We discuss an interesting case of a 67 years old female patient with an abdominal lump leading to a reporting dilemma among female genital tract lesions in which even though clinical acumen, radiological findings and gross examination of the resected specimen pointed towards a certain malignant provisional diagnosis, actually turned out to be a rare benign entity of Aggressive Angiomyxoma when seen under the microscope and proved on immunohistochemistry, pressing upon the importance of correlation of all the findings (clinical, radiological, gross and microscopy) while making a diagnosis. We also press upon the gravity of proper communication between the reporting pathologist and treating physician for the best possible patient management.

Introduction: Surgical site infection is defined as infection occurring within 30 days after surgical operation and affecting either incision or deep tissues at the operation site. SSIs cause substantial morbidity and mortality. This study was aimed at obtaining the incidence of SSI and to evaluate the risk factors as well as to formulate an antibiotic policy. Aims and Objectives: To determine the incidence, risk factors and the bacteriological profile for SSI and their antimicrobial susceptibility patterns at PDUMC, Rajkot. Materials & Method: Total of 872 pus samples from surgical ward were studied from January 2022 to June 2022. The isolates were identified by colony morphology, Gram’s stain and conventional biochemical reactions. Antibiotic sensitivity testing was done by Kirby-Bauer disc diffusion method as per CLSI guidelines 2021. Results: Total 272 microbial pathogens were isolated. Out of these, 28(10.29%) were Gram- positive Cocci, 244(89.70%) were Gram-negative Bacilli whereas 64 showed polymicrobial growth. Out of total Gram negative isolates, 108(44.26%) showed Klebsiella species followed by Pesudomonas aeruginosa 72(26.50%). Out of total Gram positive isolates, Staphylococcus aureus 16(57.14%) is the predominant pathogen followed by Coagulase Negative Staphylococci 12(42.85 %). Conclusion: The study gives an insight into bacterial pathogens and their antibiotic sensitivity patterns isolated from surgical site infections. Surveillance of SSI helps in early detection, appropriate use of antibiotics & to reduce the rate of SSI.

Testicular tuberculosis (TB) is a rare form of genitourinary TB. It presents as a painless or slightly painful scrotal swelling and so it is difficult to differentiate from typical epididymo-orchitis or other conditions such as tumor or infraction. Middle aged males, especially of 20–40 years of age are most commonly affected, and presented with painful or painless scrotal swelling with or without discharging sinus. Epididymal involvement is usually seen in testicular TB. Ultrasound (USG) and USG-guided fine needle aspiration cytology of testicular swelling for the diagnosis was done, CBNAAT of aspirated fluid of testicular swelling confirm the diagnosis. Anti-TB chemotherapy is the mainstay of treatment to ensure the complete resolution of the lesion. However, in very few cases, surgical removal is required for both diagnosis and treatment. Here, we report a very rare case of left sided isolated testicular TB in a 60-year-old male who was completely cured with 6 months regimen of anti-TB chemotherapy.

Chromoblastomycosis also known as chromomycosis is a chronic fungal infection of the skin and subcutaneous tissue. The infection usually results from traumatic injury or inoculation of microorganism from a specific group of dematiaceous fungi.

Host genetics of COVID-19 patients is constantly evolving and may play an important role in the management of hospitalized patients and the identification of new biomarkers. In 2022, numerous studies have been published examining genetic factors that may be associated with severe outcomes of COVID-19 disease, as well as different genetic biomarkers have been suggested for early diagnosis of severe SARS-CoV-2 infection. In this literature review, we provide relevant updated analyses, examining studies published in 2022 in the literature that correlate with what was published in previous years and that focused on host genetics in patients with severe or fatal forms of COVID-19, Studies using different genotyping and sequencing techniques for the identification of genetic polymorphisms with promising results on different genes of the Renin angiotensin system, Interferon system, ABO system, Apolipoprotein E, Dipeptidyl petptidase, Leucine Zipper Transcription Factor-Like Protein 1(LZTFL1) and HLA system in diverse populations.