The primary dentition is essential in the maintenance of normal occlusion in the permanent dentition. Both dentitions enhance aesthetic, speech and are functional in nature. Early loss of the primary dentition necessitates the placement of space maintainers. This study determined the pattern of tooth extraction of patients attending the paediatric dental clinic in Lagos State University Teaching Hospital, Ikeja and the use of space maintainers. A retrospective study carried out using the dental records of patients who attended the Paediatric dental clinic, Lagos State University Teaching Hospital, Ikeja, Lagos. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) software, version 20 (IBM, New York). The prevalence of tooth extraction was 49.8% among a population of 410 subjects with a total of 353 extracted teeth. The male to female ratio was 1:1.37. Majority (58.3%) of the subjects had only one tooth extracted. The commonest reason for extraction was retained primary teeth (35.8%). The commonest arch and segment of extraction was the mandible (56.1%) and the anterior teeth (51.0%). The commonest tooth extracted was upper right primary central incisor (7.6%). The most common space maintainer was band and loop. Retained teeth was the most common reason for tooth extraction followed by sequelae of dental caries, caries and trauma. This highlights the need for implementation of oral health prevention policies with regards to the use of fluoride, fissure sealants, silver diamine fluoride increased awareness of safety protocols to mitigate traumatic injuries and introduction of dental health education programs in schools and community.

Hepatic teratoma is an extremely rare tumour. Since 1898 only 28 cases of hepatic teratoma have been reported in the literature, including 21 in pediatrics. The diagnosis is often confirmed by the anatomopathological study and the therapeutic approach is multidisciplinary based essentially on surgery. We report the case of a 45-year-old woman with a history of ductal carcinoma of the right breast for which she underwent surgery. The patient presented with pain in the right hypochondrium, a diagnosis of hydatid cyst of the liver was made based on a cystic image of the right liver on ultrasound. It showed a heterogeneous thin-walled cystic image in the right liver suggesting a type IV hydatid cyst. The MRI was in favor of a fluid lesion of the hepatic dome evoking a remodeled hydatid cyst. During surgery, the liver was found of normal size and segment VIII is the seat of an oval formation 70/60 mm in diameter. A resection of the cystic formation with a closed cyst was performed. Histological analysis concluded with the diagnosis of mature teratoma with no signs of malignancy. After a follow-up of 12 years, the patient is in good health and without recurrence.

Small bowel lymphoma associated with celiac disease is rare. The annual incidence varies from 0.5 to 1 per million inhabitants. We report two cases of small bowel lymphoma associated with celiac disease. The first case is a 50-year-old patient, treated for celiac disease since 2010 and whose tumor was revealed on abdominal CT as part of the etiological assessment of abdominal pain with an anemic syndrome. In the other case, it was a 52-year-old patient presenting the same symptomatology, in whom endoscopy revealed total villous atrophy, indicating the diagnosis of celiac disease, and CT showed a small bowel tumor. Both patients underwent segmental resection with single-stage anastomosis. The anatomopathological study concluded to a small lymphoma. Adjuvant chemotherapy was administered in both cases, and their evolution was favorable.

Biomedical Waste (BMW) is defined as any waste, which is generated during the diagnosis, treatment or immunization of human beings or animals, or in research activities pertaining thereto, or in the production or testing of biological substances. The management of Bio-medical waste is still infant all across the world. Improper management of waste generated in Health Care Facilities (HCFs) causes a direct negative impact on the community, health care workers and on the environment. The waste generated in these facilities essentially consists of solids and liquid, which may be infectious / biological (10% to 15%) and non-infectious / non-biological (85% to 90%). Effective management of BMW is not only a legal necessity but also a social responsibility. It is imperative upon all the health facilities, irrespective of their size and number of patients catered, to ensure appropriate BMW management at all levels starting from its generation to its final disposal. This study provides a comprehensive overview of India’s current BMW scenario, impact on society, legal management and various other management methods.

Background: Idiopathic Orbital Inflammatory Syndrome (OIS) ranks as the third most prevalent orbital disease, following thyroid eye disease and orbital lymphoma. In cases of localized inflammation, various structures within the orbit can be affected. This includes the Extraocular Muscles (orbital myositis), lacrimal gland (dacryoadenitis), sclera (scleritis), uvea (uveitis), as well as the superior orbital fissure and cavernous sinus (Tolosa-Hunt syndrome). Case Presentation: In this report, we discuss the case of a 35-year-old man who went to the Emergency Department due to intense, throbbing pain in his eye orbit and half of his head on the right side. He had been experiencing this pain for two days. The pain was aggravated by eye movement and accompanied by ipsilateral redness, mild photophobia, and blurred vision. The patient had no significant medical history prior to this episode. Upon eye evaluation, findings included mild swelling of the right eyelids, painful eye movements, inferior corneal erosions, and conjunctival chemosis with superficial and deep vessel congestion. Visual acuity was reduced due to myopic refractive error. Magnetic Resonance Imaging (MRI) revealed a soft tissue lesion in the right orbital apex extending into the right cavernous sinus, suggesting an inflammatory etiology such as Tolosa-Hunt syndrome. To investigate further, the patient underwent various diagnostic tests, including laboratory investigations, chest X-rays, and serological tests. These tests revealed unremarkable findings, ruling out systemic pathology. The patient received intravenous Solumedrol (Methylprednisolone) followed by oral Prednisolone, resulting in a dramatic improvement in symptoms. Conclusion: This case highlights the importance of a comprehensive diagnostic approach in evaluating severe orbital and hemi cranial pain. Prompt initiation of corticosteroid therapy can lead to rapid symptom resolution and favorable outcomes in patients with Tolosa-Hunt syndrome.

Aims: The World Health Organisation defines self-medication as the act of selection and use of medicine by individuals to treat self-recognized illnesses and symptoms or by health professionals to use drugs not prescribed by the treating physician. WHO has reported a prevalence of self-medication of 32.5% to 81.5% worldwide. In Cameroon a prevalence of 67,8%, and 41,9% has been reported in some studies. This study sought to assess the socio-demographic characteristics, prevalence, associated risk factors and the common medications of self-medication at the Bonassama and Cite des Palmiers Health Districts of Douala, Cameroon. Place and duration of the study: the study was conducted from December 2022 to May 2023 in two health districts in Douala, Bonassama and Cite des Palmiers. Methodology: It was a descriptive and analytic cross-sectional study. Sociodemographic, reasons for self-medication, class of medications commonly self-medicated data was collected. Descriptive statistics, univariate and multivariate analyses will be made by Chi square and Fisher’s exact test and reported as odd ratios, adjusted odd ratios and 95% confidence intervals. Statistical significance was set at p<0.05. Results: 83% of participants carried out the practice of self-medication. One of the major reasons for self-medicate was the fact that they thought that the illness was not serious with a prevalence of 46,6%, followed by cost saving (33,2%). The most common disease treated by self-medication was headache (81,5%), and the most represented class of drug were analgesics (84,7%); drugs were bought in community pharmacies (64,7%) and illicit market (44,9%). The statistically significant reasons for self-medication were cost saving, convenience, not serious illness, prior experience, long wait times in hospitals and accessibility of pharmacies. Conclusion: Self-medication is a widespread practice throughout the world, particularly in developing countries. This study has illuminated the prevalence and causes of self-medication in our environment. The prevalence of self-medication is high due to several factors and arguments, including cost saving, convenience, illness was not serious, prior experience, long wait times at hospitals, and availability of pharmacies.

The integration of Generative AI (GenAI) in Education presents immense potential for reshaping learning experiences and empowering students and educators. However, harnessing this potential requires collective action and responsible decision- making to ensure the effective and ethical use of AI technologies. This paper presents a series of recommendations and proposals aimed at effectively integrating GenAI in the higher education sector, catering to the perspectives of government, AI developers, students, educators, universities, schools, and researchers. By exploring diverse viewpoints about ChatGPT and future Google Gemini, this research aims to create a comprehensive recommendation guiding regulatory measures that address challenges, ethical considerations, and best practices of GenAI integration. Through a holistic approach, researchers believe that policymakers can foster a transformative and ethical environment, leveraging the full potential of generative AI while safeguarding students' well-being and academic integrity.

Background: The occurrence of metastatic colon lesions in various organs has been documented extensively in the literature. The liver, lungs, and bones are the most frequently affected sites. Metastasis in the duodenum due to colon cancer is an infrequent occurrence. Case Presentation: We present a detailed case report of a 65-year-old female patient diagnosed with metastatic colon cancer to the duodenum. The patient initially underwent extended right hemicolectomy for stage III low-grade adenocarcinoma of the colon. Adjuvant chemotherapy was administered, resulting in a period of apparent remission. However, in 2020, the patient experienced elevated tumor marker levels, prompting further investigations. Endoscopy revealed an irregular mass infiltrating the muscle layer in the duodenum, confirming malignant involvement. The patient underwent curative distal gastric duodenectomy, with pathology results indicating a colonic origin of the tumor. The patient received first-line palliative chemotherapy with FOLFOX rechallenge and the addition of AVASTIN. Several cycles of chemotherapy were completed, with satisfactory tumor response observed in follow-up PET scans. Maintenance therapy was initiated after achieving disease-free status on CT scans. However, in October 2022, the patient exhibited increasing tumor marker levels and new findings on PET scan, leading to the initiation of second-line palliative therapy with FOLFIRI and ramucirumab. The patient has received multiple cycles of second-line therapy, with the most recent PET scan in February 2023 showing a favorable treatment response, including a decrease in the size of existing nodes and no identification of new lesions. Conclusion: In conclusion, this case exemplifies the journey of a patient with stage 3 colon cancer who initially responded well to surgery and adjuvant chemotherapy, but experienced subsequent relapse in the duodenum. Despite surgical intervention and palliative chemotherapy, the patient developed metastasis in the liver, lung, and multiple lymph nodes.

Estimation and investigation of an earth’s albedo is significant in the evaluation and design of solar energy collectors, atmospheric radiative transfer and studies that relates to atmospheric thermal balance. This study employed the shortwave solar energy balancing at the edge of the Earth’s atmosphere to estimate and compare the variation of albedo for Nguru situated in the Sahelian region of Nigeria, using measured monthly mean daily meteorological parameter of global solar radiation obtained from the National Aeronautics and Space Administration (NASA) during the period of thirty-eight years (1984 – 2021). The variation of albedo with surface temperature, maximum wavelength, clearness index, global solar radiation, relative humidity and mean temperature for this location was investigated. The results in this study show that the estimated surface albedo depicts a direct opposite relationship with the clearness index, an inverse relationship with the emitting Earth’s surface temperature and a direct relationship with the wavelength for the studied location. The highest and lowest values of albedo for the location was in the months of August and January with 0.4628 and 0.3403 respectively. The emitting Earth surface temperature ranged between 238.5837 K in August and 251.1607 K in January. These values agreed closely to the standard emitting Earth surface temperature value (255.0000 K). The maximum emitting wavelength values for the location revealed that the radiation is longwave and is found within the infrared region of the electromagnetic spectrum.

Marjolin ulcer is a rare malignancy that arises in previously traumatised or chronically inflamed skin, particularly after burns, with an average latency period of 36 years. Nearly 75-90% marjolin ulcers are diagnosed as squamous cell carcinoma but other neoplasms like basal cell carcinoma, melanoma, fibrosarcoma etc have also been rarely reported. In this case, a 52-year-old male presented with a painless bleeding mass over lower chest wall rapidly increasing in size from last 2 years. He had suffered burn at the same site 20 years ago. Biopsy was reported as spindle cell neoplasm. Wide local excision revealed a poorly circumscribed subcutaneous spindle cell neoplasm exhibiting variable cellularity, fascicular to storiform architecture, mild to moderate nuclear atypia and scattered gaping thin-walled blood vessels. The neoplastic cells showed diffuse strong staining with CD34 in the less cellular area and patchy positivity in the cellular more mitotically active areas. The tumor cells were immunonegative for EMA, p63, SMA, CD99 and STAT6. The final diagnosis rendered was Dermatofibrosarcoma Protuberans dedifferentiating in to fibrosarcoma. Although sarcoma presenting as a Marjolin ulcer is exceedingly rare, it should be kept in mind in differential diagnosis of spindle cell malignancy arising at a burn site.

In this paper, the monthly variation of Surface Water Vapour Density (SWVD) with meteorological parameters of monthly average daily mean temperature, relative humidity, surface pressure, cloud cover and sunshine hours during the period of thirty-eight (38) years (1979 - 2016) for Akure (Latitude 7.280N, Longitude 5.300E, 375m above sea level) were investigated. The daily variation of surface water vapour density for the two distinct seasons considering two typical months in each during the period of year 2014 was examined. The results showed fluctuation in the amount of surface water vapour density in each day of the month for the period under investigation. The monthly average daily values indicated that the surface water vapour densities are greater during the rainy season than in the dry season. It was observed that the maximum average value of surface water vapour density of 20.1019 gm-3 occurred in the month of September during the rainy season and minimum value of 15.5110 gm-3 in the month of January during the dry season. The highest value of surface water vapour density was observed on the 4th of June, 2014 with 26.3320 gm-3 and the lowest on the 31st day of December, 2014 with 6.0276 gm-3. The comparison assessment of the developed two variable SWVD based models was carried out using statistical indices of coefficient of determination (R2), Mean Bias Error (MBE), Root Mean Square Error (RMSE), Mean Percentage Error (MPE), Nash – Sutcliffe Equation (NSE) and Index of Agreement (IA). The developed multivariate correlation regression model that relates pressure and precipitable water vapour with R2 = 100%, MBE = -0.0177, RMSE = 0.0179, MPE = 0.1034, NSE = 99.9956% and IA = 99.9989% was found more suitable for surface water vapour density estimation with good fitting and therefore can be used for estimating surface water vapour density in Akure.

Autotransplantation of a maxillary premolar tooth is a considerable option for tooth replacement in young adult patients, while Hemisection is a conservative way of preserving teeth. In this case report, we describe successful autotransplantation of the mesial root of the mandibular molar to replace the first maxillary premolar with complete root formation. The donor root was immediately placed at the recipient site and splinted for 14 days. Root canal treatment (RCT) was initiated 3 weeks after transplantation. Clinical and radiographic findings at 24 months of follow-up are compared with the results described in the literature. In case of non-extraction, adjacent teeth can be preserved in an economical way, also, case selection is essential in performing sequences of procedures for the success of treatment.

Colorectal carcinomas (CRC) are associated with several histopathological and molecular factors of prognostic and hence therapeutic implications, including for epithelial mesenchymal transition (EMT) and angiogenesis. Downregulation of E-cadherin is a crucial step in EMT, directly related to tumor progression, invasion, and metastasis. Vascular endothelial growth factor (VEGF) induces angiogenesis and thereby tumour progression and metastases. Our objective was to analyse VEGF and E-cadherin expression in patients with CRC and to effectively assess the relationship of these with histopathological factors. 50 cases of CRC obtained over eighteen months duration, were included in the study. Haematoxylin and Eosin-stained sections were studied for histopathological factors. Immunohistochemistry with E-Cadherin and VEGF were performed on representative sections and evaluated. Histopathological features of importance noted were low grade tumour budding (55.5%), Infiltrative invasive front (83%), lympho-vascular invasion (50%). Preserved expression of E-Cadherin was seen in 66% of the cases, and 34% reduced expression, predominantly noted in patients above the age of 50, increased tumour size, mucinous variants, advanced TNM stage, lymph node involvement and high-grade tumour budding. VEGF staining was seen in 64% of the cases with varying intensity. Increased VEGF expression was noted in poorly differentiated tumours, advanced Duke’s stage and with lymph node metastasis. Colorectal carcinomas with high grade tumour budding were associated with lymph vascular invasion, infiltrative invasive front and significantly correlated with TNM stage. High grade tumours and adverse histopathological prognostic factors revealed a reduced E-cadherin expression and increased VEGF expression.

Vasculitis may be due to various causes, including connective tissue disorders, medications, and infections. Histopathology shows similar features in different diseases so DIF (direct immunofluorescence) helps to categorize these vasculitic lesions on basis of positivity of different immunoglobulins. In this study, 40 cases of suspected vasculitis were confirmed by histopathology. Females were more commonly affected and the age range was from 9 to 71 years. Among these cases, 21 were immune complex mediated vasculitis of which c3 and IgG were the most commonly found immunoglobulins. Two of these cases were IgA mediated vasculitis. DIF was of great importance for the diagnosis of the disease for appropriate treatment.

Background: Ankylosing spondylitis can lead to heart disease, including aortic incompetence, conduction defects, mitral valve disease, cardiomyopathy, and pericarditis. Early detection of cardiac abnormalities is crucial for effective treatment and prognosis, as they increase with age, disease duration, and peripheral arthritis presence. Objectives: This study aimed to determine the type, prevalence, and extent of cardiac involvement in patients diagnosed with ankylosing spondylitis. Methods: The study were collected in the Department of Medicine and Rheumatology units of Bangabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital from January 2022 to December 2022. Diagnosis was established based on clinical features, physical examinations, and relevant laboratory and imaging studies. Patients with a history of rheumatic fever, syphilis, or those who declined participation were excluded from the study. Results: A total of 80 patients with ankylosing spondylitis underwent clinical examination, electrocardiography, and echocardiography to assess cardiac involvement. Among the participants, eight patients (10%) were found to have aortic insufficiency. Two patients had both aortic insufficiency and first-degree heart block, one had only first-degree heart block, and one had mitral insufficiency. Presents the cardiovascular manifestations detected in 12 patients (14%) with ankylosing spondylitis. Peripheral arthritis was present in 64% of the 12 patients with cardiovascular lesions, compared to only 34% of the 68 patients without such lesions. Conclusion: This hospital-based observational study investigated cardiac involvement in ankylosing spondylitis patients. Due to the small sample size, definitive conclusions were difficult to make, but the findings suggest that cardiac involvement is relatively common, emphasizing the need for early detection of cardiac abnormalities for effective treatment and prognosis.