Introduction: Primary tonsillar tuberculosis is exceptional even in endemic country like Morocco. the diagnosis was ‘not evocable on clinical signs because of their non specificity, diagnosis made after surgery and histological analysis.no primary location been found on radiological pulmonary exam. Case report: Herein, we report the exceptional case of a primary tonsil tuberculosis discovered in a 12 years child .no specific local or general symptom was observed. confirmation made by histology. Actually, the child is doing well under therapy. conclusion: primary tonsillar tuberculosis is exceptional, only histology can confirm the diagnosis. Thus, must make us keeping in mind this eventual diagnosis, particularly in pediatric population, every time symptoms are not specific.

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of renal cancer, accounting for approximately 75% of all kidney malignancies in adults. Despite advances in diagnosis and therapy, the molecular mechanisms underlying ccRCC progression remain incompletely understood. MicroRNAs (miRNAs), as post-transcriptional regulators of gene expression, play critical roles in cancer initiation, progression, and metastasis. This study aimed to identify key dysregulated miRNAs and their target genes involved in ccRCC pathogenesis using an integrative in-silico bioinformatics approach. Three Gene Expression Omnibus (GEO) datasets (GSE116251, GSE95384, and GSE6357) were analyzed through the GEO2R tool to identify differentially expressed genes (DEGs) and miRNAs (DEMs) using |logFC| > 1 and adjusted p-value < 0.05 as thresholds. Overlapping miRNAs were determined using the Venny tool, and their corresponding target mRNAs were predicted through TargetScan. Functional annotation and pathway enrichment of DEGs were performed using the DAVID database, while protein–protein interaction (PPI) networks were constructed through STRING. The miRIAD and OncomiR databases were employed to elucidate miRNA–gene interactions, and the OncoLnc database was utilized for survival analysis. Our analysis revealed several dysregulated miRNAs, including miR-155-5p, miR-210-3p, and miR-21-5p, along with key tumor-related genes such as VHL, PBRM1, SETD2, TP53, and PTEN, which significantly influence ccRCC prognosis. Functional enrichment analysis demonstrated that these genes are involved in critical oncogenic pathways, including the cell cycle, p53 signaling, and PI3K–Akt pathways. In conclusion, this study provides a comprehensive bioinformatic framework that highlights novel miRNA–gene interactions potentially involved in ccRCC progression. The identified molecules may serve as valuable biomarkers for diagnosis, prognosis, and targeted therapy in renal cancer, supporting further experimental validation and clinical investigation.

Background: Fibro-osseous pseudotumor of the digit (FOPD) is a rare benign ossifying lesion of the soft tissues of fingers or toes. It may mimic other periungual tumors or malignant lesions, leading to diagnostic confusion. Case presentation: We report a case of a 46-year-old woman with a 6-month history of a painless, progressively enlarging nodule of the right index finger. The lesion was excised for cosmetic concern. Histopathological examination revealed a well-circumscribed spindle-cell proliferation with osteoid and trabecular bone formation, overlaid by hyperplastic and orthokeratotic epidermis. No cytologic atypia or mitotic activity was noted. Conclusion: Recognition of FOPD is essential to avoid misdiagnosis and overtreatment. Molecular studies may show USP6 rearrangements, supporting its classification as a benign transient neoplasm. Complete local excision is curative with excellent prognosis.

Background: The integration of healthcare technologies in nursing has revolutionized patient care delivery and educational practices. Understanding nursing students’ perceptions toward these innovations is crucial for ensuring workforce readiness in technology-driven healthcare systems. Objectives: This study assessed nursing students’ awareness, readiness, and attitudes toward healthcare technologies, examined demographic variations, and identified perceived educational and training needs. Methods: A descriptive cross-sectional study was conducted among 149 students at Prince Sultan Military College of Health Sciences using a 24-item Likert-scale questionnaire covering awareness, readiness, attitudes, training needs, and perceived effectiveness. Reliability was confirmed (Cronbach’s α = 0.963). Descriptive statistics and one-way ANOVA tests were performed using SPSS v25, with significance set at p < 0.05. Results: Students demonstrated high awareness (76%), confidence (86%), and willingness to use technology (84%). Year of study, GPA, and prior exposure significantly affected perceptions, while age did not. Participants emphasized the need for simulation-based learning, electronic health records training, and telehealth exposure. Conclusion: Although nursing students recognize the benefits of technology, structured training remains insufficient. Educational institutions must integrate comprehensive digital health competencies into nursing curricula to enhance readiness and promote patient-centered innovation.

Professional Roadside sweeping is associated with significant exposure to dust and vehicular emissions. Port Harcourt, the industrial and economic hub of Nigeria’s oil-rich Rivers State is a nidus for such environmental pollutants. Assessing the functionality of the cardiovascular and respiratory systems in such personnel will be quite revealing. Thus, this study assessed the cardiovascular and pulmonary functions of Professional Road Sweepers in Port Harcourt (PRS-PH). Using the multistage approach, including the purposive and snowball sampling techniques, the present study sampled a total of one hundred subjects (comprising 50 female road sweepers and 50 female non-road sweepers) who were within the ages of 18 and 60 years and residents of the area for five (5) years and above. Following standard methods, the digital spirometer was used to assess the lung functions (Forced Vital Capacity (PVC), Forced Expiratory Volume (FEV1), FVC/FEVI ratio) of Professional Road Sweepers in Port Harcourt Metropolis. The result indicated significant (p<0.05) difference in the blood pressures of the exposed group with respect to that of the unexposed group. The study revealed significantly (p<0.05) raised levels of Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and FEV1/FVC ratio. This outcome is suggestive of a possible restrictive lung disorder in the road sweepers; In conclusion, the results of the study reveal a risk of cardiopulmonary disorders among the road sweepers. These findings will offer valuable insight and raise awareness and establish comprehensive measures that could protect these essential workers from cardiorespiratory hazards associated with their occupation.

Unsafe working conditions, lack of safety awareness and obvious restricted access to protective gears make artisanal workers highly vulnerable to different forms of occupational risks. Thus, the present study set out to evaluate some biochemical stress markers and atherogenic profile changes in automobile artisans in Port Harcourt. The study adopted a cross-sectional approach to survey automobile repair workers or auto-artisan in various workshops located in Port-Harcourt Metropolis. The purposive and snowball sample size determination tools to recruit the study participants. Eventually, a sample of 60 automobile repair artisans (Automobile Artisans) and 40 control individuals (Non-Automobile Artisans) totaling 100 participants were recruited for the study. Upon ethical approvals and consent issuance by the study participants, blood samples were obtained from the antecubital vessel by phlebotomists, using standard procedures. Quantitative data got from the study were subjected to statistical screening using version 25.0 of the IBM Statistical Product and Service Solutions (SPSS) programme. Statistical significance were determined using one-way analysis of variance (ANOVA) followed by post-Hoc LSD multiple comparison test. The result of the study showed that the automobile artisans’ job naturally selected people mainly within their thirties to their forties of age and that the job may not exert adverse effects on the BMI status of the workers as their was only marginal difference in their mean BMI from that of the non-automobile artisans. On the lipid profile examination, there was generally significant (p<0.05) elevation of TG and reduction in HDL-C levels in artisans compared to those of non-artisan subjects. The atherogenic indices indicated significant (p<0.05) increases in atherogenic coefficient (AC) and Castelli risk index-1 (CRI-1). The levels of GSH, GPx, CAT and SOD were seen to be significantly (p<0.05) depressed in virtually all auto-workers when compared to that of the non-artisans (control group). The frequent use of personal protective equipment (PPE) and timely/good health seeking behaviours amongst the automobile artisans are recommended.

Acquired Immunodeficiency Syndrome (AIDS) remains a major global health concern. This study explores awareness, public attitudes, and misconceptions about HIV/AIDS within a general community. A survey of 100 participants aged 18–50 years was conducted using structured questions to assess knowledge of HIV transmission routes, perceptions of openness, and social stigma. Results indicate that awareness of sexual transmission is high, but misconceptions about other transmission modes persist. Nearly half of respondents believe individuals with HIV should not disclose their status, reflecting ongoing stigma. The findings emphasize the need for continuous educational efforts to promote accurate knowledge and foster a supportive environment for people living with HIV/AIDS (PLHIV).

Background: People living with HIV (PLHIV) experience balance impairments due to neuropathy, muscle weakness, and central nervous system alterations, which increase fall risk. While most studies focus on level walking, there is limited information about motor control adaptation during gait on inclined surfaces. Objective: To determine whether postural sway while walking differs between PLHIV at risk of falls and those not at risk during flat and inclined surfaces. Methods: Thirty-two PLHIV (21 fall risk; 11 non–fall risk) completed walking trials at 0% and 8% incline. The Activities-specific Balance Confidence (ABC) Scale classifies fall risk. Postural sway parameters (RMS and centroidal frequency) were captured with accelerometers. A 2 × 2 mixed MANOVA compared groups and conditions. Results: A significant main effect of incline was observed (F(6,25) = 2.980, p = .025, partial η² = .417). Sway RMS and sagittal RMS were greater on level ground than on the incline (p < .001). No significant group differences or interactions were found. Conclusion: Inclined walking reduced sway amplitude while slightly increasing sway frequency, suggesting adaptive neuromuscular control. Incline walking may create a rigid or frizzing postural strategy in PLHIV regardless of fall-risk status. These findings highlight the importance of incorporating environmental challenges into fall-risk assessments and interventions.

The pursuit of excellence in healthcare quality is perpetually challenged by systemic fragmentation, where siloed operations among critical departments like Nursing, Radiology, and Health Administration lead to communication breakdowns, clinical errors, and operational inefficiencies. This comprehensive research paper argues that the strategic and deliberate integration of these three pillars is not merely beneficial but essential for achieving superior, patient-centered care. The analysis begins by deconstructing the inherent weaknesses of the traditional "siloed system," demonstrating how it acts as a fundamental barrier to quality. It then elucidates the unique and complementary roles of each discipline: Nursing as the continuous, holistic clinical bedrock; Radiology as the pivotal diagnostic lens guiding decision-making; and Health Administration as the essential architectural framework that enables synergy through resource allocation, policy, and culture. The paper further explores practical models for "forging the link," including multidisciplinary teams, structured communication protocols, integrated clinical pathways, and interprofessional education. By synthesizing evidence from a wide range of literature, this research concludes that a conscious, system-wide commitment to dissolving interdisciplinary boundaries is the definitive pathway to enhancing patient safety, improving clinical outcomes, boosting patient satisfaction, and achieving operational excellence in the modern healthcare landscape.

Background: Vitamin D deficiency is associated with cardiovascular dysregulation and increased blood pressure; however, evidence in pregnant women in South Asia remains limited. This study aimed to evaluate the correlation and regression between maternal serum vitamin D levels and blood pressure components during late pregnancy. Methods: A hospital-based case–control study was conducted at Sir Salimullah Medical College Mitford Hospital, Dhaka, from March 2019 to March 2020, involving 106 pregnant women (53 preeclamptic and 53 normotensive). Serum 25-hydroxyvitamin D [25(OH)D] levels were measured using a chemiluminescence immunoassay and categorized as deficient (≤20 ng/mL), insufficient (21–29 ng/mL), or sufficient (≥30 ng/mL). Blood pressure was recorded according to standard protocols. Correlation and linear regression analyses were performed using SPSS version 23.0, with significance set at p < 0.05. Results: Serum vitamin D levels were inversely correlated with both systolic (r = –0.449, p < 0.001) and diastolic (r = –0.449, p < 0.001) blood pressures. Regression analysis indicated that each 1 ng/mL rise in serum vitamin D corresponded to a decrease of 1.68 and 1.2 mmHg in systolic and diastolic pressure, respectively. Sun exposure duration and antenatal attendance were positively associated with vitamin D sufficiency. Conclusion: Maternal serum vitamin D concentration was inversely associated with systolic and diastolic blood pressures. Maintaining adequate vitamin D levels through sunlight exposure and supplementation may support cardiovascular stability during pregnancy.

Mosquitoes are important vectors of diseases that pose major public health challenges. This study investigated the prevalence and distribution of Aedes and Culex species within Ajayi Crowther University, Oyo State, Nigeria. Larvae were collected from ten randomly selected sites over a five-month period (November–March). A total of 10,033 mosquitoes were recorded, comprising Culex spp. (5,141; 53.8%) and Aedes spp. (4,892; 46.2%). Statistical analysis showed significant variation across months (p = 0.005) and locations (p = 0.002), while no significant interaction was observed (p = 0.074). The predominance of Culex highlights the risk of diseases such as lymphatic filariasis and West Nile virus, whereas Aedes remains relevant for dengue, yellow fever, and chikungunya transmission. These findings provide baseline data for vector control programs in Atiba Local Government and contribute to understanding mosquito distribution in Oyo State.

Plant Based Ingredients to make edible inks for 3D food printing might help solve issues about food quality, food nutrition, and sustainability of food. We examine the molecular, functional, & nutritional characteristics of different plant proteins, plant Fibers & Hydrocolloids to determine their potential & their use as food industry. Additionally, we look at the possibilities of plant protein-based edible inks for 3D printing applications, where a material's form or other characteristics might alter over time to allow for precise issue profiles & texture modulations. Because of their superior structure-forming capabilities, and also their functional & nutritious qualities, Wheat gluten, pea protein, Lentil protein & soy proteins are frequently utilized as an ink for the 3D food printing applications. The use of 3D printing technology to create texture & improve probiotic & nutrient encapsulation in plant-based compositions was emphasized. Recent developments in 3D printing have been documented using edible smart materials that have been subjected to air-drying and microwaving processes. It was determined that the market sector for plant-based foods will be disrupted in three ways by 3D printing, Plant based meat, Personalized nutrition & Sustainability. This review addresses the latest developments in plant-based functional ingredients, or non-traditional food sources, that can be used as basis materials for 3D ink formulations & attention to the novel ingredients, their physiological role, and how their inclusion affects the product's rheological, structural, and printing qualities. 3D food printing has shown remarkable results in providing individualized nutrition and customized foods

Background: Pre-eclampsia is a hypertensive disorder of pregnancy associated with significant maternal and fetal morbidity. Identifying socio-demographic, obstetric, and biochemical risk factors is crucial for early detection and management. Objective: This study aimed to assess the socio-demographic profile and risk factors associated with pre-eclampsia at a tertiary care center in Bangladesh. Methods: This case-control study was conducted in the Department of Obstetrics and Gynecology, Institute of Child and Mother Health (ICMH), Dhaka, Bangladesh, from March 2023 to February 2024. In this study, A total of 70 pregnant women with a gestational age of 20–40 weeks, attending the Department of Obstetrics & Gynecology, ICMH, Dhaka, during the study period, were included in this study. Among them, 35 women diagnosed with pre-eclampsia were assigned as cases, and 35 normotensive pregnant women were taken as controls. Results: Most participants were aged 18–28 years, with no significant difference in mean age between cases (26.09 ± 5.39 years) and controls (24.94 ± 4.08 years; p = 0.321). Educational level and occupation were comparable between groups (p > 0.05). Mean parity, gravidity, and gestational age were also similar (p > 0.05). Serum CRP levels were significantly higher among cases (25.37 ± 14.70 mg/dL) than controls (4.22 ± 0.92 mg/dL; p < 0.001). Significant risk factors for pre-eclampsia included family history of hypertension (37.1% vs 14.3%; p = 0.030), obesity (BMI ≥ 27 kg/m², 45.7% vs 22.9%; p = 0.046), prior history of pre-eclampsia (17.1% vs 2.9%; p = 0.049), and elevated CRP (≥6 mg/dL, 80% vs 0%; p < 0.0001). Primigravidity showed borderline significance (57.1% vs 34.3%; p = 0.057). Conclusion: Elevated CRP, obesity, family history of hypertension, primigravidity, and prior pre-eclampsia are important risk factors for pre-eclampsia. Early identification of these factors may aid in risk stratification and timely intervention.

The tariff measures launched during Donald Trump’s presidency substantially remodeled global trade patterns, with profound impact for India’s economy. This paper examines the impact of these tariffs on India’s export potential, trade balances, and sectoral growth, particularly in steel, pharmaceuticals, textiles, and agriculture. It also explores cascade effects through supply chain disruptions, shifts in bilateral trade relations, and the strategic reform of India’s trade policy. Using trade statistics, policy analysis, and global market trends, the study appraises both short-term and long-term impressions. The findings provide insights into how protectionisms abroad impact emerging economies like India, designing their economic sustainability and resilience measures.

Background: Small-cell neuroendocrine carcinoma of the prostate (SCPC) is a rare and aggressive malignancy, accounting for less than 2% of prostate cancers. It is typically characterized by low prostate-specific antigen (PSA) levels, rapid progression, and poor response to hormonal therapy. Case Presentation: We report the case of a 71-year-old male with multiple comorbidities, who presented with lower urinary tract symptoms. Imaging revealed a large pelvic mass, extensive lymphadenopathy, and innumerable pulmonary nodules, while PSA was 1.4 ng/ml. Pathology review confirmed small-cell neuroendocrine carcinoma of the prostate (SCPC). The patient underwent systemic chemotherapy with six cycles of carboplatin and etoposide, achieving an eight-month disease-free interval. Surveillance imaging revealed significant locoregional progression with recurrent hydronephrosis, retroperitoneal lymphadenopathy and new liver metastases. Immediate rechallenge with carboplatin and etoposide. Conclusion: This case highlights the aggressive course of small-cell carcinoma of the prostate, characterized by atypical PSA kinetics, early visceral metastasis, and rapid progression despite systemic therapy.