Researches have been geared at not only ameliorating the rising cost of providing affordable housing units to the ever increasing populace but also tackling global challenges such as climate change, environmental degradation, pollution, biodiversity and others concerns and animal bones which have posed challenges through its disposing, treating and processing is the focus of this research by investigating the possibility of its use as coarse aggregate in concrete. Animal bones were crushed in sizes ranging from 10-20mm, these crushed cow bone (CCB) aggregate, were used in concrete specimens as a partial replacement for conventional aggregates in percentages 0%, 5%, 10%, 20%, 25%, and 30%. The particle size distribution of fine aggregates, granite, and cow bone aggregate will be determined in line with BS EN 933-2:2020. Slump test was executed in line with the provisions of BS EN 12350 Part 2: (BSI, 2019). The compressive strength test was carried out using concrete cube (150 mm) specimens in line with the provisions of British Standard codes for concrete (BS EN 12390-3 (BSI, 2019) and cured by immersion for 7, 14, and 28 days. The results of the compressive strength of the concrete made with different percentages of CCB showed very promising strengths between 5- 15% but with optimal strength values at 15% replacement. This implies that CCB can be used to ease the cost of construction in the use of coarse aggregates provided its use is limited to 15% replacements.

From time immemorial and even as it is nowadays, mining operations has been coined as one of the world’s most dangerous activities that are associated with a lot of high risks including loss of lives and untold accident and diseases. This issue of the protection of the health and safety of mineworkers in Cameroon in particular and the world at large has been a called for concern for quite some time and even as we speak. Mining being relatively a new field, the Cameroonian Government still has so many things to put together, especially in the domain of it legislation. One of such is the protection of workers therein. Given that the 1992 Cameroonian Labour code on the one hand has no express or specific provisions for the health and safety of mineworkers and the newly 2016 mining code of Cameroon on the other hand which is the main piece of legislation governing mining operations has not done any better, especially as the protection of the health and safety of such categories of workers in the national territory is concern, and even as a member of the ILO, she has failed to ratify some important ILO Conventions, especially Convention no 176 concerning safety and health of workers in mines, whose purpose is to ensure the social protection of workers and to safeguard fundamental human rights in the mineral exploitation sector. This paper adopts a purely qualitative research method involving an in-depth content analysis based on primary and secondary sources of data collection, this paper questions the effectiveness of the protection of the health and safety of mineworkers in the Cameroonian mining milieu and challenges encountered.

The CRISPR toolbox can perform precise programmable genetic sequence insertions to the development of new technologies. The Cas9 nuclease is one of the proteins that make up the so-called genetic scissors, a system of directed cutting of foreign DNA and, RNA that is the subject of extensive research among all known Cas proteins. The correction of alpha1 antitrypsin deficiency and cancer immunotherapy are two important therapeutic development scenarios where HDR-mediated CRISPR-Cas9 editing has demonstrated encouraging outcomes in the clinical testing. Protospacers are DNA segments that are targeted by the prokaryotic immune system and resemble the corresponding spacers at the CRISPR locus, with the exception of the PAM motif. The transpiration is the loss of water by a plant, mostly through the stomata on its leaves. Drought is a dangerous occurrence that significantly affects how well plants perform. It sets off physiological and biochemical processes that help the plant withstand drought by lessening its impacts. Medicinal plants and other soil-grown agricultural goods are often impacted by oil pollution. The existence of hazardous heavy metals in the soil, such as cadmium, mercury, lead, chromium, arsenic, nickel, copper, and zinc, is one of the many other explanations for why some bacteria and germs have become resistant to medications this century.

The raw fruit extract of Morinda citrifolia plant and its commercially available formulation in the market as Noni max (Best-selling brand of Brihans pharmaceutical in India and abroad) were obtained from Brihans Pharmaceuticals Pvt. Ltd. Mulund, Mumbai, India. 80 Wistar rats of either sex weighing between 200 to 250 gms were used for experimentation. In the present study, it was found that the Morinda citrifolia fruit extract and its formulation found safe for the developmental stages of foetus. It was also found that there was no significant difference was noted in body weight and the relative weight of the ovary, uterus and placenta of female rat. There was no structural and functional manifestation was noted in the developing foetusin the pregnant female rats. From the present study it is confirm that, both Morinda citrifolia fruit extract and its formulation (Noni max) did not produce any teratogenic effect in rats up to 1000 mg/kg and 40 ml/kg respectively.

Objective: To investigate the population of endophytic fungi accompanying to Nerium olender plant. Materials and Methods: The study was conducted on three different sites in two governorates for three consecutive months with five samples from each site. The identification of the fungi was carried out using microscopic and molecular methods while the isolation, identification of fungal pathogen and preparation of aqueous extract were also successfully done. Results: 14 species of fungi (Penicillium notatum, Rhizopus nigricans, Rhizopus stolonifera, Fusarium Solani, Fusarium oxysporum, Alternaria sp., Cladosporium sp .and Curvularia sp.), while the other sex species were identified by DNA investigation method and where (Aspergillus spp. (40%), Penicillium spp. (20%), Rhizopus spp. (12%), Fusarium spp. (10%), Alternaria sp. (4%), Mucor circinelloides (4%), Neurospora Crassa (3%), Cladosporium sp. (1%) and Curvularia sp. (1%). Conclusions: The highest percentage of inhibition was for fungi Aspergillus Flavus, Penicillium commune and Mucor circinelloides which amounted to 100% and from the third day of growth until the completion of the control dish, then Aspergillus niger and Rhizopus stolonifera, with a 90% on the seventh day of growth, and Penicillium commune, Rhizopus nigricans with a rate ranging between 82-68%, while the rest of the fungi showed an antagonistic effect, but with rates less than 50%.

Background: The magnitude of health problems related to ear and nose in Bangladesh has not been estimated in a larger scale and very little is known about the prevalence and types of ENT diseases. Commonest cause of hearing impairment in our country is middle ear infection. Conductive type of deafness mostly occurs due to otitis media with or without its complications. Goal of primary health eare services is to achieve "Sound hearing by 2030" will never be achieved if we could not find out possible association of middle ear disease with other health conditions. Objective: To determine the prevalence of ear and nasal diseases in Bangladeshi patients. Methods: Two hundred patients complaining of middle ear discharge and or nasal symptoms were included in this study, to see the association of COM with nasal disorders. This cross sectional study was conducted in Dhaka Medical College Hospital from July 2012 to June 2014.Sample was taken by purposive sampling. Sample was divided into four groups as exposed and diseased, exposed and not diseased, not exposed diseased and not exposed and not diseased. Results: Two hundred patients were studied in the department of ENT and Head Neck Surgery of Dhaka Medical College Hospital complaining of either COM or Sinonasal disease. Among them 107 were female and 93 were male and male female ratio was 1:1.15. On analyzing age distribution it was ranging from 10 years to 50 years with mean age 30±7.86% clustering around 25 years. This study revealed that 65 % of COM is in the age group of 10-30 years. Conclusion: A study on the prevalence of the Ear Nose throat and Head and Neck diseases in developing country like Bangladesh can provide basic data which can be relevant and beneficial to the development of medical ENT curriculum in the regional setup and subsequent medical practice.

Background: Pre-eclampsia is a multisystem disorder of pregnancy characterized by Hypertension and proteinuria. It is a common pregnancy related disorder that originates in the placenta and causes variable maternal and fetal problems. Objective: To find out the feto-maternal outcome of severe pre-eclamptic patient. Methodology: It was a cross-sectional study among the pregnant woman who were admitted with severe pre-eclampsia in labour and in antenatal ward in the hospital during the study period in Department of Gynaecology, Dhaka Medical College and Hospital, Dhaka from July 2015 to January 2016. A total of 50 pregnant women with severe pre-eclampsia were included in the study. After detailed history, clinical examination, blood pressure measurement and bedside urinary protein levels, patients were diagnosed as severe pre-eclampsia. The data were analyzed by SPSS. Results: Commonest age group of the patients suffering from severe pre-eclampsia was found to be ranging from 15-35 years of age and the mean age was 26 years. Majority of the study, patients were primiparous (56%) coming from rural areas (56%). Literacy has a great impact on the incidence of pre-eclampsia which was reflected from the study of educational status. The study revealed that 40% of patients were under secondary school level and only 28% of them were graduates or above HSC. Data was collected regarding their occupation, which showed 80% of them were house-wives and 12% were day laborer. Most of them gave a positive family history of hypertension and 32% of them gave no relevant history. Incidence of antenatal care was assessed which showed majority (60%) were on irregular antenatal care which again contributes to the progress of severity of the disease. 92% of severe pre-eclamptic patients were found to be present in last trimester. Blood pressure levels were assessed and 80% of patients had systolic pressure more than 160 mmHg and 76% had diastolic pressure more than 110 mmHg. Among the various symptoms of severe pre-eclampsia most common symptom were Oedema (76%), headache (40%), epigastric pain (12%) and Insomnia (32%). Study of blood biochemistry levels showed high levels of uric acid (72%) and raised serum creatinine levels (26%). Caesarean section rate was found to be extremely high. 72% of the patients underwent caesarean section and rest was delivered vaginally. Overall neonatal outcome was- healthy babies 40%, premature 20%, IUGR 20% and IUD was 8%. Most of them had average birth weight (56%). And overall maternal outcome was Eclampsia 4%, HELLP Syndrome 4%, Abruptio placenta 4%, Renal Insufficiency2% and maternal death 2%. Conclusion: The incidence of morbidity and mortality related to sever pre-eclampsia are remarkably higher in developing countries like Bangladesh. Therefore, measures should be taken to control this deadly condition through Behavioral Change Communication (BCC) regarding antenatal care, danger signs, delivery plan etc. involving public and private sector.

Against the backdrop of quality education, integrating physical education and health courses in China has been regarded as essential to fostering students' comprehensive development. This study explores leveraging interdisciplinary case-based teaching to promote the in-depth integration and fusion of physical education and health courses in China. The research systematically reviews the theoretical foundations of integrating physical education and health courses, interdisciplinary teaching, and case-based teaching methods in China. The study summarizes the comprehensive cases for conducting interdisciplinary case-based teaching while also pointing out the challenges in the implementation process, such as teachers' professional development lag, deficiencies in the evaluation system, and the scarcity of high-quality case resources. Finally, the study proposes strategies and recommendations in management, teacher development, and evaluation for promoting integrating physical education and health courses through interdisciplinary case-based teaching. This research provides a new practical path for optimizing physical education and health courses in China. It offers valuable insights for the integration of other disciplines, possessing both theoretical value and practical significance.

The paper presents the development and analysis of "Eventful," an innovative event management system designed to streamline the planning process and enhance the connection between event organizers (customers) and service providers (vendors). By integrating technology advancements from the late 20th century to the present, including the internet, social media, cloud computing, and artificial intelligence, "Eventful" offers a comprehensive solution to the challenges of event management. The platform allows for direct communication, efficient vendor selection, and centralized planning, aiming to improve the overall efficiency and experience of organizing events. The research methodology includes qualitative interviews and surveys to identify user requirements and inform system design, ensuring that "Eventful" addresses the specific needs of its users effectively.

The microsatellite instability (MSI-H) or mismatch repair deficient (dMMR) colorectal tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability of a tumor detection index. Many studies have shown that there are many heterogeneous phenomena in patients with MSI tumors in terms of immunotherapy, prognosis and chemotherapy sensitivity. Here we mainly review the research results of MSI detection methods, its mechanisms, occurrence and its relationship with related tumors, aiming in such a way for brief analysis of the micro satellite instability. Microsatellites (MS) are the repeated sequences of DNA that play an important role in maintaining the tissue morphology. Any mutation of the DNA or chromosomes, lead to the instability of the microsatellites, thereby causing the microsatellite instability. There are three types of microsatellite instability (MSI). High microsatellite instability (MSI-H), low microsatellite instability (MSI-L) and microsatellite stability (MSS). Recent clinical research tends to classify MSS-L and MSS as similar. Microstaellite instability plays an important role in colorectal carcinoma. Based on different molecular mechanisms, MSI in colorectal cancer can be divided into colorectal cancer (CRC) with no obvious family genetic history and Lynch syndrome with non-polyposis with family genetic history. Lynch syndrome is an autosomal dominant disorder and syndrome caused by mutations in MMR strains, and it can also cause tumors in other parts of the colon and rectum. With the recent development of MSI detection technology and immunosuppressant in tumor therapy, researchers found that MSI-H tumors respond well to immunotherapy. There are several methods to detect the microsatellite instability. 1. Next Generation sequencing (NGS), 2. Fluoresence multiplex PCR and capillary electrophoresis. 3. Immunohistochemistry. 4. Single molecule- molecular inversion probes (SmMIP). The main mechanism of MSI includes, Slipped strand mispairing, MMR deficient.

Politeness strategies play a crucial role in maintaining social harmony and establishing interpersonal relationships. The interpersonal function of language in Systemic Functional Grammar (SFG) provides a framework to analyze how language is used to interact with others. Our research aims to analyze the interpersonal functions of politeness strategies in conversation from the perspective of mood, modality, and person in SFG, with a focus on politeness theory, face theory, and politeness strategies. It shows how language is used to manage social relationships and establish social hierarchies in communication, and how understanding politeness strategies can help communicate more effectively and respectfully in different contexts.

Assessment’s increasing prominence in educational discourses and practices, especially in the past 20 years, has not always resulted in increasing clarity as to what the new terms in vogue actually mean. Questions include: does carrying out formative assessment really mean that we have to duplicate assessment; is summative assessment inevitably linked to problems and negative perceptions, as the UK’s National Student Survey results seem to indicate; are summative and formative assessment different beasts or are they two sides of the same coin as Scriven (1967) noted when he made the original distinction; is assessment really our weakest link? By asking questions to ascertain tutor beliefs and understandings, we clarify the areas where these misunderstandings arise in a Bahraini context. This work builds on research in different contexts which similarly found that the clarity of our assessment understandings is tainted by contradictions in the literature. The questionnaire used here asked neutral questions on assessment and collected both quantitative and qualitative data. Several responses were consistent, all: used formative assessment, associated it with feedback, which appears essential in their perception, and almost all valued theory. However, inconsistencies were in: definitions of formative and summative assessment, their functions and uses, and the relationship between them. How we interpret the results, to some degree, reflects our epistemological and theoretical positions; even though most of the data were unambiguous. By questioning our own beliefs, we found that we are not immune to our emotions and hopes influencing our interpretations.

Hyper-IgE syndrome (also known as Job or Buckley syndrome) is a hereditary immune deficiency of autosomal dominant inheritance. It is clinically characterized by the occurrence of recurrent staphylococcal, skin abscesses, bacterial and fungal pneumopathies, and a significant increase in immunoglobulin E. Its association with systemic lupus erythematosus has been described, the mechanism of which involves the deposition of immune complexes. We report the case of an 11-year-old girl with hyper IgE syndrome who was admitted to our clinic with severe renal failure, diagnosed as lupus glomerulonephritis on kidney biopsy.

Telling China’s story well is an effective way to enhance students’ English application ability and promote moral education. However, the insufficient integration of China’s story in current English textbook needs to be addressed. Based on the Outcome based education (OBE), this article aims to elaborate on teaching design and explore a blended learning model for integrating telling China’s story into college English courses.

This paper examines the intricate relationship between exchange rate policies and stock market performance, focusing on Kuwait and Saudi Arabia in the Gulf region. It investigates the historical evolution of exchange rate regimes in both countries, analyzing their unique policy objectives. Using empirical analysis, the research explores the correlation between exchange rates and stock market indices, employing statistical methods and regression analysis to identify patterns. Comparative assessments reveal distinct patterns in stock market performance, shedding light on the effectiveness of different exchange rate systems in shaping economic dynamics. The findings contribute to the literature by offering insights into the nuanced relationship between exchange rate policies and stock markets, with implications for policymakers, investors, and financial analysts. By focusing on Kuwait and Saudi Arabia, two pivotal economies, the study addresses a gap in the literature, providing a comparative perspective. Policymakers can use the findings to understand the potential impact of exchange rate policies on economic indicators. Investors can leverage the conclusions to inform their decision-making, considering the nuances of exchange rate dynamics. The study finds that both countries peg their currencies to major world currencies, primarily the USD, and identifies a strong correlation between the Kuwait Stock Index and the Saudi Tasi Index.