Climate change has emerged as a critical global threat, exerting profound stress on food systems and accelerating nutritional insecurities across regions. Rising temperatures, shifting precipitation patterns, soil degradation, and extreme weather events are increasingly disrupting agricultural productivity, diminishing nutrient quality, and destabilizing food supply chains. These changes have intensified the triple burden of malnutrition undernutrition, micronutrient deficiencies, and obesity particularly in vulnerable populations with limited access to affordable, diverse, and nutritious foods. Despite ongoing global efforts, existing food and dietary systems remain ecologically unsustainable, heavily dependent on high-emission production practices, and constrained by socioeconomic and cultural barriers. This study critically examines the intersection of climate stress, food system vulnerabilities, and nutritional challenges, presenting an integrated framework that links environmental pressures with dietary outcomes. Using a comparative and analytical approach, the research identifies the limitations of current strategies and highlights the need for climate-resilient food production, including climate-smart agriculture, crop diversification, technological innovation, and localized circular food systems. The study further outlines pathways toward sustainable human diets that balance nutritional adequacy with environmental stewardship, emphasizing plant-based dietary patterns, biofortified crops, and culturally adaptive nutrition models. The findings underscore that achieving nutritional security under climate stress requires coordinated action across policy, governance, production systems, and consumer behavior. This work contributes to the evolving discourse by proposing strategic, science-driven solutions for building adaptive, nutritious, and sustainable global food futures.

The supply and bioavailability of mineral elements in heavily weathered soils are limited and continuously declining, leading to low agricultural production; hence the need to find sustainable alternatives to maintain the fertility of various soils. The objective of this study was to evaluate the change in the chemical properties of soils induced by the addition of Bradyrhizobium japonicum in soybean cultivation across three types of soil in the Haut-Katanga province. Two soil samplings were conducted to carry out this study. The first was done before the start of the trial; and the second during the experimental phase at the flowering stage of the soybeans. This experiment was conducted using a split-plot design, replicated three times. The collected soil samples were subjected to chemical analyzes. According to the results obtained, the changes in chemical properties were significantly different between the soil types. On one hand, a negative change was observed in the eutric Cambisol, namely a decrease in organic matter, total nitrogen, available and total phosphorus, as well as magnesium; on the other hand, a positive change was observed in the two Ferralsols (acric and xanthic), namely an increase in several chemical properties, except for ammoniacal nitrogen which decreased. Regardless of the soils, the addition of external strains led to a decrease in available phosphorus, while only the USDA 142 strain induced similar effects to the control on the increase of K as well as CEC. This has demonstrated the importance of soybean inoculation with Bradyrhizobium japonicum strains as an alternative option to improve crop productivity in acidic soils.

Giant cell fibroblastoma (GCF) is a rare soft tissue most often discovered during the first two decades of life. We report the case of a 4-month-old infant examined for a mass in his right arm. The patient underwent total excision of the mass. Histological, immuno-histochemical showed giant cell fibroelastoma. This tumor poses diagnostic challenges to the pathologist because it may be confused with malignant mesenchymal tumors with different prognosis.

Cephalic duodenopancreatectomy (CDP), also known as the Whipple procedure, is a major surgery performed on the pancreatobiliary junction. It is mainly indicated for cancers of this region, as well as for certain benign tumors or chronic pancreatitis. Despite technical advances, this procedure remains associated with high morbidity, with postoperative complications such as pancreatic or digestive fistulas, gastroparesis, hemorrhage, infections, and, in the long term, pancreatic insufficiency. A retrospective study conducted in the Department of Visceral Surgery at the Avicenne Military Hospital of Marrakech between 2017 and 2021 analyzed 35 cases of CDP. The average age of patients was 62 years, with a male predominance. The main indications were: Vaterian ampulloma (45.7%), Adenocarcinoma of the pancreatic head (34.3%), Adenocarcinomas of the distal bile ducts (11.4%), And a few rare cases of duodenal or cystic tumors. Most tumors were well-differentiated (74%). The Child reconstruction technique was used in 65.7% of cases, while pancreaticogastric anastomosis was performed in 34.3%. The postoperative mortality rate was 11.4%, mainly due to hemorrhagic shock. Early complications occurred in 42.8% of patients, predominantly gastroparesis (17.1%) and hemorrhage (8.6%). The results are consistent with those reported in the literature. The study emphasizes the importance of thorough preoperative assessment, close postoperative monitoring, and an experienced surgical team to reduce complications and improve prognosis.

We present the case of a ruptured splenic artery aneurysm occurring in a 39year-old patient treated by embolization.

Aim: The aim of this observational study was to evaluate the relationship between neck pain and fatigue levels among individuals engaged in desk-based occupations. Methodology: Neck pain–related disability was assessed using the Neck Disability Index (NDI). Fatigue levels were measured using the Fatigue Severity Scale (FSS) and the Visual Analogue Fatigue Scale (VAFS). A total of 20 office-based workers (13 females, 7 males) participated in the study. The mean age of the sample was 31.30 years. The mean height was 1.64 ± 7.6 m, and the mean weight was 63.4 ± 9.8 kg. Participants completed the NDI, FSS, and VAFS questionnaires through a survey method after providing written informed consent. Results: A statistically significant negative correlation was found between NDI and VAFS scores (Pearson’s r = –0.45421, p = 0.0037). Higher neck disability was associated with greater fatigue levels. Mean scores for individual FSS items ranged from 2.76 to 4.37. Conclusion: The study demonstrated that greater neck disability is associated with increased fatigue among desk-job workers. These findings highlight the importance of posture correction, ergonomic modifications, and early screening to reduce neck-related disability and fatigue in individuals engaged in prolonged sitting occupations.

Hodgkin's disease or Hodgkin's lymphoma is a rare malignant hemopathy characterized by the presence of Reed-Sternberg cells. It is a lymphoid disease that the cause remains unknown. Subdiaphragmatic localized forms are rare and represent 6 to 13% [4-6]. The revelation of these forms by acute intestinal intussusception is exceptional, and attested by very few data published in the literature. We report the case of a 70-year-old patient with a rare case of subdiaphragmatic Hodgkin's lymphoma revealed by acute intestinal intussusception.

The use of welded medium-carbon steels is increasing within the oil and gas industry, which requires these materials to resist corrosive environments, extreme temperatures and cyclic loading. This investigation analyzes the effects of Post Weld Heat Treatment (PWHT) upon the mechanical performance of manually arc-welded AISI 1035 (UNS G10350) steel. Rectangular test pieces were machined from carbon-steel piping that had been manually arc-welded using electrode type E6013. These samples were preheated to a temperature of 100 °C, then subsequently heat treated at 300 °C, 450 °C and 650 °C for 1 hour prior to cooling in still air. Mechanical performance of each specimen was assessed via tensile testing utilizing a Testometric machine and hardness assessment using Rockwell testing in accordance with ASTM E18. The results indicated an increase in tensile strength with increasing temperature during heat treatment and maximum tensile strength at 650°C; this was due to the formation of precipitated carbides and stabilization of the weld structure through heat treatment. The stress-strain plots illustrated an increase in flow stress that corresponded to a reduction in the elongation to failure for PWHT specimens; a trend indicative of a strength-ductility trade off. Decreases in Rockwell hardness relative to the as-welded condition were exhibited across all heat-treated conditions; this reflected both relief of residual stresses present within the heat affected zone and tempering of martensitic microstructures within this zone. Overall, the results indicate that heat-treatment parameters may be selected to decrease hardness (and therefore associated SSC/HIC risks), while simultaneously increasing strength for load bearing applications within oil and gas fabrication and/or repair operations involving AISI 1035 components. The relationship between PWHT parameters and material properties will aid in establishing practical guidelines for specification of PWHT within oil and gas fabrication and/or repair operations involving AISI 1035 components.

Cystic tumors of the pancreas are a rare entity, accounting for approximately 15-20% of pancreatic cystic lesions, largely due to advances in imaging techniques. The most common types of pancreatic cystic tumors are intraductal papillary mucinous tumors (TIPMP) and mucinous cystadenomas (CM), while serous cystadenomas (CS) and solid pseudopapillary tumors (TPPS) are less frequent. This study aims to report the experience of the General Surgery Department at the Avicenne Military Hospital in Marrakech regarding the diagnostic and therapeutic management of cystic tumors of the pancreas.

Cervical cancer is the second most common gynecological malignancy in developing countries and remains a major cause of cancer-related mortality among women worldwide. This retrospective descriptive study, conducted on 38 cases at the General Surgery Department of the Avicenne Military Hospital in Marrakech from 2018 to 2022, revealed a predominance of squamous cell carcinoma in women aged 50 to 60 years. Vaginal bleeding was the main presenting symptom. Concomitant chemoradiotherapy based on weekly cisplatin followed by uterovaginal brachytherapy was the most frequently used treatment. Strengthening and expanding cervical cancer screening programs remain crucial to improve early detection and patient outcomes.

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This paper examines how designers engage with sustainable materials through a practice-based methodology that integrates reflection, experimentation, and material understanding. It repositions sustainability not as a static design objective, but as a dynamic, iterative process that emerges through the act of making. By engaging with renewable, bio-based, and waste-derived materials, the research demonstrates how creative practice fosters ecological literacy and responsible production. Drawing upon design research and case-based evidence, this study argues that sustainability evolves from experiential learning, material dialogue, and systemic thinking rather than prescriptive frameworks. The outcomes emphasize the designer’s evolving role as a mediator between creativity, ecology, and technology.

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of renal cancer, accounting for approximately 75% of all kidney malignancies in adults. Despite advances in diagnosis and therapy, the molecular mechanisms underlying ccRCC progression remain incompletely understood. MicroRNAs (miRNAs), as post-transcriptional regulators of gene expression, play critical roles in cancer initiation, progression, and metastasis. This study aimed to identify key dysregulated miRNAs and their target genes involved in ccRCC pathogenesis using an integrative in-silico bioinformatics approach. Three Gene Expression Omnibus (GEO) datasets (GSE116251, GSE95384, and GSE6357) were analyzed through the GEO2R tool to identify differentially expressed genes (DEGs) and miRNAs (DEMs) using |logFC| > 1 and adjusted p-value < 0.05 as thresholds. Overlapping miRNAs were determined using the Venny tool, and their corresponding target mRNAs were predicted through TargetScan. Functional annotation and pathway enrichment of DEGs were performed using the DAVID database, while protein–protein interaction (PPI) networks were constructed through STRING. The miRIAD and OncomiR databases were employed to elucidate miRNA–gene interactions, and the OncoLnc database was utilized for survival analysis. Our analysis revealed several dysregulated miRNAs, including miR-155-5p, miR-210-3p, and miR-21-5p, along with key tumor-related genes such as VHL, PBRM1, SETD2, TP53, and PTEN, which significantly influence ccRCC prognosis. Functional enrichment analysis demonstrated that these genes are involved in critical oncogenic pathways, including the cell cycle, p53 signaling, and PI3K–Akt pathways. In conclusion, this study provides a comprehensive bioinformatic framework that highlights novel miRNA–gene interactions potentially involved in ccRCC progression. The identified molecules may serve as valuable biomarkers for diagnosis, prognosis, and targeted therapy in renal cancer, supporting further experimental validation and clinical investigation.

Background: Thyroid carcinoma initially presents with clinical symptoms due to metastatic lesions in less than 5% of cases. Spinal cord compression from an epidural metastatic lesion as a first symptom is extremely rare. One would expect such a presentation to occur much later in the course of the disease. Case presentation: We report an unusual case of a 57-year-old-woman with the complaint of back pain for one year. A process was detected at the corpus of L5-S1 to S3 vertebra, by the sacrococcygeal MRI. Conclusion: Spinal metastasis as initial finding is very rare in the patients with FTC. However, prognosis is quite well with total tumor resection and adjuvant treatment. This cancer type must be kept in mind for differential diagnosis and must be screened in the patients with spinal tumors.

One of the core texts of Mahāyāna Buddhism, the Larger Sukhāvatīvyūha Sūtra, presents a deep existential and moral worldview based on compassion (karuṇā). The sutra offers a dynamic ethical framework in which compassion serves as both the ontological foundation of existence and the route to emancipation, far from being purely devotional. Moral behavior is changed into a soteriological process of self-transcendence through the vows of Amitābha Buddha, where the limited human situation opens up to boundless life (amitāyus). This study investigates the sutra's ethical philosophy using the dialectical interplay between self-power (jiriki) and other-power (tariki), revealing how compassion bridges the conflict between individual agency and universal salvation. The Larger Sukhāvatīvyūha Sūtra combines Buddhist moral theory with existential contemplation to present a vision of human fulfillment based on relationship and altruism. The thesis contends that the sutra's ethical vision goes beyond ceremonial piety to provide a universal philosophy of compassionate being applicable to both Buddhist and modern moral