Alchornea laxiflora is a shrub belonging to the family of Euphobiaceae and is widely distributed in tropical Africa. The present study evaluated the in vitro antioxidant activities, in vivo antioxidant activities, anti-toxicity potentials of Alchornea laxiflora root extract, possible hepatoprotective effect against methylcholanthrene-induced cancer and the hepatoprotection compared to cyclophosphamide using adult Wistar rats. N-hexane root extract of Alchornea laxiflora demonstrated appreciable in vitro antioxidant capacity and radical scavenging ability compared with reference standards. Oral administration of the extract at varying doses (50, 100, and 200mg/kg body weight) was shown to significantly decrease (p<0.05) the effect of liver damage on methylcholanthrene-induced (50mg/kg) cancer when compared to the group administered cyclophosphamide (20mg/kg body weight) by reducing the activities of aspartate aminotransferase, alanine aminotransferase and alkaline Phosphatase (AST, ALT and ALP) in the serum. In the 3-Methylcholanthrene administered groups (50 mg/kg), there was significant increase (p<0.05) in Malondialdehyde (MDA) level as well as a decrease in reduced glutathione (GSH) content when compared to the positive control. Animals administered with Alchornea laxiflora (50, 100, 200mg/kg) showed a significant increase in GSH content and significant decrease in malondialdehyde (MDA) level relative to the animals administered cyclophosphamide. The result from the histological assay showed that there was no observable lesion in groups administered Alchornea laxiflora when compared to the negative control which showed plates of hepatocellular atrophy. These findings suggest that Alchornea laxiflora root has potent antioxidant activity which may be responsible for some of its reported anticancer activities.

Luteolin (LT), a flavonoid known for its health benefits was investigated for possible ameliorative effects against hepato-renal toxicity induced by diethylnitrosamine and carbon tetrachloride in rats. Thirty-six male Wistar rats were assigned into six groups; One and two served as control and intoxicated groups, groups three-five were intoxicated and treated with LT at 10, 20 and 40mg/kg, respectively and group six received LT only (20mg/kg). The LT was given orally three times a week while Diethylnitrosamine (DEN) (50mg/kg) and CCl4 (0.5mL/kg) were administered intraperitoneally once a week for four consecutive weeks. Toxicants exposure significantly increased the activities of serum aminotransferases (ALT and AST) by 28% and 30%, and levels of serum urea and creatinine by 15% and 28%, respectively. The intoxication increased lipid peroxidation by 81% and 25%, and also decreased superoxide dismutase by 16% and 17%, and reduced glutathione by 31% and 25% in the liver and kidney of rats, respectively. In addition, inflammatory markers, myeloperoxidase and nitric oxide increased in the liver by 650% and 49%, and in the kidney by 367% and 11%, respectively in the intoxicated rats. Histology of liver revealed necrosis and multifocal hepatocellular coagulation while glomerular atrophy and tubular epithelial necrosis were seen in kidneys of intoxicated rats. Interestingly, LT pretreatment significantly attenuated markers of oxidative stress and inflammation in the liver and kidney of intoxicated rats. In conclusion, luteolin may serve as chemotherapeutic agent to mitigate the adverse effects of chemicals on the hepato-renal tissues of animals.

This is a retrospective study of 11 cases of traumatic dislocation of the fibular tendons in footballers, collected from the archives of the Department of Orthopedic Trauma Surgery at Avicenne Hospital, University Hospital Center of Rabat, from 2016 to 2025. The aim of this work is to study the epidemiological, clinical, paraclinical, and surgical characteristics of this entity. Dislocation of the fibular tendons is a rare lesion, accounting for less than one percent of ankle injuries. The mean age of our patients was 25.8 years. All patients were male (100%). The impairment was exclusively unilateral (100%), with no preferential side. The etiologies were dominated by sports activity. A total of 85.7% of cases had a prior medical history, predominantly ankle sprains. Imaging confirmed the diagnosis and allowed classification according to Davis and Eckert. All patients underwent surgical treatment based on the creation of a fibro-periosteal flap, supplemented by systematic immobilization for 6 weeks in a resin boot. At a mean follow-up of 5 years, ligament stabilization was achieved in the entire study population within 6 to 8 weeks, with resumption of sports activity at 3 months.

The viral Monumental Labs Instagram post showing robotic reproduction of Michelangelo's David sparked global debate about artificial intelligence (AI)'s role in art creation, garnering 2.9 million views and revealing deep cultural tensions around technological intervention in creative practices. Building upon the aforementioned discourse, and approaching this unique opportunity, this paper aims to examine how artistic expertise shapes public reception of automated art production. This research uses a mixed-methods analysis of 1,437 organic social media comments, combining automated sentiment analysis with human-coded thematic categorization across six professional artist categories. Comments were systematically filtered from 2,913 initial responses and analyzed using two-way ANOVA, chi-square tests, and qualitative discourse analysis to examine relationships between artistic identity and technological reception. Results illustrate that while both artists (-0.289) and non-artists (-0.272) showed negative sentiment on average, Fine Arts & Traditional Media practitioners expressed significantly more negative attitudes than Digital & Multimedia Arts professionals (p=0.041). Professional background significantly predicted comment themes (χ²=69.07, p=0.038, Cramér's V=0.155), with traditional artists emphasizing authenticity concerns and skill preservation, while digital artists focused on technical innovation and collaboration advocacy. In conclusion, artistic identity influences both the emotional depth and the conceptual structures used to assess technological integration in arts. Traditional artists express their concerns using philosophical concepts like ‘soul’ and ‘authenticity’ while non-artists emphasize concrete attributes such as ‘handmade’ features. These results are significant for cultural organizations and technology firms involved in the incorporation of artificial intelligence into creative processes.

This study examines how knowledge management affects Akwa Ibom State SMEs' work quality. The knowledge management aspects included in the study were knowledge creation and knowledge acquisition. Cross-sectional survey research was used for this study. The study's population included 9,483 SMEs registered in Akwa Ibom State. The sample size was 384 using the Krecjie and Morgan (1970) table. Data was collected with a standardized Likert scale questionnaire. Data was analyzed using descriptive and inferential statistics. The inferential statistics used a simple linear regression procedure. The study's results indicate that knowledge creation had an R-value of 0.571, but knowledge acquisition had an R-value of 0.406 concerning work quality. Thus, it was concluded that knowledge management significantly improves the quality of work produced by SMEs in Akwa Ibom State. Since knowledge creation is necessary to guarantee the promotion of competitive advantage in their operations, it was suggested at the conclusion that managers of SMEs should make sure that knowledge is created inside the company in order to improve performance. SMEs should also create policies that support knowledge management techniques. Through staff learning and training, their companies will be able to enhance their performance.

Interest rate is an important economic factor that can determine the level of investment in any economy, hence, the need for any organization or economy that wishes to grow to pay attention to it dynamism. This study was conducted to examine the effect of interest rate on the growth of insurance industry in Nigeria. Total insurance investment, and gross premium income which represents the insurance industry growth constitute the dependent variables while interest rate was the independent variable. The researcher employed a pooled ordinary least square (OLS) regression using secondary data drawn from audited annual financial statements of insurance industry in Nigeria from 2003-2023, a period of twenty-one years. The results show that interest rate (INTR) has significant effect on Total Insurance Investment (TII), while it has no significant effect on Gross Premium Income (GPI). It was concluded that there is a statistically significant of interest rate on total insurance investment, indicating that interest rate is very important in determining the growth of insurance companies in Nigeria. The second hypothesis shows insignificant effect of interest rate on the gross premium income of insurance, this could be attributed to low patronage of the insurance business, or by factors that enhanced premium collection such as compulsory insurances, among others. Therefore, it was recommended that premium income generated should be put into viable investment as it is not significantly influence by interest rate, this will help in increasing total insurance investment. Also, the government through the insurance regulatory authority should implement the compulsory insurance mechanism, to enables more patronage, while also mandating the insurance companies to follow the doctrine of interest rate set by the Central Bank of Nigeria (CBN) when pricing their products so as to avoid unfair, deceptive and abusive practices of overpriced policies which consequently affect the industry growth.

Mercuric chloride is highly toxic and known to cause significant liver and kidney damage through degeneration and inflammation of the tissues. Sarcocephalus latifolius is a medicinal plant traditionally used for its antioxidant and therapeutic properties. This study investigates the protective effects of Sarcocephalus latifolius on mercuric chloride-induced hepatorenal toxicity in albino Wistar rats. The animals were divided into six groups (A-F); A. control group, B. mercuric chloride-induced group, three treatment groups (C, D, E) with two receiving Sarcocephalus latifolius extract and one vitamin C, in addition to mercuric Chloride. The last group (F) received Sarcocephalus latifolius extract only. The result showed that mercuric chloride caused disruption and degeneration of hepatocytes around the central vein while the groups that received Sarcocephalus latifolius showed structural organization relative to that of the control group. Significant improvement was observed in kidney function test (urea and creatinine) when compared to the mercuric chloride treated group. AST and ALT activity showed significant increase but the group (s) treatment with Sarcocephalus latifolius and vitamin C showed significant reduction AST and ALT activity when compared with the mercuric chloride treated group. Histological examination revealed hepatic and glomerular degeneration and disruption in the mercuric chloride treatment group while Sarcocephalus latifolius exhibits potent hepatorenal effects against mercuric chloride-induced hepatorenal damages which could be due to its anti-inflammatory and anti-oxidant properties