We describe the first case report of an Adult Onset Still’s Disease (AOSD) in a previously healthy young man from Jazan, Saudi Arabia in the summer of 2017. The patient symptoms, signs and investigations fulfilled Yamaguchi’s criteria for the diagnosis of Adult Onset Still’s disease [1]. The patient experienced a sore throat, high grade fever, right knee arthralgia, left knee arthritis, a generalized salmon colored rash, leukocytosis, elevation of liver transaminases, high LDH, high ferritin, absence of ANA, RF, AMA, ASMA and DNA and reactive bone marrow aspiration and biopsy without any evidence of infectious diseases etiologies or malignancies that were satisfactory to confirm the diagnosis of AOSD. We have observed an evidence of two different bacterial sources simultaneously as triggering etiologies; positive ASO titer and positive blood culture for E. Coli where the clinical features and laboratories investigations derangement post antibiotics treatment have remained. The patient has responded to the pulse methylprednisolone and tapering doses of prednisolone. Our successful clinical experience in the case is that the prednisolone lower doses combined with NSAID (voltaren) to minimizing the steroid adverse effects was sufficiently effective to maintaining remission.

Cyclospora cayetanensis is a protozoan responsible for cyclosporosis, it is a digestive coccidiosis in the tropical and intertropical area. The human being constitutes the only reservoir and his transmission is related to the fecal content based on the ingestion of water and / or food contaminated by infectious oocysts. This infection is mainly responsible for watery diarrhea which can be severe in immunocompromised patients. We report a case of a little girl with acute lymphoid leukemia type B in whom we diagnosed a digestive infection with Cyclospora cayetanensis.

The aim of this study is to identify the most informative cerebrospinal fluid (CSF) markers in the diagnosis of active neurosyphilis and in surveillance during antibiotic treatment. It is about a retrospective, analytical, epidemiological study over a period of 10 years, from 1 January 2006 to 31 December 2016 conducted in the laboratory of microbiology of CHU HASSAN II of Fez. We have identified 30 cases of neurosyphilis over a 10-year period. All patients were HIV negative. We realised: on the CSF, a cytochemical examination, white and red blood cell count, a total protein and glucose levels. On CSF and serum, VDRL and TPHA tests for the detection of specific antibodies. The CSF study showed 6 cases (20%) of meningitis with cytology varying between 20 and 890 cells / ml predominantly lymphocytic. 40% of cases had hyper-proteinuria with extremes 0.2 and 4.3 g / l, glycorachia was normal in all cases. The initial titration of VDRL and TPHA was positive in 18 (60%) and 22 (74%) in the CSF, respectively, and 20 (67%) and 26 (87%) in the serum. An accurate and simple approach to the diagnosis of neurosyphilis remains elusive and the diagnosis continues to require a thorough assessment of the patient, including exposure to the risk, presence of compatible clinical signs and symptoms, and laboratory. While direct tests (such as microscopy or PCR) are useful in early infection, serological testing remains the mainstay of the diagnosis of neurosyphilis.

Marine organisms are potential sources of unique natural products with pharmacological and biological activities. In mariculture, diseases of microbial origin can cause huge economic losses worldwide. The evolution of microorganism resistance to antibiotics has resulted in a growing need for new antibacterial compounds that are effective in veterinary medicine and characterized by limited undesirable side effects. Increased attention has recently been turned to plants as a promising source for metabolites with antimicrobial activity. Achyranthes aspera is one such important plant with various established pharmacological properties. The aim of the present study was to assess the antibacterial activity of the Achyranthes aspera extract against Vibrio alginolyticus 1374. Aqueous extract of Achyranthes aspera was prepared. Different concentrations of the root and stem extracts of Achyranthes aspera were transferred to the agar plates, which had been streaked with the bacterium Vibrio alginolyticus; 1374. The plates were incubated aerobically at 37°C for 24 h and the zones of inhibition were measured using well diffusion method. Achyranthes aspera extract showed significant zones of inhibition. Achyranthes aspera showed marked antibacterial activity against Vibrio alginolyticus 1374.

Antimicrobial resistance became a growing public health problem in the world and sexually transmitted infections (STIs) are one of the five types of pathologies which special care should be given. Staphylococcus aureus appear the most prevalent bacteria encountered causing infections in male urethral discharge (MUD) at Cotonou in Benin. It prevalence and it resistance to antibiotics were evaluated. This paper aims to describe the bacterial profile and antimicrobial susceptibility of S aureus strains isolated from MUD specimens at the National Laboratory (NL) of Heath Ministry. A retrospective study included 81 men at Cotonou suspected MUD during 1st January 2004 and 31st December 2015. MUD swabs were collected and analyzed to identify the bacteria by standard biochemical reactions, screening of trichomonads and detection of intracellular Gram-negative diplococci within phagocytes. The three main pathogens encountered among 81 MUD were Staphylococcus aureus (30/81; 37.04%), Staphylococcus spp (19/81; 23.46%) and Staphylococcus dore (12/81; 14.81%). S aureus susceptibility ranged from 60- 80% for minocyclin, lincomycin, chloramphenicol and gentamycin. But resistance was observed to ofloxacin, kanamycin, amoxicillin, amoxicillin-clavulanic acid, oxacillin, ceftriaxon, tetracyclin, trimethoprim+Sulfonamides and ampicillin between 59-100%. Conclusion: This study highlights the importance of routine susceptibility tests to antibiotics in the treatment of S aureus responsible of MUD in Benin.

Primary Squamous cell carcinoma of the gallbladder is extremely rare and constitutes 0.5- 3% of all gall bladder malignancies. We report a 50-year-old female who presented with vague symptom of right upper quadrant pain. She was operated on a presumptive diagnosis of chronic cholecystitis according to clinical and ultrasonography findings. Histopathological examination showed an infiltrating mass of the gallbladder which revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluation revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is very rarely reported. Clinicians must be aware of its vague clinical presentations.

The scalp is a specific anatomic district, in which the most elevated density of pilo-sebaceous follicles is available and terminal hairs are concentrated. Scalp lesions are the most disregarded since they are not effortlessly seen with ensuing deferral in recognition and late treatment. This examination is expected to decide the histopathological investigation of Scalp Lesions. The present review think about assessed 65 instances of scalp lesions from the record of one of the tertiary care hospital of Uttar Pradesh over a span of three years. All the histopathologically demonstrated instances of scalp lesions were explored and clinical points of interest were gotten from the documents. Age, sex, and histology of the considerable number of examples were assessed. Among the 65 cases, 38 (58%)) cases were benign lesions. The male to female proportion was 1.5:1. Benign conditions were most conspicuous and small portion were malignant. Age appropriation in benign lesions was 20-40 years though malignant lesions were found in the elderly. Scalp injuries are uncommon, benign lesions are more common. For each situation of a scalp lesion a wide differential conclusion must be considered. Enhanced clinical experience and hospital participation with more thorough detailing would yield more illustrative information.

This study reports baseline information about melanocytic neoplasms in TUTH. The objective was to study the histological spectrum of melanocytic nevi and melanoma, and to make a clinicohistopathological correlation. 50 consecutive cases of melanocytic neoplasms were studied from December 2010 to December 2011.Of the 50 cases, 12 (24%) were malignant melanoma and 38 (76%) were melanocytic nevi. Cutaneous melanocytic nevi was the commonest, 30/38, (79%) followed by 8/38 (21%) conjunctival nevi. Head and neck was the commonest site (25/38) and the mean age at presentation was 32.66 +16.19 years, the female to male ratio being 5.3:1.In melanoma, 4 (33%) were extracutaneous, of the cutaneous, 2 (17%) were acral lentiginous, and 6 (50%) were nodular. Mean age was 50 + 16.99 years with an equal female to male ratio. Commonest site was extremities (6/8) in cutaneous and choroid in extracutaneous (2/4) lesions. Concordance between clinical and histopathological diagnosis were found in 30/50 (60%) cases. Melanocytic nevi are quite common in females, melanoma is rare, affecting men and women equally. In our context melanoma likely represents a sporadic disorder. Difference from the western societies is the common occurrence of nodular melanoma here and the topographical distribution.

Trichomonas vaginalis amongst other STIs facilitate the natural history of HIV infection and may play an important role in the transmission dynamics of HIV. In this study we determined the prevalence of T. vaginalis infection and associated risk factors among HIV-1 infected women attending antiretroviral treatment Center at Jos University of Teaching Hospital. The study was a cross sectional survey of 168 HIV-1 infected women who presented to the STI clinic with symptoms and/or without symptoms of T. vaginalis infection from November 2015 to January 2016 after obtained informed consent. Demographic data and high vaginal swabs were collected by trained nurse. The samples were examined by light Microscope to identify T. vaginalis, Candida species and bacterial vaginosis. Of 168 HIV-1 infected women, 87 (51.8%) were positive for T. vaginalis infection. The rate of co-infection of T. vaginalis with bacterial vaginosis, Candidiasis was 44.8% and 5.7% respectively, both showed no statistical significance, P=0.360. The highest prevalence of T. vaginalis infection 29.8% was among individuals in the 30-41 years age group while the lowest 3.05% was among individuals in the 54-65 years age group. In the univariate analyses; age, occupation, educational status, marital status, previous history of STI, condom use, multiple sexual partners, pregnancy, ART status and symptoms manifestations showed no significant association, but in multivariate analyses, history of STI , symptoms manifestations showed significant association with p>0.05. The high prevalence of T. vaginalis highlights the need for routine screening among HIV-infected women.