Extraskeletal myxoid chondrosarcoma is a rare malignant soft tissue tumor of uncertain differentiation, constituting less than 3% of all soft tissue sarcomas. This low grade malignant tumor with high recurrence and metastatic potential, occurs predominantly in proximal extremities and limb girdles of males with thigh being the most common location. Here we present a case in a 35 years old female, who presented with pain and large swelling of around 8cm in lateral side of left leg since five months. Wide local excision of the tumor was done and on histopathology a diagnosis of Extraskeletal myxoid chondrosarcoma was rendered. On Immunohistochemistry the tumor cells showed reactivity for Vimentin, S100 and NSE and was non-reactive for CK. Thus our histopathological diagnosis was reconfirmed by immunohistochemistry. Despite high incidence of local recurrence and metastasis, ESMC has an excellent overall survival rate.

Introduction: Prostatic adenocarcinoma is one of the most frequently diagnosed cancer in adult males which seldom metastasizes to testis. Method: In current study the authors retrospectively analysed the 154 cases of bilateral orchiectomy done as hormonal ablation therapy in cases of prostatic adenocarcinoma. Result: We received a total 154 bilateral orchiectomy specimens of patients with prostatic adenocarcinoma in the period of three years. The Patients presented were from 42-86 year of age with a mean age of 60 years. In most (83.11%) of the cases testes were atrophied, 15.58% cases presented with normal histology and only two cases (1.30%) were reported positive for metastasis in testicles. Interestingly both of our cases also had a low PSA level. Conclusion: Testicular atrophy is the most common histopathological finding in patients of bilateral orchiectomy done for prostatic adenocarcinoma. Testicular metastasis is very rare but its possibility highlights the need for continued monitoring of patients with a history of prostatic cancer for local recurrences as well as metastatic disease. It also shows the importance of detecting metastasis to rare locations such as testicles specially in the setting of low PSA levels.

Background: Stromal tumors arising in GastroIntestinal tract were generally regarded as smooth muscle neoplasms such as leiomyoma, leiomyosarcoma, leiomyoblastoma and bizarre leiomyomas but relatively few of these neoplasms had convincing ultrastructural evidence of smooth muscle differentiation. Aims & objectives: The main aim of the study is to review cases of Gastrointestinal Stromal Tumors and to categorize these neoplasms based on the “risk of metastasis”. Materials & methods: The study was done for three years and we received 30 specimens consisted of resections and biopsies from gastrointestinal tract in the department of pathology and diagnosed as Gastrointestinal Stromal Tumors, for which we assessed the risk of metastasis. Results: There was a preponderance of high risk Gastrointestinal Stromal Tumors with 21 cases (70%), followed by intermediate risk 5 cases (16.67%), low risk 2 cases (6.67%) and very low risk 2 cases (6.67%). Conclusion: Gastrointestinal stromal tumors are a heterogenous group of neoplasms. With the advent of targeted therapy using gleevac the responsibility of the pathologists has increased to give a specific diagnosis. It is also important to suggest the prognosis based on the pathological findings.

Candida is yeast like fungus and ubiquitous human commensal. They become pathogens and cause infections when the host's resistance to infection is lowered either locally or systemically [1]. The present study was conducted to evaluate the advantages of CHROM agar from various clinical samples for Isolation of Candida. In this study Candida albicans was isolated in 48.4% species. 248 samples were collected, where Urine sample was the most common sample (68.1%) followed by Pus (13.3%) and blood (14.3%). The percentage of other samples was less than 4.3%. Candida culture was positive in 25% of the samples. The most common organism isolated among bacteria was E.coli (10.2%). Growth on Saboraud dextrose agar culture was positive in 25% of the samples. Gram staining was positive in 25% of the samples. Germ tube test was positive in 51.6% of the samples. Candia albicans was the most common species isolated (51.6%) followed by C.tropicalis (38.7%), C.kruseik (8.1%) and C.glabrata (1.6%). Non-Candia albicans was isolated in 48.4% species.

Among the branchial cysts, those arising from second arch, which appear in the mid neck are the most common. It is followed by cysts arising from the third and fourth arch, which appears in the lower neck, supraclavicular or suprasternal location. But branchial cysts presenting as a mediastinal mass is very rare. Here we present four different clinical presentations of branchial cysts with their gross morphology and microscopic findings.