Congenital Cystic Adenomatoid Malformation of Lung: A Case Report
Dr. Seena Susan Itty, Dr. Sankar S
Page Numbers : 29-32
DOI : 10.36348/sjpm.2022.v07i01.005
Congenital cystic adenomatoid malformation (CCAM), also known as Congenital Pulmonary Airway Malformation (CPAM) is a rare developmental anomaly of lung with unknown etiology. It is seen most commonly in the lungs of infants and has features of both immaturity and malformation of the small airways and distal lung parenchyma. With the increasing use of prenatal ultrasonography, cystic lung lesions are detected more often antenatally, which allows for better neonatal management. We report a case of 3 day old female baby presenting with respiratory distress soon after birth.
Case Report
Jan. 26, 2022
Tropical Pulmonary Eosinophilia
Nidhi Aley Alex
Page Numbers : 33-34
DOI : 10.36348/sjpm.2022.v07i01.006
Tropical Eosinophilia was first described in 1940 and labelled as “pseudotuberculosis with eosinophilia” [2], the term tropical pulmonary eosinophilia (TPE) was first coined by Weingarten in 1943 [3] to a syndrome of wheezing, fever, eosinophilia and bilateral mottling of the lungs. This was followed by a series of reports describing similar conditions from the tropical regions such as the Indian subcontinent [4-6]. Here we present a case of a 12 year old boy who presented with complaints of ear ache and swelling on side of neck bilaterally and on examination multiple neck nodes were palpable. On peripheral smear examination and followed by bone marrow study, Tropical eosinophilia was diagnosed.
Case Report
Jan. 24, 2022
Multifocal Diffuse Sclerosing Papillary Thyroid Carcinoma: A Rare Variant with Diagnostic Challenges
Dr. Ann Maria Sunny, Dr. Sankar S
Page Numbers : 20-23
DOI : 10.36348/sjpm.2022.v07i01.003
Diffuse sclerosing papillary thyroid carcinoma (DS PTC) is a relatively rare variant of papillary thyroid carcinoma. It is characterized by distinct histological features like scattered microscopic tumor islands, diffuse sclerosis, lymphocytic infiltration, numerous psammoma bodies, radiological features like snowstorm appearance and biologically aggressive behavior in the form of invasion and metastasis. A preoperative diagnosis is often challenging in the absence of nodules and scanty fine needle aspiration cytology sample. We describe a case of multifocal diffuse sclerosing variant of papillary thyroid carcinoma in a 29 year old young male who presented with a swelling in the right side of neck of 2 month duration in the absence of a visible thyroid swelling. Neck swelling was non tender, well defined, firm, not moving with deglutition. Laboratory studies showed normal thyroid function, neck ultrasound revealed heteroechoic right lobe with multiple punctate echogenic foci and enlarged right sided cervical nodes with echogenic foci, fine needle aspiration cytology of which was consistent with metastasis from papillary adenocarcinoma. Based on the above investigations, a total thyroidectomy with central compartment lymph node dissection and modified radical neck dissection of right side was performed. Histological analysis revealed Multifocal Diffuse Sclerosing variant of papillary Thyroid Carcinoma. Clinical and histological challenges usually occur when DS PTC present as diffuse thyroid enlargement, dispersed microscopic tumor islands, extensive fibrosis, abundant lymphocytic infiltration mimicking thyroiditis and when the fine needle aspiration cytology sample is non representative.
Review Article
Jan. 24, 2022
Microbiology and Evolutionary Advances of Different Types of Pathogens in Human and Biological Conservation
Muhammad Tahir, Ahmed Aniq Raza, Hira Iqbal, Faiza Marrium, Ghazanfar Hameed, Muhammad Iqbal, Faryal Manzoor, Warda Yasmeen
Page Numbers : 24-28
DOI : 10.36348/sjpm.2022.v07i01.004
Different factors involved in increasing the risk of infectious diseases caused by genetic and environmental changes. Due to high risk of infectious diseases such as chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, advances have been made in the fields of molecular sciences and engineering technology for highly effective tools and high-throughput omics technologies. Ebola virus is the most contagious as compared to the other viruses colds, influenza, or measles. Pathogenic bacteria are involved in causing of infectious diseases. Hib disease is the serious public health concern disease caused by Haemophilus influenza. Norwalk virus also causes serious abnormalities in the digestive system that ultimately leads to muscle cramp. Antimicrobial resistance have been challenging in the fields of biomedical sciences. Sequencing of bacterial genomes helpful for track the different status of fates of mutations that rise and fall through indication of multiple replicates. Genetic engineering based biomedical therapies needed to understand the target microbial cell, protein factory that secreted the variety of products.
Review Article
Jan. 10, 2022
Endophytic, Non-endophytic Fungal Alkaloids and its Applications
Archana O, Praveen Kumar Nagadesi
Page Numbers : 4-19
DOI : 10.36348/sjpm.2022.v07i01.002
Alkaloids are a secondary metabolite, which are extracted from a wide – array of organisms include Bacteria, Fungi, Plants and Animals. Here in present review mainly focused on the alkaloids derived from endophytic fungi and non – endophytic fungi. Fungi have provided a great source of spirit for novel drug compounds as fungi derived alkaloids have done major boon to human health and well - being. In the present review listed 35 different group of alkaloids from endophytes. In which 12 different alkaloids are kept under derivatives of Indole group, 4 different alkaloids are kept under Quinoline group, 4 different alkaloids kept under amines and amide group, from non-endophytic alkaloid 27 different group of alkaloids are reported. In which 9 different type of alkaloid are mentioned under indole group of alkaloids, 4 alkaloids are reported under diketopiperazine alkaloids, 4 different alkaloids are mentioned under ergot group of alkaloids, 3 alkaloids under prenylated indole alkaloids, 3 alkaloids are mentioned under pyridine classes. The main applications of these alkaloids are antimicrobial, Antibacterial, Antifungal, Antiviral Activity Antihelmenthic, Anticancerous, Nutrient Pedaling, Photo stimulation, Endophytes in Tissue Culture Antidiabetic Activity, and Immunosuppressive Activity; hence all the alkaloids should be used as medicines in Ayurvedam. The alkaloids derived from different fungi were reviewed and their uses in medical fields were also report.
Case Report
Jan. 8, 2022
Malignant Peritoneal Mesothelioma: A Case Report
Purushotham Reddy, Nayantara M. Nirgude
Page Numbers : 1-3
DOI : 10.36348/sjpm.2022.v07i01.001
Mesothelioma of peritoneum is a rare malignancy of serosal membranes. Here we report a case of 55year old female with mass per abdomen reported as epithelioid type of peritoneal mesothelioma. The diagnostic challenge in our cases was due to non specific presentation and the varied histologic morphology of tumor cells for which immunohistochemical studies with markers calretinin, vimentin, cytokeratin 20, cytokeratin5/6, CD34 and HMB34 had to be performed to arrive at the diagnosis. The tumor cells showed positvity for calretinin, vimentin and cytokeratin 20. The final diagnosis was possible due to correlation of histological and immunohistochemical characteristics been consistent with mesothelial origin.
Review Article
Dec. 29, 2021
Cancer Burden in a Tertiary Care Hospital in Andhra Pradesh –A Retrospective Two and Half Years Study
Dr. Bhagyalakshmi Atla, Dr. Monica Molli, Dr. Lalitha Kotha, Dr. Susan Sangeet, T. Krishna Srivathsav, Dr. Sunil Kumar Komanapalli
Page Numbers : 475-481
DOI : 10.36348/sjpm.2021.v06i12.007
Introduction: Cancer is one of the leading causes of death worldwide and is also one of the major causes of morbidity in both developed and developing countries like India. In 2020, total number of new cases in India was 13, 24, 413 and number of deaths reported was 8, 51, 678. Number of cancer cases is on an increasing trend every year. As resources are very few in our country a well-developed cancer registry and statistics would help in identifying the risk factors for various cancers and thereby preventing their occurrence. Objectives: 1) To study the incidence of cancer cases in a tertiary care center with respect to organ system, site, age, gender and type of cancer. 2) To ascertain the leading cancers in a tertiary care hospital and compare the incidence with various other epidemiologic studies. Materials and methods: The present study is a Hospital based Retrospective study done from January 2019 to June 2021 for a period of two and half years in Department of pathology, Andhra medical college. A total of 1760 cases are studied during this period. Various demographic details like age and sex are collected along with site and clinical diagnosis for the study. Data was entered and analyzed using MS excel 2013 and pie charts and frequency graphs were plotted for easy analysis of the data. Results: Out of 1760 cancer patients’ females were 993(56.4%) and 767 were males (43.5%), larger number of the male patients with cancer were in the age group of 51 -60 years and females showed up in the age group of 45 to 55 years. In our study the most common tumors were tumors of Head and neck (oral cavity included) with 491cases (27.89%) followed by cervical cancers with 279 cases (15.8%). In males out of total 767 cases the most common cancer was oral cavity cancers (250cases/32.59%) followed by GIT cancers (140 cases/18.25%) and in females out of 993 cases the most common cancer was cervical cancer(279 cases/28.09%) followed by breast cancers(196 cases/19.73%). Conclusion: The present study emphasizes on burden of various cancers at the level of a tertiary care center. In recent years there is an increasing incidence of cancers in females.
