskilled teachers. Conclusion: The special schools are very instrumental in improving the quality of life of persons with intellectual disabilities.

The objectives of this study are to analyze the weaknesses in the regulation of False Statements In Corruption Cases Pretrial Currently and how to reconstruct the regulation of False Statements In Corruption Case Pretrial As Quasi-Delict based on the value of justice, using the constructivism paradigm. The approach method used in this research is social legal research, concept approach, and comparative approach. The results of the study found that the Weaknesses is regarding the fact that whistleblowers (reporters) and justice collaborators (who participate in providing the information) have actually been included in the scope of parties that need to be protected in Law no. 13 of 2006, however, due to the lack of strict provisions, problems arose in its implementation, not to mention the long process of making the minutes of examination, the low understanding of law enforcement officials in the pretrial mechanism, and the low public awareness in giving correct witness testimony. Therefore, The Reconstruction proposed by the author is in the form of harmonization of the article, Article 174 Paragraph (1) of the Criminal Procedure Code by highlighting the punishment in the form of a minimum sentence of 3 (three) years and maximum 12 (twelve) years and/or a fine of at least Rp. 150,000,000.00 (one hundred fifty million rupiahs) and a maximum of Rp. 600,000,000.00 (six hundred million rupiahs) for false statement.

Background: The E-test involves using a predefined antibiotic gradient on a strip, which is then placed on an agar plate containing the bacterial culture. The point at which the antibiotic concentration on the strip causes inhibition of bacterial growth is taken as the MIC. This method allows for the rapid and accurate determination of the MIC of antibiotics against specific bacterial strains and can aid in selecting appropriate antibiotics for treatment. Objectives: The aim of this study was also to include a comparison of the results with those of previous studies and an evaluation of the study's limitations. Method: A cross-sectional microbiological study was conducted at the Department of Microbiology, and the Department of ENT Rajshahi Medical College, Bangladesh, from January to December 2019. This section will provide a detailed description of the methods used in the study, including the study design, sampling methods, and procedures for collecting and analyzing the data. The methods section will also explain the E-test method used to determine MIC, including the procedure for performing the test and the criteria for interpreting the results. Results: A total of 96 samples, among 73 isolates from 68 culture-positive cases, 37 isolates showed intermediate susceptibility towards selected antibiotics such as beta-lactams, aminoglycosides and quinolones by disc diffusion method. Regarding MIC breakpoint in terms of susceptibility, out of 21 intermediate isolates of S. aureus, 16(76.2%) were susceptible, 01(4.8%) was intermediate, and 04(19%) were resistant to different antibiotics by E-test. Conclusion: In general, the conclusion of such an article would likely summarize the study's findings, such as the MIC values for the different antibiotics tested and how they compare to established MIC breakpoints, and any significant observations or trends noted. It may also discuss the clinical relevance of the results and provide recommendations for future research.

The purpose of this research is to find the weakness of the Juvenile Crime System and how to reconstruct the law based on dignified justice in socio-legal research, using the constructivism paradigm. The approach method used in this research is social legal research, concept approach, and comparative approach. Research result shows the Weaknesses that causes the law cannot be implemented properly because the provisions on the terms of Diversion regarding the limitation of criminal penalties under 7 years in Article 7 of the Juvenile Crime System (SPPA) Law which are based on the application of the article during investigations and prosecutions allow for subjective views in addition to the fact that there are several law enforcers who do not implement a legal provision as they should. Therefore, the legal reconstruction is in the form of the Elimination of the conditions for imprisonment under 7 (seven) years in Article 7 paragraph (2) letter (a) of the SPPA Law. The general principles contained in the Convention on the Rights of the Child should be taken into consideration to amend or remove conditional restrictions on diversion for imprisonment under 7 years because they have deviated from the essence of children's rights and the general principles contained in the Convention on the Rights of the Child.

Mycotoxins are secondary metabolites produced by fungi and are capable of causing various diseases in humans and animals. They are naturally occurring chemical substances and are chemically stable which is why they pose a great threat to public health. Accumulation of mycotoxins in the food chain can cause hazardous effects in human. The gut microbiota has a bidirectional relationship with mycotoxin, being the leading cause of the development of mycotoxicosis. These fungal toxins exhibit a number of adverse health effects in animals, even at very low concentrations, and have been associated to cases of acute and chronic poisoning of humans and farm animals since historical times. Preventive measure for controlling contamination should be adopted both before and after harvest. Mycotoxin occurrence cannot be completely avoided, but a number of measures aiming at minimizing mycotoxin levels and mycotoxin exposure can be implemented at multiple points in the food and feed chains.

Several factors contributed to the elevated levels of water pollution in the earth surface increasing the risk of wastewater pollution. Inorganic metal irons and suspended liquid metals are also leads cause of water pollution. Physical treatments for water treatment include the use of effective membrane filters in two ways. Small membrane filter and large membrane filters also used for commercial applications. Different types of nanoparticles are used for the treatment of organic contaminants suspended in the wastewater. The adsorption of a reactive dye through the hydroxyapatite (HAP) leads the excellent filtration of ions in the wastewater. Different types of photocatalytic reactors are used for the treating the large amount of wastewater in effective ways. These included the titanium based photocatalytic reactors that employed the sub-micron TiO2 particles from the treated water which accompany the treatment process. Polymer composites are used for removal of wastewater due to their low operating temperat Nanofiltration also used for removal of wastewater due to the formation of utilizing of the semipermeable membrane allows the fine removal of the different ions and different types of pollutants ure and susceptibility to environmental degradation as compared to other operations.