Introduction: The femoral nerve is one of the vital nerves of the thigh region, which has importance in various fields of clinical areas, as well as in the field of Anatomy and the research areas. Femoral nerve blockade plays an important role in surgical interventions of the anterior thigh. Although the femoral nerve is superficial and easier to identify, a profound knowledge regarding the dimensions of the nerve is inevitable to perform successful surgeries and blockades. Objective: The describing study was an attempt to analyze the different dimensions of the femoral nerve in the thigh region of the Malaysian cadavers with relevant clinical implications, as there is a paucity of these studies involving Malaysian cadavers has been reported. Methods: This study had been conducted with the involvement of 78 adult lower limb specimens (cadaveric and disarticulated) of both genders and different ethnicity. Result: The average length of the femoral nerve from the inguinal ligament (IL) till its division and the width at the IL resembled the previous studies conducted on other geographical locations. The width at the division was similar to that of the IL level. The thickness at the IL was 1.32 ± 0.21 (right) and 1.29 ± 0.17 (left); and at the division was 1.50 ± 0.196 (right) and 1.43 ± 0.16 (left). The circumference of the nerve at the IL was 25.44 ± 1.26 (right) and 25.98 ± 0.89 (left); and that at the division was 25.65 ± 1.32 (right) and 25.66 ± 1.25 (left). Conclusion: The knowledge of the morphometric anatomy of the femoral nerve in the thigh region will not only assist neurologists and future researchers but also facilitate clinicians to prevent misdiagnoses and iatrogenic neurological damage.

Enhancing aesthetics, occlusion and functions is a primary motivation for individuals with open-bite malocclusion seeking orthodontic treatment. Open-bite malocclusion, characterized by a lack of vertical overlap of the anterior teeth, can be effectively treated using anterior vertical elastics. It’s a common, non-surgical orthodontic approach to correct open-bite issues. In this case report, we present the treatment of a male patient with anterior open-bite malocclusion. Initially, the patient underwent a lingual frenectomy followed by an active and passive phase of swallowing rehabilitation by wearing a nocturnal lingual envelope (NLE). Subsequently, a fixed orthodontic appliance was bonded to achieve well-aligned arches, normalize the overjet and overbite with the use of anterior vertical elastics (AVE) and enhance both aesthetics and functions.

Soil salinity poses a significant constraint on plant growth and productivity of maize. Salinity causes reduction in water content in plant tissues, ultimately reducing the photosynthetic capacity and resulting in decreased productivity. Normally in saline soils, chloride ions (Cl−) are particularly considered toxic to certain crops, but in case of maize, sodium ion (Na+) is the main ion responsible for toxicity due to its competition with K+ for binding sites at the plasma membrane. Mycorrhizoremediation which is an enhanced form of phytoremediation is one of the key players in remediation saline soils. Inoculation of these beneficial arbuscular mycorrhizae fungi can alleviate growth inhibition and the adverse effects of salinity in both halophytes and glycophytes by establishing symbiotic relationships with plants. AM fungi colonize the roots of maize plants, perform a crucial role in nutrient cycles in terrestrial ecosystems and own highly efficient and various mitigation mechanisms. Under saline conditions, AM fungi restrict the absorption and translocation of Na+ to shoot tissues and enhance the uptake of K+ in plants. An experiment aiming to enhance salt tolerance in maize through AMF symbiosis was conducted. In this experiment three AMF were evaluated at two salinity levels 66 mM and 100 mM. analysis of data revealed that AMF Ri collect showed showed highest percentage of root colonization at all salinity levels. While plants inoculated with AMF Ce CdG showed highest shoot and root biomass. Furthermore, plants inoculated with Sc CdG and Ce CdG showed a significant reduction in Na+ accumulation and enhance K+ accumulation in shoot and root tissues as compared to non-mycorrhizal plants.

Introduction: Immunotherapy is a form of oncologic treatment directed towards enhancing the host immune system against cancer. Immunotherapeutic agents were significantly associated with a higher risk of developing adverse effects in cancer patients. Bevacizumab was significantly associated with higher risk of developing venous thromboembolism, GI perforation such as bleeding and leukopenia in cancer patients. Trastuzumab has led to a significant improvement in the treatment of both advanced and early breast cancer by over expressing HER-2 receptors. It was associated with an important adverse effect, cardiotoxicity. Cetuximab and Panitumumab are monoclonal antibodies targeting the endothelial growth factor receptors (EGFR) currently used for systemic treatment of metastatic colorectal cancer in combination or alone have been reported to be able to induce skin toxicities. Nausea, diarrhea and rash were the most common adverse effects in Pertuzumab alone and Pertuzumab – based therapies. Pertuzumab also increases the risk of clinical heart failure, but not asymptomatic/minimally symptomatic left ventricular systolic dysfunction, in HER2-positive cancer patients. Materials and Methods: An ambispective observational single center study was conducted by collecting details of patients prescribed with Trastuzumab, Bevacizumab Pertuzumab, cetuximab and panitumumab. Retrospective study period of 5 years (2017 November to 2022 November) and Prospective study period of 6 months were conducted (December 2022 to May 2023). Patients of all age groups prescribed with immunotherapeutic agents other than immune checkpoint inhibitors was included and patients who were discharged against medical advice and incomplete data was excluded. Results: Majority of patients in our study were in age groups of 56-65 years with 38.5%. Among 65 patients, 4 of them reported with trastuzumab induced cardiotoxicity and 3 of the patients taking trastuzumab along with pertuzumab also reported with cardiotoxicity. Among 30 patients who were taking bevacizumab, one patient was reported with pneumonitis. We conducted a correlation analysis using chi-square test between study considered drugs and the reported adverse reactions. All of the patients prescribed with Trastuzumab + Pertuzumab were having ADR. Also, majority of the patients prescribed with Bevacizumab were not having ADR. Since the p-value of chi-square test was found to be <0.001 so there exist a significant relation between drugs prescribed and ADR. Conclusion: We assessed the safety profile of immunotherapeutic agents other than immune check point inhibitors in cancer patients. We also correlated the study considered drugs and adverse drug reaction occurrence, there existed a significant correlation.

The phenomenon of suicide is a significant concern for public health globally, as it ranks among the top causes of mortality in different age demographics. The objective of this analysis is to offer a thorough examination of existing strategies for preventing suicide, which include psychological, medical, and community-based approaches. Through evaluating the efficacy of diverse interventions and pinpointing areas that require enhancement, this article aims to contribute to the creation of more comprehensive and all-encompassing frameworks for suicide prevention. The analysis emphasizes the significance of early identification, availability of mental healthcare, and the influence of societal support in reducing the risks associated with suicide.

Extremely wide bony ridges require surgical procedures in order to insert dental implants. When less than 3 mm is present, different procedures are available, with ridge splitting being one of the most commonly used. The main limitation of this procedure is the angulation of the inserted implant. The two-stage split with transitional implants was created to overcome this drawback and achieve greater bone volume in the intervention area. This case series shows patients treated with this novel procedure. Material and Method: We retrospectively analysed patients who had undergone two-stage ridge expansion (using transitional implants) with at least 9 years of follow-up from the loading of the definitive implant, both in the maxilla and mandible. Data collection was performed by two independent examiners (different from those performing the prosthetic or surgical phase). All data were entered into a database which was managed by computer for the subsequent statistical analysis. The implant was the unit of analysis for descriptive statistics in terms of location, implant dimensions, and radiographic measurements. The primary variable was implant survival and as secondary variables mesial and distal bone loss and final bone crest width achieved after transitional implant integration, before replacement, were recorded. Results: Thirteen patients were recruited, and 30 transitional implants were inserted for width expansion in two surgical stages. These transitional implants were subsequently replaced by definitive implants at 5 months in the maxilla and at 3 months in the mandible. The mean initial ridge width of all two-stage split sites was 2.65 mm (+/- 0.63), range 1.32 to 3.70 mm. After placement of the transitional implants and bone healing, the final mean width of the specimen was 7.60 mm (+/- 0.26), range 4.31 to 12.20 mm. The mean mesial bone loss after loading of the final implant was 0.80 mm (+/- 0.26) and the mean distal bone loss was 0.85 mm (+/- 0.25). Conclusion: The two-stage split technique to achieve a gain in width of the residual bone crest is minimally invasive, predictable and the implants placed in the final (definitive) stage have a high survival rate, as we have seen in the present study with 9 years of follow-up.

This study aims to evaluate the effectiveness of applying measures to improve students' positivity during Vovinam lessons at FPT University Ho Chi Minh City (FPT University). Thereby, it serves as a basis for monitoring, adjusting, and changing the content of Vovinam subjects to suit the students being trained in the school. We conducted indirect interviews with research subjects using a questionnaire on a Likert scale (5 levels) to identify difficulties and obstacles while teaching and learning Vovinam. After interviews, 10 possible solutions were selected to put into practice. At the same time, conduct a reality check to understand the change in students' positivity after applying measures to enhance positivity during Vovinam lessons. After the experimental period, it was shown that the positivity (including intellectual positivity; cognitive positivity; learning positivity) of students in the experimental group (experimental group) and the control group (control group) both increased. However, the growth of the experimental group was clearly and statistically significantly higher (with P<0.05) than that of the control group’s.

We assessed the ameliorative effect of Virgin Coconut Oil (VCO) following atrazine-induced inflammation in rats. Adult male Wistar rats weighing 180 - 200 g body weight were separated into two major experimental groups. 35 rats in the test group were divided into five groups of 7 rats: Group 1,2 and 3 received 10 ml/kg body weight of distilled water, 10 ml/kg VCO and 123 mg/kg Atrazine (ATZ) respectively, group 4 was diabetic control and group 5 was diabetic group treated with 10 ml/kg of VCO for 2 weeks, after which the animals were sacrificed, and blood collected for analysis. 35 rats for the recovery group were also divided into 5 groups of 7 rats; group 1 and 2 received 10 ml/kg body weight of distilled water and 10 ml/kg of VCO; group 3,4 and 5 received 123 mg/kg of ATZ for 2 weeks. After the first 2 weeks, group 1,2,3 continued the initial treatment while the rats in group 4 and 5 were administered 10 ml/kg of VCO and 10 ml/kg of distilled water respectively. After 2 weeks all the animals were sacrificed and blood collected for analysis. C-reactive protein (CRP) and interleukin 6 (IL-6) were significantly (p<0.05) raised in VCO control, atrazine and diabetic untreated group when compared to normal control. Following recovery, CRP and IL-6 were significantly lowered in the VCO treated group when compared to ATZ group. ATZ toxicity resulted in increase in inflammatory markers but the withdrawal of ATZ significantly reversed some of these derangements; with more pronounced effect following VCO administration.

We describe the evolution of patients with perineal Crohn's disease (PCD) treated with immunomodulators (IM): the purine anti-metabolites or methotrexate (MTX) in the absence of biotherapy. This was a retrospective descriptive study including all patients with (PCD) treated with (IM) and who cannot get biotherapy. The evaluation of the response was based on clinical response and / or morphology. Overall, 62 patient were under (IM). a good result was observed in 63% with complete healing in 79.2% and a partial response in 20.8%. The response time was variable with a median of 4 [2-24] months. Our study shows that despite the progress of biotherapy, the purine anti-metabolites retain their place in the treatment of Crohn's disease in general and in (PCD) more specifically.

Background: Platelet-rich plasma (PRP) therapy has emerged as a promising treatment for androgenetic alopecia (AA), addressing the need for effective hair restoration with minimal invasiveness. However, questions remain regarding the optimal frequency and duration of PRP treatment. Objective: This study aimed to assess the impact of PRP therapy on hair density and diameter in AGA patients, considering variations in treatment response across different AGA grades and alopecia durations. Method: A 6-month open-labeled pilot study was conducted on 30 male participants with AGA Grades III-VII. PRP was administered every 15 days for six sessions, and hair parameters were evaluated using trichoscan. Results: The study demonstrated a significant increase in both hair diameter and density over six months of platelet-rich plasma (PRP) therapy for androgenetic alopecia (AGA). Initially, the mean hair diameter was 0.055 mm, rising to 0.075 mm by the study's end, with a substantial increase of 0.021 mm at six months, equating to a 39.85% improvement. Similarly, hair density increased notably from 6.13 to 8.43 hairs per 10 mm², with the most significant rise at the six-month mark, showing a mean increase of 2.3 hairs per 10 mm², reflecting a 39.73% enhancement. All AGA grades experienced increased hair diameter and density, with Grade 5 showing the highest diameter increase (0.03 mm), and Grade 4A exhibiting the highest density increase (3.0 hairs per 10 mm²). Statistical analysis confirmed significant improvements across all grades (p = 0.0446 for diameter; p = 0.0196 for density). Additionally, patients with alopecia durations up to five years experienced the highest improvements in both diameter (0.026 mm) and density (2.68 hairs per 10 mm²), while longer durations showed lower enhancements (p = 0.0485 for diameter; p = 0.0096 for density). Conclusion: PRP therapy demonstrated efficacy across all AGA grades and durations, suggesting its potential as a promising treatment option for AGA. Further research is needed to validate these findings and establish PRP therapy as a standard AGA treatment.

Primary ciliary dyskinesia is a cause of bronchial dilatation, associated with rheumatoid lung is rare. This is why we report a case with the aim of discussing the clinical, diagnostic characteristics and therapeutic possibilities of ciliary pathology and showing the link between it and rheumatoid arthritis. Observation: This is a 40-year-old African patient, married without children, from a consanguineous couple, with a family history of a brother who died in adulthood in a picture of respiratory failure and productive cough. She presented with recurrent rhinorrhea since childhood and bronchorrhea in a picture of progressively worsening dyspnea and clubbing. During the evolution of the disease, inflammatory polyarthralgia was associated. The ultrastructural ciliary study by electron microscopy and the measurement of nasal nitrogen oxide are the confirmatory examinations of primary ciliary dyskinesia. They are not achievable in our practice. However, based on the history and clinical findings, the patient presented several elements in favor of this pathology. additional investigations, notably the rheumatoid factor and the chest CT scan, allowed us to suggest rheumatoid lung. Our therapeutic conduct was the administration of antibiotic therapy, oxygen therapy, immunosuppressant, anti-inflammatory and the practice of respiratory physiotherapy. Conclusion: Primary ciliary dyskinesia associated with pulmonary involvement in rheumatoid arthritis increases the risk of developing respiratory failure.

With increasing concerns over fossil fuel depletion and environmental pollution, research into alternative energy sources has gained significant momentum. Organic wastes, particularly from animals and food, offer a promising substrate for biogas production, providing dual benefits of energy generation and waste reduction. This study evaluates the suitability of food waste, cow regurgitates, and cow dung for biogas production through biodigestion. The objectives were to design a lab-scale biodigester, compare biomethane yields from each waste, and evaluate their effectiveness as fertilizers. The results indicate that all three samples have properties within the acceptable range for digestion. Food waste exhibited the highest methane yield with a daily biogas production of 0.4979 m³/day, corresponding to an energy content of 27,699.45 KJ/day. Cow regurgitates produced 0.2656 m³/day of biogas, yielding an energy content of 14,739.6 KJ/day. Cow dung yielded 0.3213 m³/day of biogas, translating to an energy content of 17,723.65 KJ/day. Microbial analysis indicated the presence of beneficial bacteria and fungi, such as Staphylococcus spp, Proteus vulgaris, Escherichia coli, Enterobacter aerogens, Aspergillus spp, and Mucor spp, which are advantageous for soil conditioning and nutrient cycling. The study highlights the importance of assessing physicochemical properties, nutrient content, and microbial composition to optimise biogas production and explore the potential of organic waste as a sustainable energy source and soil conditioner.

This work was initiated with an objective that would screen for bioactive specifically antibacterial molecules secreted by actinomycetes growing in fresh water pond soil. Actinomycetes being treasure trove of thousands of bioactive molecules. It is recommended that either novel or present day bio molecule derivatives should be detected and pertinent drug development process be carried out with this background this study was proceeded to identify strains of Microbacterium barkeri (LMA4), Corynebacterium argetoratense (LMA5) and Streptomyces shenzhenensis (LMA6) form the local marshy pond soil. The actinomycetes was with Arial mycelia was gram positive with profuse branching. In a test considering MDR strain of Escherichia coli (BME4) and Staphylococcus aureus (BMS4) as test bacteria. The 16s rRNA sequences and the BLASTn analysis helped out to predict the sequence identification as the actinomycetes isolates.

Background: A needle stick injury is a serious occupational health hazard in health care settings. Health care workers are at risk of bloodborne diseases and the psychological consequences of these injuries. Objectives: we aimed in this study to assess the prevalence of NSI among health care workers in King Saud Medical City and to assess their knowledge, attitude and practices regarding needle stick injuries. Methods: A cross-sectional study was conducted from 17th August 2022 until 30th November 2023. A structured questionnaire from Saudi Ministry of Health guidelines was used to collect the data. The content validity was evaluated by four academics from King Khalid University in Abha, and some minor changes were made. Results: As regard the prevalence of NSI, out of 220 participants, 132 individuals did not report any needle-stick injuries (NSI). While 92.3% of participants accurately defined NSI and acknowledged blood-borne disease transmission risks, only 39.1% followed preventive measures like recapping needles and proper disposal. There were knowledge gaps observed, with varying awareness levels on Hepatitis B and C prevention. Participants demonstrated awareness of post-exposure guidelines but lacked knowledge on immediate actions to take post-injury. Attitudes towards NSI varied, with a significant percentage 44.1% prioritizing patient care over healthcare worker safety. Interestingly, significant support was shown for immediate reporting of sharp injuries and the belief that NSIs are preventable. In terms of practice, adherence to safe needle practices varied, with the majority 90.9% using assigned disposal containers and being vaccinated against Hepatitis B, but not all receiving recent training on safe devices. Conclusion: This study revealed that NSIs remain a prevalent occupational health hazard among healthcare workers. Although a significant number of participants demonstrated adequate knowledge and awareness of NSIs and bloodborne disease transmission risks, there were noticeable gaps in their implementation of preventive measures and immediate post-injury actions. Attitudes towards NSIs varied, with some prioritizing patient care over healthcare worker safety. However, there was strong support for the immediate reporting of sharp injuries and belief in the preventability of NSIs.

Soil contaminated with heavy metals has a negative impact on plant development and survival. On the other hand, plants have developed intricate physiological mechanisms to resist these kinds of environmental stimuli. Anthropogenic sources of emissions are the many industrial point sources, including transporters, smelters and foundries, present and former mining sites, and combustion byproducts. Mercury is released via the degassing of the earth's crust, whereas lead is emitted during its mining and smelting operations, from automotive exhausts by burning petroleum fuels coated with tetraethyl lead antiknock, and from old lead paints. The process of refining zinc releases cadmium as a byproduct and occasionally lead. Emissions are generally released during the mining and processing of metals. Stress from heavy metals affects plants absorb nutrients through interactions with other essential elements. Chromium restricts the quantity of nutrients the soil may absorb by forming insoluble compounds. An intriguing method for managing plastic waste, particularly micro/nano plastics, is photocatalysis. Through the use of suitable light energy, nanostructured semiconductors are excited, producing exciton pairs that react with surrounding water or moisture to produce highly reactive species like superoxide’s and hydroxyl radicals that can effectively oxidize organic species, including polymers. Climate variability affects the sustainability of human and environmental health together with other man-made and natural stresses.