ORIGINAL RESEARCH ARTICLE | March 30, 2018
A Comparative Study - Manual Method against Automated Peripheral Smear Preparation
Dr. Anbumozhi M.K
Page no 83-85 |
10.21276/sjpm.2018.3.3.4
A blood film or peripheral blood smear is a thin layer of blood smeared on
a microscope slide and then stained in such a way to allow the various blood cells to
be examined microscopically. This can be done by manual method or with automated
analysers. This study is based on comparative study of manual method and
automation (SC 120 auto slide maker and stainer) in making of blood films for
evaluation.
CASE REPORT | March 30, 2018
Acute Megacaryoblastic Leukemia in Infants (About a Case)
Mahha Mariam, Tlemçani Imane, Hendi Rajae, Bouramdane Sanae, Benmiloud Sara, Hida Moustapha, Amrani Hassani Moncef
Page no 73-75 |
10.21276/sjpm.2018.3.3.1
Acute megakaryoblastic leukemia, or type 7 (AML 7), is a rare entity
defined by a proliferation of blasts of which at least 50% are megakaryoblasts. It
represents 0.5 to 2% of acute leukemias (LA) in children and 3 to 10% of acute
myeloid leukemias (AML). Patients may have nonspecific symptoms. His diagnosis is
based on the presence in the blood or in the marrow of blasts with typical morphology
and expressing specific platelet antigens. This observation describes the clinical case
of a 19-month-old infant with pancytopenia. The diagnosis of AML7 was made based
on explorations of peripheral blood, myelogram, and immunophenotypic analysis.
Chemotherapy has been started, with a poor therapeutic response. The patient died in
a state of septic shock. We recall through a literature review the clinical, histological
and immunophenotypic features of acute megakaryoblastic leukemia.
ORIGINAL RESEARCH ARTICLE | March 30, 2018
The Distribution of Sexually Transmitted Infections (STI) in Batticaloa, Eastern Province of Sri Lanka
Thirukumar M
Page no 76-79 |
10.21276/sjpm.2018.3.3.2
In developing countries, the sexually transmitted infection is one of top
five diseases to which adults seek for medical help. There is an association between
common STIs and sexual transmission of HIV. Therefore, control of STIs receives
attention to control the spread of HIV. A retrospective study was conducted in
Teaching Hospital Batticaloa during the period between 2014 and 2016. A total of
1190 cases were newly registered in STD clinic, of which 317 cases were confirmed
to be having STIs. A total of 317 confirmed cases of infection episodes were recorded
in all patients attended to STD clinics during this three years. Of which, 96.8% were
due to STI and 3.2% due to lower reproductive infections. Among the STIs; genital
herpes (22.71; Syphilis (16.71%). gonorrhoea infection 4.41%. Trichomonas vaginalis
was 7.25%. During the period of three years only one case of HIV was identified.
Hepatitis B infection constitutes to 15.14% stays in order next to Syphilis .bacterial
infections shows a decreasing trend while a gradual increase of viral infections is
observed. Public health should be strengthened especially use of condom and
avoiding sexual contact with unreliable sexual partner in order to control STIs
CASE REPORT | March 30, 2018
Microscopic Thymoma in a Patient with Early Onset Myasthenia Gravis- A Case Report
Dr. Umasankar P, Dr. Lakshmi Priya U, Dr. P. V Ramnarayan, Dr Abdul Jaleel, Dr Mansoor C Abdulla
Page no 80-82 |
10.21276/sjpm.2018.3.3.3
We present a rare entity of incidentally detected microscopic thymoma in
the thymectomy specimen of a female with early onset myasthenia gravis. The
thymus was of normal size radiologically and macroscopically. Histological sections
examined show multifocal tiny thymic epithelial proliferation suggestive of
microscopic thymoma. Microscopic thymomas are rare tumours and less than 20
cases have been reported worldwide
ORIGINAL RESEARCH ARTICLE | March 30, 2018
Study of Dermal Vascular Changes in Inflammatory Skin Diseases
Dr. Charusheela R. Gore, Dr. Pradnya Shende, Dr. Sourabh P. Paranjape, Dr. Padmakar R. Bardapurkar, Dr. Shirish S. Chandanwale, Dr. Namrata Patro
Page no 86-92 |
10.21276/sjpm.2018.3.3.5
The skin is the largest organ in the body. A multitude of diseases are linked
to an insufficient or overactive dermal vasculature. Vessels change their
phenotype,i.e. vascular remodelling in inflammatory conditions. The aim of this study
was to analyse the dermal vascular alterations in various inflammatory skin diseases
& to assess their utility in establishing the differential diagnosis. A unicenter study of
55 (fifty five) skin biopsies received from patients of various non tumorous common
inflammatory skin diseases such as, psoriasis, lichen planus, erythema multiform,
blistering (bullous) lesions and 10 control samples were studied. Morphometric
analysis was performed on CD 34 immunostained sections using image analysis
software (Leica Q Win V3 software analysis system). Mean vascular density (MVD)
and mean vascular calibre (MVC) was calculated. The MVD was maximum in
psoriasis, followed by lichen planus, bullous lesions and erythema multiform. MVD
in psoriasis was significantly higher than the controls. MVC was highest in psoriasis
followed by erythema multiform, lichen planus and bullous lesions. The MVC in
psoriasis, erythema multiform, lichen planus, bullous lesions were significantly higher
than the controls. Elongated, tortuous blood vessels were more prominent in psoriasis.
The endothelial changes noted were swelling in the form of nuclear hypertrophy,
increased cytoplasm and endothelial gaps. Angiogenesis was increased in
inflammatory skin diseases and it was highest in psoriasis. Therefore, therapeutic
intervention at the level of vasoproliferation may prove to be useful.
ORIGINAL RESEARCH ARTICLE | March 30, 2018
Antimicrobial Activity of solvent Extracts of Selected Red Sea Macroalgae against Some Pathogenic Microorganisms
Ehab Omer Abdalla, Mohammed Taha Abdalla Shigidi, Hassan Elsubki Khalid
Page no 93-98 |
10.21276/sjpm.2018.3.3.6
This study was carried out to evaluate the antimicrobial activity of hexane,
chloroform, ethyl acetate and water extracts of six marine macroalgae belonging to
different families namely green algae (Chlorophyceae), brown algae (Phaeophyceae)
and the red algae (Rhodophyceae) collected from the intertidal area of the Sudanese
Red Sea coast near Port Sudan. Successive extraction techniques using hexane,
chloroform, ethyl acetate and water were used for extracting the active principles of
the algae and the disc-diffusion method was performed to examine the activity of the
crude extracts against four pathogenic bacteria and one fungus. Most of the tested
algal extracts exhibited considerable bioactivity and inhibited the growth of most of
pathogenic microorganisms under investigation. The chloroform extract of the red
alga Gracillaria sp produced a maximum inhibition zone of 22 mm against
Escherichia coli whereas the chloroform extract of the red alga Laurencia papillosa
showed a low antimicrobial activity with a minimum inhibition zone of 5 mm against
Bacillus subtilis.