This study aims to test whether the moderation of regional financial supervision can affect the accountability of regional financial reports and the sensitivity of the budget to SKPD performance. The population and samples selected in this study were regional work units (SKPD) in the DKI Jakarta area, questionnaires which would be distributed to regional work units (SKPD) in the DKI Jakarta area with a total of 246 samples. The software used is SmartPLS (partial least square). The results of hypothesis testing in this study found that regional financial accountability has a positive effect on SKPD performance, budget sentiment has a positive effect on SKPD performance, regional financial supervision has a positive and significant effect, regional financial supervision can strengthen the influence of regional financial accountability on SKPD performance and moderation on regional financial supervision is not able to strengthen the effect of budget transparency on SKPD performance. The results of this fifth hypothesis research are to prevent such a situation, SKPD should be able to improve regional financial supervision so that ASN as government employee can preparing the budget have information about public finances, because ASN as government employee that have information complexity about public finances may have optimal SKPD performance .

Milk thistle (Silybum marianum L.) is a baceous plant that belongs to the Asteraceae (daisy) family and is a member of the Carduae clan. Since antiquity, a several diseases has been treated by milk thistle such as to treat liver problems, spleen problems, gallbladder problems, hepatitis, and gallstones. Milk thistle seeds are utilized in herbal remedies, and there are six flavonolignans that make up silymarins: silychristin, silydianin, silybin A& B, isosilybin A & B. Because of its membrane-stabilizing qualities, silymarin is effective in chronic liver disorders. Many disorders, such as anti-cancer, anti-diabetic, anti-hypertenshaion, and anti- Alzheimer's, are caused by S. Marianum. Milk thistle is now utilized in a diversity of supplements, including oil seed and capsules of soft gel.

Background: Abortion or miscarriage is a common health intervention. Incomplete abortion is a term given to miscarriage where there are retained product of conception still within uterus. Complications of incomplete abortion includes haemorrhage, infection, shock even DIC (Disseminated intravascular coagulation). Treatment of incomplete abortion has traditionally been surgery like D&C or MVA. Though these treatments are effective but they require specialized equipment, trained person and associated with dangers like uterine trauma, perforation, bleeding to instrumentation, infection & reaction to anaesthesia. For these reasons determining an effective nonsurgical approach for treatment of incomplete abortion is important. Materials & Methodology: During the period of June 2021 to December 2022, 100 women diagnosed as incomplete abortion, were selected in Popular Diagnostic Centre (Badda, Dhaka) and in US-Bangla Medical College Hospital (Narayanganj) as per inclusion criteria and treated with Tablet Misoprostol 6ooµg orally and success to treatment was noted. Results: Treatment was found successful in 94% cases. 6% Cases needed MVA. Among 94% cases 32% was successful after 1st dose of Misoprostol and 62% was after 2nd dose of Misoprostol. Conclusions: Oral Misoprostol is very effective method with high patient satisfaction.

Many plant species have their own toxicity, direct or indirect. On this point, the perfect knowledge of the metabolite constituents of the plants as well as the toxicity related to them is necessary for an adequate use in the formulation of the Improved Traditional Medicines and all other products related to the plants. Our study aims to carry out the quantitave screening and the study of the subchronic toxicity of ethanolic extract of the stem bark of Canarium schweinfurthii. Harvested in Bamendjou in the West Cameroon region, the stem bark of C. schweinfurthii was extracted with ethanol at 700. The estimation of total polyphenols, total flavonoids, tannins, saponins and alkaloids has been evaluated by different methods described in the literature. The subchronic toxicity assessment was performed over a 90-day period, with 4 batches of 10 rats (5 males and 5 female’s albino Wistar rats) following OECD 408 guidelines. The determination of biochemical parameters, and hematological parameters was done in serum and histological sections on organ. Among the quantified compounds, saponins were the most abundant followed by polyphenols, alkaloids, then flavonoids and finally tannins. On repeated dosing for 90 days, the extract contributed to non-significant weight growth in rats at all dose levels in both male and female rats. Analysis of biochemical, hematological and histological parameters and histological sections did not show any serious signs of toxicity in the treated groups. Finally, the ethanolic extract of the stem bark of C. schweinfurthii even rich in secondary metabolites appears to conserve an acceptable safety for the formulation of improved traditional medicines.

Background: The perioral region plays an important role in facial recognition, gender classification, esthetics, facial expression, speech and eating. Aim: To establish normative perioral data for South-East, Nigerian children Methods: A sample of 120 healthy subjects within the age range of 1 to 5 years were enrolled in this study. Two dimensional photographs of the face were captured non-invasively using a Nikon D 90 camera, ten perioral landmarks were identified and four indices deduced Results: It was observed that vertical mouth height index, upper lip thickness and lip index in the males showed higher values when compared to the females which indicates sexual dimorphism (P≤0.05). Most children in our cohort were classified as having a thick lip index, mouth of intermediate height in relation to the height of the face, thick upper and lower lip thickness index, narrow mouth in relation to the width of the eyes. The mean values of Vermillion height of Lower lip and Lower Lip Thickness Index was also observed to be consistently higher when compared to upper lip in both sexes. Conclusion: The study presents a primary data base for perioral anthropometric indices of children in South-East Nigerian which can aid ethnic specific postoperative evaluation of congenital or post-traumatic orofacial reconstructive surgeries.

Aim: This study was conducted to gather data on the normal measurements of facial features in healthy children from South-East Nigeria. The aim was to measure the distance between the pupils (IPD), the distance between the inner corners of the eyes (ICD), and the distance between the outer corners of the eyes (OCD) in order to establish a reference for ophthalmological assessments and diagnoses. The study was based on the understanding that these orbitofacial measurements and canthal indices are important tools for anatomists and craniofacial surgeons in evaluating systemic syndromes, craniofacial abnormalities, and post-traumatic telecanthus. Method: A sample of 120 healthy subjects within the age range of 1 to 5 years was enrolled in this study. The photographs of the face were captured non- invasively using a Nikon D 90 camera, orbitofacial landmarks were identified and measured using Image J Software. The data was then analyzed to determine the normal measurements for these facial features in healthy children from South- East Nigeria. Results: showed that all parameters measured (IPD, ICD, OCD) were higher in females than in males, but the difference was not statistically significant. Conclusion: The study presents a primary data base for orbitofacial anthropometric indices of children in South-East Nigerian which can be used as a reference for ophthalmological assessments and diagnoses. This data can be used to aid in the diagnosis of craniofacial abnormalities and post-traumatic telecanthus, as well as to evaluate systemic syndromes. Additionally, this study can be used as a benchmark for future studies on this topic in the same population or other population as well.

The objectives of this study are to analyze the weaknesses of the absentee land registration arrangements through Complete Systematic Land Registration (PTSL) that are not yet fair, and how to reconstruct the law based on justice value. The research method used is socio-legal research, using the constructivism paradigm. The approach method used in this research is social legal research, concept approach, and comparative approach. This research uses primary data and secondary data. Data collection techniques through interviews, observation, and literature studies. The data collected was analyzed qualitatively. The legal theory used as an analysis tool is the grand theory of Pancasila justice and the rule of law theory, the middle theory of legal system theory, and the applied theory of development law theory and progressive law theory. The results of the study found that the Weaknesses in legal substance namely Article 5, Article 7, Article 25 paragraph 1, Article 30 paragraph 2, and Article 32 of Minister of Agrarian Regulation Number 6 of 2018 concerning Complete Systematic Land Registration (PTSL), Weaknesses in the legal substance of absentee land registration arrangements in the Minister of Agrarian Regulation Number 6 of 2018 concerning Registration Complete Systematic Land (PTSL), while the legal structural weaknesses in absentee land registration are limited land management, limited number and capacity of human resources, limited quantity and quality of measurement facilities and infrastructure, and weaknesses in the legal culture of society, namely economic and social factors. Therefore the Reconstruction of absentee land registration arrangements through the Complete Systematic Land Registration based on Pancasila values of justice in the arrangement of absentee land registration must not contradict religious values and beliefs, protect the rights of citizens, and uphold the values of unity and equality, and able to protect the wider community, and the rules are clear and do not cause conflicts with higher rules as contained in the Minister of Agrarian Regulation Number 6 of 2018 concerning Complete Systematic Land Registration (PTSL).

In a very rapid economic development, it cannot be denied that the absorption of credit in people's lives is growing rapidly. In this case, in all the use of products or services by consumers, consumers have the right to obtain legal certainty corporate bullying billing financial technology is one of the most publicly highlighted violations of law today. This study has 2 (two) main problems, namely to identify and analyze the weaknesses that result in the implementation of criminal sanctions regulations in financial technology criminal cases in Indonesia that are currently not fair and attempts to reconstruct criminal sanctions regulations in financial technology criminal cases based on Pancasila justice. This research method uses a juridical-empirical approach. Analysis of primary and secondary data is carried out using a descriptive-analytical method. The results of the research and discussion show that the weaknesses that result in the implementation of criminal sanction regulations in financial technology crime cases in Indonesia are that they do not contain criminal threats for violating the provisions of Article 44 paragraph (1) of the Republic of Indonesia Financial Services Authority Regulation Number 10/Pojk.05/ 2022 Regarding Technology-Based Co-Funding Services. Efforts to reconstruct the regulation of criminal sanctions in financial technology crime cases based on Pancasila justice, namely by adding criminal provisions to the criminal provisions in Article 44 of the Regulation of the Financial Services Authority of the Republic of Indonesia Number 10/Pojk.05/2022 Concerning Information Technology-Based Joint Funding Services by adding one paragraph. So that the provisions in Article 44 of the Regulation of the Financial Services Authority of the Republic of Indonesia Number 10/Pojk.05/2022 Concerning Information Technology-Based Joint Funding Services.

Land registration is a series of activities, carried out by the State/Government continuously and regularly, in the form of collecting certain information or data regarding certain lands in certain areas, processing, storing, and presenting them for the benefit of the people, to provide guarantees legal certainty in the field of land including the evidence and its maintenance. This research focuses on 2 (two) problems, namely the weaknesses of customary land registration regulations based on the value of dignified justice and efforts to reconstruct customary land registration regulations based on dignified justice. This research approach method uses a juridical-empirical approach with research specifications that use analytical descriptive. The results of the research and discussion state that (1) Weaknesses in the regulation of customary land registration are based on the value of dignified justice. Land registration of parcels has weaknesses from the regulatory aspect, weaknesses from the legal structural aspect, weaknesses from the legal cultural aspect, then in reality there is growing dissatisfaction with the negative publicity system (positive elements in the bureaucratic system and public services of the National Land Agency. (2) Reconstruction regulations on customary land registration based on dignified justice Article 97 Government Regulation of the Republic of Indonesia Number 18 of 2021 Concerning Management Rights, Land Rights, Flats Units, and Land Registration states that land certificates, compensation certificates, village certificates, and others of the same type intended as information on land tenure and ownership issued by the village head/sub-district head may be used as a guide in the context of land registration.

Any evaluation model plays a backwash effect on teaching. English Test for International Communication (ETIC) is a new evaluation method which focuses on examining students’ comprehensive English application ability and helps selecting talents. Through interviews and questionnaires, this paper studies the backwash effect of ETIC on college English teaching. The survey results indicate that ETIC has a positive backwash effect on college English teaching. Its effects are shown in the following three aspects: it helps optimize teaching content; it promotes the innovation of teaching methods; and it improves evaluation models. The results of this research can be used as reference for college English teaching reform.

This study aims to identify and analyze the construction of the position of the Corruption Eradication Commission in the current state administration system, find the weaknesses and position of the Corruption Eradication Commission in the current state administration system, and find answers to the efforts that should be made in the future to ideally reconstruct the position of the Corruption Eradication Commission—based on Pancasila. The approach method used is socio-legal research which is a study that "integrates" doctrinal legal studies with social studies. The results of this study were obtained and it was concluded that: (1) The position of the Corruption Eradication Commission legally is a state institution of the executive family which has implications if the Corruption Eradication Commission can be made the object of the Right of Inquiry by the People's Representative Council of the Republic of Indonesia and the position of the Supervisory Board which is one of its powers increasingly giving a new color, which includes the permit process for Wiretapping, searches, and confiscation, which is mandatory for the Corruption Eradication Commission to the Supervisory Board which will have implications for the problem of intervention, certain political interests towards the Corruption Eradication Commission that enter through the Supervisory Board. (2) Reconstruction of the ideal position of the Corruption Eradication Commission in a constitutional system based on Pancasila values of justice is the Corruption Eradication Commission as a unique agency carrying out the functions of judicial power in the field of prevention and prosecution of criminal acts of corruption that are free, independent and may not receive interference from the executive or legislature in carrying out its position. By the values of Pancasila, namely social justice for all Indonesian people, where the relevance is that the Corruption Eradication Commission's power as a law enforcer must be positioned by efforts to achieve justice with the support of the Corruption Eradication Commission's ideal position in the constitutional system. To strengthen the reconstruction of values, the legal reconstruction should ideally be carried out by amending several articles, namely Article 3, Article 21, Article 30, and Article 37B paragraph 1 b, in Law Number 19 of 2019 concerning the Corruption Eradication Commission. So that the position of the Corruption Eradication Commission is no longer under the auspices of the executive but at the judiciary which is independent and independent.

Background: White-collar crime refers to illegal activities that individuals or organizations commit during business or professional activities. These crimes are often financially motivated and include embezzlement, fraud, bribery, money laundering, and insider trading. White-collar crime can have significant consequences for individuals, organizations, and society. Objectives: The objectives of research on white-collar crime may include understanding the motivations and behaviors of those who engage in such activities and identifying the organizational and societal factors. That contributes to the prevalence of white-collar crime and the development of new methods for detecting and preventing white-collar crime. Method: This review highlights and assesses recent (primarily during the past decade) contributions to white-collar crime theory, new evidence regarding the sentencing and punishment of white-collar offenders, and controversies surrounding crime prevention and control policies. Several promising new directions for white-collar crime research are identified, as are methodological and data deficiencies that limit progress. Results: The results of a study on white-collar crime can vary depending on the specific research question and methods used. However, some common findings include the prevalence of certain types of white-collar crime, the characteristics of individuals and organizations that are most likely to engage in such activities, and the impact of white-collar crime on individuals, organizations, and society as a whole. Conclusion: The research conclusion on white-collar crime may summarize the main findings, highlight the implications of the research, and make recommendations for future research. Evaluation of Current Investigations and Future Directions: Current investigations on white-collar crime have greatly improved our understanding of white-collar offenders' motivations, behaviors and methods. However, there are still areas that need further exploration, such as the study of the psychological profiles of white-collar offenders, the impact of technology on white-collar crime and its detection, and the examination of the role of organizational culture in the commission of the white-collar crime. It is also crucial to focus on the development of effective interventions and policies to prevent white-collar crime from happening. Future research may also consider the global and cross-cultural dimensions of white-collar crime.

Protection of agricultural land, especially sustainable food agricultural land has become an obligation for the government to make various policies, both in the form of laws and other regulations. However, if the efforts to control food agricultural land do not receive adequate support or are not integrated into the integrated development of the agricultural sector, these efforts will not succeed. This research uses a descriptive method is a method that examines the status of human groups, an object and a condition, a system of thought or an event in the present. It was conducted in North Sulawesi Province as a research location based on the reality of the many spatial problems in this area. The results showed that the implementation of LP2B in North Sulawesi Province is only in planning and has not been implemented properly by the local government or the Land Office in the implementation of land conversion because there is no regional regulation that stipulates LP2B and there is no map available as a reference in controlling the conversion of agricultural land in North Sulawesi Province. Efforts that can be made in optimizing the implementation of control over land use change through LP2B are the effectiveness of communication, socialization, coordination between agencies, formation of the LP2B team, capacity building of resources that are implementing policies, and financial resources. The government of North Sulawesi Provincial needs to form a Regional Regulation on sustainable agricultural food land accompanied by a map attachment so that it does not create uncertainty in its implementation.

The purpose of this research is to analyze and find weaknesses in the regulation of parking management in public spaces that are unable to fulfill justice value and how to reconstruct the law. The method used by researchers is a sociological juridical approach, research conducted on the real situation of society or in this case, the Medan City in Indonesia to find facts, and then identify which ultimately leads to problem-solving of the problem regarding Parking Land Management. The results of the study show that based on the weaknesses found by the author, the Reconstruction of Regulations for Parking Management in Public Spaces Based on the Value of Justice can be done by revising the regional spatial layout as requested, reducing access to spatial planning information, Mitigating sanctions for spatial violations, improving planning synchronization, and, lastly, evaluating the planning budget.

Background: Human epidermal growth factor receptor 2 (HER2) overexpression and amplification have been considered as a therapeutic and prognostic target in a quantity of tumors although conflicting data exist about the incidence and clinical consequence of HER2/neu status in the patients. The growth risk of bladder cancer is age dependent. In general, adolescent and young adults tend to develop well differentiated non-invasive, rather than invasive bladder cancer. Objectives: The aim of this study is to assess the Immunohistochemical study of HER-2/NEU Expression in urothelial bladder carcinoma and its correction with histopathological Grade. Methods: This was a cross sectional study. Patients with paraffin blocks of urinary bladder tissue which were histologically diagnosed as urothelial carcinoma at the Department of Pathology, BIRDEM and other private laboratories were included in our study during the period of January 2016 to December 2018. Results: This study shows that, a total of 56 histologically diagnosed cases of urothelial carcinoma were included. There were 34 cases (60.7%) of high grade and 22 cases (39.3%) of low-grade urothelial carcinomas. The age of the patient ranged from 23 years to 98 years (mean 66.34±15.3 years). Majority of patients (50.98 %) belonged to 61 to 80 years age group. High grade tumors were predominantly seen at an older age. There were 42 males (75.0%) and 14 females (25.0 %) with a male to female ratio of 3:1. Conclusions: Significant correlation in expression of HER-2/Neu was found with grading of urothelial carcinoma. A positive HER-2 status is associated with aggressive urothelial carcinoma and provides independent prognostic information for urothelial carcinoma recurrence and mortality.