Background: Over the years, aligner therapy has undergone a great evolution. The use of aligners is now an alternative to braces for aesthetic reasons. Their effectiveness and impact have yet to be evaluated. Objective: The objective of this study was to compare the effectiveness of dental movements with aligners versus the use of conventional appliances, as well as the effectiveness and impact on periodontal health and root resorption. Materials and Methods: A systematic search of PubMed, Ebsco Host and Scopus was performed using a well-designed formula. Articles published in the last 10 years in English and French were included after filtering the titles, abstracts then full texts. Results: Twenty-six records were deemed suitable for the objectives of our systematic review. All records focused on the comparison of treatment with aligners and fixed appliances. The difference in treatment and time efficiency was assessed in 17 papers, 6 papers evaluated the impact of orthodontic appliances on periodontal health, and the remaining 3 records focused on the occurrence of root resorption. Conclusion: Clear aligners produce clinically acceptable outcomes that could be comparable to fixed appliance therapy. Aligners facilitate oral hygiene practices which results in better periodontal health. However, it appears that Invisalign may not be as effective as fixed appliances in achieving certain tooth movements like vertical, radicular and rotational movements.

Ketamine, an N-methyl –D-aspartate (NMDA) antagonist, has been abused as a recreational drug due to its euphoric, dissociative, and hallucinogenic characteristics. Series of studies have been carried out on the effect of ketamine on cognition and memory. However, there is dearth literature on the activities of ketamine as a recreational drug of abuse; its effect on motor response in association with cognitive behaviours in Wistar rat models. Hence, this study is necessary to investigate the effects of chronic administration of sub-anesthetic doses of ketamine on perceptual, cognitive, and motor responses in Wistar rats. 25 Wistar rats (160-180 kg) were randomly selected into five groups and treated for three weeks thus: Group 1 (control), Group 2 (0.2 mL Ketamin-i.p), Group 3 (0.4 mL Ketamin-i.p), Group 4 (0.6 mL Ketamin-i.p) Group 5 (0.5 mL Cerebrex-orally). Neurobehavioral (Barnes, rotarod, and handgrip) activities exhibited by the various groups were recorded and analyzed using ANOVA. In the Barnes maze test, there was a significant increase (p<0.05) in escape time from weeks 1, 2 and 3 in groups 2, 3 and 4 when compared to control. In week 2 and 3 of the handgrip test, animals in group 4 had a significant improvement (p<0.05) in grip strength when compared to control. In weeks 1 and 2 of the rotarod test, groups 2 and 4 animals respectively, showed a significant increase (p<0.05) in balance compared to control. Sub-anesthetic doses of ketamine inhibited cognitive function but not motor responses in Wistar rats.

Laurus nobilis is one of the most popular species belonging to the lauraceae family and it has been reported to possess many physiological properties such as antimicrobial, antifungal and wound healing effects. In this study, effects of ethanolic leaf extract of Laurus nobilis on some oxidative stress markers and liver function parameters of female Wistar rats were investigated. Five rats were randomly assigned into each of groups 1-4, of which group one (1) served as control and received distilled water. Groups 2-4 were treated with 100mg/kg bw, 200mg/kg bw and 400mg/kg bw of the ethanolic extract of the leaves of Laurus nobilis respectively, for a period of 14 days. The results obtained indicated that the superoxide dismutase and catalase enzyme activities as well as, gluthathione reductase and peroxidase activities were not significantly affected. The malondialdehyde level did not change significantly after two weeks of extract administration. The extract caused no significant (P<0.05) alteration in the enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), as well as serum concentrations of total protein (TP), albumin (ALB) and total bilirubin. This study have shown that extract of Laurus nobilis neither altered hepatic function parameters nor promoted toxic stress in the female Wistar rats.

Background: Breast cancer is a heterogeneous, phenotypically complex disease made up of various biologic subgroups with unique behaviors and therapeutic responses. Noted that despite lack of a cure for metastatic breast cancer (MBC), there have been appreciable advancements in survival that have occurred at the same time as newer systemic treatments. BRCA1 or BRCA2 mutations cause homologous recombination deficient (HRD) cells, which are vulnerable to PARPi agent treatment. Case Report: This case report presents a 40 years old single female, known case of multiple co-morbidities who was diagnosed with Bilateral breast cancer in June 2022. She has a Positive family history of malignancy; mother died from endometrial cancer and aunt from paternal side has breast cancer. She underwent needle core biopsy from her Right breast mass, which revealed Invasive high-grade ductal carcinoma with metaplastic features (foci of keratinizing squamous differentiation, and myxoid stromal change). DCIS, of intermediate and high grades and a solid pattern, was noted, focally suspicious for lymphovascular invasion, Triple negative (ER negative (<1%), PR negative (<1%) and her-2 (+2) FISH negative (Her-2 Low), KI 67= 70%. Left breast mass Biopsy done on 12/9/2022 showed Invasive Lobular carcinoma, grade 3, ER negative, PR negative, Her-2 +1, KI 67=70%, BRCA2 POSITIVE & PDL1 CPS score 10%. Staging positron emission tomography scan done on 10 October 2022. She had a Large hypermetabolic fungating right breast mass infiltrating the chest wall, consistent with biopsy-proven malignancy. Additional smaller FDG-avid lesions noted in the right breast. Moreover, she had FDG-avid right axillary and right internal mammary nodal metastases. Mildly FDG-avid left breast mass, consistent with biopsy-proven malignancy. FDG-avid liver and pleural metastases. She was started on PARP inhibitor (Olaparib) on 20/9/2022 after which she had amazing fast clinical response leading to falling off the large fungating mass. Conclusion: The chance of developing breast and ovarian cancer is extremely elevated if one possesses BRAC 1 or BRCA 2 mutation. In this situation, PARP inhibitors, mutation-targeted therapy, has better outcomes in reducing the morbidity and mortality associated with metastatic breast cancer (Olaparib).

The combination of gastric tumor and hiatal hernia is a rare event, that makes management delicate, and the prognosis pejorative given the risk of multidirectional lymphatic dissemination. Through this case report, we present a fully laparoscopic management, in an 80-year-old woman with a gastric tumor of the upper 1⁄3 of the stomach, associated with a huge hiatal hernia. This lady presented to the emergencies during the period of the Covid 19 pandemic, for dyspnea crisis of progressive worsening. thoraco-abdominopelvic CT showed a huge hiatal hernia explaining its symptomatology. Esogastroduodenal fibroscopy showed a cardia-gastric tumor. A total laparoscopy gastrectomy with lymph node dissection D1.5 associated with a cure of hiatal hernia were performed. The postoperative follow-up was simple and the patient declared outgoing on Day 5 postoperative.

The present study was undertaken to examine the direct effect of second line anti-tuberculosis drugs Ethionamide (ETH), Para amino salicylic acid (PAS), Aloe vera on Mycobacterium tuberculosis (MTB) strain H37Rv ATCC No- 27294. It is found that Aloe vera does not interfere with single or in the combination of both ETH and PAS showing the bioenhancer activity. In vitro study of Aloe vera observed that the extract inhibited the growth of H37Rv strains. The present results will pave new avenues to find a new medicine that possesses Aloe vera alone or in combination with drugs to combat H37Rv strains controlling tuberculosis.

Primary plasma cell leukemia (pPCL) is a rare lymphoproliferative disease characterized by a malignant proliferation of plasma cells in the bone marrow and peripheral blood. It is either primary (in 60% of cases) or a secondary complication of multiple myeloma [1]. In this context, we report the case of a 37-year-old patient with respiratory distress, whose bone marrow smear showed the presence of 64% of dystrophic plasma cells. A serum protein electrophoresis with immunofixation was performed, revealing results in favor of pPCL. A cytogenetic study was not performed due to lack of resources. The patient was put on multidrug therapy with a favorable evolution.

Introduction: There are millions of people in the world but no two humans are exactly alike not even identical twins. Genetic variations in man are caused by several environmental factors acting alongside with selection, gene flow, genetic drift and migration. Studies have been done on morphogenetic traits such as the pattern of hand clasping in some parts of Africa and among some tribes in southern region of Nigeria but there is no available data on the pattern of hand clasping among the Idoma tribe of Benue State. Hence, this study aimed to determine the pattern of hand clasping among the Idoma people of Benue State, Nigeria. Materials and Methods: The study was community-based, descriptive, and cross-sectional with a sample size of 401. Data was collected using a closed-ended questionnaire that was administered by an interviewer following an examination of hand clasping pattern. Results and Discussion: The proportion of participants that expressed hand clasping with the left thumb on top was 16.7%, while right thumb on top was 83.3%. There were no significant socio-demographic characteristics among participants (p > 0.05). Conclusions: The study implies that hand clasping with the right thumb on top is a marked characteristic of the people of Idoma and, as such, can be used to identify them amongst other tribes where the identity of the tribes is not known ab initio.

Despite decades of research, the causes and biology of schizophrenia remain unknown. The condition is associated with metabolic symptoms such as hyperinsulinemia, dyslipidaemia, type 2 diabetes (T2DM), and obesity. These sensations are a prevalent side effect of the new antipsychotic medications. Nevertheless, metabolic dysfunction in schizophrenia has been studied before the antipsychotic phase, and it has also been documented in patients with first- onset schizophrenia prior to antipsychotic treatment. We investigate the evidence for metabolic abnormalities in schizophrenia patients, both in the central and peripheral nervous systems. Post-mortem brain tissue molecular analysis indicated alterations in glucose metabolism and insulin signalling pathways, whereas blood-based molecular profiling revealed hyperinsulinemia and abnormalities in insulin and co-released factor synthesis after the development of symptoms. Yet, such features are not seen in all patients with the disorder, and not all people with such defects have schizophrenia symptoms. One explanation of these facts is the presence of an underlying metabolic sensitivity in a subset of persons that interacts with environmental or hereditary factors to create the disorder's overt symptoms.

Therapeutic phlebotomy is the removal of red blood cells or serum iron from the blood. It is one of the preferred treatments for blood disorders. In ancient times this process was known as bloodletting. Generalized method included were venesection and arteriotomy and systemic methods included were cupping and by leeches. It stimulates bone marrow stem cells to generate new red blood cells (RBCs). Iron for hemoglobin synthesis is taken from the body thus reducing serum iron. Different indications of therapeutic phlebotomy include Polycythemia Vera, Hemochromatosis, Porphyria cutanea tarda, Sickle cell disease, Non-Alcoholic Fatty liver disease (NAFLD) with hyperferritinemia. Other methods available for reducing RBC and iron level include apheresis and administration of desferroxamine. Phlebotomy can cause rare adverse effects, such as thrombosis, mostly seen in patients with polycythemia Vera. Other adverse effects include Hematoma at phlebotomy site. Usually hematoma is mild but in severe cases can cause damage in nerves and surrounding tissue. Haemoconcentration, extravasation, Syncope and Fainting, petechiae, Excessive Bleeding, edema, arterial puncture, pain and anemia are some of the adverse effects caused by therapeutic phlebotomy. Unsafe phlebotomy can expose patients and health workers to various infections like Hepatitis B virus (HBV), Hepatitis C virus (HCV) and Human Immunodeficiency virus (HIV); syphilis and malaria. Different countries have approved allogenic use of blood units obtained from therapeutic phlebotomy. Mostly blood collected from patients with hemochromatosis is permitted. The article also discusses criteria for initiating therapeutic phlebotomy and various regimen followed in different diseases.

We discuss an interesting case of a 67 years old female patient with an abdominal lump leading to a reporting dilemma among female genital tract lesions in which even though clinical acumen, radiological findings and gross examination of the resected specimen pointed towards a certain malignant provisional diagnosis, actually turned out to be a rare benign entity of Aggressive Angiomyxoma when seen under the microscope and proved on immunohistochemistry, pressing upon the importance of correlation of all the findings (clinical, radiological, gross and microscopy) while making a diagnosis. We also press upon the gravity of proper communication between the reporting pathologist and treating physician for the best possible patient management.

This study aimed at examining the effects of insecurity on farming activities, community member mobility, community development projects and extent to which insecurity promote disunity amongst members in Ibarapa North Local Government Areas of Oyo State, Nigeria. The study adopted field survey methods through social survey approach involving a descriptive survey design through structured questionnaire to sample the opinion of residents of Igangan, Tapa and Ayete on the effects of insecurity on their community and as well granted interviews to some affected victims. A population of 3000 residents’ consisting Igangan, Tapa and Ayete communities was targeted. However, random and proportionate-stratified sampling techniques were applied to select 1000 community residence. Two hypotheses consisting of three questions were formulated for this study. Hypotheses were tested to show if there is or no significant relationship between the effects of insecurity and the promotion of disunity among community members in the study areas. Responses to the questionnaire was analysed using Likert scale of Agreed (A), Strongly Agreed (SA), Disagreed (D), and Strongly Disagreed (SD) and the hypotheses was tested using Chi square statistical tools. The results from the study shows effects of insecurity are on faming activities, community people mobility; community development projects and greatly promotes disunity amongst the members of the community. Therefore, this study recommends that the Government, security agencies, local government chairpersons, political office holders, companies operating in these crimes prone areas and also engages stakeholders (i.e. the chiefs, youth leaders, and other community leaders) in town hall meetings and collectively come up with lasting solutions to the insecurity that is affecting their communities.

The extraction of Ni2+ and Pb2+ ions from aqueous medium using unmodified (ROSE) and the 4-aminophenol modified red onion skin extract (ROSEDS) has been successfully achieved. Cold solvent extraction technique using a 50:50 acetone/water ratio was used for extraction of the red onion skin at 125 µm mesh size. The metal concentrations were determined using Atomic Absorption Spectrometry technique. Optimum percentage removal of the metal ions was achieved at pH 6.26 for Ni2+ (89.40 % for ROSE and 97.60 % for ROSEDS) and pH 7.57 for Pb2+ (80.10 % for ROSE and 82.56 % for ROSEDS). Optimum adsorption capacities of ROSE and ROSEDS for Ni2+ were 6.30 mg/g and 7.10 mg/g respectively; while for Pb2+ ions, values obtained for ROSE and ROSEDS were 5.87 mg/g and 6.34 mg/g respectively. Varying adsorbents dosage at fixed metals ion concentration yielded optimum percentage removal of 89.90 % and 97.90 % for Ni2+, while 86.85 % and 90.80 % for Pb2+, using ROSE and ROSEDS, respectively. Adsorption capacities of the adsorbents varied inversely with adsorbent dosages. In general, 4-aminophenol modified red onion skin extract (ROSEDS) gave comparatively, better results for the extraction of Ni2+ and Pb2+ ions from aqueous medium; relative to the unmodified red onion skin extract (ROSE). Additionally, extraction of Ni2+ ions gave higher percentage removal values in both adsorbents when compared to extraction of Pb2+ ion under similar conditions. This result has been attributed to differences in their ionic radii.

Functional polymers has great importance in the field of electrochemical sensing and biosensors due to adaptable chemical, electrical, and structural features, functional polymers are a significant class of materials that have been extensively used to create electrochemical biosensors. Additionally, conducting polymers can be made nanostructured, functional group-grafted chemically, or combined with other functional materials, like nanoparticles, to significantly enhance the sensitivity, selectivity, stability, and reproducibility of the biosensor's response to a variety of bioanalytes. Since these biosensors offer benefits such being affordable and having a low detection limit, they are anticipated to play an increasingly important role in providing diagnostic information and monitoring therapy. Because of this, this article begins with a description of the electroanalytical techniques (amperometry, potentiometry, conductometry, impedometry, voltammetry) used in electrochemical biosensors, and then moves on to a review of recent developments in the use of conducting polymers in the identification of bioanalytes that led to the development of enzyme-based biosensors, immunosensors, DNA biosensors, and whole-cell biosensors.

Introduction: Over half a million women die each year from pregnancy-related causes, 99% in low and middle-income countries. In many low-income countries, complications of pregnancy and childbirth are the leading cause of death amongst women of reproductive years. Overall, 10% to 15% of direct maternal deaths are associated with pre-eclampsia and eclampsia, where maternal mortality is high; most deaths are attributable to eclampsia, rather than pre- eclampsia. This study aimed to analyze the obstetric outcomes of pregnant women with eclampsia. Methods: This prospective study was conducted at the Department of Obstetrics & Gynecology in Uttara Adhunik Medical College & Hospital, Dhaka, Bangladesh for 6 months; from June 2019- November 2019. A total of 50 subjects were included in this study. Informed written consent was taken from the study subjects. Data was collected using a pre-formed data sheet. Data processing and analysis were done by using SPSS version 17. All patients underwent necessary investigations. All information was kept confidential and used only for this study purpose. The ethical Clearance Certificate was obtained from Bangladesh Medical College. Result: In this study, most of the patients (30, 60.0%) belong to the age group of 18- 25 years, followed by 12 patients (24.0%) were from the>35 years age group and the rest 08 (16.0%) patients belonged to 26-35 years, age group. Most of the patients (35, 70.0%) were nulliparous followed by multiparous (15, 30.0%). Maximum respondents (26, 52.0%) developed seizures at the antepartum stage, followed by 18 patients (36.0%) at the intrapartum stage and the rest 03 (6.0%) patients developed seizures at the postpartum stage. Concerning complications, maximum patients (08, 16.0%) suffered from hemorrhage, followed by anemia (7, 14.0%), abruptio placenta (6, 12.0%), sepsis (5, 10.0%), obstructed labor (4, 8.0%). Regarding maternal and fetal outcomes in eclampsia, this study revealed satisfactory outcomes in 37 (74.0%) patients with prompt actions taken during the condition. However, perinatal death occurred in 2 (4.0%) cases, and maternal death occurred in 1 (2.0%) case. Preterm delivery was done on 10 (20.0%) patients. Conclusion: Obstetric outcome was somewhat satisfactory in this study due to immediate diagnosis and actions taken during eclampsia, however, perinatal death occurred in 2 (4.0%) cases and maternal death occurred in 1 (2.0%) case and 10 (20.0%) cases underwent preterm delivery.