Background: Pesticide ubiquity and extensive applications have attendant public health implications. This study examines the immediate and prolonged inhalation toxicity of various commonly used insecticides in male Wistar rats. Methods: 192 male Wistar rats were utilized and kept in regular housing. The study was carried out in three stages: a preliminary test, an acute test, and a sub-acute. Wistar rats, housed in an improvised chamber, were exposed to varying doses of insecticides in each phase to assess their toxicities to insecticides. For comparativeness, we withdrew 57 of the rats from exposure to ascertain possible recovery. The study included monitoring behavioral changes, recording mortality rates, and conducting necropsies to evaluate organ pathology. Dose-response relationships were analyzed to determine lethal doses (LD50) and potential sublethal effects. Results: Overall, we found a dose-related increase in the severity of the response, which potentially indicates an alteration of a specific biochemical process. The range-finding test assessed the effects of DD Force, Sniper, Industrial Camphor, Edible Camphor, Kerosene, and combined pesticides. It revealed significant physiological impacts followed by mortalities at specific dosage levels. Subsequent acute toxicity testing determined LC50 values for each insecticide. Rats showed a dose-dependent health deterioration following sub-acute exposure, particularly in the combined pesticide group, indicating synergistic toxicity. Conclusion: Exposure to the combined pesticide at high doses was associated with severe toxicities in the tested rats. This evidence suggests that commonly used pesticides could potentiate adverse health outcomes when results are extrapolated in humans.

This paper delves into the rapidly evolving domain of Artificial Intelligence (AI), with a particular focus on Machine Learning (ML), a dynamic and influential subset of AI. It explores how ML empowers computers to learn from data, identify patterns, and make decisions with minimal human intervention. The manuscript examines the broad utility of ML across various real-world scenarios, emphasizing its critical role in enabling organizations to evolve and maintain a competitive edge in the fast-paced technological landscape. It discusses the necessity for organizations to adopt new ways of working and embrace the opportunities presented by AI to remain viable in the global, online marketplace. The paper reviews the evolution of ML, evaluates its advantages and disadvantages, and contemplates the future directions ML could lead organizations willing to integrate this powerful technology. The overarching theme is the transformative potential of ML in reshaping organizational strategies and operations for a more interconnected and intelligent future.

Introduction: Bladder pain syndrome (BPS) is a chronic condition characterized by pelvic pain and urinary urgency/frequency. While the exact cause of BPS is unknown, various treatment options exist. This study aimed to evaluate bladder hydrodistension's short- and long-term efficacy in BPS patients. Methods: A retrospective analysis of four female BPS patients treated with bladder hydrodistension over 10 years was conducted. Symptoms, cystoscopy findings, and treatment outcomes were reviewed. Results: The average patient age was 40 years. All patients reported pain, with an average of 13 daytime and 3 nighttime urinary voids per day. Hydrodistension improved symptoms in 75% of patients, reducing daytime frequency and nocturia. Cystoscopy after hydrodistension revealed Hunner's ulcers in one patient and petechiae in three. One patient required a second hydrodistension. Transient worsening of symptoms and hematuria occurred in one patient each. Discussion: Bladder hydrodistension appears to be a safe and effective treatment for BPS, improving symptoms in most patients in our study. The findings are consistent with previous reports suggesting. Our study adds to the growing body of evidence supporting hydrodistension as a valuable tool in managing BPS. Conclusion: Bladder hydrodistension is a simple and minimally invasive technique that has proven its efficacy with a low complication rate. Our findings support the existing literature on the benefits of hydrodistension for BPS.

Background: Since the pandemic of COVID-19 started from December 2019, remarkable numbers of infections and deaths associated with COVID-19 have been recorded worldwide. Chronic kidney disease patients are particularly at high risk of infections due to impairments in the innate and adaptive immune systems. Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize pathogen entry and promote pathogen clearance to enable infection control. Vaccination can generate cellular and humoral immunity against this specific pathogen. COVID-19 prevention through successful vaccination is therefore paramount in chronic kidney disease population. But vaccination efficacy is diminished in these patients because premature ageing of the immune system and chronic systemic low- grade inflammation are the main causes of immune alteration in these patients. Therefore, it is urgently necessary to establish a different vaccination strategy for chronic kidney disease and dialysis patient in terms of the dose and administration time. Aims: This study aimed to assessment of antibody titers after vaccination against SARS-COV-2 in patients with chronic kidney disease stage 4, 5 on conservative management and maintenance haemodialysis. Methods: This prospective observational comparative was conducted in Nephrology department of Dhaka Medical College Hospital. Selectionof patients was done by purposive sampling according to inclusion and exclusion criteria. Total 135 patients distributed in three groups: 45 patients of chronic kidney disease (CKD) stage 4, 5 on conservative management, 45 patients on maintenance haemodialysis (MHD) and 45 healthy controls were approached for the study who were receiving SARS-COV-2 vaccination. Demographic, clinical and laboratory data were collected initially. At first a pre vaccination sample or 1st sample was taken for antibody measurement. Then participants from all groups were given 2 doses MODERNA vaccine containing 100 µg in 0.5 ml each in 28 days apart. Then after 14 days of 1st dose of vaccination the 2nd samples were taken, 3rd samples were taken 14 days after the 2nd dose vaccination. Study populations were subdivided into two groups according to pre vaccination SARS-COV-2 antibody titer; seropositive- positive response before vaccination and seronegative- negative response before vaccination. They were also divided into two groups according to quantitive antibody response; positive response- values ≥10 DU/mL were positive Negative response- values of <10 DU/mL were negative. Result: Seroconversion rate was around 20% among study participants before vaccination. 14 days after the 1st dose of vaccination, 90.04% patients had positive immune response in CKD stage 4, 5 on conservative management group whereas in MHD group 84.82% responded to vaccination and immune response in control group was 100%. Immune response is 100% among all the groups after 14 days of 2nd dose of vaccination but the concentration of antibody differs significantly among the study groups. Responders were comparatively younger with normal BMI. Conclusion: Haemodialysis patients as well as patients with chronic kidney disease stage 4, 5 on conservative management showed a favorable but profoundly lower early antibody response, which decreased substantially during follow-up.

Background: Cerebral Palsy (CP) is a prevalent motor disability affecting children globally, emphasizing the need for early identification and intervention. The Rapid Neurodevelopmental Assessment (RNDA) offers a comprehensive approach to predict CP and other motor developmental trajectories in high-risk neonates. Objective: This longitudinal cohort study aims to evaluate the effectiveness of RNDA in predicting CP and motor developmental trajectories. Method: Seventy term neonates from Dhaka Shishu (Children) Hospital were included, with neurodevelopmental assessments conducted using RNDA. Assessments were performed at 3 months and 6-9 months, with CP evaluation at 12 months using clinical examinations. Results: Prolonged labor (44.3%) and delayed cry after birth (31.4%) were common among the study patients (n=70), with varying modes of delivery including normal vaginal delivery (50.0%), vaginal delivery with complications (12.9%), and lower uterine cesarean section (37.1%). Muscle tone, primitive reflexes, gross and fine motor skills, epilepsy, and microcephaly were evaluated across visits to identify impending CP. Significant associations were found between hypertonicity, primitive reflex impairment, gross motor impairment, and fine motor impairment with impending CP across visits, particularly in the 3rd visit (p<0.05). Sensitivity, specificity, accuracy, and predictive values varied across parameters and visits, with fine motor skills and gross motor skills showing the highest sensitivity in the 3rd visit (86.4% and 100.0%, respectively). Additionally, abnormal EEG, USG of the brain, and MRI findings were significantly associated with impending CP, with USG of the brain demonstrating the highest sensitivity (93.3%) and MRI showing the highest specificity (70.0%). Conclusion: RNDA emerges as a valuable tool for early prediction of CP and motor developmental trajectories in high-risk neonates. Early identification through RNDA facilitates timely interventions, optimizing long-term neurodevelopmental outcomes.

Earned Value Management (EVM) is a project management tool primarily used in engineering and project management to assess performance in terms of cost and schedule. Earned Value Management/Scheduling systems (EVM/ES) have been fundamental in project control, providing key metrics that measure deviations between planned and actual performance in terms of time and cost. However, its application as a project control technique is not very common in Mexico. In this article, EVM was applied to the intralogistics improvement of a manufacturing process in the automotive sector located in Aguascalientes, Mexico. The case study concluded in February 2024 and includes the project scope, scheduling charts, physical progress reports, and budgeted versus actual cost reports. The aim of this article is to provide practical evidence on how to apply EVM in manufacturing projects in Mexico. This will enable project professionals to more effectively utilize EVM for schedule and cost control in their manufacturing projects, with a specific emphasis on intralogistics.

Background: HELLP syndrome, a severe pregnancy complication characterized by hemolysis, elevated liver enzymes, and low platelet count, occurs in 0.5 to 0.9% of all pregnancies and in 10–20% of severe preeclampsia cases. It poses significant risks to both mother and fetus, presenting diagnostic and therapeutic challenges. Patients often experience epigastric or right upper quadrant pain, hypertension, proteinuria, fatigue, nausea, vomiting, sudden weight gain, and headaches. HELLP syndrome typically occurs in the second and third trimesters (27-37 weeks) and 15–30% of cases present postpartum. The exact causes remain unclear but may involve placental origins, autoimmune factors, gene mutations, or fatty acid oxidation disorders. Aims and Objectives: To analyze the clinical profile of HELLP syndrome cases and to assess maternal and perinatal outcomes, including morbidity and mortality. Material and Methods: This prospective cross-sectional study was conducted in the Obstetrics and Gynecology department at Pravara Rural Hospital, Loni, involving 45 patients with severe preeclampsia and eclampsia above 28 weeks of gestation diagnosed with HELLP syndrome. Patients were admitted to the ICU, and detailed histories and examinations were recorded. Patients were divided into two groups: those with HELLP syndrome (Group A) and those without (Group B). Results: Group A had a higher representation in the 20-22 age bracket, while Group B had more members aged 22-24. Cesarean sections were more common in Group A, whereas vaginal deliveries were more frequent in Group B. Blood pressure readings were higher in Group A. Maternal complications, such as abruption placentae, DIC, hepatic infarction, acute renal failure, and ascites, were more frequent in Group A, as were neonatal complications like IUGR, preterm delivery, neonatal thrombocytopenia, and RDS. Conclusion: The study reveals significant differences between patients with and without HELLP syndrome. Group A included younger patients, more first-time mothers, and a higher incidence of complications and mortality. These findings highlight the need for tailored management strategies for severe preeclampsia/eclampsia, especially in those with HELLP syndrome, to improve maternal and neonatal outcomes.

Introduction: Supracondylar fractures of the distal humerus, occurring just above the elbow joint, are the most common pediatric fractures around the elbow, accounting for 60-70% of all elbow injuries in children. Methods: This prospective observational study, conducted from June 2023 to May 2024 at NITOR, Dhaka, Bangladesh, focuses on managing displaced supracondylar fractures (Gartland Type-III) in children. Result: The average age of the patients in the study is reported as 6.5 years. The number and percentage of male and female patients are presented, with a total of 17 males (56.7%) and 13 females (43.3%) respectively. The average time for radiographic healing of the fractures was 5.2 weeks. Satisfactory radiographic outcomes were observed in 28 patients (93.3%), indicating favorable radiographic evidence of fracture healing and alignment. K-wires were typically removed around the 1-month mark postoperatively, once radiographic healing was confirmed and satisfactory outcomes were achieved. Conclusion: In conclusion, our study supports the efficacy and safety of closed reduction and percutaneous cross K-wire fixation for treating displaced supracondylar fractures of the humerus in children.

Background: Breast cancer with advanced stages at a young age is a significant new challenge in Sudan. The purpose of this study was to determine the most common presentations of breast cancer patients in western Sudan. Methodology: For this retrospective descriptive investigation, materials for 183 breast cancer patients were obtained from two histopathology centers (Kordofan histopathology center and El-Obeid International Hospital). A full coverage sample was collected, spanning from January 2019 to May 2024. All data pertaining to the patient's essential identifying, clinical, and histological data were gathered. Results: This study looked at 183 breast cancer patients (177 (96.7%) women and 6 (3.3%) men). Their ages ranged from 20 to 90, with a mean ± standard deviation of 50.78 ± 13.6 years. The majority of participants were aged 41-50 years, followed by ≥61 and 51-60 years, with 50/183 (27%), 43 (23%), and 35 (19%), respectively. For clinical appearance, the most common skin change was unremarkable, followed by ulcerated skin change, which accounted for 127/183 (69%) and 48 (26%) respectively. Conclusion: Breast cancer with advanced stages upon presentation is common in Sudan. The majority of patients presented at a younger age and had distinct initial manifestations.

Background and Objectives: A high prevalence of thyroid disorder is found worldwide and it is a serious public health problem. A community‑based investigations showed that; overall occurrence of thyroid disease was 20.43%, highest incidence of diffuse goiter (7.35%), followed by sub-clinical hypothyroidism (6.59%), hypothyroidism (4.97%), hyperthyroidism (0.86%) and sub-clinical hyperthyroidism (0.65%) in Khulna, Bangladesh. Antithyroid autoantibodies are one of the most important causes of thyroiditis resulting hypothyroidism. The aim of this study was to investigate the prevalence of antithyroid antibody to hypothyroid patients in Khulna region. Methods: This cross‑sectional study was done on Hypothyroid patients of Khulna Medical College Hospital and Institute of Nuclear Medicine and Allied Science (INMAS), Khulna, from July 2023 to December 2023. After having informed written consent of adult sixty hypothyroid patients, was interviewed and examined the blood sample for relevant information; data recorded in a preformed, semi-structured data collection sheet (Patient particulars form) and analyzed. Results: About 20 percent had positive family history of hypothyroidism, 27 percent patient was associated with other autoimmune diseases and about 80 percent was associated with anti-thyroid antibody. Out of the sixty hypothyroid patients about fifty percent was obese, eighty percent was female of 30-60 years age group. Ninety percent of them belongs to poor socioeconomic conditions and came from rural area of Khulna district. Conclusions: Most of the patients were rural female of low socioeconomic back ground of reproductive age groups. There was very significant association of anti-thyroid antibody with these patients. They also associated with chronic autoimmune diseases and poverty.

The use of musculoskeletal ultrasound to assess sports-related injuries has been increasing worldwide. This case report focuses on an unusual form of synovitis of the talocrural joint in a 33-year-old male amateur weightlifter who presented to our sports medicine clinic with acute non-traumatic left ankle pain lasting for 2 days. He reported a recent change in his squatting technique and had no significant medical history other than a recent viral upper respiratory illness. Weight-bearing ankle X-rays were inconclusive, however, ultrasound evaluation revealed effusion in the talocrural joint upon assessment of the ankle’s anterior joint capsule. Additionally, the ultrasound examination helped rule out other common soft tissue ankle pathologies that can affect athletes. The athlete's symptoms resolved by day 5 with conservative measures, including weight bearing as tolerated, nonsteroidal anti-inflammatory drugs, and lymphatic drainage techniques. This report demonstrates the utility of musculoskeletal ultrasound in diagnosing an uncommon cause of ankle pain in athletes.

Nowadays, logistics activities are growing annually by 4.4%, reaching annual valuations of up to 10 billion dollars. This area is key for manufacturing companies and commerce in general, which is why the central question arises in this area of knowledge about how to approach proposals or improvement actions in a sustainable way. On the other hand, technological tools such as simulation are an important element to evaluate sustainability alternatives and operational strategies due to their flexibility and high scope. This article addresses a systematic literature review about the use of system dynamics within the management of current supply chains, covering 144 articles in databases such as Scopus and ScienceDirect, for the period between 2000 and 2022 to generate an overview for new sustainability proposals in México.

The music ministry is an invaluable ministry of the church. A church music ministry exists to develop a comprehensive music programme that ministers to all areas of the church’s life. An effective music ministry, therefore, provides the church with good music that members may use for worship, education and evangelism. The study adopts literary and theological approaches and engages pertinent scholarly literature. It discusses the value of music ministry to the congregation, the choir, the instrumentalists who play musical instruments and individuals who lead in the ministry. Furthermore, the study examines the various activities of the music ministry and factors that must be considered when organising a church’s music ministry. Finally, the paper discusses the criteria for enlisting leaders and workers for the music ministry. The study concludes that an effective music ministry must be put in place if the church music will be functional within the church.

Background: The purpose of this study is to compare the biomotor fitness variables between basketball and volleyball players in Ignatius Ajuru University of Education. This study adopted an ex post facto research design. Methodology: The population for this were all volleyball and basketball players, from which a sample size of 10 participants from each team were selected. To test for balance, a stork stand test was carried out, vertical jump test was used to test for power, an Illinois Agility Test (IAT) was used to test for agility, a 30m sprint/dash was used to assess the speed of the participants, and timed push-up test for muscular endurance. Statistical Package for Social Sciences (SPSS) version 25 was used for data analysis. Results & Discussion: The findings revealed a 0.13 percent difference in power which was no statistically significant difference (p>.05, p=0.987). There was 30.8 percent in balance which was statistically significant (p<05, p=0.037). A 1.4 percent difference in agility was not deemed statistically significant (p>.05, p=0.827). Volleyball players' performed 13.1% better in muscle endurance test, though not considered statistically significant (p>.05, p=0.142). Conclusion & Recommendation: Based on the findings from the study, it was evident that biomotor fitness variables among volleyball and basketball players in Ignatius Ajuru University of Education was virtually the same as the players demonstrated no significant difference in most biomotor variables such as speed, agility, power and muscular endurance. While being a jack of all trade (sports) makes one better than a master of none, in sports there is need for proper focus on a specific sports niche. Thus, coaches and trainers of volleyball and basketball players should help both category of players concentrate their efforts on a specific sport so as to achieve maximum biomotor fitness required for maximal performance in a specific sport.

This paper explores the rich tradition of Hausa cuisine and its potential role in managing diabetes, focusing on traditional medicinal foods used by the Hausa people. Drawing from the abundant natural resources surrounding them, the Hausa people have long relied on a holistic approach to health, incorporating various trees, plants, roots, and herbs into their diet. Traditional remedies often blur the line between food and medicine, reflecting the Hausa belief that dietary choices play a crucial role in overall health. Through an extensive examination of traditional Hausa foods and their therapeutic effects on diabetes, this paper provides insights into potential culinary solutions for managing the condition. From fresh moringa leaves to baobab fruits, from hibiscus to fish and local fowls, the paper explores a wide range of traditional remedies used by the Hausa people to alleviate symptoms of diabetes. Furthermore, the paper discusses the harmful types of foods that diabetics should avoid and highlights non-harmful foods beneficial for diabetes management. By shedding light on the intricate relationship between Hausa cuisine and diabetes management, this paper contributes to our understanding of traditional medicinal practices and offers avenues for further research and exploration.