This article presents results of the study on 100 patients with pathology of gastrointestinal tract (erosive bulbitis, nonspecific ulcerative colitis, chronic gastritis, ulcer disease and gastric cancer) in order to investigate association of these pathologies with different genotypes of Helicobacter pylori in Uzbekistan. The researches showed, that the most frequent association with Cag+ was noted in the patients with ulcer disease and gastric cancer, and in a less degree with erosive bulbitis and nonspecific ulcerative colitis.

Xanthogranulomatous gastritis is an extremely rare condition and only few cases have been reported in literature. It is an inflammatory tumor like lesion usually misdiagnosed preoperatively as an advanced gastric cancer. We report one such rare case in a 68 year old female who came with complaint of epigastric pain and vomiting for 15 days. Endoscopy revealed solitary elevated nodule in the gastric lesser curvature. Clinical diagnosis was suspicious of gastric carcinoma. Histopathologically foamy histiocytes with dense chronic inflammatory infiltrate were seen in gastric wall suggestive of xanthogranulomatous gastritis

They include Cell surface antigens; Cytoplasmic proteins, Enzymes, Hormones and most of them are proteins. They can be products of cancer cells themselves or of the body in response to cancer or other conditions. A marker represents a qualitative or quantitative alteration or deviation from normal of a molecule, substance, or process that can be detected by some type of assay. An elevated level of a tumor marker can indicate cancer; however there can also be other causes of the elevation. Thus, Tumour markers cannot be construed as primary modalities for the diagnosis of cancer. These tumor markers help in screening, diagnosing the diseased condition, staging of the disease, guiding and monitoring the treatment, to determine the prognosis and to prevent recurrence.

Spinal tuberculosis (pott’s disease) is a common manifestation of extrapulmonary tuberculosis. Spinal langerhans cell histiocytois is also a granulomatous condition which can resemble pott’s disease in many aspects.In the tropics where pott’s disease is common, diagnosis of spinal langerhans cell histiocytois may be masked. We describe a case of recurrent langerhans cell histiocytosis with a long lag period whereas the first presentation was compatible with spinal langerhans cell histiocytosis on retrospective analysis. This case highlights the importance of high index suspicion of langerhans cell histiocytois in the tropical medicine.

This paper devoted to the results of Helicobacter pylori infection spreading in Uzbekistan, its molecular-genetic characteristics, antibiotic resistance. It is shown that Uzbekistan belongs to the regions with a high degree of infection of the population of the HP. Pathogenic Cag positive bacterial strains were associated with chronic Helicobacter pylori associated gastritis. The resistance of HP to clarithromycin in the region was 13.3%. The effectiveness of the 7-day eradication triple therapy was 65%. Prolongation of the period of eradication therapy to 14 days and the inclusion of a complex of therapies of bismuth preparations allowed increasing the effectiveness of therapy to 95%.

Xanthogranulomatous inflammation is an unusual destructive chronic inflammatory process that involves various organs & tissues particularly gallbladder (xanthogranulomatous cholecystitis) & kidney (xanthogranulomatous pyelonephritis). Xanthogranulomatous appendicitis (XA) is a rare form of appendiceal inflammation that has been regarded as an unusual healing pattern of appendicitis associated with delayed or interval appendectomy. It poses a significant diagnostic challenge because it can mimic clinically, radiologically, & even pathologically malignant tumors as well as other inflammatory processes of appendix. Little information has been written in the literature regarding this entity. In this review article, data have been collected from all the previously reported cases in the literature including my observation in a XA case I have diagnosed.

Leprosy is a skin disease affecting also the nerves was caused by Mycobacterium leprae. Multidrug therapy (MDT) cures the infection, but immunological reactions may occur and neuropathy may lead to disability and deformity. The current study aimed to understand the immune status of the patient before and after treatment by correlating histological subtype and peripheral blood lymphocyte count. Total number of 35 cases was studied. Blood samples were taken from the patients and complete blood picture was done before instituting the MDT including TLC and DLC. After 6 months of treatment, patients were followed up with complete blood picture. In lepromatous leprosy group (BL+LL) total mean WBC count was increased with 11,414 (range 7,000- 22,600 mm3) above the range of normal limits before treatment. It was in the mean normal range after treatment with 8514 (range 5,900- 11,000mm3). Lymphocyte count has increased after treatment. After the treatment, there is considerable increase in lymphocyte count. It was in the range of 34% to 42% with a mean value of 38.1%.

Surgical resection of gall bladder is a common surgery and the most common indication for it, is inflammation. Incidental diagnosis of malignancy in such specimens changes the entire perspective of future management for the patient as gall bladder carcinoma is a malignancy with poor prognosis and high fatality. The aim of the study is to study the clinicopathological to study the clinic pathological correlation of the cholecystectomy specimens received in our pathology laboratory. This was a retrospective study over a period of 2 years from June 2015 to May 2017. The case reports were reviewed and data collected. The age and sex incidence, the presenting complaint with duration, the investigations done, the clinical diagnosis and histological diagnosis were analysed. A total of 200 cases of gall bladder were received in the lab during the study period. About 65% were women and the age group commonly involved was 40 to 60yrs. The most common presenting symptom was right upper quadrant pain. The clinical diagnosis correlated with the histopathological diagnosis in 99% of patients while it was different in two cases (1%). Both the cases were adenocarcinoma of gall bladder diagnosed incidentally during histopathological examination. Though the two patients had had CT done preoperatively, gall bladder malignancy was diagnosed histopathologically only. This stresses the importance of meticulous examination of gall bladder specimens and the importance of examining the surgically resected margins of the gall bladders.