Endometrial Adenocarcinoma is one of the common malignancies of the female genital tract. It is associated with specific risk factors, which can be acquired and genetic. There are various precursor lesions of this condition, which warrants detection by proper screening methods to aid in earlier diagnosis and thereby treat these conditions to prevent their progression to well established adenocarcinoma. There are Several Histo-pathological mimickers which simulate Adenocarcinoma, that need to be differentiated by proper clinicopathological evaluation, so the correct diagnosis is made, which helps in overall management of patient. This study is an attempt to describe various precursor lesions of Endometrial Adenocarcinoma and also the differentiation of Pathological conditions that are the look alike of Endometrial Adenocarcinoma. In addition various clinicopathological methods will be described which help to arrive at proper diagnosis. Risk categories for Endometrial carcinoma will be identified which helps in early diagnosis of Disease.

Background: Rabies is a cosmopolitan anthropozoonosis for which humans are accidental victims. In Morocco, rabies is an endemic disease, with new cases of human rabies reported every year. The aim of our study is to analyze the epidemiological aspects of rabies in the province of Ouarzazate. Materials and Methods: This is a retrospective study using records available at the Ouarzazate Municipal Hygiene Office. It includes 1,759 cases of exposure to animal bites between 2016 and 2019. Results: We identified 1,759 cases of animal bites during the period of 4 years of study, representing an average annual exposure rate of 190/100,000 inhabitants. Most cases were rural (65%). The median age of bitten cases was 28 years, with people under 15 years of age exposed in 32% of cases. Males predominate, with 61.3% of cases. Dogs are the main animal aggressors at 47.8%, followed by cats at 33%. The upper limbs are the preferred sites of aggression (89.2%). Exposure was grade III in 76.8% of cases. Lesions were multiple in 52.1% and superficial in 62.6%. No cases of human rabies have been recorded since 2001, despite 20 cases being exposed to a biologically confirmed rabid animal during our study. Conclusion: Rabies remains a public health concern in the province of Ouarzazate, despite the presence of a national rabies control program. Effective control of this zoonosis requires strengthening education and community engagement, as well as close collaboration between animal health and human health sectors for integrated management of bite cases.

The rapid rise of antimicrobial resistance to commercially available antibiotics has led researchers to search for an alternative drug source. Medicinal plants pose as a potential source of natural antimicrobial drugs that compact drug resistant microorganisms. The qualitative phytochemical analysis of M. oleifera leaves and flowers extracts led to the identification of an important pharmacological bioactive natural compounds. The antibacterial activity of leaves and flowers extract were determined using agar disc diffusion method and MIC assay against selected human pathogens. The ethanolic and methanolic leaves and flowers extracts yielded 19.5%, 24.38%, 15.62% and 18.02% respectively. Leaves and flowers extracts were active against bacterial strains in a dose dependent manner. The ethanolic leaves extract (100 mg/mL) possessed potential antibacterial activity against the two tested Gram-negative bacteria: E. coli, A. baumannii and three Gram-positive bacteria: Staphylococcus aureus, S. saprophyticus and E. Faecalis by producing 20.00±0.50, 20.67±0.84, 15.33±1.04, 20.43±0.63, 25.83±0.76 mm zone of growth inhibition respectively compared to the control. However, methanolic leaves extract exhibited considerable inhibitory efficacy against two bacterial strains A. baumannii and S. saprophyticus with 17.17±0.59 and 15.81±0.62 respectively. The tested strains were highly sensitive to 200 mg/mL where the highest zone of inhibition was 30.29±0.92 mm observed against E. faecalis, and the lowest zone of inhibition was against Staphylococcus aureus with 20.33±1.04 mm. Both ethanolic and methanolic extracts showed antimicrobial efficacy more than that exhibited by ethanolic and methanolic flowers extracts. Ethanolic and methanolic leaves extracts had MIC of 200 mg/mL against all tested strains where ethanolic leaves extract showed MIC of 100 mg/mL against three strains, E. coli, A. baumannii and S. saprophyticus. This study suggests that the extracts of M. oleifera can be used to discover antibacterial agent for developing new pharmaceuticals against human pathogens.

We describe the evolution of patients with perineal Crohn's disease (PCD) treated with immunomodulators (IM): the purine anti-metabolites or methotrexate (MTX) in the absence of biotherapy. This was a retrospective descriptive study including all patients with (PCD) treated with (IM) and who cannot get biotherapy. The evaluation of the response was based on clinical response and / or morphology. Overall, 62 patient were under (IM). a good result was observed in 63% with complete healing in 79.2% and a partial response in 20.8%. The response time was variable with a median of 4 [2-24] months. Our study shows that despite the progress of biotherapy, the purine anti-metabolites retain their place in the treatment of Crohn's disease in general and in (PCD) more specifically.